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11. 发明申请

US20120184782A1 HEPARANASE ACTIVITY INHIBITOR, WRINKLE IMPROVING AGENT CONTAINING SAME, AND PHARMACEUTICAL COMPOSITION 有权
标题翻译： HEPARANASE活性抑制剂，含有其的改性剂的改性剂和药物组合物
公开(公告)号：US20120184782A1
公开(公告)日：2012-07-19
申请号：US13261236
申请日：2010-09-29
申请人： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
发明人： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
IPC分类号： C07C39/08
CPC分类号： A61K31/05 , A61K8/347 , A61K2800/782 , A61Q19/08
摘要： A heparanase activity inhibitor containing, as an active ingredient, a 4-alkylresorcinol represented by formula (I): wherein R represents a C1-6 linear or branched alkyl group.
摘要翻译：含有由式（I）表示的4-烷基间苯二酚作为活性成分的乙酰肝素酶活性抑制剂：其中R表示C1-6直链或支链烷基。

12. 发明申请

US20100316664A1 Agent For Growing Fibroblasts 审中-公开
标题翻译：用于生长成纤维细胞的药剂
公开(公告)号：US20100316664A1
公开(公告)日：2010-12-16
申请号：US12867771
申请日：2009-03-30
申请人： Masato Iino , Satoshi Amano
发明人： Masato Iino , Satoshi Amano
IPC分类号： A61K8/99 , A61Q19/08 , A61Q19/00 , C12N5/077
CPC分类号： A61Q19/08 , A61K8/97 , A61K8/99
摘要： An agent for growing fibroblasts contains a yeast extract and a safflower extract as effective constituents. A method of growing fibroblasts comprises using a yeast extract and a safflower extract. An anti-aging agent for skin contains a yeast extract and a safflower extract as effective constituents.
摘要翻译：生长成纤维细胞的药剂含有酵母提取物和红花提取物作为有效成分。培养成纤维细胞的方法包括使用酵母提取物和红花提取物。皮肤抗衰老剂含有酵母提取物和红花提取物作为有效成分。

13. 发明授权

US5763094A Sheet material and process for production thereof 失效
标题翻译：片材及其制造方法
公开(公告)号：US5763094A
公开(公告)日：1998-06-09
申请号：US428554
申请日：1995-04-25
申请人： Satoshi Amano , Takahiko Ito
发明人： Satoshi Amano , Takahiko Ito
IPC分类号： C08L21/00 , C08L79/00 , C08L79/08 , B32B5/02 , B32B5/06 , B32B27/00 , B32B27/06
CPC分类号： C08L79/00 , C08L21/00 , C08L79/08 , Y10T428/31678 , Y10T428/31681 , Y10T428/31721 , Y10T442/3594 , Y10T442/3642
摘要： A sheet material including at least: an inorganic filler other than asbestos, a rubber material, a polycarbodiimide resin powder, and, as necessary, an organic or inorganic fiber; or a sheet material including (1) a sheet having the same constitution as the above sheet material and (2) a reinforcing material treated with a polycarbodiimide resin, and a process for producing the sheet material. The sheet material containing no asbestos is free from the problems of the asbestos-containing sheet materials of the prior art, has excellent flexibility, sealing property and heat resistance, and can be used as a gasket, a packing, etc. which are superior in chemical resistance, particularly flon substitute resistance.
摘要翻译：至少包括：除石棉以外的无机填料，橡胶材料，聚碳化二亚胺树脂粉末和根据需要的有机或无机纤维的片材; 或片材，其包括（1）具有与上述片材相同构成的片材和（2）用聚碳化二亚胺树脂处理的增强材料，以及片材的制造方法。不含石棉的片材不含现有技术的含石棉片材的问题，具有优异的柔软性，密封性和耐热性，可用作垫片，填料等优点耐化学性，特别是氟利昂替代耐药性。

14. 发明授权

US5679730A Epoxy resin composition and epoxy resin-based adhesive 失效
标题翻译：环氧树脂组合物和环氧树脂基胶粘剂
公开(公告)号：US5679730A
公开(公告)日：1997-10-21
申请号：US643923
申请日：1996-05-07
申请人： Satoshi Amano , Hideshi Tomita
发明人： Satoshi Amano , Hideshi Tomita
IPC分类号： C09J163/00 , C09J179/00 , C08L63/00 , C08L63/02
CPC分类号： C09J163/00 , C09J179/00
摘要： An epoxy resin composition consisting essentially of an epoxy resin, a thixotropy-imparting agent, a filler used as necessary, water and a polycarbodiimide resin; and an epoxy resin-based adhesive comprising the above epoxy resin composition and a curing agent. The above epoxy resin composition has excellent thixotropy and low stringiness; and the above epoxy resin-based adhesive, when cured, shows neither metal corrosion nor reduction in moisture resistance despite the presence of water in the adhesive, and has excellent heat resistance and adhesivity.
摘要翻译：主要由环氧树脂，触变性赋予剂，根据需要使用的填充剂，水和聚碳化二亚胺树脂组成的环氧树脂组合物; 以及包含上述环氧树脂组合物和固化剂的环氧树脂基粘合剂。上述环氧树脂组合物具有优异的触变性和低的拉丝性; 上述环氧树脂类粘合剂固化时，即使在粘合剂中存在水，也不显示金属腐蚀性和耐湿性降低，并且具有优异的耐热性和粘合性。

15. 发明授权

US5650476A Process for production of polycarbodiimide resin powder 失效
标题翻译：生产聚碳二亚胺树脂粉末的方法
公开(公告)号：US5650476A
公开(公告)日：1997-07-22
申请号：US541157
申请日：1995-10-11
申请人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito , Hideshi Tomita , Norimasa Nakamura
发明人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito , Hideshi Tomita , Norimasa Nakamura
IPC分类号： C08G18/02
CPC分类号： C08G18/025 , C08G2140/00
摘要： A process for producing a polycarbodiimide resin powder, which includes reacting an organic diisocyanate in the presence of a carbodiimidization catalyst in a solvent to produce a polycarbodiimide resin and obtaining the resin in a powder form, where the organic diisocyanate is represented by the following formula ##STR1## where R.sub.1 is a lower alkyl group or a lower alkoxyl group, or ##STR2## where R.sub.2 and R.sub.3 are independently a hydrogen atom, a lower alkyl group or a lower alkoxyl group, and X is an oxygen atom or a methylene group, or ##STR3## where R.sub.4 and R.sub.5 are independently a hydrogen atom, a lower alkyl group or a lower alkoxyl group; the solvent is a mixed solvent of a good solvent to polycarbodiimide resin and a poor solvent to the resin, having a precipitation number of 30-80; and when the reaction has reached a certain stage, the reaction system is cooled to make the system a slurry of a polycarbodiimide, and then the polycarbodiimide is obtained in a powder form.
摘要翻译：一种聚碳化二亚胺树脂粉末的制造方法，其特征在于，在碳二亚胺化催化剂存在下，在溶剂中使有机二异氰酸酯反应，生成聚碳化二亚胺树脂，得到粉末状的树脂，其中有机二异氰酸酯由下式 IMAGE>或，其中R1是低级烷基或低级烷氧基，或者其中R2和R3独立地是氢原子，低级烷基或低级烷氧基，X是氧原子或亚甲基或者其中R 4和R 5独立地是氢原子，低级烷基或低级烷氧基; 溶剂是良溶剂与聚碳二亚胺树脂的混合溶剂和对树脂的不良溶剂的混合溶剂，其沉淀数为30-80; 当反应达到一定阶段时，将反应体系冷却，使体系成为聚碳化二亚胺的浆液，得到粉末状的聚碳化二亚胺。

16. 发明授权

US5416184A High-molecular weight polycarbodiimide solution and methods for producing the same 失效
标题翻译：高分子量聚碳化二亚胺溶液及其制备方法
公开(公告)号：US5416184A
公开(公告)日：1995-05-16
申请号：US517124
申请日：1990-05-01
申请人： Satoshi Amano , Yasuo Imashiro
发明人： Satoshi Amano , Yasuo Imashiro
IPC分类号： C08G73/00 , C08G18/02 , C08G18/00
CPC分类号： C08G18/025
摘要： This invention provides methods for producing a high-molecular weight polycarbodiimide solution from an organic diisocyanate in the presence of a carbodiimidation catalyst, wherein 1) a chlorinated aliphatic hydrocarbon or 2) an alicyclic ether is used as a solvent. This invention also provides a polycarbodiimide solution with excellent stability in preservation.
摘要翻译：本发明提供了在碳二亚胺化催化剂存在下由有机二异氰酸酯制备高分子量聚碳二亚胺溶液的方法，其中1）氯化脂族烃或2）脂环醚用作溶剂。本发明还提供了具有优异的保存稳定性的聚碳化二亚胺溶液。

17. 发明授权

US08475835B2 Transdermal preparation 有权
公开(公告)号：US08475835B2
公开(公告)日：2013-07-02
申请号：US13318370
申请日：2010-04-30
申请人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
发明人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
IPC分类号： A61K9/70
摘要： Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.

18. 发明申请

US20080319084A1 Wrinkling Prevention or Remedy with Adam Activity Inhibiting Substance 审中-公开
标题翻译：亚当活动抑制物质起皱预防或治疗
公开(公告)号：US20080319084A1
公开(公告)日：2008-12-25
申请号：US11665213
申请日：2005-10-13
申请人： Yukiko Matsunaga , Satoshi Amano , Yuki Ogura
发明人： Yukiko Matsunaga , Satoshi Amano , Yuki Ogura
IPC分类号： A61K31/166 , C12Q1/02 , A61Q19/00 , C12Q1/68
CPC分类号： A61Q19/08 , A61K8/42 , A61K8/442 , A61K2800/782
摘要： A composition contains a substance, which is capable of inhibiting activity of ADAM (a disintegrin and metalloprotease) present in a skin, in a proportion efficient for preventing or remedying wrinkling. Wrinkling is prevented or remedied with a method comprising the step of applying a substance, which is capable of inhibiting activity of ADAM present in a skin, to the skin. Anti-wrinkling effects are evaluated with a method wherein enzymatic activity or a gene expression level of ADAM in a skin, a skin tissue, or cells is used as an index.
摘要翻译：组合物含有能够以有效预防或补救皱纹的比例抑制存在于皮肤中的ADAM（解聚蛋白和金属蛋白酶）的活性的物质。通过包括将能够抑制存在于皮肤中的ADAM的活性的物质施用于皮肤的步骤来防止或补救皱纹。使用其中使用皮肤，皮肤组织或细胞中的ADAM的酶活性或基因表达水平作为指标的方法来评价抗皱效果。

19. 发明申请

US20060159782A1 Material for promoting skin basement formation 审中-公开
标题翻译：促进皮肤基底层形成的材料
公开(公告)号：US20060159782A1
公开(公告)日：2006-07-20
申请号：US11304886
申请日：2005-12-16
申请人： Satoshi Amano , Yukiko Matsunaga , Shinji Inomata
发明人： Satoshi Amano , Yukiko Matsunaga , Shinji Inomata
IPC分类号： A61K36/84 , A61K36/53 , A61K36/48 , A61K36/52 , A61K31/445
CPC分类号： A61L27/60 , A61K8/64 , A61K31/00 , A61K31/445 , A61K36/65 , A61K36/74 , A61K36/82 , A61K45/06 , A61K2800/782 , A61L27/22 , A61L27/54 , A61L2300/414 , A61L2300/434 , A61Q19/00 , A61K2300/00
摘要： A method for promoting skin basement membrane formation comprises administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.
摘要翻译：促进皮肤基底膜形成的方法包括施用基质金属蛋白酶抑制剂或基质金属蛋白酶抑制剂和基质蛋白生产促进剂。基质金属蛋白酶抑制剂是N-羟基-2（R） - [[（4-甲氧基苯基）磺酰基]（3-吡啶甲基）氨基] -3-甲基丁酰胺盐酸盐。

20. 发明授权

US06486266B2 Thermosetting resin composition 失效
标题翻译：热固性树脂组合物
公开(公告)号：US06486266B2
公开(公告)日：2002-11-26
申请号：US09924305
申请日：2001-08-08
申请人： Satoshi Amano , Hideshi Tomita
发明人： Satoshi Amano , Hideshi Tomita
IPC分类号： C08L7900
CPC分类号： C08L79/00 , C08G18/025 , C08G59/4042 , C08L63/00 , C09D163/00 , C08L2666/04
摘要： A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: —(NCN—R1)- wherein R1 represents a divalent organic group, with an aromatic diamine represented by the general formula: H2N—R2—NH2 wherein R2 represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.
摘要翻译：通过使包含由以下通式表示的重复单元的碳二亚胺树脂与其中由通式H2N-R2-NH2表示的芳族二胺反应得到的改性碳化二亚胺树脂： - （NCN-R1） - 其中R 1表示二价有机基团其中R2表示具有苯环的二价有机基团，和包含改性碳二亚胺树脂和环氧树脂的热固性树脂组合物。

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