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11. 发明申请

US20050255521A1 59079 and 12599, protein kinase family members and uses therefor 审中-公开
标题翻译： 59079和12599，蛋白激酶家族成员及其用途
公开(公告)号：US20050255521A1
公开(公告)日：2005-11-17
申请号：US11186731
申请日：2005-07-21
申请人： Rosana Kapeller-Libermann , Susan Acton
发明人： Rosana Kapeller-Libermann , Susan Acton
IPC分类号： A61K38/00 , C12N9/12 , C12Q1/68 , C07H21/04 , C07K14/705 , C12N15/09
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 59079 and 12599 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 59079 or 12599 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 59079 or 12599 gene has been introduced or disrupted. The invention still further provides isolated 59079 and 12599 proteins, fusion proteins, antigenic peptides and anti-59079 and anti-12599 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为59079和12599核酸分子，其编码新的蛋白激酶家族成员。本发明还提供了反义核酸分子，含有59079或12599核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及其中已导入或破坏59079或12599基因的非人转基因动物。本发明还进一步提供分离的59079和12599蛋白，融合蛋白，抗原肽和抗59079和抗12599抗体。还提供了利用本发明组合物的诊断和治疗方法。

12. 发明申请

US20050214893A1 Novel human genes and methods of use thereof 审中-公开
标题翻译：新型人类基因及其使用方法
公开(公告)号：US20050214893A1
公开(公告)日：2005-09-29
申请号：US10968812
申请日：2004-10-19
申请人： Rachel Meyers , Rory Curtis , Maria Glucksmann , Rajasekhar Bandaru , Rosana Kapeller-Libermann
发明人： Rachel Meyers , Rory Curtis , Maria Glucksmann , Rajasekhar Bandaru , Rosana Kapeller-Libermann
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N9/02 , C12N9/10 , C12N9/48 , C12N9/90 , C12Q1/26 , G01N33/574
CPC分类号： C12N9/0004 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C12N9/1048 , C12N9/48 , C12N9/90 , G01N33/57411 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875,46842,33201, 83378,84233,64708, 85041,84234,21617, 55562,23566,33489, and 57779 nucleic acid molecules, which encode novel human genes. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人基因的分离的核酸分子，命名为47476,67210,49875,46842,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489和57779核酸分子。本发明还提供反义核酸分子，包含47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,161617,55562,23566,33489或57779核酸分子的重组表达载体，宿主细胞已经引入了表达载体的非人类转基因动物，以及引入了47476,67210,49875,4642,43708,85041,84234,16617,55562,23566,33489或57779基因的非人类转基因动物，或中断了本发明还进一步提供分离的47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489或57779号蛋白，融合蛋白，抗原肽和抗-47476,67210， 49875,4462,33201,83378,84233,66708,85041,84234,21617,55562,253566,33489或57779抗体。还提供了利用本发明组合物的诊断方法。

13. 发明申请

US20050158759A1 68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor 审中-公开
标题翻译：人类泛素羧基末端水解酶家族成员68999，用于此
公开(公告)号：US20050158759A1
公开(公告)日：2005-07-21
申请号：US11013897
申请日：2004-12-16
申请人： Rosana Kapeller-Libermann
发明人： Rosana Kapeller-Libermann
IPC分类号： C12N9/18 , C12Q1/68 , C07H21/04 , C12N9/10 , C12N9/64
CPC分类号： C12N9/18 , C12Y301/02015
摘要： The invention provides isolated nucleic acids molecules, designated 68999 nucleic acid molecules, which encode novel ubiquitin carboxyl-terminal hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 68999 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 68999 gene has been introduced or disrupted. The invention still further provides isolated 68999 proteins, fusion proteins, antigenic peptides and anti-68999 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为68999核酸分子，其编码新的泛素羧基末端水解酶家族成员。本发明还提供了反义核酸分子，含有68999个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及68999基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的68999蛋白，融合蛋白，抗原肽和抗-68999抗体。还提供了利用本发明组合物的诊断和治疗方法。

14. 发明授权

US06900044B2 68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor 失效
标题翻译：人类泛素羧基末端水解酶家族成员68999，用于此
公开(公告)号：US06900044B2
公开(公告)日：2005-05-31
申请号：US10107695
申请日：2002-03-27
申请人： Rosana Kapeller-Libermann
发明人： Rosana Kapeller-Libermann
IPC分类号： C12N9/18 , C12N9/64 , C12N15/57 , C12Q1/68
CPC分类号： C12N9/18 , C12Y301/02015
摘要： The invention provides isolated nucleic acids molecules, designated 68999 nucleic acid molecules, which encode ubiquitin carboxyl-terminal hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 68999 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 68999 gene has been introduced or disrupted. The invention still further provides isolated 68999 proteins, fusion proteins, antigenic peptides and anti-68999 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为68999核酸分子，其编码泛素羧基末端水解酶家族成员。本发明还提供了反义核酸分子，含有68999个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及68999基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的68999蛋白，融合蛋白，抗原肽和抗-68999抗体。还提供了利用本发明组合物的诊断和治疗方法。

15. 发明授权

US06362324B1 17867 a novel human aminopeptidase 有权
标题翻译： 17867是一种新的人氨基肽酶
公开(公告)号：US06362324B1
公开(公告)日：2002-03-26
申请号：US09345650
申请日：1999-06-30
申请人： Rosana Kapeller-Libermann , Mark Williamson
发明人： Rosana Kapeller-Libermann , Mark Williamson
IPC分类号： C07H2104
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/48 , G01N2500/00 , Y02A50/475
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译：本发明涉及新鉴定的人类氨基肽酶。本发明还涉及编码氨基肽酶的多核苷酸。本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

16. 发明授权

US08808694B2 Therapeutic peptidomimetic macrocycles 有权
标题翻译：治疗性拟肽大环化合物
公开(公告)号：US08808694B2
公开(公告)日：2014-08-19
申请号：US13352223
申请日：2012-01-17
申请人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
IPC分类号： A61K39/395 , C12N15/00 , A61K38/12 , A61K38/17
CPC分类号： C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要： The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译：本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。

17. 发明申请

US20120178700A1 PEPTIDOMIMETIC MACROCYCLES 审中-公开
公开(公告)号：US20120178700A1
公开(公告)日：2012-07-12
申请号：US13120360
申请日：2009-09-22
申请人： Huw M. Nash , Rosana Kapeller-Libermann , Jiawen Han , Tomi K. Sawyer , Justin Noehre
发明人： Huw M. Nash , Rosana Kapeller-Libermann , Jiawen Han , Tomi K. Sawyer , Justin Noehre
IPC分类号： A61K38/10 , A61P35/00 , A61K38/16 , C07K7/08 , C07K14/00
CPC分类号： C07K14/47
摘要： The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

18. 发明申请

US20120115783A1 PEPTIDOMIMETIC MACROCYCLES 审中-公开
标题翻译：胶原蛋白
公开(公告)号：US20120115783A1
公开(公告)日：2012-05-10
申请号：US13120376
申请日：2009-09-22
申请人： Huw M. Nash , Rosana Kapeller-Libermann , Jiawen Han , Tomi K. Sawyer , Justin Noehre
发明人： Huw M. Nash , Rosana Kapeller-Libermann , Jiawen Han , Tomi K. Sawyer , Justin Noehre
IPC分类号： A61K38/12 , A61P27/02 , A61P35/00 , C07K7/56 , C07K14/00
CPC分类号： C07K14/4702 , C07K7/56
摘要： The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
摘要翻译：本发明提供新颖的拟肽大环化合物和使用这种大环化合物治疗疾病的方法。

19. 发明授权

US07910346B2 Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 失效
标题翻译：人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途
公开(公告)号：US07910346B2
公开(公告)日：2011-03-22
申请号：US12378703
申请日：2009-02-17
申请人： Ruth E. Gimeno , Rosana Kapeller-Libermann , Zhidan Wu , Brian K. Hubbard
发明人： Ruth E. Gimeno , Rosana Kapeller-Libermann , Zhidan Wu , Brian K. Hubbard
IPC分类号： C12N9/10 , C12N1/20 , C12P7/64 , C12P15/70 , C07H21/04
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译：本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。

20. 发明申请

US20100009384A1 ACTR-1, a novel human acyltransferase and uses thereof 有权
公开(公告)号：US20100009384A1
公开(公告)日：2010-01-14
申请号：US12217258
申请日：2008-07-02
申请人： Rosana Kapeller-Libermann , Thomas Joseph Logan
发明人： Rosana Kapeller-Libermann , Thomas Joseph Logan
IPC分类号： G01N33/53 , C07H21/00 , C12N5/00 , C12N9/10 , C07K16/00 , C12P21/00 , C12N9/99
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

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