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11. 发明授权

US5520883A Test devices for determination of glucose 失效
标题翻译：用于测定葡萄糖的测试装置
公开(公告)号：US5520883A
公开(公告)日：1996-05-28
申请号：US402689
申请日：1989-09-05
申请人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
发明人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
IPC分类号： G01N33/50 , C07H15/04 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N33/72
CPC分类号： C12Q1/28 , C12Q1/54 , G01N33/725 , Y10S436/904 , Y10T436/104998 , Y10T436/144444
摘要： Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.
摘要翻译：公开了可用于测定包含载体基质，葡萄糖氧化酶，指示剂系统和葡萄糖衍生物的葡萄糖或潜血的测试装置，其在加水水解产生葡萄糖时。

12. 发明授权

US5300637A 2-benzothiazolyl tetrazolium salt indicators 失效
标题翻译： 2-苯并噻唑基四唑盐指示剂
公开(公告)号：US5300637A
公开(公告)日：1994-04-05
申请号：US077796
申请日：1993-06-18
申请人： Robert P. Hatch , Nan-Horng Lin , Scott Ruetten
发明人： Robert P. Hatch , Nan-Horng Lin , Scott Ruetten
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04
摘要： 2-Benzothiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.
摘要翻译：已经发现2-苯并噻唑基四唑鎓盐化合物的特征在于反射光谱表现出高于约600-650nm的扩展平台。这些化合物可用作还原物质如NADH的显色指标。反射平稳度使分析测定的准确性提高，特别是对于医学诊断意义的分析物的测定，其中通过反射率测量试剂载体基质上的比色响应。

13. 发明授权

US5187265A Chromogenic thiol indicating benzoisothiazolone compounds 失效
标题翻译：显色硫醇表示苯并异噻唑酮化合物
公开(公告)号：US5187265A
公开(公告)日：1993-02-16
申请号：US843143
申请日：1992-02-28
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： C07D275/04 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22 , G01N31/221 , Y10S436/815 , Y10S534/03 , Y10T436/141111
摘要： The present invention relates to a chromogenic benzoisothiazolone polymer derivative for measuring the presence or appearance of thiols in an aqueous system.
摘要翻译：本发明涉及用于测量水系统中硫醇的存在或外观的显色苯并异噻唑酮聚合物衍生物。

14. 发明授权

US4806631A Immobilization of nucleic acids on solvolyzed nylon supports 失效
标题翻译：固定在溶剂化尼龙支架上的核酸
公开(公告)号：US4806631A
公开(公告)日：1989-02-21
申请号：US781514
申请日：1985-09-30
申请人： Robert J. Carrico , Robert P. Hatch , William L. Patterson
发明人： Robert J. Carrico , Robert P. Hatch , William L. Patterson
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C12Q1/68 , G01N33/50 , G01N33/545
CPC分类号： G01N33/545 , C12Q1/6834 , Y10S435/803
摘要： Immobilization of nucleic acids, e.g., DNA and RNA, by contact with a solid support comprising nylon whose amide groups have been partially solvolyzed. Solvolysis of the nylon support can be accomplished by treatment with an alkylating agent such as a trialkyloxonium salt under anhydrous conditions followed by addition of water. The immobilized nucleic acid is particularly useful as an immobilized probe in hybridization assays to detect specific polynucleotide sequences in a test sample.
摘要翻译：通过与包含其酰胺基部分溶剂分解的尼龙的固体支持物接触来固定核酸，例如DNA和RNA。尼龙载体的溶剂解可以通过在无水条件下用烷基化剂如三烷基氧鎓盐处理然后加入水来完成。固定的核酸在用于检测测试样品中的特异性多核苷酸序列的杂交测定中作为固定化探针是特别有用的。

15. 发明授权

US06210978B1 Method and device for the detection of analyte in a fluid test sample 失效
标题翻译：用于检测流体测试样品中分析物的方法和装置
公开(公告)号：US06210978B1
公开(公告)日：2001-04-03
申请号：US09032884
申请日：1998-03-02
申请人： Robert P. Hatch , Meitak Teresa Yip
发明人： Robert P. Hatch , Meitak Teresa Yip
IPC分类号： G01N33548
CPC分类号： G01N33/54306 , G01N33/54366 , Y10S436/815
摘要： Disclosed is a method for the immobilization of an analyte such as deoxypyridinium (DPD) onto a solid support. The method involves binding an antigen-amino acid-deoxypyridinium complex to the support via an anti-antigen binding partner located in a capture zone of the solid support. Preferably, the support is nitrocellulose and the antigen has the fluorescein structure.
摘要翻译：公开了一种将分析物如脱氧吡啶鎓（DPD）固定在固体支持物上的方法。该方法包括通过位于固体支持物的捕获区域中的抗原抗原结合配偶体将抗原 - 氨基酸 - 脱氧吡啶络合物结合到载体上。优选地，载体是硝酸纤维素，抗原具有荧光素结构。

16. 发明授权

US6033918A Method and device for the detection of analyte in a fluid sample 失效
标题翻译：用于检测流体样品中分析物的方法和装置
公开(公告)号：US6033918A
公开(公告)日：2000-03-07
申请号：US967580
申请日：1997-11-10
申请人： Robert P. Hatch , Meitak Teresa Yip
发明人： Robert P. Hatch , Meitak Teresa Yip
IPC分类号： G01N33/53 , G01N33/543 , G01N33/548 , G01N33/553
CPC分类号： G01N33/54353 , Y10S436/815
摘要： Disclosed is an improvement to the technique for immobilizing an analyte onto a solid surface for use in a competitive immunoassay. The improvement involves immobilizing the analyte on the solid surface by reacting the analyte or derivative thereof with polyethylene glycol which has been functionalized with a group which is reactive with the analyte contacting the resulting conjugate with the solid surface to thereby immobilize the analyte.
摘要翻译：公开了用于将分析物固定在固体表面上用于竞争性免疫测定中的技术的改进。改进之处在于通过将分析物或其衍生物与聚乙二醇反应来固定分析物，所述聚乙二醇已经与被分析物反应的基团官能化，所述分析物与所得到的共轭物与固体表面接触，从而固定分析物。

17. 发明授权

US5130433A Chromogenic thiol indicators based on an isobenzothiazolone ring system 失效
标题翻译：基于ISOBENZOTHIAZOLONE环系统的色谱THIOL指示剂
公开(公告)号：US5130433A
公开(公告)日：1992-07-14
申请号：US546703
申请日：1990-07-02
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： G01N31/00 , C07D275/04 , C09B29/039 , C09B57/00 , C09B69/00 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22
摘要： Newly synthesized chromogenic thiol-indicating benzoisothiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristic light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.

18. 发明授权

US5128457A Chromogenic thiol indicators based on an isobenzothiazolone ring system 失效
标题翻译：基于异苯并噻唑酮环系的显色硫醇指示剂
公开(公告)号：US5128457A
公开(公告)日：1992-07-07
申请号：US802527
申请日：1991-12-05
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： C07D275/04 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22 , G01N31/221
摘要： Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.
摘要翻译：具有以下结构的新合成的显色硫醇指示苯并噻唑酮衍生物：其中R1，R2和R3如说明书中所定义，可用于检测硫醇，特别是在水系统中。该方法包括使含水系统与如本文所述的显色硫醇表示的苯并异噻唑酮衍生物接触。然后发生由于硫醇介导的苯并噻唑酮衍生物的还原引起的发色变化。这种变化可以在溶液中或与接触的或与水系统接触的指示剂表面上。由于苯并异噻唑酮衍生物还原后特征光吸收的红移发生的发色变化与水系中硫醇的出现量或速率成正比。

19. 发明授权

US5126275A Analytical method using tetrazolium salt indicators having a reflectance plateau 失效
标题翻译：使用具有反射率的四氯化钡盐指示剂的分析方法
公开(公告)号：US5126275A
公开(公告)日：1992-06-30
申请号：US584907
申请日：1990-09-19
申请人： Robert P. Hatch , Jurgen Kocher , Nan-Horng Lin , Scott Ruetten , Klaus Wehling
发明人： Robert P. Hatch , Jurgen Kocher , Nan-Horng Lin , Scott Ruetten , Klaus Wehling
IPC分类号： C07D417/04 , C12Q1/00 , G01N21/78 , G01N31/22 , G01N33/50 , G01N33/52
CPC分类号： C12Q1/008 , G01N33/52 , G01N33/521 , Y10S435/805
摘要： General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

20. 发明授权

US4895798A Test devices for determination of occult blood 失效
标题翻译：用于测定隐血的测试装置
公开(公告)号：US4895798A
公开(公告)日：1990-01-23
申请号：US119977
申请日：1987-11-13
申请人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
发明人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
IPC分类号： G01N33/50 , C07H15/04 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N33/72
CPC分类号： C12Q1/28 , C12Q1/54 , G01N33/725 , Y10S436/904 , Y10T436/104998 , Y10T436/144444
摘要： Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.

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