专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US3987047A Tetrahydro-azepinoquinolines 失效
标题翻译：四氮唑腈
公开(公告)号：US3987047A
公开(公告)日：1976-10-19
申请号：US520965
申请日：1974-11-05
申请人： Gerhart Griss , Rudolf Hurnaus , Wolfgang Grell , Robert Sauter , Richard Reichl
发明人： Gerhart Griss , Rudolf Hurnaus , Wolfgang Grell , Robert Sauter , Richard Reichl
IPC分类号： C07D471/04 , C07D491/14 , C07D491/147
CPC分类号： C07D471/04 , C07D491/14 , Y10S514/96 , Y10S514/966
摘要： Compounds of the formula ##SPC1##Wherein ##EQU1## where R.sub.1 is hydrogen, straight or branched aliphatic acyl of 1 to 12 carbon atoms, methoxy-substituted straight or branched aliphatic acyl of 1 to 12 carbon atoms, benzoyl, halo-benzoyl, carbalkoxy of 2 to 7 carbon atoms, carbcycloalkoxy of 4 to 7 carbon atoms, benzyl, methylbenzyl, phenylsulfonyl, halo-phenylsulfonyl, tolylsulfonyl, alkenyl of 2 to 6 carbon atoms, phenyl, trifluoroacetyl, amidino, amido, thioamido, phenoxycarbonyl, benzyloxycarbonyl, methylsulfonyl or--B -- XwhereB is straight or branched alkylene of 1 to 6 carbon atoms, andX is hydrogen, hydroxyl, methoxy, carboxyl, cyano, dimethylaminocarbonyl, morpholino-carbonyl or carbalkoxy of 2 to 6 carbon atoms,R.sub.2 is hydrogen, hydroxyl, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, alkanoyloxy of 1 to 3 carbon atoms, alkoxycarbonyloxy of 2 to 4 carbon atoms, amino, dimethylamino, morpholino or halogen,R.sub.3 is hydrogen, halogen, hydroxyl, carboxyl, straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxy of 1 to 3 carbon atoms, phenyl-alkoxy of 1 to 3 carbon atoms, carbalkoxy of 2 to 4 carbon atoms -- alkoxy of 1 to 3 carbon atoms, carbalkoxy of 2 to 4 carbon atoms, hydroxymethyl, phenyl, phenoxy, amino, pyrrolidino or morpholino,R.sub.4, r.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen, halogen, methyl, hydroxyl, methoxy, cyano, amino, nitro, trifluoromethyl, carboxyl, acetyl or carbalkoxy of 2 to 4 carbon atoms, or any two of R.sub.4, R.sub.5 and R.sub.6 together are methylenedioxy, andX.sub.1 and X.sub.2 are hydrogen or together form a double bond,6-N-oxides thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anoretics.

12. 发明授权

US5312924A Phenylacetic acid benzylamides 失效
标题翻译：苯乙酸苄基酰胺
公开(公告)号：US5312924A
公开(公告)日：1994-05-17
申请号：US919820
申请日：1992-07-24
申请人： Wolfgang Grell , Rudolf Hurnaus , Gerhart Griss, deceased , Robert Sauter , Manfred Reiffen , Eckhard Ruprecht
发明人： Wolfgang Grell , Rudolf Hurnaus , Gerhart Griss, deceased , Robert Sauter , Manfred Reiffen , Eckhard Ruprecht
IPC分类号： C07D295/135 , C07D295/155 , C07D307/14 , C07D309/04 , C07D211/32 , A61K31/40 , A61K31/445
CPC分类号： C07D307/14 , C07D295/135 , C07D295/155 , C07D309/04 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： The present application relates to the uses of phenylacetic acid benzylamides and new (S)(+)-2-ethoxy-4-[N-[1-2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]benzoic acid and the salts thereof, which have valuable pharmacological properties, namely an effect on the intermediate metabolism, but particularly the effect of lowering blood sugar.
摘要翻译：本申请涉及苯乙酸苄基酰胺和新的（S）（+） - 2-乙氧基-4- [N- [2-哌啶子基 - 苯基）-3-甲基-1-丁基] - 氨基羰基甲基] 苯甲酸及其盐具有有价值的药理学性质，即对中间代谢的作用，特别是降低血糖的作用。

13. 发明授权

US4575504A Thienothiazole derivatives 失效
标题翻译：噻吩噻唑衍生物
公开(公告)号：US4575504A
公开(公告)日：1986-03-11
申请号：US649898
申请日：1984-09-12
申请人： Robert Sauter , Gerhart Griss, deceased , Wolfgang Grell , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler
发明人： Robert Sauter , Gerhart Griss, deceased , Wolfgang Grell , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler
IPC分类号： A61K31/435 , A61K31/55 , A61P9/06 , C07D495/04 , C07D513/14 , A61K31/44
CPC分类号： C07D495/04 , C07D513/14
摘要： Compounds of the formula ##STR1## wherein A is ##STR2## and R is hydrogen, alkyl of 1 to 5 carbon atoms, alkanoyl of 1 to 5 carbon atoms, alkenyl of 3 to 5 carbon atoms, (alkoxy of 1 to 4 carbon atoms)carbonyl, or aralkyl of 7 to 11 carbon atoms optionally halo-substituted,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
摘要翻译：其中A为X，R为氢，1至5个碳原子的烷基，1至5个碳原子的烷酰基，3至5个碳原子的烯基，（1至4个碳原子的烷氧基））羰基或任选被卤素取代的7至11个碳原子的芳烷基，以及无毒的药学上可接受的酸加成盐。化合物及其盐可用作心动过缓。

14. 发明授权

US5604225A Substituted thiazoles and oxazoles and 2-hydroxy-morpholines 失效
标题翻译：取代的噻唑和恶唑和2-羟基吗啉
公开(公告)号：US5604225A
公开(公告)日：1997-02-18
申请号：US449174
申请日：1995-05-24
申请人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
发明人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
IPC分类号： A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/30 , C07D265/32 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14 , C07D413/06
CPC分类号： C07D277/22 , C07D263/32 , C07D265/32 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
摘要： Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.
摘要翻译：描述了可用于治疗糖尿病和肥胖症的取代的噻唑，恶唑和2-羟基吗啉化合物。

15. 发明授权

US5219852A Substituted thiazoles and oxazoles and pharmaceutical compositions and methods thereof 失效
标题翻译：取代的噻唑和恶唑及其药物组合物和方法
公开(公告)号：US5219852A
公开(公告)日：1993-06-15
申请号：US629509
申请日：1991-12-18
申请人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
发明人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
IPC分类号： C07D263/32 , C07D265/32 , C07D277/22 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号： C07D277/22 , C07D263/32 , C07D265/32 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
摘要： Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.
摘要翻译：描述了可用于治疗糖尿病和肥胖症的取代的噻唑，恶唑和2-羟基吗啉化合物。

16. 发明授权

US4886814A Substituted thiazoles and oxazoles and 2-hydroxy-morpholines 失效
标题翻译：取代的噻唑和恶唑和2-羟基 - 吗啉
公开(公告)号：US4886814A
公开(公告)日：1989-12-12
申请号：US93415
申请日：1987-09-04
申请人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
发明人： Manfred Reiffen , Rudolf Hurnaus , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
IPC分类号： C07D263/32 , C07D265/32 , C07D277/22 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号： C07D277/22 , C07D263/32 , C07D265/32 , C07D277/24 , C07D277/32 , C07D277/40 , C07D277/42 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14 , Y10S514/866
摘要： Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.
摘要翻译：描述了可用于治疗糖尿病和肥胖症的取代的噻唑，恶唑和2-羟基吗啉化合物。

17. 发明授权

US5232946A Phenylethanolamines, their use as pharmaceuticals and as performance enhancers in animals 失效
标题翻译：苯乙醇胺，它们用作药物和作为动物中的性能增强剂
公开(公告)号：US5232946A
公开(公告)日：1993-08-03
申请号：US572969
申请日：1990-08-20
申请人： Rudolf Hurnaus , Manfred Reiffen , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
发明人： Rudolf Hurnaus , Manfred Reiffen , Robert Sauter , Wolfgang Grell , Eckhard Rupprecht
IPC分类号： A61K31/13 , A61K31/135 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/40 , A61P3/00 , A61P43/00 , C07C213/00 , C07C215/30 , C07C215/32 , C07C215/48 , C07C215/54 , C07C215/68 , C07C217/56 , C07C217/62 , C07C221/00 , C07C225/16 , C07C227/00 , C07C229/38 , C07C233/43 , C07C237/30 , C07C253/30 , C07C255/53 , C07C255/59
CPC分类号： C07C255/00 , C07C229/38
摘要： The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group,B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group,R.sub.1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group,R.sub.2 represents a hydrogen atom or an amino group,R.sub.3 represents a cyano group, a hydrogen, chlorine or bromine atom andR.sub.4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group,the optical isomers and diastereoisomers and acid addition salts thereof.The new compounds of formula I, the optical isomers and diastereoisomers and acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof with inorganic or organic acids, have valuable pharmacological properties, namely an effect on the metabolism, preferably the effect of lowering blood sugar and reducing body fat and they may also be used as performance enhancers in animals.The new compounds of general formula I above may be prepared by methods known per se.
摘要翻译： PCT No.PCT / EP88 / 01083 Sec。 371日期1990年8月20日 102（e）1990年8月20日日期PCT提交1988年11月29日PCT公布。 WO90 / 06299 PCT出版物日本1990年6月14日。本发明涉及通式为（I）的新型苯乙醇胺，其中A表示直链或支链亚烷基，B表示键，亚烷基，羰基或羟基亚甲基，R1 表示氢原子，卤原子或三氟甲基，R 2表示氢原子或氨基，R 3表示氰基，氢，氯或溴原子，R 4表示氢或卤素原子，烷基，羟基，烷氧基羰基，烷氧基羰基，氨基羰基，烷基氨基羰基或二烷基氨基羰基或由羧基，烷氧基羰基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，羟基，烷氧基，氨基，烷基氨基，二烷基氨基，吡咯烷子基，哌啶子基或六亚甲基亚氨基取代的烷氧基。光学异构体和非对映异构体及其酸加成盐。式I的新化合物，其光学异构体和非对映异构体及其酸加成盐，特别是其与无机或有机酸的生理上可接受的酸加成盐具有有价值的药理学性质，即对代谢的影响，优选降低血液的作用糖和减少身体脂肪，并且它们也可以用作动物中的性能增强剂。上述通式I的新化合物可以通过本身已知的方法制备。

18. 发明授权

US5068325A 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as pharmaceutical compositions 失效
标题翻译： 4,5,7,8-四氢-6H-噻唑（5,4-D）亚胺，其制备及其作为药物组合物的用途
公开(公告)号：US5068325A
公开(公告)日：1991-11-26
申请号：US368753
申请日：1989-06-20
申请人： Wolfgang Grell , Rudolf Hurnaus , Manfred Reiffen , Robert Sauter , Ludwig Pichler , Walter Kobinger , Michael Entzeroth , Joachim Mierau , Gunter Schingnitz
发明人： Wolfgang Grell , Rudolf Hurnaus , Manfred Reiffen , Robert Sauter , Ludwig Pichler , Walter Kobinger , Michael Entzeroth , Joachim Mierau , Gunter Schingnitz
IPC分类号： A61K31/55 , A61P9/00 , A61P25/00 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to new 4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepines of general formula II ##STR1## wherein the substituents are defined herein below, which compounds have valuable pharmacological properties, namely selective effects on the dopaminergic system which are achieved by stimulating (predominantly D2) dopamine receptors.
摘要翻译：本发明涉及通式II（II）的新的4,5,7,8-四氢-6H-噻唑并[5,4-d]吖庚因，其中取代基如下文所定义，该化合物具有有价值的药理学性质，即通过刺激（主要是D2）多巴胺受体而实现的对多巴胺能系统的选择性作用。

19. 发明授权

US4886812A Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals 失效
标题翻译：四氢 - 苯并噻唑，其制备方法及其作为中间产物或药物的用途
公开(公告)号：US4886812A
公开(公告)日：1989-12-12
申请号：US256671
申请日：1988-10-12
申请人： Gerhart Griss, deceased , Claus Schneider , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler , Rudolf Bauer , Joachim Mierau , Dieter Hinzen , Gunter Schingnitz
发明人： Gerhart Griss, deceased , Claus Schneider , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler , Rudolf Bauer , Joachim Mierau , Dieter Hinzen , Gunter Schingnitz
IPC分类号： A61K31/425 , C07D277/82
CPC分类号： C07D277/82
摘要： This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms,R.sub.2 represents a hydrogen atom or an alkyl group,R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms,R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.
摘要翻译：本发明涉及通式为（I）的新的四氢苯并噻唑，其中R 1表示氢原子，烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而上述苯基核酸可各自被1或2个卤素原子取代，R2表示氢原子或烷基，R3表示氢原子，烷基，环烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基基团可以被氟，氯或溴原子取代，R4表示氢原子，烷基，烷基或烯基，或者R3和R4与它们之间的氮原子一起代表吡咯烷子基，哌啶子基，六亚甲基亚氨基或吗啉代基，其对映异构体及其酸加成盐。上述通式I的化合物，其中R1或R3基团或R1和R3两个基团之一表示酰基，是制备其它具有有价值的药理学性质的通式I化合物的有价值的中间产物。新化合物可以使用本身已知的方法制备。

20. 发明授权

US4731374A Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals 失效
标题翻译：四氢 - 苯并噻唑，其制备方法及其作为中间产物或药物的用途
公开(公告)号：US4731374A
公开(公告)日：1988-03-15
申请号：US810947
申请日：1985-12-19
申请人： Gerhart Griss, deceased , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler , Rudolf Bauer , Joachim Mierau , Dieter Hinzen , Gunter Schingnitz
发明人： Gerhart Griss, deceased , Rudolf Hurnaus , Walter Kobinger , Ludwig Pichler , Rudolf Bauer , Joachim Mierau , Dieter Hinzen , Gunter Schingnitz
IPC分类号： A61K31/425 , C07D277/82
CPC分类号： C07D277/82
摘要： This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynylk group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms,R.sub.2 represents a hydrogen atom or an alkyl group,R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by flurorine, chlorine or bromine atoms,R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.
摘要翻译：本发明涉及通式为（I）的新的四氢苯并噻唑，其中R 1表示氢原子，烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而上述苯基核可各自被1或2个卤素原子取代，R2表示氢原子或烷基，R3表示氢原子，烷基，环烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基基团可以被氟里酰，氯或溴原子取代，R4表示氢原子，烷基，烷基或烯基，或者R3和R4与它们之间的氮原子一起代表吡咯烷子基，哌啶子基，六亚甲基亚氨基或吗啉代基，其对映异构体及其酸加成盐。上述通式I的化合物，其中R1或R3基团或R1和R3两个基团之一表示酰基，是制备其它具有有价值的药理学性质的通式I化合物的有价值的中间产物。新化合物可以使用本身已知的方法制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式