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11. 发明申请

US20070050375A1 Extended HTTP error channel 审中-公开
标题翻译：扩展HTTP错误通道
公开(公告)号：US20070050375A1
公开(公告)日：2007-03-01
申请号：US11243350
申请日：2005-10-04
申请人： V.R. Chintalapati , David Kruse , Ahmed Mohamed , Andrew Watson , Dustin Friesenhahn , Jay Paulus , Sundar Subbarayan , Sean McAteer
发明人： V.R. Chintalapati , David Kruse , Ahmed Mohamed , Andrew Watson , Dustin Friesenhahn , Jay Paulus , Sundar Subbarayan , Sean McAteer
IPC分类号： G06F17/30
CPC分类号： H04L67/02
摘要： Techniques for clients and servers to use the web authoring extensions, and in particular, extended error handling to allow servers to provider richer web authoring error information to clients.
摘要翻译：客户端和服务器使用Web创作扩展的技术，特别是扩展错误处理，允许服务器向客户端提供更丰富的Web创作错误信息。

12. 发明申请

US20060165311A1 Spatial standard observer 有权
标题翻译：空间标准观察员
公开(公告)号：US20060165311A1
公开(公告)日：2006-07-27
申请号：US11045041
申请日：2005-01-24
申请人： Andrew Watson
发明人： Andrew Watson
IPC分类号： G06K9/36
CPC分类号： G06T7/0002 , G06T2207/30168 , H04N17/04 , H04N19/60 , H04N19/86
摘要： The present invention relates to devices and methods for the measurement and/or for the specification of the perceptual intensity of a visual image, or the perceptual distance between a pair of images. Grayscale test and reference images are processed to produce test and reference luminance images. A luminance filter function is convolved with the reference luminance image to produce a local mean luminance reference image. Test and reference contrast images are produced from the local mean luminance reference image and the test and reference luminance images respectively, followed by application of a contrast sensitivity filter. The resulting images are combined according to mathematical prescriptions to produce a Just Noticeable Difference, JND value, indicative of a Spatial Standard Observer, SSO. Some embodiments include masking functions, window functions, special treatment for images lying on or near borders and pre-processing of test images.
摘要翻译：本发明涉及用于测量和/或指定视觉图像的感知强度的装置和方法，或一对图像之间的感知距离。处理灰度测试和参考图像以产生测试和参考亮度图像。亮度滤波器功能与参考亮度图像卷积以产生局部平均亮度参考图像。测试和参考对比度图像分别从本地平均亮度参考图像和测试和参考亮度图像产生，然后应用对比度敏感度滤波器。所得到的图像根据数学处方结合起来，产生一个“Just Noticeable Difference”，JND值，表示一个空间标准观察者SSO。一些实施例包括屏蔽功能，窗口功能，位于边界上或附近的图像的特殊处理以及测试图像的预处理。

13. 发明申请

US20060008921A1 Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels 审中-公开
公开(公告)号：US20060008921A1
公开(公告)日：2006-01-12
申请号：US10911364
申请日：2004-08-03
申请人： Robert Daniels , Andrew Watson
发明人： Robert Daniels , Andrew Watson
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N30/02 , B01D15/3804
摘要： Immunochromatographic test strip assays which employ semiconductor nanocrystals as detectable labels are disclosed, as are methods for detecting and quantifying one or more analytes of interest in a test sample using those assays. The test strips of the present invention permit detection and quantitation of one or more analytes of interest present in a test sample suspected of containing them, by using more than one semiconductor nanocrystal as a detectable label, each of which emits exhibits a unique emission peak.

14. 发明申请

US20130295567A1 DIGITAL ANALYTE ANALYSIS 有权
公开(公告)号：US20130295567A1
公开(公告)日：2013-11-07
申请号：US13866126
申请日：2013-04-19
申请人： Darren Roy Link , Qun Zhong , Andrew Watson
发明人： Darren Roy Link , Qun Zhong , Andrew Watson
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/686 , C12Q2563/159 , C12Q2565/629
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.

15. 发明申请

US20060128034A1 Diagnostic test using gated measurement of fluorescence from quantum dots 审中-公开
标题翻译：使用量子点荧光的门控测量进行诊断测试
公开(公告)号：US20060128034A1
公开(公告)日：2006-06-15
申请号：US11008912
申请日：2004-12-10
申请人： Patrick Petruno , Daniel Roitman , Rong Zhou , John Petrilla , Marcel Bruchez , Andrew Watson
发明人： Patrick Petruno , Daniel Roitman , Rong Zhou , John Petrilla , Marcel Bruchez , Andrew Watson
IPC分类号： G01N33/551 , C12M1/34
CPC分类号： G01N21/6428 , G01N21/8483
摘要： A rapid diagnostic test system or process uses a gated measurement of the fluorescent light from quantum dots after shutting off an illuminating light source. A delay between shutting off the illumination and measuring allows background fluorescence from substances other than the quantum dots to drop significantly when compared to the intensity of the fluorescence from the quantum dots. Using quantum dots permits high measurement repetition rates and good extinction of background fluorescence.
摘要翻译：快速诊断测试系统或过程在关闭照明光源之后使用来自量子点的荧光的门控测量。关闭照明和测量之间的延迟允许来自量子点以外的物质的背景荧光与来自量子点的荧光强度相比显着下降。使用量子点允许高测量重复率和背景荧光的良好消光。

16. 发明授权

US06257546B1 Slip casting 失效
标题翻译：滑动铸造
公开(公告)号：US06257546B1
公开(公告)日：2001-07-10
申请号：US09155433
申请日：1999-07-21
申请人： Robert Norman Deakin , Andrew Watson
发明人： Robert Norman Deakin , Andrew Watson
IPC分类号： B28B126
CPC分类号： B28B1/265 , B28B1/263
摘要： A method of slip casting wherein reduced pressure is applied to the mold during casting by virtue of a network of piping extending through the mold. The mold has an impermeable outer coating. Heat may also be applied to the mold during casting, by for example a heated fluid passing through piping located in the walls of the mold.
摘要翻译：一种滑动铸造的方法，其中通过延伸穿过模具的管道网在铸造期间将压力施加到模具。模具具有不透水的外涂层。热也可以在铸造期间通过例如通过位于模具壁中的管道的加热流体施加到模具上。

17. 发明授权

US09176031B2 Labeling and sample preparation for sequencing 有权
标题翻译：标记和样品制备用于测序
公开(公告)号：US09176031B2
公开(公告)日：2015-11-03
申请号：US13774437
申请日：2013-02-22
申请人： Andrew Watson
发明人： Andrew Watson
IPC分类号： C12Q1/68 , G01N1/30
CPC分类号： G01N1/30 , C12Q1/6806 , C12Q1/6869 , C12Q2531/113 , C12Q2563/131 , C12Q2563/159 , C12Q2563/179 , C12Q2525/191 , C12Q2535/122 , C12Q2537/159 , C12Q2563/149 , C12Q2565/629
摘要： The invention provides methods for sequencing and sample preparation for sequencing and amplification.
摘要翻译：本发明提供了用于测序和扩增的测序和样品制备的方法。

18. 发明授权

US09150852B2 Compositions and methods for molecular labeling 有权
标题翻译：分子标记的组成和方法
公开(公告)号：US09150852B2
公开(公告)日：2015-10-06
申请号：US13398677
申请日：2012-02-16
申请人： Michael Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren Roy Link
发明人： Michael Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren Roy Link
IPC分类号： C40B50/08 , C12N15/10 , G01N33/543 , G01N33/58
CPC分类号： C12N15/1075 , C12Q1/6874 , C40B50/08 , G01N33/5436 , G01N33/58
摘要： The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
摘要翻译：本发明提供条形码文件库及其制备和使用方法，包括获得多个核酸构建体，其中每个构建体包含独特的N-聚体和功能性N-聚体，并将构建体分离成流体隔室，使得每个隔室含有一个或更多的独特构造的副本。本发明还提供数字PCR和数字PCR中条形码库的使用方法。

19. 发明授权

US08545497B2 Apparatus for use in the prophylaxis or treatment of tissue 有权
标题翻译：用于预防或治疗组织的装置
公开(公告)号：US08545497B2
公开(公告)日：2013-10-01
申请号：US11525204
申请日：2006-09-22
申请人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton A. M Prior , Andrew Watson , Peter McGeehin
发明人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton A. M Prior , Andrew Watson , Peter McGeehin
IPC分类号： A61B18/18
CPC分类号： C12M35/02 , A61B18/1477 , A61B18/1492 , A61B2018/0016 , A61B2018/00291 , A61B2018/00482 , A61B2018/00494 , A61B2018/1425 , A61B2018/143 , A61B2218/002 , A61N1/0424 , A61N1/0476 , A61N1/327 , A61N5/0601 , A61N5/062
摘要： Apparatus (20) for carrying out a prophylactic or treatment procedure on tissue comprises a device (21) having a chamber (22) and at least one active element such as an electrode (23) within the chamber (22). The chamber (22) has an opening (26) through which tissue is drawn into the chamber (22). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices (25) in the chamber (22). Treatment such as electroporation may be applied to tissue in the chamber (22).
摘要翻译：用于在组织上执行预防或治疗过程的装置（20）包括在腔室（22）内具有腔室（22）和至少一个有源元件（例如电极（23））的装置（21）。腔室（22）具有一个开口（26），组织被吸入腔室（22）中。用于将组织拉入腔室的装置可以包括在腔室（22）中具有真空孔（25）的真空腔。诸如电穿孔的治疗可以施加到腔室（22）中的组织。

20. 发明申请

US20130210638A1 METHODS FOR SEQUENCING NUCLEIC ACID 审中-公开
标题翻译：用于测序核酸的方法
公开(公告)号：US20130210638A1
公开(公告)日：2013-08-15
申请号：US13762843
申请日：2013-02-08
申请人： Jeffrey Charles Olson , James Brayer , Andrew Watson
发明人： Jeffrey Charles Olson , James Brayer , Andrew Watson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2525/155 , C12Q2525/191 , C12Q2563/159 , C12Q2565/629
摘要： The invention generally relates to methods for sequencing a nucleic acid template from both a 5′ and a 3′ end in a single sequencing reaction. In certain embodiments, methods of the invention involve amplifying a nucleic acid template to produce a plurality of amplicons, splitting the amplicons into first and second portions, attaching a first oligonucleotide including a first universal primer site to a 5′ end of the amplicons in the first portion, and attaching a second oligonucleotide including a second universal primer site to a 3′ end of the amplicons in the second portion. The first and second primer sites may be the same or may be different. The method additionally involves pooling the first and second portions, and sequencing the pooled amplicons, thereby sequencing a nucleic acid template from both a 5′ and a 3′ end in a single sequencing reaction.
摘要翻译：本发明一般涉及在单次测序反应中从5'和3'末端测序核酸模板的方法。在某些实施方案中，本发明的方法包括扩增核酸模板以产生多个扩增子，将扩增子分裂成第一和第二部分，将包含第一通用引物位点的第一寡核苷酸连接到扩增子的5'末端第一部分，并且在第二部分中将包含第二通用引物位点的第二寡核苷酸连接到扩增子的3'末端。第一和第二引物位点可以相同或可以不同。该方法另外涉及合并第一和第二部分，并对合并的扩增子进行测序，从而在单个测序反应中从5'和3'末端测序核酸模板。

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