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11. 发明授权

US5350571A Emulsions of highly fluorinated organic compounds 失效
标题翻译：高氟化有机化合物的乳液
公开(公告)号：US5350571A
公开(公告)日：1994-09-27
申请号：US840389
申请日：1992-02-24
申请人： Robert J. Kaufman , Thomas J. Richard
发明人： Robert J. Kaufman , Thomas J. Richard
IPC分类号： A61K31/02 , A01N1/02 , A61K9/00 , A61K9/107 , A61K49/00 , A61K49/04 , A61K51/00 , B01J13/00 , A61B5/055 , A61B8/08 , A61K31/685
CPC分类号： A61K9/0026 , A61K31/02 , Y10S514/832 , Y10S514/833 , Y10S514/937 , Y10S514/941 , Y10S514/943 , Y10S514/975 , Y10T436/24
摘要： Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
摘要翻译：改进的高度氟化有机化合物的乳液。乳液包含高度氟化的有机化合物，基本上不具有表面活性且不显着水溶性的油，以及表面活性剂。它们的特征在于三个组分的相对量之间有明确的关系。

12. 发明授权

US5295953A Method and apparatus for extracorporeal separation of fluorochemicals from whole blood of a patient 失效
标题翻译：含氟化合物与患者全血的体外分离方法和装置
公开(公告)号：US5295953A
公开(公告)日：1994-03-22
申请号：US888987
申请日：1992-05-26
申请人： Thomas J. Richard , Donald W. Schoendorfer , Robert J. Kaufman , Thomas H. Goodin
发明人： Thomas J. Richard , Donald W. Schoendorfer , Robert J. Kaufman , Thomas H. Goodin
IPC分类号： A61M1/02 , A61M1/36 , A61N1/03
CPC分类号： A61M1/3693 , A61M1/3696
摘要： Methods and apparatus for practical extracorporeal separation of fluorochemicals from clinically fluorochemical-containing whole blood of a patient. The methods incorporate centrifugal apheresis devices, preferably with low extracorporeal volumes, that provide a means for continuously removing separated fluorochemical-enriched fractions from the centrifuge during processing and return of whole blood-enriched fractions to the patient.
摘要翻译：含氟化学物质与患者临床含氟化合物全血的实际体外分离方法和装置。所述方法包括优选具有低体外体积的离心分离装置，其提供在处理并将全部富血级分返回到患者期间从离心机中连续除去分离的富含氟化合物的馏分的手段。

13. 发明授权

US5171755A Emulsions of highly fluorinated organic compounds 失效
标题翻译：高荧光有机化合物的乳液
公开(公告)号：US5171755A
公开(公告)日：1992-12-15
申请号：US187854
申请日：1988-04-29
申请人： Robert J. Kaufman , Thomas J. Richard
发明人： Robert J. Kaufman , Thomas J. Richard
IPC分类号： A61K31/02 , A01N1/02 , A61K9/00 , A61K9/107 , A61K49/00 , A61K49/04 , A61K51/00 , B01J13/00
CPC分类号： A61K9/0026 , A61K31/02 , Y10S514/832 , Y10S514/833 , Y10S514/937 , Y10S514/941 , Y10S514/943 , Y10S514/975 , Y10T436/24
摘要： Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
摘要翻译：改进的高度氟化有机化合物的乳液。乳液包含高度氟化的有机化合物，基本上不具有表面活性且不显着水溶性的油，以及表面活性剂。它们的特征在于三个组分的相对量之间有明确的关系。

14. 发明申请

US20110287535A1 Histone Deacetylase Inhibitors 失效
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US20110287535A1
公开(公告)日：2011-11-24
申请号：US12977335
申请日：2010-12-23
申请人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman , Norbert L. Wiech
发明人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman , Norbert L. Wiech
IPC分类号： C12N5/071
CPC分类号： A61K31/16 , C07C57/42 , C07C57/60 , C07C259/06 , C07D307/54
摘要： Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
摘要翻译：组蛋白脱乙酰酶是在活性位点具有锌的金属酶。具有锌结合部分的化合物，例如异羟肟酸基或羧酸基可以抑制组蛋白脱乙酰酶。组蛋白脱乙酰酶可抑制基因表达，包括与肿瘤抑制有关的基因的表达。因此，组蛋白脱乙酰酶的抑制可以提供用于治疗癌症，血液学疾病例如血红蛋白病和遗传相关代谢紊乱（例如囊性纤维化和肾上腺嗜甲基营养不良）的替代途径。

15. 发明授权

US07579372B2 Histone deacetylase inhibitors based on alpha-ketoepoxide compounds 失效
标题翻译：基于α-酮氧化物化合物的组蛋白脱乙酰酶抑制剂
公开(公告)号：US07579372B2
公开(公告)日：2009-08-25
申请号：US11198293
申请日：2005-08-08
申请人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman
发明人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman
IPC分类号： A61K31/336
CPC分类号： C07D303/32
摘要： Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or to stimulate hematopoietic cells ex vivo.
摘要翻译：组蛋白脱乙酰酶是在活性位点具有锌的金属酶。具有锌结合部分的化合物，例如α-酮氧化物基团，例如α-酮硫基，可以抑制组蛋白脱乙酰酶。组蛋白脱乙酰酶抑制可抑制基因表达，包括与肿瘤抑制相关的基因的表达。因此，组蛋白脱乙酰酶的抑制可以提供治疗癌症的替代途径，血液学病症，例如血红蛋白病，常染色体显性疾病，例如常染色体显性疾病。脊髓性肌肉萎缩和亨廷顿病，遗传相关的代谢紊乱，例如囊性纤维化和肾上腺脑白质营养不良，或离体刺激造血细胞。

16. 发明授权

US5321000A Benzhydryl compounds as herbicide antidotes 失效
标题翻译：作为除草剂解毒剂的二苯甲基化合物
公开(公告)号：US5321000A
公开(公告)日：1994-06-14
申请号：US906107
申请日：1992-06-29
申请人： Lawrence H. Brannigan , Ronald J. Brinker , Robert J. Kaufman , Suzanne Metz
发明人： Lawrence H. Brannigan , Ronald J. Brinker , Robert J. Kaufman , Suzanne Metz
IPC分类号： A01N25/32 , C07C69/708 , A01N37/10 , C07C69/76
CPC分类号： C07C69/708 , A01N25/32
摘要： Acids, esters, amides and salts of benzhydryl compounds are antidotes for thiocarbamate and acetamide herbicides. These antidote compounds are especially effective to safen acetamide herbicides used to control grassy weeds and broadleaf weeds in rice, sorghum, corn and wheat.
摘要翻译：二苯甲基化合物的酸，酯，酰胺和盐是硫代氨基甲酸盐和乙酰胺除草剂的解毒剂。这些解毒剂化合物特别有效地安全用于控制水稻，高粱，玉米和小麦中的草地杂草和阔叶杂草的乙酰胺除草剂。

17. 发明授权

US4496389A Amide derivatives of N-trifluoroacetyl-N-phosphonomethylglycine, herbicidal compositions and use 失效
标题翻译： N-三氟乙酰-N-膦酰甲基甘氨酸的酰胺衍生物，除草组合物和用途
公开(公告)号：US4496389A
公开(公告)日：1985-01-29
申请号：US609263
申请日：1984-05-11
申请人： John E. Franz , Robert J. Kaufman
发明人： John E. Franz , Robert J. Kaufman
IPC分类号： A01N57/26 , C07F9/44 , C07F9/572 , C07F9/59 , C07F9/6533 , C07F9/36
CPC分类号： C07F9/6533 , A01N57/26 , C07F9/4407 , C07F9/4496 , C07F9/5721 , C07F9/591
摘要： This disclosure relates to alkyl N-trifluoroacetyl-N-phosphonomethylglycine amide and hydrazide derivatives, to herbicidal compositions containing same and to the herbicidal use thereof. These amide and hydrazide derivatives are useful as pre-emergent and/or post-emergent herbicides.
摘要翻译：本公开内容涉及N-三氟乙酰基-N-膦酰基甲基甘氨酸烷基酰胺和酰肼衍生物，含有其的除草组合物及其除草用途。这些酰胺和酰肼衍生物可用作芽前和/或芽后除草剂。

18. 发明授权

US4218235A Ester derivatives of n-trifluoroacetyl-n-phosphonomethylglycine and the herbicidal use thereof 失效
标题翻译：正三氟乙酰基正膦酰基甲基甘氨酸的酯衍生物及其除草用途
公开(公告)号：US4218235A
公开(公告)日：1980-08-19
申请号：US922920
申请日：1978-07-10
申请人： John E. Franz , Robert J. Kaufman
发明人： John E. Franz , Robert J. Kaufman
IPC分类号： A01N57/22 , A01N57/14 , A01N57/18 , C07F9/38 , C07F9/40 , A01N9/36 , C07F9/02
CPC分类号： C07F9/4087 , A01N57/18 , C07F9/4006 , C07F9/4078 , C07F9/4084
摘要： This disclosure relates to ester derivatives of N-trifluoroacetyl-N-phosphonomethylglycine, to herbicidal compositions containing same and to the herbicidal use thereof. The ester derivatives of N-trifluoroacetyl-N-phosphonomethylglycine are useful as herbicides.
摘要翻译：本公开涉及N-三氟乙酰基-N-膦酰基甲基甘氨酸的酯衍生物，含有其的除草组合物及其除草用途。 N-三氟乙酰基-N-膦酰基甲基甘氨酸的酯衍生物可用作除草剂。

19. 发明授权

US08138225B2 Histone deacetylase inhibitors based on alpha-ketoepoxide compounds 失效
标题翻译：基于α-酮氧化物化合物的组蛋白脱乙酰酶抑制剂
公开(公告)号：US08138225B2
公开(公告)日：2012-03-20
申请号：US12545712
申请日：2009-08-21
申请人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman
发明人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman
IPC分类号： A61K31/336
CPC分类号： C07D303/32
摘要： Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or to stimulate hematopoietic cells ex vivo.
摘要翻译：组蛋白脱乙酰酶是在活性位点具有锌的金属酶。具有锌结合部分的化合物，例如α-酮氧化物基团，例如α-酮硫基，可以抑制组蛋白脱乙酰酶。组蛋白脱乙酰酶抑制可抑制基因表达，包括与肿瘤抑制相关的基因的表达。因此，组蛋白脱乙酰酶的抑制可以提供治疗癌症的替代途径，血液学病症，例如血红蛋白病，常染色体显性疾病，例如常染色体显性疾病。脊髓性肌肉萎缩和亨廷顿病，遗传相关的代谢紊乱，例如囊性纤维化和肾上腺脑白质营养不良，或离体刺激造血细胞。

20. 发明申请

US20110288168A1 HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译： HISTONE脱乙酰酶抑制剂
公开(公告)号：US20110288168A1
公开(公告)日：2011-11-24
申请号：US12955470
申请日：2010-11-29
申请人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman , Norbert L. Wiech
发明人： Hsuan-Yin Lan-Hargest , Robert J. Kaufman , Norbert L. Wiech
IPC分类号： A61K31/202 , A61K31/19 , A61P25/00 , A61K31/21 , A61K31/11 , A61K31/336 , A61K31/195 , A61K31/12
CPC分类号： A61K31/19 , A61K31/202 , A61K31/336 , A61K31/34 , A61K31/381
摘要： Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, genetic disorders, e.g. Huntington's disease and spinal muscular atrophy and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
摘要翻译：组蛋白脱乙酰酶是在活性位点具有锌的金属酶。具有锌结合部分的化合物，例如异羟肟酸基或羧酸基可以抑制组蛋白脱乙酰酶。组蛋白脱乙酰酶抑制可抑制基因表达，包括与肿瘤抑制相关的基因的表达。因此，组蛋白脱乙酰酶的抑制可以提供治疗癌症的替代途径，血液病症，例如血红蛋白病，遗传疾病，亨廷顿氏病和脊髓性肌肉萎缩以及遗传相关的代谢紊乱，例如囊性纤维化和肾上腺脑白质营养不良。

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