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11. 发明申请

US20060149047A1 N-CARBOBENZYLOXY (N-CBZ)-DEPROTECTING ENZYME AND USES THEREFOR 失效
标题翻译： N-CARBOBENZYLOXY（N-CBZ）-EPROTECTING ENZYME AND USES THEREFOR
公开(公告)号：US20060149047A1
公开(公告)日：2006-07-06
申请号：US10453418
申请日：2003-06-03
申请人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
发明人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
IPC分类号： C07H21/04
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及分离或重组的N-CBZ脱保护酶多肽，其催化从CBZ保护的氨基酸和醇及其变体，修饰和片段中除去CBZ。还涉及编码N-CBZ-脱保护酶多肽的分离的核酸及其变体，修饰和片段，以及包含这些核酸的载体和宿主细胞。本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用多肽的方法。

12. 发明申请

US20050090539A1 Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权
标题翻译：二肽基肽酶IV抑制剂的生产方法和化合物及其中间体
公开(公告)号：US20050090539A1
公开(公告)日：2005-04-28
申请号：US10716012
申请日：2003-11-18
申请人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
发明人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
IPC分类号： A61K31/403 , A61K31/435 , C07C62/06 , C07C69/00 , C07C69/716 , C07C229/28 , C07C271/22 , C07D20060101 , C07D201/00 , C07D207/22 , C07D207/277 , C07D209/02 , C07D209/52 , C07D221/02
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译：提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。

13. 发明申请

US20060223832A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
公开(公告)号：US20060223832A1
公开(公告)日：2006-10-05
申请号：US10917031
申请日：2004-08-12
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/497 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

14. 发明申请

US20060264459A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
公开(公告)号：US20060264459A1
公开(公告)日：2006-11-23
申请号：US11338587
申请日：2006-02-15
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/4709 , A61K31/407 , C07D491/02
CPC分类号： C07D487/18
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

15. 发明申请

US20060100422A1 Pichia pastoris formate dehydrogenase and uses therefor 审中-公开
公开(公告)号：US20060100422A1
公开(公告)日：2006-05-11
申请号：US11180275
申请日：2005-07-13
申请人： Steven Goldberg , Paul Cino , Ramesh Patel , Venkata Nanduri , Robert Johnston
发明人： Steven Goldberg , Paul Cino , Ramesh Patel , Venkata Nanduri , Robert Johnston
IPC分类号： C07H21/04 , C12P21/06 , C12N9/04 , C12N15/74 , C12N1/18
CPC分类号： C12N9/0004 , C12Q1/26 , G01N2333/04
摘要： This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

16. 发明申请

US20050272799A1 Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效
标题翻译：融合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂
公开(公告)号：US20050272799A1
公开(公告)日：2005-12-08
申请号：US11176810
申请日：2005-07-07
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译：稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

17. 发明申请

US20050192253A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译：稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂
公开(公告)号：US20050192253A1
公开(公告)日：2005-09-01
申请号：US10974049
申请日：2004-10-25
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译：稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

18. 发明授权

US07845223B2 Condensing chamber design 有权
标题翻译：冷凝室设计
公开(公告)号：US07845223B2
公开(公告)日：2010-12-07
申请号：US11220672
申请日：2005-09-08
申请人： Ramesh Patel , Albert Tsang , James Sawabe , Hwang Choe
发明人： Ramesh Patel , Albert Tsang , James Sawabe , Hwang Choe
IPC分类号： G01F23/00
CPC分类号： G01F23/14 , G01F23/162 , G21C17/035
摘要： The disclosed apparatus includes a condensing chamber (CC) that maintains a volume of a condensate obtained from vapor emitting from a vessel, for example a reactor pressure vessel (RPV). The condensing chamber is connected to a reference leg (RL), a variable leg (VL) and a vapor or steam leg (SL). RL connection provides a flow path for the CRD drive water system backfill to flow into the CC and overflow into the VL. The excess backfill and/or condensate will be returned to the vessel, typically at a point below the liquid level within the vessel. Non-condensable gases will thereby be returned from the CC to the RPV in a substantially continuous manner, thereby tending to prevent the introduction of non-condensable gas enriched liquid from the CC into the RL and improving the tolerance and reliability of the level measurements and/or reducing thermal stresses on the various CC connections.
摘要翻译：所公开的设备包括冷凝室（CC），其保持从容器（例如反应堆压力容器（RPV））发射的蒸汽获得的冷凝物的体积。冷凝室连接到参考腿（RL），可变腿（VL）和蒸汽或蒸汽腿（SL）。 RL连接提供了CRD驱动水系统回填流入CC并溢出到VL中的流路。多余的回填物和/或冷凝物将返回到容器中，通常在容器内的液面以下。因此，不可冷凝的气体将以基本上连续的方式从CC返回到RPV，从而倾向于防止将不可冷凝的富含气体的液体从CC引入RL并提高液位测量的公差和可靠性， /或降低各种CC连接上的热应力。

19. 发明授权

US06828119B2 Enzymatic deprotection of amines and hydroxides 失效
标题翻译：胺和氢氧化物的酶解脱保护
公开(公告)号：US06828119B2
公开(公告)日：2004-12-07
申请号：US10017711
申请日：2001-12-14
申请人： Ramesh Patel , David Brzozowski , Venkata Nanduri
发明人： Ramesh Patel , David Brzozowski , Venkata Nanduri
IPC分类号： C12P100
CPC分类号： C12P41/007 , C12P17/00 , C12P17/10 , C12P41/004
摘要： Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH2)n—O—C(═O)— where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.
摘要翻译：本发明提供了一种使由一组取代基保护的氢氧化物或胺脱保护的方法，所述取代基如下所述，所述方法包括：使被保护的氢氧化物或胺与有效除去保护基团的酶接触; 并回收胺。还提供了分离产生有效去除保护基团的酶的细菌的方法，包括：在具有生长选择量的如上所述保护的胺化合物的培养基上生长未来的细菌; 并分离在所述培养基上生长的细菌。

20. 发明申请

US20050250795A1 Synthesis of acyclic nucleoside derivatives 失效
标题翻译：无环核苷衍生物的合成
公开(公告)号：US20050250795A1
公开(公告)日：2005-11-10
申请号：US11131646
申请日：2005-05-18
申请人： M. Leanna , Steven Hannick , Michael Rasmussen , Jien-Heh Tien , Lakshmi Bhagavatula , Pulla Singam , Bradley Gates , Lawrence Kolaczkowski , Ramesh Patel , Greg Wayne , Greg Lannoye , Weijiang Zhang , Zhenping Tian , Kirill Lukin , Bikshandarkoil Narayanan , David Riley , Howard Morton , Sou-Jen Chang , Cynthia Curty , Daniel Plata , John Bellettini , Bhadra Shelat , Tiffany Spitz , Cheng-Xi Yang
发明人： M. Leanna , Steven Hannick , Michael Rasmussen , Jien-Heh Tien , Lakshmi Bhagavatula , Pulla Singam , Bradley Gates , Lawrence Kolaczkowski , Ramesh Patel , Greg Wayne , Greg Lannoye , Weijiang Zhang , Zhenping Tian , Kirill Lukin , Bikshandarkoil Narayanan , David Riley , Howard Morton , Sou-Jen Chang , Cynthia Curty , Daniel Plata , John Bellettini , Bhadra Shelat , Tiffany Spitz , Cheng-Xi Yang
IPC分类号： C07D473/18 , A61K31/522 , C07B53/00 , C07B61/00 , C07C303/30 , C07C309/45 , C07C309/73 , C07D473/00 , C07D473/12 , C07D473/32 , C07D473/40
CPC分类号： C07D473/00 , C07C309/73 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
摘要翻译：用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，另一个是R _{1和R 2是-C（O）C 3 -C 21饱和或单不饱和的任选取代的烷基和 R 3是OH或H; 或其药学上可接受的盐。}

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