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11. 发明授权

US11065036B2 Instrument port for minimally invasive cardiac surgery 有权
公开(公告)号：US11065036B2
公开(公告)日：2021-07-20
申请号：US14858106
申请日：2015-09-18
申请人： Children's Medical Center Corporation , Massachusetts Institute of Technology
发明人： Christopher DiBiasio , Keith Durand , Jonathan Brigham Hopkins , Zach Traina , Alexander Slocum , Samir Nayfeh , Pedro J. del Nido , Nikolay V. Vasilyev
IPC分类号： A61B17/34 , A61B17/02 , A61B17/00 , A61B90/00 , A61B90/30
摘要： An instrument port for introducing instruments into a surgical site, including a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and fluid flow for removing emboli efficiently from the instrument port, wherein the fluid flow includes the gap is provided. A fluid flow system for use in an instrument port is provided. A method of removably securing an instrument sleeve to a port body by anchoring the instrument port to heart tissue, making at least one flood line in a channel, flushing out emboli, and performing surgery with the instrument port.

12. 发明授权

US09844394B2 Instrument port for minimally invasive cardiac surgery 有权
公开(公告)号：US09844394B2
公开(公告)日：2017-12-19
申请号：US13792916
申请日：2013-03-11
申请人： Children's Medical Center Corporation , Massachusetts Institute of Technology
发明人： Christopher DiBiasio , Keith Durand , Jonathan Brigham Hopkins , Zach Traina , Alexander Slocum , Samir Nayfeh , Pedro J. del Nido , Nikolay V. Vasilyev
IPC分类号： A61B17/02 , A61B17/34 , A61B17/00 , A61B90/00 , A61B90/30
CPC分类号： A61B17/3498 , A61B17/0218 , A61B17/3421 , A61B17/3423 , A61B17/3462 , A61B90/06 , A61B2017/00119 , A61B2017/00243 , A61B2017/00876 , A61B2017/0243 , A61B2017/3445 , A61B2017/347 , A61B2017/3488 , A61B2090/306 , A61B2090/3614 , A61B2090/373 , A61B2090/3925 , A61B2217/005 , A61B2217/007
摘要： The instrument ports for introducing instruments into a surgical site that are disclosed herein include a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and a fluid flow element for removing emboli efficiently from the instrument port, wherein the fluid flow element includes the gap. Disclosed fluid flow systems are for use in the disclosed instrument ports. Methods are also disclosed for removably securing an instrument sleeve to a port body by anchoring the instrument port to heart tissue, making at least one flood line in a channel, flushing out emboli, and performing surgery with the instrument port.

13. 发明申请

US20130261400A1 Instrument Port For Minimally Invasive Cardiac Surgery 有权
标题翻译：微创心脏手术仪器端口
公开(公告)号：US20130261400A1
公开(公告)日：2013-10-03
申请号：US13792916
申请日：2013-03-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Christopher DiBiasio , Keith Durand , Jonathan Brigham Hopkins , Zach Traina , Alexander Slocum , Samir Nayfeh , Pedro J. del Nido , Nikolay V. Vasilyev
IPC分类号： A61B17/02
CPC分类号： A61B17/3498 , A61B17/0218 , A61B17/3421 , A61B17/3423 , A61B17/3462 , A61B90/06 , A61B2017/00119 , A61B2017/00243 , A61B2017/00876 , A61B2017/0243 , A61B2017/3445 , A61B2017/347 , A61B2017/3488 , A61B2090/306 , A61B2090/3614 , A61B2090/373 , A61B2090/3925 , A61B2217/005 , A61B2217/007
摘要： The instrument ports for introducing instruments into a surgical site that are disclosed herein include a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and a fluid flow element for removing emboli efficiently from the instrument port, wherein the fluid flow element includes the gap. Disclosed fluid flow systems are for use in the disclosed instrument ports. Methods are also disclosed for removably securing an instrument sleeve to a port body by anchoring the instrument port to heart tissue, making at least one flood line in a channel, flushing out emboli, and performing surgery with the instrument port.
摘要翻译：用于将仪器引入到本文公开的外科手术部位的器械端口包括端口主体，其具有从近端延伸到远端的通道，与通道滑动接触的器械套筒，在其间产生间隙，以及流体用于从仪器端口有效地去除栓塞的流动元件，其中流体流动元件包括间隙。公开的流体流动系统用于所公开的仪器端口。还公开了用于通过将仪器端口固定到心脏组织上来将仪器套件可移除地固定到端口主体的方法，在通道中形成至少一个泛水线，冲洗栓塞，并用仪器端口进行手术。

14. 发明授权

US10736626B2 Tissue clip 有权
公开(公告)号：US10736626B2
公开(公告)日：2020-08-11
申请号：US15094083
申请日：2016-04-08
申请人： Children's Medical Center Corporation
发明人： Pedro J. del Nido , Nikolay V. Vasilyev , Franz Freudenthal
IPC分类号： A61B17/064 , A61B17/068 , A61B17/12 , A61B17/08 , A61B17/10 , A61B17/00 , A61B17/11 , A61F2/24 , A61B90/00
摘要： A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.

15. 发明授权

US10478290B2 Expandable stent valve 有权
公开(公告)号：US10478290B2
公开(公告)日：2019-11-19
申请号：US15039510
申请日：2014-11-26
申请人： Children's Medical Center Corporation
发明人： Sitaram Emani , James E. Lock , Pedro J. del Nido , Audrey C. Marshall
IPC分类号： A61F2/24 , A61F2/06
摘要： An expandable valve (100) and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member (160) surrounding the valve frame (130) at a region between upstream and downstream ends of the device, for attaching the device to surrounding tissue. The device may include a membrane (140) for blocking leakage out the side of the valve frame between opposite ends. However, the membrane may include a side opening (170) for guiding fluid flow toward an appropriate anatomical outflow tract. The device may include a hood-like covering attached to a tissue wall, for smoothly receiving and guiding fluid flow along a perpendicular bend. The device may further include a flared opening at a downstream end, providing adequate space for device attachment.

16. 发明申请

US20180057610A1 Therapeutic Use of Mitochondria and Combined Mitochondrial Agent 审中-公开
公开(公告)号：US20180057610A1
公开(公告)日：2018-03-01
申请号：US15803543
申请日：2017-11-03
申请人： Children's Medical Center Corporation , Beth Israel Deaconess Medical Center, Inc.
发明人： James D. McCully , Sidney Levitsky , Douglas B. Cowan , Pedro J. del Nido , Sitaram M. Emani
IPC分类号： C07K16/46 , A61K51/12 , C12N15/11 , A61B6/00
CPC分类号： C07K16/468 , A61B6/42 , A61B6/503 , A61B8/0883 , A61K9/0019 , A61K35/12 , A61K35/28 , A61K35/34 , A61K47/6901 , A61K49/0002 , A61K49/1821 , A61K49/1896 , A61K51/0421 , A61K51/1203 , A61K51/1282 , A61K2039/505 , C12N15/11
摘要： The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

17. 发明授权

US10370458B2 Therapeutic use of mitochondria and combined mitochondrial agent 有权
公开(公告)号：US10370458B2
公开(公告)日：2019-08-06
申请号：US15803543
申请日：2017-11-03
申请人： Children's Medical Center Corporation , Beth Israel Deaconess Medical Center, Inc.
发明人： James D. McCully , Sidney Levitsky , Douglas B. Cowan , Pedro J. del Nido , Sitaram M. Emani
IPC分类号： A61K47/69 , A61K9/00 , A61K35/34 , A61K35/28 , A61K35/12 , A61K49/18 , A61K51/12 , A61K51/04 , A61B6/00 , A61B8/08 , C07K16/46 , C12N15/11 , A61K49/00 , A61K39/00
摘要： The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

18. 发明申请

US20190183486A9 Tissue Clip 审中-公开
公开(公告)号：US20190183486A9
公开(公告)日：2019-06-20
申请号：US15094083
申请日：2016-04-08
申请人： Children's Medical Center Corporation
发明人： Pedro J. del Nido , Nikolay V. Vasilyev , Franz Freudenthal
IPC分类号： A61B17/064 , A61F2/24 , A61B17/11 , A61B17/068
CPC分类号： A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/08 , A61B17/083 , A61B17/10 , A61B17/11 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B2017/00243 , A61B2017/1107 , A61B2090/3925 , A61F2/2463
摘要： A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.

19. 发明申请

US20170014228A1 EXPANDABLE STENT VALVE 审中-公开
标题翻译：可扩展的阀门
公开(公告)号：US20170014228A1
公开(公告)日：2017-01-19
申请号：US15039510
申请日：2014-11-26
申请人： Children's Medical Center Corporation
发明人： Sitaram Emani , James E. Lock , Pedro J. del Nido , Audrey C. Marshall
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2002/061 , A61F2220/0008 , A61F2220/0075 , A61F2230/0067 , A61F2250/0039 , A61F2250/0069
摘要： An expandable valve (100) and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member (160) surrounding the valve frame (130) at a region between upstream and downstream ends of the device, for attaching the device to surrounding tissue. The device may include a membrane (140) for blocking leakage out the side of the valve frame between opposite ends. However, the membrane may include a side opening (170) for guiding fluid flow toward an appropriate anatomical outflow tract. The device may include a hood-like covering attached to a tissue wall, for smoothly receiving and guiding fluid flow along a perpendicular bend. The device may further include a flared opening at a downstream end, providing adequate space for device attachment.
摘要翻译：可膨胀阀（100）和阀框架装置，其可被植入体内，例如在心脏的位置。该装置可以手术植入，随后在稍后的时间内扩大。该装置可以包括在装置的上游和下游端之间的区域处围绕阀框架（130）的可扩张缝合构件（160），用于将装置附接到周围组织。该装置可以包括用于在相对端部之间阻挡泄漏出阀架侧面的膜片（140）。然而，膜可以包括用于将流体流引向适当的解剖学流出道的侧开口（170）。该装置可以包括附接到组织壁的罩状覆盖物，用于沿着垂直弯曲部平滑地接收和引导流体流动。该装置还可以包括在下游端的扩口开口，为装置附接提供足够的空间。

20. 发明申请

US20230039350A1 DEVICE FOR VISUALIZATION OF VALVE DURING SURGERY 有权
公开(公告)号：US20230039350A1
公开(公告)日：2023-02-09
申请号：US17794861
申请日：2021-01-22
申请人： Children's Medical Center Corporation
发明人： Peter E. Hammer , Ignacio Berra , David Hoganson , Pedro J. del Nido , Douglas P. Perrin
IPC分类号： A61B17/02 , A61B1/313 , A61B1/00
摘要： Method and devices for viewing one or more valve leaflets via a viewer. In some embodiments the viewer includes a body having a first end and a second end opposite the first end, the first end being closed and having a transparent viewing window, the second end arranged to be attached to an aorta or a pulmonary artery, and one or more ports arranged to provide fluid access to an internal portion of the viewer to pressurize the one or more leaflets. A diameter of the viewing window is larger than an outer diameter of the second end. An outer diameter of the first end of the body is larger than an outer diameter of the second end. The body is a tubular body.

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