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11. 发明申请

US20090004645A1 Methods for Identifying Genes that Mediate a Response of a Living Cell to an Agent 审中-公开
标题翻译：识别将活细胞反应到基因的基因的方法
公开(公告)号：US20090004645A1
公开(公告)日：2009-01-01
申请号：US11578216
申请日：2005-04-12
申请人： Mao Mao , Aimee Jackson , Peter S. Linskey , Hongyue Dai
发明人： Mao Mao , Aimee Jackson , Peter S. Linskey , Hongyue Dai
IPC分类号： C12Q1/68
CPC分类号： C12N15/1072 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12
摘要： In one aspect, the present invention provides methods for determining whether a gene mediates the response of a living cell to an agent. In another aspect, the present invention provides methods to identify a mammalian subject responsive to a KSP inhibitor.
摘要翻译：一方面，本发明提供了确定基因介导活细胞对药剂的反应的方法。在另一方面，本发明提供了鉴定对KSP抑制剂的哺乳动物受试者的方法。

12. 发明申请

US20070134660A1 Methods for identifying modulators of kinesin activity 审中-公开
标题翻译：识别驱动蛋白活性调节剂的方法
公开(公告)号：US20070134660A1
公开(公告)日：2007-06-14
申请号：US10558463
申请日：2004-05-28
申请人： Mao Mao , Peter Linsley , Carolyn Buser , Christopher Marshall
发明人： Mao Mao , Peter Linsley , Carolyn Buser , Christopher Marshall
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/175
CPC分类号： G01N33/5011 , A61K31/175 , A61K38/00 , C12Q1/34 , G01N33/573 , G01N33/57415
摘要： In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ ID NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity of a target protein. Some embodiments of this aspect provide methods for treating a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein.
摘要翻译：在第一方面，本发明提供了筛选靶蛋白的调节剂的方法，包括以下步骤：使靶蛋白与候选试剂接触并确定候选试剂是否调节靶蛋白的活性，其中靶蛋白包含与KIF14（SEQ ID NO：2）或KIF14运动结构域（SEQ ID NO：3）具有80％以上氨基酸序列同一性的序列。在第二方面，本发明提供了调节细胞增殖的方法，包括向细胞施用有效量的靶蛋白活性的调节剂。该方面的一些实施方案提供了用细胞过度增殖病症如癌症治疗受试者的方法。在第三方面，本发明提供用于鉴定候选受试者用靶蛋白活性抑制剂治疗的方法。

13. 发明申请

US20050181385A1 Synthetic lethal screen using RNA interference 审中-公开
标题翻译：合成致死屏幕采用RNA干扰
公开(公告)号：US20050181385A1
公开(公告)日：2005-08-18
申请号：US10947637
申请日：2004-09-22
申请人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
发明人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
IPC分类号： C07H21/02 , C12N15/11 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12
摘要： The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and/or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
摘要翻译：本发明提供了一种用于鉴定与例如药物的作用相互作用的细胞类型的细胞中的一种或多种基因的方法。例如，鉴定的基因可赋予药物抗药性或敏感性，即降低或增强药物的作用。本发明还提供STK6和TPX2作为与编码驱动蛋白样运动蛋白的KSP呈现合成的致死相互作用的基因，以及通过调节STK6或TPX2基因的表达和/或治疗疾病例如癌症的方法和组合物 STK6或TPX2基因产物的活性。本发明还提供涉及对DNA损伤的细胞反应及其治疗用途的基因。

14. 发明申请

US20050054826A1 Human diaphanous-3 gene and methods of use therefor 审中-公开
标题翻译：人类透明-3基因及其使用方法
公开(公告)号：US20050054826A1
公开(公告)日：2005-03-10
申请号：US10848755
申请日：2004-05-18
申请人： Mao Mao
发明人： Mao Mao
IPC分类号： C07H21/04 , C07K14/47 , C07K14/705
CPC分类号： C07K14/705 , C07H21/04 , C07K14/4738
摘要： The present invention is directed to the full-length cDNA sequence encoding human diaphanous-3 (DIAPH3), to DIAPH3 encoded thereby, and to fragments of DIAPH3 and the cDNA. The present invention also provides for the use of the cDNA, and of DIAPH3, as a marker of poor prognosis of breast cancer. Because DIAPH3 appears essential for proper spindle pole formation during mitosis, DIAPH3 is a useful target for screening assays designed to identify inhibitors or modulators of DIAPH3 activity, which are useful for the treatment of cancer, particularly breast cancer. Thus, the invention further provides methods of using DIAPH3, or fragments thereof, in assays to identify such compounds.
摘要翻译：本发明涉及编码人透皮质-3（DIAPH3）的全长cDNA序列，由此编码的DIAPH3以及DIAPH3和cDNA片段。本发明还提供了使用cDNA和DIAPH3作为乳腺癌预后差的标志物。因为DIAPH3对于在有丝分裂期间正确的心轴形成是必不可少的，所以DIAPH3是用于筛选测定的有用靶标，用于鉴定用于治疗癌症，特别是乳腺癌的DIAPH3活性的抑制剂或调节剂。因此，本发明还提供了在测定中使用DIAPH3或其片段鉴定此类化合物的方法。

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