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    • 12. 发明申请
    • Method for analyzing the spatial distribution of a chemical substance retained by a biological matter
    • 分析由生物物质保留的化学物质的空间分布的方法
    • US20060160077A1
    • 2006-07-20
    • US10516712
    • 2003-06-05
    • Jukka LausmaaPeter SjovallHakan Nygren
    • Jukka LausmaaPeter SjovallHakan Nygren
    • C12Q1/68G01N33/53G01N33/00
    • G01N33/6848G01N15/1475G01N33/54306G01N33/68G01N33/6851
    • A method of analyzing the spatial distribution of at least one chemical substance retained by a biological matter comprises the steps of (a) supplying a sample of said biological matter as a specimen surface; (b) producing at least one imprint of said specimen surface on at least one corresponding separate substrate surface, said at least one chemical substance being transferred to the same with retained lateral distribution thereon; (c) subjecting said at least one imprint to imaging mass spectrometry, at least one signal from at least two points being produced, the magnitude of said at least one signal being dependent on the amount of said at least one chemical substance laterally present on said substrate surface; (d) recording said at least one signal from said at least two points; and (e) determining said spatial distribution of said at least one chemical substance from said at least one image of said at least one imprint.
    • 分析由生物物质保留的至少一种化学物质的空间分布的方法包括以下步骤:(a)将所述生物物质的样品作为样品表面供应; (b)在至少一个对应的分离的衬底表面上产生所述样品表面的至少一个压印,所述至少一种化学物质被转移到其上,并在其上保留横向分布; (c)对所述至少一个印记进行成像质谱分析,产生至少两个点的至少一个信号,所述至少一个信号的大小取决于所述至少一个化学物质在所述 基材表面; (d)从所述至少两个点记录所述至少一个信号; 和(e)从所述至少一个印记的所述至少一个图像确定所述至少一种化学物质的所述空间分布。