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11. 发明授权

US09566433B2 Focused stimulation in a medical stimulation device 有权
标题翻译：在医疗刺激装置中聚焦刺激
公开(公告)号：US09566433B2
公开(公告)日：2017-02-14
申请号：US12979676
申请日：2010-12-28
申请人： Christopher van den Honert
发明人： Christopher van den Honert
IPC分类号： A61N1/00 , A61N1/36 , H04R25/00 , A61N1/05 , A61N1/32
CPC分类号： A61N1/36036 , A61N1/0541 , A61N1/323 , H04R25/305 , H04R25/606
摘要： A medical stimulation device such as a cochlear implant configured to provide stimulation of one or more spatially-restricted contiguous portion(s) of the spiral array of auditory nerve fibers in the cochlear (“discrete stimulation regions”). Each discrete stimulation region is defined by the constructive and/or destructive interference of stimulating and limiting signals simultaneously applied to electrode channels of an implanted electrode array, the stimulating and limiting signals being determined based upon transimpedance measurements of intracochlear electrode channels of the implanted electrode array representing specific spread functions of an individual recipient. The stimulating signal is preferably applied through a targeted electrode channel; that is, one or more successive electrodes which is/are adjacent to the discrete stimulation region. The targeted electrode channel is selected to represent a sound based on the outputs of a sound processor to stimulate neural activity in the discrete stimulation region to thereby cause a percept of the represented sound. The size of the discrete stimulation region is defined by the limiting signal(s) applied to electrode channel(s) other than the targeted electrode channel, and which negate(s) current spread which would otherwise occur in response to the stimulating signal.
摘要翻译：医疗刺激装置，例如耳蜗植入物，被配置成在耳蜗（“离散刺激区域”）中提供听觉神经纤维螺旋阵列的一个或多个空间受限的连续部分的刺激。每个离散刺激区域由同时施加到植入电极阵列的电极通道的刺激和限制信号的结构性和/或相消干扰限定，刺激和限制信号基于植入电极阵列的耳内电极通道的跨阻抗测量来确定代表个人收件人的具体传播功能。刺激信号优选通过目标电极通道施加; 即与离散刺激区域相邻的一个或多个连续电极。选择目标电极通道以基于声音处理器的输出来表示声音，以刺激离散刺激区域中的神经活动，从而引起对所示声音的感知。离散刺激区域的大小由施加到目标电极通道之外的电极通道的限制信号定义，并且否定当前的扩展，否则这些电流扩展响应于刺激信号而发生。

12. 发明申请

US20110288613A1 MULTI-ELECTRODE CHANNEL CONFIGURATIONS 有权
标题翻译：多电极通道配置
公开(公告)号：US20110288613A1
公开(公告)日：2011-11-24
申请号：US12782604
申请日：2010-05-18
申请人： Zachary M. Smith , Christopher van den Honert
发明人： Zachary M. Smith , Christopher van den Honert
IPC分类号： A61N1/05
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/36036 , A61N1/37264 , H03G9/005 , H04R25/70
摘要： An apparatus and method for determining stimulation channels for a stimulating device is provided. This method and apparatus may involve computing a set of weights for the plurality of stimulation channels of the stimulating hearing prosthesis. These weights may be determined by determining a transimpedance matrix for the stimulating hearing prosthesis where a diagonal of the transimpedance matrix is determined by extrapolation. A transadmittance matrix may then be computed for this transimpedance matrix. An error may then be computed base on positive off-diagonal terms of the transadmittance matrix. The apparatus and method may determine the weights for the stimulation channels by determining an adjustment to the diagonal of the transimpedance matrix that results in a computed error that does not exceed a specified criterion level.
摘要翻译：提供了一种用于确定刺激装置的刺激通道的装置和方法。该方法和装置可以包括计算刺激性听觉假体的多个刺激通道的一组权重。这些权重可以通过确定用于刺激性听力假体的跨阻抗矩阵来确定，其中跨阻抗矩阵的对角线通过外推来确定。然后可以为该跨阻抗矩阵计算交纳导纳矩阵。然后可以基于导纳矩阵的正偏离对角项来计算误差。该装置和方法可以通过确定导致计算出的误差不超过指定标准水平的跨阻抗矩阵的对角线来确定刺激通道的权重。

13. 发明授权

US5000194A Array of bipolar electrodes 失效
标题翻译：双极电极阵列
公开(公告)号：US5000194A
公开(公告)日：1991-03-19
申请号：US236516
申请日：1988-08-25
申请人： Christopher van den Honert , David C. Michow
发明人： Christopher van den Honert , David C. Michow
IPC分类号： A61F11/04 , A61N1/05
CPC分类号： A61N1/0541 , A61F11/04
摘要： The invention provides an array of electrodes suitable for use as an auditory prosthesis. The array comprises a carrier member formed from electrically insulating flexible material, having a surface and a core, the carrier member including at least a pair of electrodes molded therein, the electrodes comprising a length of contact material formed in a semi-circular shape, having a convex contact surface and a locking portion defining an internal space. The electrode is molded in the carriers so that the convex contact surface of the electrode is preferably flush with the carrier member surface. The locking portion of the electrode is molded into the core of the carrier member in the electrode connected to a lead wire which is molded in the core of the carrier member. The invention further provides a method for fabricating such an array of bipolar electrodes.
摘要翻译：本发明提供了适合用作听觉假体的电极阵列。阵列包括由电绝缘的柔性材料形成的载体部件，具有表面和芯部，所述载体部件至少包括一对模制在其中的电极，所述电极包括形成为半圆形的一定长度的接触材料，凸接触表面和限定内部空间的锁定部分。电极被模制在载体中，使得电极的凸形接触表面优选地与载体构件表面齐平。电极的锁定部分被模制到与形成在承载部件的芯部中的引线相连接的电极中的载体部件的芯部中。本发明还提供了制造这种双极电极阵列的方法。

14. 发明授权

US4944301A Method for determining absolute current density through an implanted electrode 失效
标题翻译：通过植入电极确定绝对电流密度的方法
公开(公告)号：US4944301A
公开(公告)日：1990-07-31
申请号：US207774
申请日：1988-06-16
申请人： Gregory P. Widin , Christopher van den Honert
发明人： Gregory P. Widin , Christopher van den Honert
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36032 , A61N1/05
摘要： A method for determining absolute current density through an implanted electrode measures the fundamental and harmonic components of an electrical current passing through the electrode and estimates the absolute current density from the ratio between the magnitude of the electrical current measured at one of the harmonics on the fundamental frequency. Another method of the invention applies a wideband noise input voltage to the electrode under investigation and measures the spectrum of the input voltage and output current to determine a first transfer function. A second transfer function representing an increase magnitude of wideband noise input voltage is also obtained. A difference transfer function is computed and used to determine absolute current density through the electrode. The methods may be practiced non-invasively.
摘要翻译：用于通过注入电极确定绝对电流密度的方法测量通过电极的电流的基波和谐波分量，并根据在基波的一个谐波上测量的电流的大小之间的比率来估计绝对电流密度频率。本发明的另一种方法是对正在研究的电极施加宽带噪声输入电压，并测量输入电压和输出电流的频谱以确定第一传递函数。还获得了表示宽带噪声输入电压的增加幅度的第二传递函数。计算差分传递函数并用于确定通过电极的绝对电流密度。这些方法可以非侵入式地实施。

15. 发明授权

US08996127B2 Using interaction to measure neural excitation 有权
标题翻译：使用相互作用来测量神经激励
公开(公告)号：US08996127B2
公开(公告)日：2015-03-31
申请号：US13761640
申请日：2013-02-07
申请人： Christopher van den Honert , Zachary Smith , Christopher J. Long , Daniel M. Lisogurski , Robert P. Carlyon
发明人： Christopher van den Honert , Zachary Smith , Christopher J. Long , Daniel M. Lisogurski , Robert P. Carlyon
IPC分类号： A61N1/36 , A61B5/12 , A61B5/00
CPC分类号： A61B5/121 , A61B5/4041 , A61B5/7217 , A61N1/36032 , A61N1/36036
摘要： Assessment of neuron excitation is implemented by quantifying the interaction between focused and unfocused stimulation applied to a cochlear array. By applying focused and unfocused stimulation to the electrode array and comparing the difference in the responses to the two types of stimulation the interaction may be determined. The magnitude of the interaction may be related to neural excitation and using this data a neural excitation profile may be determined.
摘要翻译：通过量化应用于耳蜗阵列的聚焦和未聚焦刺激之间的相互作用来实现神经元激发的评估。通过将聚焦和未聚焦的刺激应用于电极阵列并且比较两种类型刺激的响应差异，可以确定相互作用。相互作用的大小可能与神经激发有关，并且使用该数据可以确定神经激动分布。

16. 发明授权

US08369958B2 Independent and concurrent processing multiple audio input signals in a prosthetic hearing implant 有权
标题翻译：在辅助听力植入物中独立并且处理多个音频输入信号
公开(公告)号：US08369958B2
公开(公告)日：2013-02-05
申请号：US11335563
申请日：2006-01-20
申请人： Bomjun Kwon , Christopher van den Honert
发明人： Bomjun Kwon , Christopher van den Honert
IPC分类号： A61N1/00 , A61N5/04
CPC分类号： A61N1/36036
摘要： A prosthetic hearing implant capable of independently and concurrently processing multiple audio input signals such that each audio input signal is separately utilized to stimulate the basilar membrane of the implant recipient. A prosthetic hearing implant of the present invention simultaneously receives discrete audio signals from each of one or more audio sources, generates a separate set of one or more stimulations signals for each audio signal, and concurrently applies the stimulation signals to the cochlear. Different channels of stimulation may be allocated to each audio input signal. Alternatively, different modes of stimulation may be used for each input signal. Or, in yet another example, the audio input signals may be time-multiplexed such that the input signals are applied in alternating timeslots. Or, in yet other examples, the input signals may be applied using a combination of stimulation channels, modes of stimulation, and alternating time slots. The stimulation signals may be delivered to the same or different electrodes depending on the quantity and frequency component of the received audio input signals, the quantity of available stimulation channels, and other factors.
摘要翻译：能够独立并且同时处理多个音频输入信号的假体听力植入物，使得每个音频输入信号被分开地用于刺激植入物接受者的基底膜。本发明的假体听力植入物同时从一个或多个音频源中的每一个接收离散音频信号，为每个音频信号产生一个或多个刺激信号的单独集合，并且同时将刺激信号施加到耳蜗。可以将不同的刺激通道分配给每个音频输入信号。或者，可以对每个输入信号使用不同的刺激模式。或者，在另一示例中，音频输入信号可以被时分复用，使得输入信号以交替的时隙被应用。或者，在其他示例中，可以使用刺激通道，刺激模式和交替时隙的组合来应用输入信号。刺激信号可以根据所接收的音频输入信号的数量和频率分量，可用刺激通道的数量和其他因素而传送到相同或不同的电极。

17. 发明授权

US08355794B2 Using a genetic algorithm in mixed mode device 有权
标题翻译：在混合模式设备中使用遗传算法
公开(公告)号：US08355794B2
公开(公告)日：2013-01-15
申请号：US12835428
申请日：2010-07-13
申请人： Sean Lineaweaver , Gregory Wakefield , Christopher van den Honert , Aaron Parkinson , Wendy Parkinson , Jim Patrick , John Parker
发明人： Sean Lineaweaver , Gregory Wakefield , Christopher van den Honert , Aaron Parkinson , Wendy Parkinson , Jim Patrick , John Parker
IPC分类号： A61N1/00
CPC分类号： A61N1/36036
摘要： Apparatus and method for at least partially fitting a medical implant system to a recipient is described. The medical implant system is configured to provide electrical stimulation and at least one other mode of stimulation to the recipient. These apparatuses and methods comprise executing a genetic algorithm to select a set of parameter values for the medical implant system. This genetic algorithm may comprise generating successive generations of child populations and then providing a determined set of parameter values to the medical implant system for use in providing stimulation to the recipient.
摘要翻译：描述了将医疗植入物系统至少部分地装配到接受者的装置和方法。医疗植入系统被配置为向受体提供电刺激和至少一种其它刺激模式。这些装置和方法包括执行遗传算法以选择用于医学植入系统的一组参数值。该遗传算法可以包括生成子代的连续世代，然后向医学植入系统提供确定的一组参数值，以用于向接受者提供刺激。

18. 发明申请

US20090132005A1 ASSESSING NEURAL SURVIVAL 有权
标题翻译：评估神经存活
公开(公告)号：US20090132005A1
公开(公告)日：2009-05-21
申请号：US12172821
申请日：2008-07-14
申请人： Christopher van den Honert , Zachary Smith , Christopher J. Long , Robert P. Carlyon
发明人： Christopher van den Honert , Zachary Smith , Christopher J. Long , Robert P. Carlyon
IPC分类号： H04R25/00 , A61B5/05
CPC分类号： A61B5/121 , A61B5/4041 , A61B5/7217 , A61N1/36032 , A61N1/36036
摘要： Neural survival related to a cochlear implant may be assessed by determining stimulus efficacy for both focused and unfocused stimulation at a plurality of locations adjacent nerve tissue; and comparing stimulus efficacy for both the focused and unfocused stimulation at a plurality of locations to determine a measure of neural survival. In particular small differences in effects produced by unfocused and focused stimulation at each of the locations tends to indicate good survival at those locations and conversely large differences in effects of focused and unfocused stimulation at a given location indicate poor survival at that location.
摘要翻译：可以通过确定在邻近神经组织的多个位置处的聚焦和未聚焦刺激的刺激功效来评估与耳蜗植入相关的神经生存; 并且比较在多个位置处的聚焦和未聚焦刺激的刺激功效以确定神经存活的量度。特别是在每个位置上由未聚焦和聚焦刺激产生的效果的微小差异往往表明在那些位置存在良好的生存，相反，在给定位置的聚焦和未聚焦刺激的影响的巨大差异表明在该位置存活较差。

19. 发明授权

US4823795A Signal processor for and an auditory prosthesis having spectral to temporal transformation 失效
标题翻译：信号处理器和具有光谱到时间变换的听觉假体
公开(公告)号：US4823795A
公开(公告)日：1989-04-25
申请号：US25485
申请日：1987-03-13
申请人： Christopher van den Honert
发明人： Christopher van den Honert
IPC分类号： A61F11/00 , A61F11/04 , A61N1/36 , G09B21/00 , H04R25/00 , A61N1/00
CPC分类号： G09B21/009 , A61N1/36032 , H04R25/356 , H04R25/505
摘要： An auditory prosthesis using and a signal processor for an electrical input signal designed to represent sound to a person. A plurality of filters each passing a different center frequency is operatively coupled to receive the electrical input signal. Each of the plurality filters is less than critically damped providing an electrical output signal whch has an impulse response which is oscillatory. Thus, the plurality of filters generate a plurality of electrical signals which selectively replicate the temporal nerve discharge pattern of individually located auditory nerve fibers within the cochlea of the person.

20. 发明授权

US09031661B2 Multi-electrode channel configurations for a hearing prosthesis 有权
标题翻译：用于听觉假体的多电极通道配置
公开(公告)号：US09031661B2
公开(公告)日：2015-05-12
申请号：US12782604
申请日：2010-05-18
申请人： Zachary M. Smith , Christopher van den Honert
发明人： Zachary M. Smith , Christopher van den Honert
IPC分类号： A61N1/05 , A61N1/36 , H04R25/00 , H03G9/00
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/36036 , A61N1/37264 , H03G9/005 , H04R25/70
摘要： An apparatus and method for determining stimulation channels for a stimulating device is provided. This method and apparatus may involve computing a set of weights for the plurality of stimulation channels of the stimulating hearing prosthesis. These weights may be determined by determining a transimpedance matrix for the stimulating hearing prosthesis where a diagonal of the transimpedance matrix is determined by extrapolation. A transadmittance matrix may then be computed for this transimpedance matrix. An error may then be computed base on positive off-diagonal terms of the transadmittance matrix. The apparatus and method may determine the weights for the stimulation channels by determining an adjustment to the diagonal of the transimpedance matrix that results in a computed error that does not exceed a specified criterion level.
摘要翻译：提供了一种用于确定刺激装置的刺激通道的装置和方法。该方法和装置可以包括计算刺激性听觉假体的多个刺激通道的一组权重。这些权重可以通过确定用于刺激性听力假体的跨阻抗矩阵来确定，其中跨阻抗矩阵的对角线通过外推来确定。然后可以为该跨阻抗矩阵计算交纳导纳矩阵。然后可以基于导纳矩阵的正偏离对角项来计算误差。该装置和方法可以通过确定导致计算出的误差不超过指定标准水平的跨阻抗矩阵的对角线来确定刺激通道的权重。

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