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11. 发明授权

US09180282B2 Implantable drug delivery system having periodic drug delivery regimen to avoid granulomas 有权
标题翻译：具有定期药物递送方案的植入药物递送系统以避免肉芽肿
公开(公告)号：US09180282B2
公开(公告)日：2015-11-10
申请号：US12555257
申请日：2009-09-08
申请人： Steven C. Adler , Paul Burke
发明人： Steven C. Adler , Paul Burke
IPC分类号： A61K9/22 , A61M31/00 , A61M5/142
CPC分类号： A61M31/002 , A61M5/14276 , A61M2205/50
摘要： An implantable drug delivery system including: a biocompatible or bio-inert housing containing a drug infusion pump, a drug chamber from which a liquid drug is dispensed when the pump applies a force to the drug chamber, and an internal controller actuating the pump; a delivery catheter extending from the housing to one or more drug delivery treatment sites in a target tissue, wherein the catheter includes a lumen having an inlet to receive a drug pumped from the drug chamber and an outlet are positioned at the target tissue, wherein the drug flows through the outlet to the target tissue, and wherein the internal controller stores and executes an automatic periodic flow regimen which commands the pump and drug chamber to periodically dispense an intermittent bolus or pulse of the liquid drug, wherein the periodic flow regimen provides a prophylactic treatment for granuloma.
摘要翻译：一种可植入药物递送系统，包括：生物相容性或生物惰性的壳体，其包含药物输注泵，药物腔室，当泵向药物腔施加力时，液体药物被分配;以及驱动泵的内部控制器; 输送导管，其从所述壳体延伸到目标组织中的一个或多个药物递送处理部位，其中所述导管包括具有入口以接收从所述药物室泵出的药物的入口并且出口位于所述靶组织处，药物流过出口到目标组织，并且其中内部控制器存储并执行自动周期性流动方案，其命令泵和药物腔室周期性地分配液体药物的间歇推注或脉冲，其中周期性流动方案提供肉芽肿的预防性治疗

12. 发明申请

US20080078232A1 PERSONAL BREATHALYZER HAVING DIGITAL CIRCUITRY 有权
标题翻译：具有数字电路的个人护肤品
公开(公告)号：US20080078232A1
公开(公告)日：2008-04-03
申请号：US11745854
申请日：2007-05-08
申请人： Paul Burke , Chi Wong
发明人： Paul Burke , Chi Wong
IPC分类号： G01N33/497
CPC分类号： G01N33/497
摘要： The present invention relates to a portable, personal breath tester device for testing the blood alcohol content of the user of the device. The breath tester comprises a circuit board, wherein a sensor, a liquid crystal display, and a processing unit are installed on and electrically connected to the circuit board. The processing unit receives a voltage signal from the sensor representing the blood alcohol content of the user and converts the voltage signal to a precise value that is displayed on the liquid crystal display.
摘要翻译：本发明涉及便携式个人呼吸测试仪装置，用于测试装置用户的血液酒精含量。呼吸测试器包括电路板，其中传感器，液晶显示器和处理单元安装在电路板上并电连接到电路板。处理单元从代表用户的血液酒精含量的传感器接收电压信号，并将电压信号转换为显示在液晶显示器上的精确值。

13. 发明申请

US20080057131A1 Method of modifying the release profile of sustained release compositions 审中-公开
标题翻译：改变持续释放组合物释放曲线的方法
公开(公告)号：US20080057131A1
公开(公告)日：2008-03-06
申请号：US11826694
申请日：2007-07-17
申请人： James Dasch , M. Gary Riley , Paul Burke , Susan Steitz-Abadi , Stephen Zale
发明人： James Dasch , M. Gary Riley , Paul Burke , Susan Steitz-Abadi , Stephen Zale
IPC分类号： A61K38/02 , A61K9/00 , A61P43/00
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/1694 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method for the sustained release in vivo of a biologically active labile agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the biologically active labile agent incorporated therein, and a corticosteroid wherein the labile is released for a period of at least about two weeks. It is understood that the corticosteroid is present in an amount sufficient to modify the release profile of the biologically active labile agent from the sustained release composition. Pharmaceutical compositions suitable for use in the method of the invention are also disclosed.
摘要翻译：本发明涉及一种用于生物活性不稳定试剂体内持续释放的方法，其包括向需要治疗的受试者施用有效量的持续释放组合物，其包含其中掺入生物活性不稳定剂的生物相容性聚合物，和一种皮质类固醇，其中不稳定性释放至少约两周。应当理解，皮质类固醇以足以改变生物活性不稳定剂从持续释放组合物的释放曲线的量存在。还公开了适用于本发明方法的药物组合物。

14. 发明申请

US20070052994A1 Printing in a framework 审中-公开
标题翻译：在框架中打印
公开(公告)号：US20070052994A1
公开(公告)日：2007-03-08
申请号：US11209217
申请日：2005-08-23
申请人： Mark Gullett , Christopher Mankle , Paul Burke
发明人： Mark Gullett , Christopher Mankle , Paul Burke
IPC分类号： G06F3/12
CPC分类号： G06F3/1222 , G06F3/1238 , G06F3/1288 , H04L67/12
摘要： In one exemplary method of printing within a framework, a message identifying a printer and indicating data to be printed is sent from a user equipment to a system proxy. A message identifying the user equipment and the printer and indicating data to be printed is sent from the system proxy to a print server. The data to be printed is sent from the print server to the printer.
摘要翻译：在框架内打印的一种示例性方法中，识别打印机并指示要打印的数据的消息从用户设备发送到系统代理。将识别用户设备和打印机以及指示要打印的数据的消息从系统代理发送到打印服务器。要打印的数据从打印服务器发送到打印机。

15. 发明申请

US20060176505A1 Printer voice portal 有权
公开(公告)号：US20060176505A1
公开(公告)日：2006-08-10
申请号：US11054551
申请日：2005-02-10
申请人： Paul Burke , Scott McGlashan
发明人： Paul Burke , Scott McGlashan
IPC分类号： G06F3/12
CPC分类号： G06F3/16 , B41J3/44 , G06F3/1293 , G10L15/26 , H04M3/38 , H04M3/42221 , H04M3/493 , H04M2201/40
摘要： A printer portal including a network connection arranged to transfer user voice command input and printer portal output, a telephony system arranged to receive user voice command input and generate printer portal output via the network connection, a printing device arranged to print information responsive to the telephony system based on the user voice command input, and an access module arranged to control user access to portions of the printer portal is described. The printer portal stores location information about the printer portal. A method for printing information at a printer portal is described. A user voice command input is received at a printer portal. The printer portal analyzes the command input using a telephony system. Information is printed at the printer portal if the command input includes a print request to print information at the printer portal.

16. 发明申请

US20060176504A1 Mobile device-based printing system and method 有权
标题翻译：基于移动设备的打印系统和方法
公开(公告)号：US20060176504A1
公开(公告)日：2006-08-10
申请号：US11053864
申请日：2005-02-10
申请人： Paul Burke , Scott McGlashan
发明人： Paul Burke , Scott McGlashan
IPC分类号： G06F3/12
CPC分类号： G06F3/1206 , G06F3/1228 , G06F3/1265 , G06F3/1268 , G06F3/1292
摘要： A mobile device-based printing system and method is described. The printer system for network printing includes a communication network adapted to transfer messages between a mobile device and a printer. The printer is connectable to the communication network to receive a print message, including a reference to a document to be printed, via the communication network. The printer has a phone number for receiving print messages via said communication network. The mobile device is connectable to the communication network to transmit the print message on the communication network. A method for printing from a mobile device to a printer using a communication network includes transmitting a print message to a phone number of the printer from the mobile device where the print message includes a reference to a document to be printed.
摘要翻译：描述了基于移动设备的打印系统和方法。用于网络打印的打印机系统包括适于在移动设备和打印机之间传送消息的通信网络。打印机可连接到通信网络，以经由通信网络接收包括对要打印的文档的引用的打印消息。打印机具有用于经由所述通信网络接收打印消息的电话号码。移动设备可连接到通信网络，以在通信网络上传送打印消息。使用通信网络从移动设备打印到打印机的方法包括从打印消息包括对要打印的文档的引用的移动设备向打印机的电话号码发送打印消息。

17. 发明授权

US5088983A Pressure regulator for implantable pump 失效
标题翻译：用于植入式泵的压力调节器
公开(公告)号：US5088983A
公开(公告)日：1992-02-18
申请号：US724032
申请日：1991-07-01
申请人： Paul Burke
发明人： Paul Burke
IPC分类号： A61M5/14 , A61M5/142 , A61M5/168 , A61M37/00
CPC分类号： A61M5/14276 , A61M5/16881 , Y10S128/12
摘要： An implantable pump system employing a flow regulator isolates the regulator sensing chamber from the path of drug flow. This is accomplished by establishing either an independent sensing chamber in the regulator or coupling it to the propellant chamber of the pump. Additionally, a downstream restrictor may be used to provide an additional pressure drop between the regulator and the outlet catheter.
摘要翻译：使用流量调节器的可植入泵系统将调节器感测室与药物流动的路径隔离开。这通过在调节器中建立独立的感测室或将其耦合到泵的推进剂室来实现。另外，可以使用下游限流器来在调节器和出口导管之间提供额外的压降。

18. 发明授权

US4716069A Process for producing a plastic laminate of low density polymeric material and high density polymeric material and laminate made thereof 失效
标题翻译：用于生产低密度聚合物材料和高密度聚合物材料的塑料层压材料及其制成的层压材料的方法
公开(公告)号：US4716069A
公开(公告)日：1987-12-29
申请号：US809475
申请日：1985-12-16
申请人： Paul Burke
发明人： Paul Burke
IPC分类号： B32B37/20 , B32B3/28
CPC分类号： B32B37/203 , B32B2305/022 , B32B2309/02 , B32B2309/12 , Y10T156/1016 , Y10T156/1025 , Y10T428/2457 , Y10T428/24661 , Y10T428/24694 , Y10T428/2495 , Y10T428/249977 , Y10T428/249993
摘要： A process and apparatus are disclosed for producing a plastics laminate material comprising a lamina of low density foamed polymeric material such as a non-cross linked polyethylene foam and a lamina of high density non-foamed polymeric material such as high density polyethylene, wherein the low density lamina is of at least 50 times greater thickness than the high density lamina, characterised in that the individual laminae are physically bonded between nip rollers at critical conditions of elevated pressure (e.g. 40 to 50 p.s.i.) and temperature (e.g. 125.degree. C. to 150.degree. C.) to bring about a very strong bond such that the bonded laminae do not readily peel apart. Temperature is particularly critical and should be brought close to and not substantially above the tackifying temperature of the low density foamed material. Air is preferably entrapped between the laminae during the process. The high density lamina is preferably pre-heated to increase its malleability prior to bonding with the low density lamina. The finished laminate may be used as a protective packaging material in sheet or bag form.
摘要翻译：公开了一种用于生产包括低密度发泡聚合物材料层（例如非交联聚乙烯泡沫）和高密度非发泡聚合物材料层（例如高密度聚乙烯）的塑料层压材料的方法和设备，其中低密度薄层的厚度比高密度薄层厚至少大50倍，其特征在于，在高压（如40至50磅/平方英寸）的临界条件和温度（例如125℃至 150℃），以产生非常强的键，使得粘合的薄层不容易剥离。温度是特别关键的，应该接近并且基本上不超过低密度泡沫材料的增粘温度。在该过程中空气优选被夹在层间。在与低密度层结合之前，高密度层优选被预热以增加其延展性。成品层压板可用作片或袋形式的保护性包装材料。

19. 发明授权

US08919704B2 Conduit hanger and support apparatus 有权
标题翻译：管道衣架和支撑装置
公开(公告)号：US08919704B2
公开(公告)日：2014-12-30
申请号：US13748656
申请日：2013-01-24
申请人： Charles Lee , Elio Evangelista , Paul Burke
发明人： Charles Lee , Elio Evangelista , Paul Burke
IPC分类号： F16L3/08 , F16L3/26
CPC分类号： F16L3/26 , F16L3/11 , H02G3/263 , Y10T29/49
摘要： A support assembly for supporting a conduit includes a support, a clamp, and a hanger. The support has a partial-cylindrical shape including a first section having a first diameter and a second section having a second diameter that is greater than the first diameter. In one aspect, at least one of the first section and the second section define a first aperture in the partial-cylindrical shape. In another aspect, at least one of the first section and the second section includes a retention member extending radially from an outer surface of the partial-cylindrical shape. The retention member includes a closed loop or a partially-open loop that defines a second aperture for receiving a strap to secure the conduit to the support. The clamp is configured to secure the conduit to the support. The hanger is configured to suspend the support from a structure.
摘要翻译：用于支撑导管的支撑组件包括支撑件，夹具和悬挂器。支撑件具有部分圆柱形形状，其包括具有第一直径的第一部分和具有大于第一直径的第二直径的第二部分。在一个方面，第一部分和第二部分中的至少一个限定了部分圆柱形形状的第一孔。在另一方面，第一部分和第二部分中的至少一个包括从部分圆柱形形状的外表面径向延伸的保持部件。保持构件包括闭环或部分开放的环，其限定用于接收带以将导管固定到支撑件的第二孔。夹具被配置成将导管固定到支撑件上。吊架构造成将结构悬挂在支架上。

20. 发明申请

US20090324493A1 METHOD FOR PREPARING A SALINE SOLUTION COMPRISING [13N] NH4 + AND USE OF A DEVICE 审中-公开
标题翻译：制备包含[13N] NH4 +的盐溶液的方法和设备的使用
公开(公告)号：US20090324493A1
公开(公告)日：2009-12-31
申请号：US11919425
申请日：2006-04-25
申请人： Paul Burke , Hannu Sipilä , John Charles Clark
发明人： Paul Burke , Hannu Sipilä , John Charles Clark
IPC分类号： A61K51/02
CPC分类号： G21G1/0005 , G21G4/08
摘要： The invention relates to a method for preparing a saline solution comprising [13N]NH4+. The method comprises following steps: preparing [13N]NH3 gas, transporting [13N]NH3 gas to a diffusion chamber, to a first side of a semipermeable membrane, transporting sterile saline solution to the diffusion chamber, to a second side of a semipermeable membrane, allowing the mixing of [13N]NH3 gas that has penetrated the semipermeable membrane with the saline solution on the second side of the semipermeable membrane, whereby saline solution comprising [13N]NH4+ is obtained, and directing the saline solution comprising [13N]NH4+ out from the diffusion chamber. The invention relates also to use of a device for preparing a radiolabelled saline solution for preparation of a saline solution comprising [13N]NH4+.
摘要翻译：本发明涉及一种制备包含[13N] NH4 +的盐溶液的方法。该方法包括以下步骤：制备[13N] NH 3气体，将[13 N] NH 3气体输送到扩散室，至半透膜的第一侧，将无菌盐水溶液输送至扩散室至半透膜的第二侧使渗透了半透膜的[13N] NH 3气体与半透膜第二面上的盐溶液混合，得到含有[13N] NH4 +的盐水溶液，将含有[13N] NH4 + 从扩散室出来。本发明还涉及用于制备用于制备包含[13N] NH 4 +的盐溶液的放射性标记盐水溶液的装置的用途。

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