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11. 发明申请

US20120145119A1 ROTARY DEVICE 有权
标题翻译：旋转装置
公开(公告)号：US20120145119A1
公开(公告)日：2012-06-14
申请号：US13379526
申请日：2010-07-01
申请人： Patrick O'Connor
发明人： Patrick O'Connor
IPC分类号： F02B53/00
CPC分类号： F01C1/18 , F01B13/067 , F01C1/084
摘要： A rotary device is described for use in a rotary engine, or a compressor, or turbine, the rotary device comprising two rotors disposed adjacent each other and rotatable about substantially parallel axes of rotation. Each of the rotors has protrusions extending therefrom at regular intervals about the circumference of each to define an open portion of a sealable compression chamber between adjacent protrusions. Each protrusion has two side surfaces and a projecting end surface, wherein the meeting point between each side surface and the projecting end surface defines a tip. The two rotors are arranged such that upon contra rotation of the rotors, a protrusion of one of the rotors engages between a pair of protrusions on the other rotor, and the tips of the engaging rotor are in constant sealing contact with the opposing side surfaces of the pair of protrusions for a predetermined period of time. During the predetermined period of time, a sealed chamber is formed and the volume of the chamber is reduced to a predetermined level by the contra rotation.
摘要翻译：描述了用于旋转发动机或压缩机或涡轮机中的旋转装置，该旋转装置包括彼此相邻设置并可大致平行的旋转轴线旋转的两个转子。每个转子具有从其周围以规则的间隔延伸的突起，每个圆周围绕相邻的突起之间限定可密封的压缩室的开口部分。每个突起具有两个侧表面和一个突出端表面，其中每个侧表面与突出端表面之间的汇合点限定一个尖端。两个转子被布置成使得当转子反转时，一个转子的突起接合在另一个转子上的一对突起之间，并且接合转子的末端与相对的侧表面保持恒定的密封接触该一对突起预定的时间段。在预定时间期间，形成密封室，并且通过反向旋转将室的体积减小到预定水平。

12. 发明授权

US07450220B2 Method and system to correct motion blur and reduce signal transients in time-of-flight sensor systems 有权
公开(公告)号：US07450220B2
公开(公告)日：2008-11-11
申请号：US11975059
申请日：2007-10-16
申请人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
发明人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
IPC分类号： G01C3/08
CPC分类号： G01C3/08 , G01C25/00
摘要： TOF system shutter time needed to acquire image data in a time-of-flight (TOF) system that acquires consecutive images is reduced, thus decreasing the time in which relative motion can occur. In one embodiment, pixel detectors are clocked with multi-phase signals and integration of the four signals occurs simultaneously to yield four phase measurements from four pixel detectors within a single shutter time unit. In another embodiment, phase measurement time is reduced by a factor (1/k) by providing super pixels whose collection region is increased by a factor “k” relative to a normal pixel detector. Each super pixel is coupled to k storage units and four-phase sequential signals. Alternatively, each pixel detector can have k collector regions, k storage units, and share common clock circuitry that generates four-phase signals. Various embodiments can reduce the mal-effects of clock signal transients upon signals, and can be dynamically reconfigured as required.

13. 发明申请

US20080108658A1 METHODS OF PROMOTING OSTEOGENESIS 审中-公开
标题翻译：促进骨质疏松症的方法
公开(公告)号：US20080108658A1
公开(公告)日：2008-05-08
申请号：US11853751
申请日：2007-09-11
申请人： Andrew Protter , David Liu , Patrick O'Connor
发明人： Andrew Protter , David Liu , Patrick O'Connor
IPC分类号： A61K31/454 , A61P19/00 , A61P19/10
CPC分类号： A61K31/404 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/517 , A61K31/53
摘要： The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.
摘要翻译：本发明涉及通过施用p38MAP激酶抑制剂的骨愈合方法。本发明涉及治疗骨折，骨疾病，骨移植，特别是增强面部重建后的骨愈合，上颌骨重建，下颌骨重建或拔牙，增强长骨延伸，增强假体向内生长以及增加骨愈合的方法，通过施用 p38 MAP激酶抑制剂。

14. 发明申请

US20080036996A1 Method and system to correct motion blur and reduce signal transients in time-of-flight sensor systems 有权
标题翻译：纠正运动模糊和降低飞行时间传感器系统信号瞬变的方法和系统
公开(公告)号：US20080036996A1
公开(公告)日：2008-02-14
申请号：US11975059
申请日：2007-10-16
申请人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
发明人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
IPC分类号： G01C3/08
CPC分类号： G01C3/08 , G01C25/00
摘要： TOF system shutter time needed to acquire image data in a time-of-flight (TOF) system that acquires consecutive images is reduced, thus decreasing the time in which relative motion can occur. In one embodiment, pixel detectors are clocked with multi-phase signals and integration of the four signals occurs simultaneously to yield four phase measurements from four pixel detectors within a single shutter time unit. In another embodiment, phase measurement time is reduced by a factor (1/k) by providing super pixels whose collection region is increased by a factor “k” relative to a normal pixel detector. Each super pixel is coupled to k storage units and four-phase sequential signals. Alternatively, each pixel detector can have k collector regions, k storage units, and share common clock circuitry that generates four-phase signals. Various embodiments can reduce the mal-effects of clock signal transients upon signals, and can be dynamically reconfigured as required.
摘要翻译：在获取连续图像的飞行时间（TOF）系统中获取图像数据所需的TOF系统快门时间减少，从而减少相对运动发生的时间。在一个实施例中，通过多相信号对像素检测器进行时钟控制，并且四个信号的积分同时发生，以在单个快门时间单位内从四个像素检测器产生四相测量。在另一个实施例中，通过提供相对于正常像素检测器的收集区域增加因子“k”的超像素，将相位测量时间减小因子（1 / k）。每个超像素耦合到k个存储单元和四个相序的信号。或者，每个像素检测器可以具有k个集电极区域，k个存储单元，以及共享产生四相信号的公共时钟电路。各种实施例可以减少对信号的时钟信号瞬变的不良影响，并且可以根据需要动态地重新配置。

15. 发明申请

US20070148625A1 Disease treatment simulation 有权
标题翻译：疾病治疗模拟
公开(公告)号：US20070148625A1
公开(公告)日：2007-06-28
申请号：US11607435
申请日：2006-12-01
申请人： George Biltz , Pradyumna Dutta , Paul Johnson , Patrick O'Connor , William Rush , JoAnn Sperl-Hillen
发明人： George Biltz , Pradyumna Dutta , Paul Johnson , Patrick O'Connor , William Rush , JoAnn Sperl-Hillen
IPC分类号： G09B23/28 , G06G7/48
CPC分类号： G09B7/00 , G06G7/48 , G09B19/00 , G09B23/28
摘要： There are provided a method, system and medium having instructions embedded to determine an attribute of a simulated patient's state resulting from a patient-physician encounter. The method includes receiving a current treatment move and an initial value of the attribute; calculating a maximal expected incremental effect value of the current treatment move over a previous treatment move on the attribute; attenuating the maximal expected incremental effect value based on amount of time between the previous treatment move and the current treatment move; summing the attenuated maximal expected incremental effect value with the initial value to generate an updated attribute of the simulated patient's state; and generating a patient-physician encounter that includes the updated attribute.
摘要翻译：提供了一种方法，系统和介质，其具有嵌入的指令以确定由患者 - 医师相遇产生的模拟患者状态的属性。该方法包括接收当前处理移动和属性的初始值; 计算当前治疗移动的最大预期增量效应值; 根据以前的处理动作和当前处理动作之间的时间量，衰减最大预期增量效应值; 将衰减的最大预期增量效应值与初始值相加以生成模拟患者状态的更新属性; 以及产生包括更新的属性的患者 - 医生遭遇。

16. 发明申请

US20060176469A1 Method and system to correct motion blur and reduce signal transients in time-of-flight sensor systems 有权
标题翻译：纠正运动模糊和降低飞行时间传感器系统信号瞬变的方法和系统
公开(公告)号：US20060176469A1
公开(公告)日：2006-08-10
申请号：US11350222
申请日：2006-02-08
申请人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
发明人： Patrick O'Connor , Ilhami Torunoglu , Rajeev Nagabhirana
IPC分类号： G01C3/08
CPC分类号： G01C3/08 , G01S17/89
摘要： TOF system shutter time needed to acquire image data in a time-of-flight (TOF) system that acquires consecutive images is reduced, thus decreasing the time in which relative motion can occur. In one embodiment, pixel detectors are clocked with multi-phase signals and integration of the four signals occurs simultaneously to yield four phase measurements from four pixel detectors within a single shutter time unit. In another embodiment, phase measurement time is reduced by a factor (1/k) by providing super pixels whose collection region is increased by a factor “k” relative to a normal pixel detector. Each super pixel is coupled to k storage units and four-phase sequential signals. Alternatively, each pixel detector can have k collector regions, k storage units, and share common clock circuitry that generates four-phase signals. Various embodiments can reduce the mal-effects of clock signal transients upon signals, and can be dynamically reconfigured as required.
摘要翻译：在获取连续图像的飞行时间（TOF）系统中获取图像数据所需的TOF系统快门时间减少，从而减少相对运动发生的时间。在一个实施例中，通过多相信号对像素检测器进行时钟控制，并且四个信号的积分同时发生，以在单个快门时间单位内从四个像素检测器产生四相测量。在另一个实施例中，通过提供相对于正常像素检测器的收集区域增加因子“k”的超像素，将相位测量时间减小因子（1 / k）。每个超像素耦合到k个存储单元和四个相序的信号。或者，每个像素检测器可以具有k个集电极区域，k个存储单元，以及共享产生四相信号的公共时钟电路。各种实施例可以减少对信号的时钟信号瞬变的不良影响，并且可以根据需要动态地重新配置。

17. 发明授权

US09174949B2 Hedgehog inhibitors 有权
标题翻译：刺猬抑制剂
公开(公告)号：US09174949B2
公开(公告)日：2015-11-03
申请号：US13520150
申请日：2011-01-06
申请人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/427 , C07D417/12 , C07D277/22 , C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
CPC分类号： C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译：本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

18. 发明授权

US08696627B2 Two way accumulator programmable valve pump 有权
标题翻译：双向蓄能器可编程阀门泵
公开(公告)号：US08696627B2
公开(公告)日：2014-04-15
申请号：US13608583
申请日：2012-09-10
申请人： Paul Burke , Patrick O'Connor
发明人： Paul Burke , Patrick O'Connor
IPC分类号： A61B17/50
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

19. 发明申请

US20120136356A1 INTRAMEDULLARY NAILS FOR LONG BONE FRACTURE SETTING 有权
标题翻译：用于长骨骨折设置的内固定钉
公开(公告)号：US20120136356A1
公开(公告)日：2012-05-31
申请号：US13389130
申请日：2010-08-12
申请人： William Doherty , Patrick O'Connor , James Harty
发明人： William Doherty , Patrick O'Connor , James Harty
IPC分类号： A61B17/56
CPC分类号： A61B17/725 , A61B17/7225 , A61B17/7241
摘要： An intramedullary nail has a proximal part for engagement with a proximal bone fragment and a distal part for engagement with a distal bone fragment. A motion assembly interconnects the parts and allows limited axial relative motion of the proximal and distal parts. This limited axial motion provides micromotion and in some embodiments also dynamisation. The nail may comprise a stem for fastening to one bone fragment and an insert within the stem for fastening to the other bone fragment, the insert being adapted to guide insertion of a bone screw through the stem and to prevent relative rotation of the distal and proximal bone fragments. The motion assembly may include spring bias and/or damping means between the parts, possibly including one or more Belleville washers.
摘要翻译：髓内钉具有近端部分，用于与近端骨片段和用于与远侧骨片段接合的远端部分接合。运动组件互连部件并允许近端和远端部分的有限的轴向相对运动。这种有限的轴向运动提供微动作，并且在一些实施例中也是动态化。指甲可以包括用于紧固到一个骨碎片的杆和用于紧固到另一个骨碎片的柄内的插入件，插入件适于引导骨螺钉穿过杆的插入并且防止远端和近端的相对旋转骨碎片。运动组件可以包括在部件之间的弹簧偏压和/或阻尼装置，可能包括一个或多个Belleville垫圈。

20. 发明申请

US20090093797A1 Two way accumulatorprogrammable valve pump 有权
标题翻译：双向蓄能器可编程阀门泵
公开(公告)号：US20090093797A1
公开(公告)日：2009-04-09
申请号：US11906826
申请日：2007-10-04
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M5/148 , F04B43/04 , G01F11/08
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

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