专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06737051B1 Cell compositions containing macrophages, presenting anti-infectious and hematopoietic properties 失效
标题翻译：含有巨噬细胞的细胞组合物，具有抗感染和造血特性
公开(公告)号：US06737051B1
公开(公告)日：2004-05-18
申请号：US09890652
申请日：2001-11-27
申请人： Bernard Klein , Zhao Yang Lu , Jacques Bartholeyns
发明人： Bernard Klein , Zhao Yang Lu , Jacques Bartholeyns
IPC分类号： A01N6300
CPC分类号： C12N5/0645 , A61K35/15 , A61K35/17 , C12N2501/22 , C12N2501/24 , A61K2300/00
摘要： The invention relates to a cell composition containing macrophages, presenting anti-infectious and hematopoietic properties. More particularly, the invention relates to a cell composition containing macrophages, myeloid cells and progenitors; said cell compositions are useful for the restoration of hematopoiesis in an aplasic patient and/or the protection of patients against infectious diseases or against residual tumors.
摘要翻译：本发明涉及含有巨噬细胞的细胞组合物，具有抗感染和造血特性。更具体地，本发明涉及含有巨噬细胞，骨髓细胞和祖细胞的细胞组合物; 所述细胞组合物可用于恢复一次性患者的造血作用和/或对患者免受感染性疾病或对于残留肿瘤的保护。

12. 发明授权

US06703016B1 Apoptotic bodies, monocyte derived cells containing the same, a process for their preparation and their uses as vaccines 失效
标题翻译：凋亡体，含有其的单核细胞衍生细胞，其制备方法及其作为疫苗的用途
公开(公告)号：US06703016B1
公开(公告)日：2004-03-09
申请号：US09700108
申请日：2000-12-28
申请人： Marc Gregoire , Jacques Bartholeyns
发明人： Marc Gregoire , Jacques Bartholeyns
IPC分类号： A61K4800
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5154 , C12N2500/36
摘要： The present invention relates to apoptotic bodies derived from human tumor cells or cell lines recovered from patient's tumor biopsy and induced to apoptotis, said apoptotic bodies having the following characteristics: they maintain plasma membrane integrity, they are vesicles above about 0,1 &mgr;m, they contain intact mitochondria and cleaved nuclear DNA originating from the tumor cells, they present unmasked tumor antigens on their membranes, they present specific tumor and MHC antigens from the patient. The invention also provides new monocytes derived cells, which can be used as anti-tumor vaccines after integration of apoptotic bodies. Apoptotic bodies are phagocytosed and processed by monocyte derived antigen presenting cells and potentiate the effective tumor antigenic presentation to the immune system.
摘要翻译：本发明涉及源自人肿瘤细胞或从患者肿瘤活组织检查中诱导凋亡的细胞系的凋亡小体，所述凋亡小体具有以下特征：它们保持质膜完整性，它们是高于约0.1μm的囊泡，它们含有源自肿瘤细胞的完整的线粒体和切割的核DNA，它们在其膜上存在未被掩蔽的肿瘤抗原，它们呈现来自患者的特异性肿瘤和MHC抗原。本发明还提供新的单核细胞衍生细胞，其可以在凋亡小体整合后用作抗肿瘤疫苗。细胞凋亡体被吞噬细胞并由单核细胞衍生的抗原呈递细胞处理，并增强免疫系统的有效肿瘤抗原呈递。

13. 发明授权

US06881413B1 Humanized biomaterials, a process for their preparation and their applications 失效
标题翻译：人造生物材料，其制备过程及其应用
公开(公告)号：US06881413B1
公开(公告)日：2005-04-19
申请号：US10069575
申请日：2000-08-22
申请人： Jacques Bartholeyns
发明人： Jacques Bartholeyns
IPC分类号： A61L27/38 , A61L27/40 , C12N5/08 , A61K9/00 , A61F2/02
CPC分类号： A61L27/3813 , A61F2/28 , A61L27/12 , A61L27/38 , A61L27/3804 , A61L27/3843 , A61L27/3895 , A61L27/40 , A61L27/507 , A61L27/60
摘要： The invention relates to humanized biomaterial comprising a porous biocompatible composite material customized and implanted with monocyte derived cells preferably with macrophages.
摘要翻译：本发明涉及包含多孔生物相容性复合材料的人源化生物材料，所述多孔生物相容性复合材料定制并植入优选与巨噬细胞的单核细胞衍生细胞。

14. 发明授权

US06713056B1 Combined preparation for the treatment of neoplasic diseases or of infectious diseases 失效
标题翻译：用于治疗新生儿疾病或感染性疾病的联合制剂
公开(公告)号：US06713056B1
公开(公告)日：2004-03-30
申请号：US09647529
申请日：2000-11-29
申请人： Jacques Bartholeyns , Yves Fouron , Jean-Loup Romet-Lemonne
发明人： Jacques Bartholeyns , Yves Fouron , Jean-Loup Romet-Lemonne
IPC分类号： A61K3514
CPC分类号： C12N5/0645 , A61K31/232 , A61K31/282 , A61K31/336 , A61K31/407 , A61K31/505 , A61K31/655 , A61K31/704 , A61K35/15 , A61K39/0011 , A61K45/06 , A61K2039/5154 , A61K2300/00
摘要： The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts: monocyte derived cells, particularly cytotoxic macrophages, chemotherapy or immunotherapy drugs, for the simultaneous, separate or sequential use, for the treatment of cancer or infectious diseases.
摘要翻译：本发明涉及包含作为活性物质的以下单独组分的组合制剂，其为成套工具：单核细胞来源的细胞，特别是细胞毒性巨噬细胞，化学疗法或免疫治疗药物，用于同时，分开或顺序使用，用于治疗癌症或传染病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式