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11. 发明授权

US4941974A Method of making liquid chromatography dual zone packing materials 失效
标题翻译：制备液相色谱双区包装材料的方法
公开(公告)号：US4941974A
公开(公告)日：1990-07-17
申请号：US335885
申请日：1989-04-10
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B01J20/32
CPC分类号： B01J20/3285 , B01J20/287 , B01J20/288 , B01J20/3227 , B01J20/3246 , B01J20/3257 , B01J20/3263 , B01D15/325
摘要： Dual zone reverse phase packing materials for use in liquid chromatographic blood serum analysis are prepared by contacting a porous support, such as porous silica, with a fluorocarbon silane, such as a perfluorobutylsilyl compound, to form a lipophobic phase in the external zone of the porous support, and, then contacting the porous support with a lipophilic silane, such as an octadecylsilyl compound, to form a lipophilic partitioning phase in the internal zone of the porous support. Ketal blocked diol groups, which later may be hydrolyzed to diol groups, are also attached to both zones of the packing materials. The dual zone reverse phase packing materials display a reduced degree of serum protein adsorption in the external zone while drug substances are retained and separated by the lipophilic partitioning phase in the internal zone.
摘要翻译：通过使诸如多孔二氧化硅的多孔载体与诸如全氟丁基甲硅烷基化合物的碳氟硅烷接触，在多孔的外部区域中形成疏水相，制备用于液相色谱血清分析的双区反相包装材料。支持，然后使多孔载体与亲脂性硅烷如十八烷基甲硅烷基化合物接触，以在多孔载体的内部区域中形成亲油性分配相。 Ketal封端的二醇基团（其随后可能被水解成二醇基团）也附着在包装材料的两个区域上。双区反相包装材料在外部区域显示血清蛋白吸附程度降低，而药物物质通过内部区域中的亲脂性分配相保留并分离。

12. 发明授权

US4782040A Porous materials having a dual surface 失效
标题翻译：多孔材料具有双面
公开(公告)号：US4782040A
公开(公告)日：1988-11-01
申请号：US598120
申请日：1984-04-09
申请人： Anthony Revis , Dwight E. Williams
发明人： Anthony Revis , Dwight E. Williams
IPC分类号： C04B41/84 , B01J20/281 , B01J20/283 , B01J20/32 , C08J7/12 , C08J9/00 , C08J9/24 , G01N30/88 , B01D15/08 , B01J20/22 , B32B5/14
CPC分类号： B01J20/3285 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3257 , Y10T428/16 , Y10T428/2995 , Y10T428/31663
摘要： Porous materials having a dual surface are disclosed. Also disclosed is a method for their preparation. An example of such a material is a silica gel reacted with a reactive silane intermediate such as (CH.sub.3).sub.2 Si.dbd.O and then, with a reactive silane such as ##STR1## to give a dual treated material having --((CH.sub.3).sub.2 SiO).sub.x H on the exterior surface and ##STR2## on the interior surface of the pores.
摘要翻译：公开了具有双面的多孔材料。还公开了它们的制备方法。这种材料的一个例子是与反应性硅烷中间体例如（CH 3）2 Si = O反应，随后与反应性硅烷如“IMAGE”反应得到具有 - （（CH 3）2 SiO）的双重处理材料的硅胶， xH在外表面和在孔的内表面。

13. 发明授权

US5110784A Dual surface porous material 失效
标题翻译：双面多孔材料
公开(公告)号：US5110784A
公开(公告)日：1992-05-05
申请号：US479133
申请日：1990-02-12
申请人： Dwight E. Williams , Thomas J. Tangney , Anthony Revis
发明人： Dwight E. Williams , Thomas J. Tangney , Anthony Revis
IPC分类号： B01J20/32
CPC分类号： B01J20/286 , B01J20/3204 , B01J20/3244 , B01J20/3246 , B01J20/3285 , C22B3/24 , B01J2220/54 , Y02P10/234 , Y10T428/2995 , Y10T428/31663 , Y10T428/31862
摘要： Porous materials having a dual surface are disclosed. Also disclosed is a method for their preparation. An example of such a material is silica gel reacted with 1,1,1-trifluoropropyldimethylsilyl-N-methylacetamide and then, with N-trimethylsilyl-N-methylacetamide to give a dual treated material having 1,1,1-trifluoropropyldimethylsilyl groups on the exterior surface and trimethylsilyl groups on the porous interior surface.
摘要翻译：公开了具有双面的多孔材料。还公开了它们的制备方法。硅胶与1,1,1-三氟丙基二甲基甲硅烷基-N-甲基乙酰胺反应，然后与N-三甲基甲硅烷基-N-甲基乙酰胺反应，得到双重处理的物质，其具有1,1,1-三氟丙基二甲基甲硅烷基外表面和多孔内表面上的三甲基甲硅烷基。

14. 发明授权

US4950635A Method for producing dual zone materials by catalyzed halosilylation 失效
标题翻译：通过催化卤代甲硅烷基化生产双区材料的方法
公开(公告)号：US4950635A
公开(公告)日：1990-08-21
申请号：US248737
申请日：1988-09-22
申请人： Dwight E. Williams , Thomas J. Tangney
发明人： Dwight E. Williams , Thomas J. Tangney
IPC分类号： B01D15/08 , B01J20/32
CPC分类号： B01D15/08 , B01J20/3204 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , Y10T428/2995
摘要： Dual zone porous materials having an external zone and an internal zone are prepared by contacting a suspension of a porous support, such as particulate silica, in a solvent with a halosilane and a catalyst for the halosilane in order to form first silyl groups predominantly on the external surfaces of the porous support. Preferably thereafter the porous support is contacted with a silane having second silyl groups in order to a form second silyl groups predominantly on the internal surfaces.
摘要翻译：具有外部区域和内部区域的双区域多孔材料通过将多孔载体（例如颗粒状二氧化硅）在溶剂中的悬浮液与卤代硅烷和卤代硅烷的催化剂接触来制备，以形成主要在多孔载体的外表面。此后优选地，多孔载体与具有第二甲硅烷基的硅烷接触，以形成主要在内表面上的第二甲硅烷基。

15. 发明授权

US4855054A Using liquid chromatography dual zone packing materials 失效
标题翻译：使用液相色谱双区包装材料
公开(公告)号：US4855054A
公开(公告)日：1989-08-08
申请号：US212100
申请日：1988-06-27
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B01D15/08 , B01J20/32
CPC分类号： B01J20/3285 , B01D15/325 , B01J20/3204 , B01J20/3219 , B01J20/3227 , B01J20/3257
摘要： Dual zone reverse phase packing materials for use in liquid chromatographic blood serum analysis are prepared by contacting a porous support, such as porous silica, with a fluorocarbon silane, such as a perfluorobutylsilyl compound, to form a lipophobic phase in the external zone of the porous support, and, then contacting the porous support with a lipophilic silane, such as an octadecylsilyl compound, to form a lipophilic partitioning phase in the internal zone of the porous support. Ketal blocked diol groups, which later may be hydrolyzed to diol groups, are also attached to both zones of the packing materials. The dual zone reverse phase packing materials display a reduced degree of serum protein adsorption in the external zone while drug substances are retained and separated by the lipophilic partitioning phase in the internal zone.
摘要翻译：通过使诸如多孔二氧化硅的多孔载体与诸如全氟丁基甲硅烷基化合物的碳氟硅烷接触，在多孔的外部区域中形成疏水相，制备用于液相色谱血清分析的双区反相包装材料。支持，然后使多孔载体与亲脂性硅烷如十八烷基甲硅烷基化合物接触，以在多孔载体的内部区域中形成亲油性分配相。 Ketal封端的二醇基团（其随后可能被水解成二醇基团）也附着在包装材料的两个区域上。双区反相包装材料在外部区域显示血清蛋白吸附程度降低，而药物物质通过内部区域中的亲脂性分配相保留并分离。

16. 发明授权

US4778600A Liquid chromatography dual zone packing materials 失效
标题翻译：液相色谱双区包装材料
公开(公告)号：US4778600A
公开(公告)日：1988-10-18
申请号：US63576
申请日：1987-06-17
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： G01N30/88 , B01D15/08 , B01J20/281 , B01J20/283 , B01J20/286 , B01J20/292 , B01J20/32
CPC分类号： B01J20/3285 , B01D15/325 , B01J20/3204 , B01J20/3219 , B01J20/3227 , B01J20/3257 , B01J20/3263
摘要： Dual zone reverse phase packing materials for use in liquid chromatographic blood serum analysis are prepared by contacting a porous support, such as porous silica, with a fluorocarbon silane, such as a perfluorobutylsilyl compound, to form a lipophobic phase in the external zone of the porous support, and, then contacting the porous support with a lipophilic silane, such as an octadecylsilyl compound, to form a lipophilic partitioning phase in the internal zone of the porous support. Ketal blocked diol groups, which later may be hydrolyzed to diol groups, are also attached to both zones of the packing materials. The dual zone reverse phase packing materials display a reduced degree of serum protein adsorption in the external zone while drug substances are retained and separated by the lipophilic partitioning phase in the internal zone.

17. 发明授权

US4367881A Vehicle steering system 失效
标题翻译：车辆转向系统
公开(公告)号：US4367881A
公开(公告)日：1983-01-11
申请号：US192711
申请日：1980-10-01
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B62D7/02 , B62D9/00
CPC分类号： B62D7/02
摘要： The steering system includes a rotatable steering control member located remotely from a steerable dirigible wheel unit, a drive sprocket mounted for common rotation with the steering control member, a short length of roller or sprocket chain trained about the drive sprocket, a driven sprocket mounted for common rotation with the dirigible wheel unit, a short length of roller or sprocket chain trained about the driven sprocket, and flexible members, such as wire cables, interconnecting the chains so that the driven sprocket is rotated in response to rotation of the drive sprocket. Two sets of coaxially aligned pairs of pulley are located between the drive and driven sprockets and the cables are trained over the same sides of the pulleys in each set and thereby are guided through a circuitous route between the sprockets. One set of pulleys is adjustably mounted relative to the cables for adjusting the tension applied on the cables to remove slack therefrom.
摘要翻译：该转向系统包括一个可转向的转向控制构件，该转动控制构件远离可转向的可拆卸轮组件，与转向控制构件共同旋转的驱动链轮，围绕驱动链轮训练的较短长度的滚轮或链轮链; 与实际轮单元共同旋转，围绕从动链轮训练的较短长度的辊或链轮链，以及互连链条的柔性构件（例如线缆），使得从动链轮响应于驱动链轮的旋转而旋转。两组同轴对准的滑轮对位于驱动链轮和从动链轮之间，并且电缆在每组中的皮带轮的相同侧面上被训练，并且由此被引导通过链轮之间的迂回路线。一组滑轮相对于电缆可调节地安装，用于调节施加在电缆上的张力以从中移除松弛。

18. 发明授权

US5559039A Method of using liquid column packing materials 失效
标题翻译：液柱包装材料的使用方法
公开(公告)号：US5559039A
公开(公告)日：1996-09-24
申请号：US292520
申请日：1994-08-18
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B01J20/32 , B01J31/02 , B01J31/08 , G01N30/02
CPC分类号： B01J20/287 , B01J20/28078 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3274 , B01J20/3282 , B01J31/0254 , B01J31/08 , B01J2220/54 , B01J2220/58 , Y10S530/811 , Y10S530/812
摘要： Packing materials for liquid chromatographic or catalytic columns are prepared by contacting a porous protein-adsorptive particulate or membranous support, such as a porous silica particulate support, with an aqueous solution into which a protein has been dissolved to form a saturated coating of protein on the external surfaces of the porous protein-adsorptive support, removing excess protein that remains in solution by washing, and, then crosslinking the protein in the coating. The result is a packing material which resists further adsorption by many different proteins but which continues to provide the adsorptive or catalytic properties of the groups on the internal surfaces of the porous protein-adsorptive support for separations, analysis, or alteration of small molecules. The packing material of the present invention is particularly useful in HPLC or solid phase extraction columns for direct injection drug analysis in plasma, serum, and urine.
摘要翻译：用于液相色谱或催化色谱柱的包装材料是通过将多孔蛋白质吸附性颗粒或膜状载体如多孔二氧化硅颗粒载体与溶解有蛋白质的水溶液接触形成蛋白质的饱和涂层而制备的多孔蛋白质吸附载体的外表面，通过洗涤去除残留在溶液中的多余蛋白质，然后在涂层中交联蛋白质。结果是一种包装材料，其抵抗许多不同蛋白质的进一步吸附，但是继续提供多孔蛋白质 - 吸附载体的内表面上的基团的吸附或催化性质用于分离，分析或改变小分子。本发明的包装材料在用于血浆，血清和尿液中的直接注射药物分析的HPLC或固相萃取柱中特别有用。

19. 发明授权

US5545317A Liquid column packing materials and method for making the same 失效
标题翻译：液柱包装材料及其制造方法
公开(公告)号：US5545317A
公开(公告)日：1996-08-13
申请号：US422803
申请日：1995-04-17
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B01J20/32 , B01J31/02 , B01J31/08 , B01D15/08
CPC分类号： B01J20/287 , B01J20/28078 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3274 , B01J20/3282 , B01J31/0254 , B01J31/08 , B01J2220/54 , B01J2220/58 , Y10S530/811 , Y10S530/812
摘要： Packing materials for liquid chromatographic or catalytic columns are prepared by contacting a porous protein-adsorptive particulate or membranous support, such as a porous silica particulate support, with an aqueous solution into which a protein has been dissolved to form a saturated coating of protein on the external surfaces of the porous protein-adsorptive support, removing excess protein that remains in solution by washing, and, then crosslinking the protein in the coating. The result is a packing material which resists further adsorption by many different proteins but which continues to provide the adsorptive or catalytic properties of the groups on the internal surfaces of the porous protein-adsorptive support for separations, analysis, or alteration of small molecules. The packing material of the present invention is particularly useful in HPLC or solid phase extraction columns for direct injection drug analysis in plasma, serum, and urine.
摘要翻译：用于液相色谱或催化色谱柱的包装材料是通过将多孔蛋白质吸附性颗粒或膜状载体如多孔二氧化硅颗粒载体与溶解有蛋白质的水溶液接触形成蛋白质的饱和涂层而制备的多孔蛋白质吸附载体的外表面，通过洗涤去除残留在溶液中的多余蛋白质，然后在涂层中交联蛋白质。结果是一种包装材料，其抵抗许多不同蛋白质的进一步吸附，但是继续提供多孔蛋白质 - 吸附载体的内表面上的基团的吸附或催化性质用于分离，分析或改变小分子。本发明的包装材料在用于血浆，血清和尿液中的直接注射药物分析的HPLC或固相萃取柱中特别有用。

20. 发明授权

US4897197A Using liquid chromatography packing materials 失效
标题翻译：使用液相色谱填充材料
公开(公告)号：US4897197A
公开(公告)日：1990-01-30
申请号：US212192
申请日：1988-06-27
申请人： Dwight E. Williams
发明人： Dwight E. Williams
IPC分类号： B01J20/32
CPC分类号： B01J20/3257 , B01J20/287 , B01J20/288 , B01J20/3227 , B01J20/3263 , B01J2220/54
摘要： Packing material for use in liquid chromatographic analysis are prepared by contacting a porous support, such as porous silica, with a ketal silane to form ketal blocked diol groups on the surfaces thereof. An end-capping reagent such as a trimethylsilyl reagent may be added. In addition, the ketal blocked diol groups may be further hydrolyzed to diol groups.
摘要翻译：用于液相色谱分析的包装材料是通过使诸如多孔二氧化硅的多孔载体与缩酮硅烷接触在其表面上形成缩酮二醇基来制备的。可以加入三甲基甲硅烷基试剂等封端剂。此外，缩酮二醇基可以进一步水解成二醇基。

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