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    • 12. 发明授权
    • Imidoyl substituted pyrroles
    • 酰亚胺基取代的吡咯
    • US4528382A
    • 1985-07-09
    • US442210
    • 1982-11-16
    • John E. Mills
    • John E. Mills
    • C07D207/32C07D207/337
    • C07D207/337
    • Novel compounds, which are aryl-pyrrolyl-imine derivatives of the Formula I ##STR1## and acid addition salts thereof are disclosed; which compounds may be prepared by the acid catalyzed condensation of an imidoyl chloride with a lower alkyl pyrrole-2-acetate; and which compounds are useful as intermediates to form by hydrolysis, the known useful ketone analogs which have anti-inflammatory and analgesic activity; and certain of which compounds have antisecretory, anti-irritable bowel, antidiarrheal and general behavior effect on the CNS properties.
    • 公开了新的化合物,其为式I的芳基 - 吡咯并 - 亚胺衍生物及其酸加成盐; 哪些化合物可以通过亚氨基氯与低级烷基吡咯-2-乙酸酯的酸催化缩合来制备; 哪些化合物可用作通过水解形成的中间体,已知有用的酮类似物具有抗炎和止痛活性; 其中某些化合物对CNS性质具有抗分泌,抗肠易激综合征,止泻药和一般行为作用。