专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US10174082B2 Amylin and calcitonin receptor agonist 有权
公开(公告)号：US10174082B2
公开(公告)日：2019-01-08
申请号：US15417671
申请日：2017-01-27
申请人： Novo Nordisk A/S
发明人： Thomas Kruse , Lauge Schaeffer , Kirsten Dahl , Christian Poulsen , Kirsten Raun
IPC分类号： A61K38/00 , A61K38/16 , C07K14/00 , C07K14/575
摘要： The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogs and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to SEQ ID NO: 1, analogs and derivatives thereof as medicaments.

12. 发明申请

US20170145059A1 Novel Amylin And Calcitonin Receptor Agonist 审中-公开
公开(公告)号：US20170145059A1
公开(公告)日：2017-05-25
申请号：US15417671
申请日：2017-01-27
申请人： Novo Nordisk A/S
发明人： Thomas Kruse , Lauge Schaeffer , Kirsten Dahl , Christian Poulsen , Kirsten Raun
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/575
摘要： The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogues and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to SEQ ID NO: 1, analogues and derivatives thereof as medicaments.

13. 发明申请

US20150025003A1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVES AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译： GLUCAGON-LIKE PEPTIDE-1衍生物及其药物用途
公开(公告)号：US20150025003A1
公开(公告)日：2015-01-22
申请号：US14506052
申请日：2014-10-03
申请人： Novo Nordisk A/S
发明人： Jane Spetzler , Lauge Schaeffer , Jesper Lau , Thomas Kruse , Patrick W. Garibay , Steffen Reedtz-Runge , Henning Thoegersen , Ingrid Pettersson
IPC分类号： C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K38/26
摘要： The invention relates to protracted Glucagon-Like Peptide-1 (GLP-1) derivatives and therapeutic uses thereof. The GLP-1 derivative of the invention comprises a modified GLP-1(7-37) sequence having a total of 2-12 amino acid modifications, including Glu22 and Arg26, and being derivatised with an albumin binding residue or pegylated in position 18, 20, 23, 30, 31, 34, 36, 37, or 39. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, stable, have long half-lives, a high affinity of binding to albumin, and/or a high affinity of binding to the extracellular domain of the GLP-1 receptor (GLP-1R), all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.
摘要翻译：本发明涉及长效的胰高血糖素样肽-1（GLP-1）衍生物及其治疗用途。本发明的GLP-1衍生物包含具有总共2-12个氨基酸修饰的修饰的GLP-1（7-37）序列，包括Glu22和Arg26，并用白蛋白结合残基衍生或在18位聚乙二醇化， 20,23,30,31,34,36,37或39.这些化合物可用于治疗或预防2型糖尿病和相关疾病。该化合物是有效的，稳定的，具有长的半衰期，与白蛋白结合的高亲和力，和/或与GLP-1受体（GLP-1R）细胞外结构域结合的高亲和力，所有这些都是对于实现长效，稳定和活性的GLP-1衍生物的总体目标的潜在相关性，具有每周一次行政的潜力。

14. 发明申请

US20130281363A1 POLYPEPTIDES 有权
公开(公告)号：US20130281363A1
公开(公告)日：2013-10-24
申请号：US13930075
申请日：2013-06-28
申请人： NOVO NORDISK A/S
发明人： Kirsten Dahl , Lauge Schaeffer , Thomas Kruse
IPC分类号： C07K14/575
CPC分类号： C07K14/47 , C07K14/575
摘要： The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
摘要翻译：本发明涉及包含作为人胰岛淀粉样多肽的类似物的氨基酸序列的多肽，包含这些多肽的药物组合物，以及用作药物的这些多肽。

15. 发明授权

US09593149B2 Amylin and calcitonin receptor agonist 有权
标题翻译：胰岛淀粉样多肽和降钙素受体激动剂
公开(公告)号：US09593149B2
公开(公告)日：2017-03-14
申请号：US15151093
申请日：2016-05-10
申请人： Novo Nordisk A/S
发明人： Thomas Kruse , Lauge Schaeffer , Kirsten Dahl , Kirsten Raun
IPC分类号： A61K38/00 , A61K38/16 , C07K14/00 , C07K14/575
CPC分类号： C07K14/001 , A61K38/00 , C07K14/575
摘要： The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogs and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to SEQ ID NO: 1, analogs and derivatives thereof as medicaments.
摘要翻译：本发明涉及包含氨基酸序列SEQ ID NO：1（EASELSTAALGRLSAELHELATLPRTETGPESP）的肽，其类似物和衍生物以及包含这些肽和衍生物的药物组合物。本发明还涉及根据SEQ ID NO：1的这些肽，其类似物和衍生物作为药物的用途。

16. 发明授权

US08575091B1 Amylin analogues and pharmaceutical compositions thereof 有权
标题翻译：胰岛淀粉样多肽类似物及其药物组合物
公开(公告)号：US08575091B1
公开(公告)日：2013-11-05
申请号：US13930075
申请日：2013-06-28
申请人： Novo Nordisk A/S
发明人： Kirsten Dahl , Lauge Schaeffer , Thomas Kruse
IPC分类号： C07K14/575 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/08 , A61P3/06 , A61P25/00 , A61P9/10 , A61P9/00 , A61P1/00 , A61P29/00 , A61P1/04 , A61P1/18 , A61P19/10 , A61P19/08
CPC分类号： C07K14/47 , C07K14/575
摘要： The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
摘要翻译：本发明涉及包含作为人胰岛淀粉样多肽的类似物的氨基酸序列的多肽，包含这些多肽的药物组合物，以及用作药物的这些多肽。

17. 发明公开

US20230331803A1 CO-AGONISTS OF THE GLP-1 AND AMYLIN RECEPTORS 审中-公开
公开(公告)号：US20230331803A1
公开(公告)日：2023-10-19
申请号：US18084088
申请日：2022-12-19
申请人： Novo Nordisk A/S
发明人： Thomas Kruse , Anne Louise Bank Kodal , Johnny Madsen , Soeren Oestergaard , Wouter Frederik Johan Hogendorf , Christian Wenzel Tornoee , Lauge Schaeffer , Alice Ravn Madsen
IPC分类号： C07K14/605 , C07K14/575 , A61K47/54 , A61P3/04
CPC分类号： C07K14/605 , A61K47/542 , A61P3/04 , C07K14/575 , C07K2319/00
摘要： The invention relates to a compound comprising a GLP-1 receptor agonist and an amylin receptor agonist. The invention also relates to a pharmaceutical formulation, suitable for but not limited to oral administration, which comprises such a compound. The compound and pharmaceutical formulation comprising it may be used for the medical treatment of subjects with overweight, obesity and associated co-morbidities.

18. 发明授权

US10919949B2 Acylated insulin analogues and uses thereof 有权
公开(公告)号：US10919949B2
公开(公告)日：2021-02-16
申请号：US15998755
申请日：2018-08-16
申请人： Novo Nordisk A/S
发明人： Grith Skytte Olsen , Bo Falck Hansen , Lauge Schaeffer , Ingrid Pettersson , Rita Slaaby , Jakob Brandt
IPC分类号： A61K38/28 , C07K14/62 , A61P9/00 , A61P3/04 , A61P3/10 , A61P35/00 , G01N33/50 , A61K38/00
摘要： The present invention relates to novel insulin analogues and derivatives thereof, such as acylated insulin analogues, and their pharmaceutical use, in particular in the treatment or prevention of medical conditions relating to diabetes, obesity and cardiovascular diseases.

19. 发明申请

US20190194285A1 Novel Acylated Insulin Analogues and Uses Thereof 审中-公开
公开(公告)号：US20190194285A1
公开(公告)日：2019-06-27
申请号：US15998755
申请日：2018-08-16
申请人： Novo Nordisk A/S
发明人： Grith Skytte Olsen , Bo Falck Hansen , Lauge Schaeffer , Ingrid Pettersson , Rita Slaaby , Jakob Brandt
IPC分类号： C07K14/62 , A61P35/00 , A61P9/00 , A61P3/04 , A61P3/10 , G01N33/50
CPC分类号： C07K14/62 , A61K38/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P35/00 , C07K2319/90 , G01N33/50 , G01N2440/14
摘要： The present invention relates to novel insulin analogues and derivatives thereof, such as acylated insulin analogues, and their pharmaceutical use, in particular in the treatment or prevention of medical conditions relating to diabetes, obesity and cardiovascular diseases.

20. 发明授权

US09409966B2 Glucagon-like peptide-1 derivatives and their pharmaceutical use 有权
标题翻译：胰高血糖素样肽-1衍生物及其药物用途
公开(公告)号：US09409966B2
公开(公告)日：2016-08-09
申请号：US14506052
申请日：2014-10-03
申请人： Novo Nordisk A/S
发明人： Jane Spetzler , Lauge Schaeffer , Jesper Lau , Thomas Kruse , Patrick W. Garibay , Steffen Reedtz-Runge , Henning Thoegersen , Ingrid Pettersson
IPC分类号： C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K38/26
摘要： The invention relates to protracted Glucagon-Like Peptide-1 (GLP-1) derivatives and therapeutic uses thereof. The GLP-1 derivative of the invention comprises a modified GLP-1(7-37) sequence having a total of 2-12 amino acid modifications, including Glu22 and Arg26, and being derivatised with an albumin binding residue or pegylated in position 18, 20, 23, 30, 31, 34, 36, 37, or 39. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, stable, have long half-lives, a high affinity of binding to albumin, and/or a high affinity of binding to the extracellular domain of the GLP-1 receptor (GLP-1R), all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.
摘要翻译：本发明涉及长效的胰高血糖素样肽-1（GLP-1）衍生物及其治疗用途。本发明的GLP-1衍生物包含具有总共2-12个氨基酸修饰的修饰的GLP-1（7-37）序列，包括Glu22和Arg26，并用白蛋白结合残基衍生或在18位聚乙二醇化， 20,23,30,31,34,36,37或39.这些化合物可用于治疗或预防2型糖尿病和相关疾病。该化合物是有效的，稳定的，具有长的半衰期，与白蛋白结合的高亲和力，和/或与GLP-1受体（GLP-1R）细胞外结构域结合的高亲和力，所有这些都是对于实现长效，稳定和活性的GLP-1衍生物的总体目标的潜在相关性，具有每周一次行政的潜力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式