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11. 发明授权

US06989371B1 Bombesin analogs for treatment of cancer 失效
标题翻译：用于治疗癌症的Bombesin类似物
公开(公告)号：US06989371B1
公开(公告)日：2006-01-24
申请号：US09630333
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
IPC分类号： A61K38/00 , C07K7/00
CPC分类号： C07K7/086 , A61K38/00
摘要： The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating α,α-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明包括作为铃蟾肽和铃蟾肽样肽的拮抗剂的新型肽，并且可用于治疗癌症。本发明特别涉及以位点特异性方式结合α，α-氨基酸的新型肽的设计和合成。本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。

12. 发明授权

US06613793B2 Anticancer activity of imino acid conjugates or methylglyoxal 失效
标题翻译：甲基乙二醛的亚氨基酸共轭物的抗癌活性
公开(公告)号：US06613793B2
公开(公告)日：2003-09-02
申请号：US10187420
申请日：2002-07-01
申请人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Kamal K. Kapoor , Sudhanand Prasad , Manju Ray
发明人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Kamal K. Kapoor , Sudhanand Prasad , Manju Ray
IPC分类号： A61K3140
CPC分类号： C07D207/28
摘要： The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of methylglyoxal for inhibition and/or treatment of cancer of the Colon, Prostate, Larynx, Kidney, Pancreas, Lung, Breast, Intestine, Oral cavity, Ovary, Glioblastoma, and Leukemia. The invention also relates to compositions and methods of inhibiting cancer using imino acid conjugates of methylglyoxal.
摘要翻译：本发明涉及甲基乙二醛的亚氨基酸偶联物用于抑制和/或治疗癌症的用途。本发明更具体地涉及使用甲基乙二醛的亚氨基酸缀合物用于抑制和/或治疗结肠，前列腺，喉，肾，胰腺，肺，乳腺，肠，口腔，卵巢，成胶质细胞瘤和白血病的癌症。本发明还涉及使用甲基乙二醛的亚氨基酸缀合物抑制癌症的组合物和方法。

13. 发明申请

US20130274211A1 BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：生物易燃，非生物降解，非毒性聚合物用于纳米脂肪药物组合物
公开(公告)号：US20130274211A1
公开(公告)日：2013-10-17
申请号：US13633638
申请日：2012-10-02
申请人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
发明人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , C08F220/56 , C08F222/12 , C08F222/385 , C08F226/10
摘要： The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
摘要翻译：本发明涉及式（I）的生物相容性，不可生物降解的和无毒的聚合物，其包含三种单体单元，其选自1-乙烯基吡咯烷酮（VP），N-异丙基丙烯酰胺（NIPAM）和马来酸酐的酯和与双官能乙烯基衍生物交联的聚乙二醇（MPEG），其纯度高，基本上不含有毒的单体污染物及其制备方法。本发明还涉及难溶于水的药物或包含本发明聚合物的化合物的纳米颗粒药物组合物，其对于有需要的患者的床边给药是安全的，毒性较小且方便的。此外，本发明涉及用于制备难溶于水的药物或化合物的纳米颗粒药物组合物的高选择性方法。

14. 发明授权

US08022055B2 Betulinic acid derivatives 失效
标题翻译：桦木酸衍生物
公开(公告)号：US08022055B2
公开(公告)日：2011-09-20
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
IPC分类号： A61K31/33 , A61K31/40 , A61K31/34
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译：本发明涉及式（I）的新颖的桦木酸衍生物，其中R是C（= CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基，烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。

15. 发明授权

US06949513B2 Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer 失效
标题翻译：共价连接的合成生物活性肽类似物用于治疗癌症的多肽
公开(公告)号：US06949513B2
公开(公告)日：2005-09-27
申请号：US10186226
申请日：2002-06-28
申请人： Sudhanand Prasad , Rama Mukherjee , Anand C. Burman , Archna Mathur , Rajan Sharma , Manu Jaggi
发明人： Sudhanand Prasad , Rama Mukherjee , Anand C. Burman , Archna Mathur , Rajan Sharma , Manu Jaggi
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/00
摘要： A polypeptide of the formula (I), Pa-L-Pb-L-Pc-L-Pd.
摘要翻译：式（I）的多肽，<？in-line-formula description =“In-line Formulas”end =“lead”？> P -β-in-line-formula description =“In-line Formulas”end =“tail”？>

16. 发明授权

US06828304B1 Peptides for treatment of cancer 失效
标题翻译：用于治疗癌症的肽
公开(公告)号：US06828304B1
公开(公告)日：2004-12-07
申请号：US09630345
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K14/57563
摘要： This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明涉及抑制血管活性肠肽受体并可用于治疗癌症的新型抗增殖和抗分解肽。本发明特别涉及含有不同大小的脂肪酸的脂质 - 肽缀合物的合成，其抑制VIP与其受体的结合。本发明包括用于产生这些肽的方法，含有这些肽的组合物以及这些肽的药理学应用，特别是在治疗和预防癌症中。

17. 发明授权

US06632832B1 Anti-cancer activity of carvedilol and its isomers 失效
标题翻译：卡维地洛及其异构体的抗癌活性
公开(公告)号：US06632832B1
公开(公告)日：2003-10-14
申请号：US10238992
申请日：2002-09-10
申请人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh
发明人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh
IPC分类号： A61K3140
CPC分类号： A61K31/403 , A61K31/00 , Y10S436/813 , Y10S514/908
摘要： The present invention provides for pharmaceutical compositions comprising carvedilol for treatment of cancer. More particularly the invention relates to the use of carvedilol for treatment of cancers of the colon, ovary, breast, prostate, pancreas, lung, melanoma, glioblastoma, oral cancer and leukemias. Although not bound to any theory, the anticancer activity of carvedilol appears to be attributed to the inhibition of Epidermal Growth Factor and Platelet derived growth factor dependent proliferation of cancer cells. Further, carvedilol exerts anticancer effect by inhibition of the Protein kinase C (PKC) activity and that of the cyclooxygenase 2 enzyme. The invention also relates to the anticancer activity of the optically pure isomers S(−) and R(+) of carvedilol and the use of carvedilol and its isomers in pharmaceutical compositions for the treatment of cancer.
摘要翻译：本发明提供包含用于治疗癌症的卡维地洛的药物组合物。更具体地，本发明涉及卡维地洛用于治疗结肠，卵巢，乳腺，前列腺，胰腺，肺，黑素瘤，成胶质细胞瘤，口腔癌和白血病的癌症的用途。虽然不受任何理论的约束，卡维地洛的抗癌活性似乎归因于表皮生长因子和血小板衍生生长因子依赖性增殖的癌细胞的抑制。此外，卡维地洛通过抑制蛋白激酶C（PKC）活性和环加氧酶2酶的活性而发挥抗癌作用。本发明还涉及卡维地洛的光学纯异构体S（ - ）和R（+）的抗癌活性以及用于治疗癌症的药物组合物中卡维地洛及其异构体的用途。

18. 发明授权

US06316414B1 Somatostatin analogs for the treatment of cancer 失效
标题翻译：生长抑素类似物用于治疗癌症
公开(公告)号：US06316414B1
公开(公告)日：2001-11-13
申请号：US09629371
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
IPC分类号： A61K3800
CPC分类号： C07K14/6555 , A61K38/00
摘要： The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating &agr;, &agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明包括作为促生长抑素激动剂的新型肽以及激动剂用于治疗癌症的用途。本发明特别涉及以特异性位点结合α，α-二烷基化氨基酸的生长抑素的新型类似物的设计和合成。本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。

19. 发明申请

US20060159783A1 Method for treating cancer using betulinic acid rich herbal extract 审中-公开
标题翻译：使用富含桦木酸的草药提取物治疗癌症的方法
公开(公告)号：US20060159783A1
公开(公告)日：2006-07-20
申请号：US11219482
申请日：2005-09-02
申请人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
发明人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
IPC分类号： A61K36/906
CPC分类号： A61K31/56 , A61K36/725
摘要： This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.
摘要翻译：本发明涉及具有广谱抗癌活性的口服有效的草药提取物组合物，更具体地，涉及治疗，抑制和/或预防结肠，肠，胃，乳腺，黑素瘤，成胶质细胞瘤，肺，子宫颈恶性肿瘤的方法，卵巢，前列腺，口腔，喉，肝，胰腺，肾，膀胱，内皮细胞，白血病和骨髓瘤，使用梓属的草药提取物，富含桦木酸。提取物的优点是桦木酸具有低的全身毒性。提取物抑制癌细胞的蛋白激酶C活性并诱导细胞凋亡。

20. 发明授权

US6156725A Drug for the treatment of cancer 失效
标题翻译：用于治疗癌症的药物
公开(公告)号：US6156725A
公开(公告)日：2000-12-05
申请号：US727679
申请日：1996-10-08
申请人： Rama Mukherjee , Manu Jaggi
发明人： Rama Mukherjee , Manu Jaggi
IPC分类号： A61K38/08 , A61K38/10 , C12N5/09 , A61K38/00
CPC分类号： C12N5/0693 , A61K38/08 , A61K38/10 , Y10S514/908
摘要： A pharmaceutical composition useful for killing or inhibiting multiplication of cancer cells. It is expected that the pharmaceutical composition will be useful in preventing, inhibiting, or modulating the hypersecretion of VIP, somatostatin, bombesin, Substance P, or a combination of VIP, somatostatin, bombesin, or Substance P. The composition may suitably comprise, consist of, or consist essentially of a therapeutically effective combination of peptide analogs of somatostatin, VIP, bombesin, and Substance P. Also provided is a method of treatment for humans or other animals suffering from cancer, the method comprising administering a therapeutically effective dose of the pharmaceutical composition so as to kill or inhibit the multiplication of cancer cells. The method of treatment may be particularly useful in the treatment of cancers of the colon and rectum. Also provided is a method of treatment for humans or animals having hypersecretion or modulation of VIP, somatostatin, bombesin, Substance P, or a combination of VIP, somatostatin, bombesin, or Substance P.
摘要翻译：用于杀死或抑制癌细胞增殖的药物组合物。预期药物组合物可用于预防，抑制或调节VIP，生长抑素，铃蟾肽，物质P或VIP，生长抑素，铃蟾肽或物质P的组合的高分泌。组合物可适当地包括，组成或基本上由生长抑素，VIP，铃蟾肽和物质P的肽类似物的治疗有效组合组成。还提供了治疗患有癌症的人或其他动物的方法，所述方法包括施用治疗有效剂量的药物组合物，以杀死或抑制癌细胞的增殖。治疗方法可能特别适用于结肠和直肠癌的治疗。还提供了对具有VIP，生长抑素，铃蟾肽，物质P或VIP，生长抑素，铃蟾肽或物质P的组合的过度分泌或调节的人或动物的治疗方法。

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