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    • 12. 发明授权
    • Method for differentiation into retinal cells from stem cells
    • 从干细胞分化成视网膜细胞的方法
    • US09359592B2
    • 2016-06-07
    • US13055709
    • 2010-10-06
    • Sung Sup ParkJi Yeon Kim
    • Sung Sup ParkJi Yeon Kim
    • C12N5/07A61P27/02C12Q1/02A61K35/44C12N5/079
    • C12N5/0621C12N2501/105C12N2501/155C12N2501/998C12N2506/02C12N2506/45
    • Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by implementing a differentiation process similar to the in vivo embryonic development in chemically defined conditions. Also, retinal cells including the photoreceptor cells and their progenitor cells, and various types of other retinal cells, generated according to the method, are disclosed. A composition comprising the retinal cells and a method are provided for treating retinal degeneration-related diseases. The differentiated photoreceptor cells, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
    • 公开了一种诱导干细胞在短时间内以高产率分化成视网膜细胞的方法,通过实施类似于在化学定义的条件下的体内胚胎发育的分化过程,而不进行基因植入和与视网膜组织的共培养 。 此外,还公开了根据该方法产生的包括感光细胞及其祖细胞的视网膜细胞和各种类型的其它视网膜细胞。 提供了包含视网膜细胞的组合物和一种治疗视网膜变性相关疾病的方法。 分化的感光细胞,当移植到退化或损伤的视网膜时,可以植入并融合在视网膜内,以预防或治愈视网膜变性。
    • 15. 发明授权
    • Method for encoding broadcast channel protocol data unit based on broadcast control channel scheduling error in universal mobile telecommunications system
    • 基于通用移动电信系统中的广播控制信道调度误差对广播信道协议数据单元进行编码的方法
    • US08121152B2
    • 2012-02-21
    • US11828105
    • 2007-07-25
    • Yunhee ChoJi Yeon KimGweon Do JoJin Up Kim
    • Yunhee ChoJi Yeon KimGweon Do JoJin Up Kim
    • H04J3/00
    • H04W48/12
    • A method for encoding a broadcast channel protocol data unit (BCH PDU) based on a broadcast control channel (BCCH) scheduling error in a universal mobile telecommunications system (UMTS) having a Node B and a radio network controller includes setting up a call between the radio network controller and the Node B to receive system information and scheduling information for a system information update from the radio network controller; initializing broadcast channel protocol data units and control information for every system frame number (SFN) at the Node B; and detecting the broadcast control channel scheduling error on the scheduling information for the system information update based on segment types of the system information when combining the system information for every system frame number. In case the broadcast control channel scheduling error is not detected, the broadcast channel protocol data units are encoded to be incorporated therein the system information.
    • 在具有节点B和无线网络控制器的通用移动通信系统(UMTS)中,基于广播控制信道(BCCH)调度误差对广播信道协议数据单元(BCH PDU)进行编码的方法包括: 无线电网络控制器和节点B从无线电网络控制器接收用于系统信息更新的系统信息和调度信息; 对节点B的每个系统帧号(SFN)初始化广播信道协议数据单元和控制信息; 以及当对于每个系统帧号组合系统信息时,基于系统信息的段类型来检测用于系统信息更新的调度信息的广播控制信道调度误差。 在没有检测到广播控制信道调度错误的情况下,广播信道协议数据单元被编码为并入其中的系统信息。
    • 19. 发明申请
    • ANTICANCER AGENT COMPRISING ANTI-PD-1 ANTIBODY OR ANTI-PD-L1 ANTIBODY
    • 包含抗PD-1抗体或抗PD-L1抗体的抗体试剂
    • US20100086550A1
    • 2010-04-08
    • US12410732
    • 2009-03-25
    • Chang Yuil KangWoo Sung ChangJi Yeon Kim
    • Chang Yuil KangWoo Sung ChangJi Yeon Kim
    • A61K39/395
    • C07K16/2818A61K39/39558A61K2039/505C07K16/2827C07K2317/76A61K2300/00
    • Provided is an anticancer agent which comprises an anti-PD-1 antibody or an anti-PD-L1 antibody as an active ingredient, functioning to reverse the unresponsiveness of iNKT cells in which anergy has been induced by administration with an iNKT cell ligand. The anti-PD-1 or anti-PD-L1 antibody blocks the PD-1/PD-L1-mediated signaling pathway not only to prevent the iNKT cell ligand-induced iNKT cell anergy, but also to reverse the unresponsiveness of already anergic iNKT cells to produce cytokines. In addition, the anti-PD1 or anti-PD-L1 antibody ensures the potent anti-tumor activity of iNKT cells as demonstrated by a significant reduction in the number of metastatic nodules in B16F10 melanoma metastasis models in vivo. Collectively, the anticancer agent can be very useful in the treatment of cancer, particularly metastatic cancer.
    • 提供一种抗癌剂,其包含抗PD-1抗体或抗-PD-L1抗体作为活性成分,其功能是通过用iNKT细胞配体施用而逆转已经诱导了无反应性的iNKT细胞的无反应性。 抗PD-1或抗PD-L1抗体阻断PD-1 / PD-L1介导的信号通路,不仅可以防止iNKT细胞配体诱导的iNKT细胞无反应,而且可以逆转已经无能的iNKT的无反应性 细胞产生细胞因子。 此外,抗PD1或抗PD-L1抗体确保iNKT细胞的有效的抗肿瘤活性,如通过体内B16F10黑素瘤转移模型中转移性结节数量的显着减少所证实的。 总的来说,抗癌剂在治疗癌症,特别是转移性癌症中是非常有用的。
    • 20. 发明授权
    • Anticancer agent comprising anti-PD-1 antibody or anti-PD-L1 antibody
    • 包含抗PD-1抗体或抗-PD-L1抗体的抗癌剂
    • US08617546B2
    • 2013-12-31
    • US13398915
    • 2012-02-17
    • Chang Yuil KangWoo Sung ChangJi Yeon KimDong-Hyeon Kim
    • Chang Yuil KangWoo Sung ChangJi Yeon KimDong-Hyeon Kim
    • A61K39/00
    • C07K16/2818A61K39/39558A61K2039/505C07K16/2827C07K2317/76A61K2300/00
    • Provided is an anticancer agent which comprises an anti-PD-1 antibody or an anti-PD-L1 antibody as an active ingredient, functioning to reverse the unresponsiveness of iNKT cells in which anergy has been induced by administration with an iNKT cell ligand. The anti-PD-1 or anti-PD-L1 antibody blocks the PD-1/PD-L1-mediated signaling pathway not only to prevent the iNKT cell ligand-induced iNKT cell anergy, but also to reverse the unresponsiveness of already anergic iNKT cells to produce cytokines. In addition, the anti-PD1 or anti-PD-L1 antibody ensures the potent anti-tumor activity of iNKT cells as demonstrated by a significant reduction in the number of metastatic nodules in B16F10 melanoma metastasis models in vivo. Collectively, the anticancer agent can be very useful in the treatment of cancer, particularly metastatic cancer.
    • 提供一种抗癌剂,其包含抗PD-1抗体或抗-PD-L1抗体作为活性成分,其功能是通过用iNKT细胞配体施用而逆转已经诱导了无反应性的iNKT细胞的无反应性。 抗PD-1或抗PD-L1抗体阻断PD-1 / PD-L1介导的信号通路,不仅可以防止iNKT细胞配体诱导的iNKT细胞无反应,而且可以逆转已经无能的iNKT的无反应性 细胞产生细胞因子。 此外,抗PD1或抗PD-L1抗体确保iNKT细胞的有效的抗肿瘤活性,如通过体内B16F10黑素瘤转移模型中转移性结节数量的显着减少所证实的。 总的来说,抗癌剂在治疗癌症,特别是转移性癌症中是非常有用的。