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11. 发明申请

US20130017230A1 JELLY-FORM PREPARATION AND METHOD FOR PRODUCING JELLY-FORM PREPARATION 有权
标题翻译：果胶形式的制备及其制备方法
公开(公告)号：US20130017230A1
公开(公告)日：2013-01-17
申请号：US13546580
申请日：2012-07-11
申请人： Takuya SHISHIDO , Daisuke Asari , Mitsuhiko Hori
发明人： Takuya SHISHIDO , Daisuke Asari , Mitsuhiko Hori
IPC分类号： A61K47/42 , A61K9/00
CPC分类号： A61K9/0056 , A61K9/006 , A61K47/42
摘要： Provided is a jelly preparation which enables easy intraoral dissolution thereof, easy adjustment of the dissolution time, and stable containment of a drug therein. The jelly preparation of the present invention is a jelly preparation including water, a gelatin, a drug, and a trivalent metal ion.
摘要翻译：本发明提供能够容易地口内溶解，容易调节溶解时间，以及药物稳定容纳的果冻制剂。本发明的果冻制剂是包含水，明胶，药物和三价金属离子的果冻制剂。

12. 发明申请

US20110293673A1 ORAL FILM-FORM BASE AND ORAL FILM-FORM PREPARATION 有权
标题翻译：口腔膜形式和口腔膜形成准备
公开(公告)号：US20110293673A1
公开(公告)日：2011-12-01
申请号：US13146829
申请日：2009-03-06
申请人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
发明人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
IPC分类号： A61K9/00 , A61P25/06 , A61K31/135 , A61P37/08 , A61K31/18 , A61P13/08 , A61P1/08 , A61K31/437 , A61K31/426 , A61P1/04 , A61K31/4184 , A61P9/12 , A61K31/4439 , A61P3/10 , A61K31/4418 , A61K31/445 , A61K31/422
CPC分类号： A61K9/0056 , A61K9/7007 , A61K47/26 , A61K47/38
摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.
摘要翻译：本发明提供一种具有分散为细颗粒的一种或多种糖或糖醇的薄膜形式的底物，并且还提供含有该基质和药物的薄膜形式的制剂。该碱是通过在溶解度参数为9.7以上的有机溶剂中分散可溶于水和有机溶剂的可食性聚合物，以及一种或两种以上选自单 - 六糖和糖醇，其平均粒度为0.1〜60μm，不溶于有机溶剂。因此，本发明可以提供在口腔中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的基质和制剂，并且在口腔中提供归因于水溶性聚合物的降低的粘稠感和当用手指。

13. 发明授权

US4847260A Composition for percutaneous administration 失效
标题翻译：用于经皮给药的组合物
公开(公告)号：US4847260A
公开(公告)日：1989-07-11
申请号：US113352
申请日：1987-10-26
申请人： Yoko Abe , Susumu Satoh , Mitsuhiko Hori , Naoko Yamanaka
发明人： Yoko Abe , Susumu Satoh , Mitsuhiko Hori , Naoko Yamanaka
IPC分类号： A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , C07D213/79 , C07D213/80
CPC分类号： C07D213/79 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K9/0014 , C07D213/80
摘要： A composition for percutaneous administration containing a nicotinic ester represented by formula (I) ##STR1## or an isonicotinic ester represented by formula (II) ##STR2## wherein R and R' each represents an alkyl group having 5 or more carbon atoms,with or without a specific polar compound. The composition improves percutaneous absorption of an active ingredient.
摘要翻译：用于经皮给药的组合物，其含有由式（I）表示的烟酸酯或由式（II）表示的异烟酸酯其中R和R'各自表示具有5或更多的碳原子，有或没有特定的极性化合物。该组合物改善活性成分的经皮吸收。

14. 发明授权

US09724309B2 Film-form preparation and method for producing the same 有权
公开(公告)号：US09724309B2
公开(公告)日：2017-08-08
申请号：US13073022
申请日：2011-03-28
申请人： Daisuke Asari , Mitsuhiko Hori , Takuya Shishido
发明人： Daisuke Asari , Mitsuhiko Hori , Takuya Shishido
IPC分类号： A61K8/02 , A61K9/70 , A61K9/00
CPC分类号： A61K9/7007 , A61K8/0241 , A61K9/0056
摘要： The present invention provides a film-form preparation having a rapid dissolution profile in the mouth and sufficient film strength, and also having excellent appearance and feel. More specifically, the present invention provides a film-form preparation including: a water-soluble and a polar organic solvent-soluble edible polymer; and polar organic solvent-insoluble drug particles.

15. 发明授权

US09238004B2 Oral film-form base and oral film-form preparation 有权
公开(公告)号：US09238004B2
公开(公告)日：2016-01-19
申请号：US13146829
申请日：2009-03-06
申请人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
发明人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
IPC分类号： A61K9/00 , A61K9/70 , A61K47/26 , A61K47/38
摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.

16. 发明授权

US08475833B2 Jelly-form preparation and method for producing jelly-form preparation 有权
标题翻译：果冻形状的制备及其制备方法
公开(公告)号：US08475833B2
公开(公告)日：2013-07-02
申请号：US13546580
申请日：2012-07-11
申请人： Takuya Shishido , Daisuke Asari , Mitsuhiko Hori
发明人： Takuya Shishido , Daisuke Asari , Mitsuhiko Hori
IPC分类号： A61K47/00
CPC分类号： A61K9/0056 , A61K9/006 , A61K47/42
摘要： Provided is a jelly preparation which enables easy intraoral dissolution thereof, easy adjustment of the dissolution time, and stable containment of a drug therein. The jelly preparation of the present invention is a jelly preparation including water, a gelatin, a drug, and a trivalent metal ion.
摘要翻译：本发明提供能够容易地口内溶解，容易调节溶解时间，以及药物稳定容纳的果冻制剂。本发明的果冻制剂是包含水，明胶，药物和三价金属离子的果冻制剂。

17. 发明授权

US08383145B2 Film-form preparation 有权
标题翻译：电影形式准备
公开(公告)号：US08383145B2
公开(公告)日：2013-02-26
申请号：US13014245
申请日：2011-01-26
申请人： Daisuke Asari , Mitsuhiko Hori , Takuya Shishido
发明人： Daisuke Asari , Mitsuhiko Hori , Takuya Shishido
IPC分类号： A61K48/00
CPC分类号： A61K9/006 , A61K9/1623 , A61K9/7007 , A61K47/38
摘要： An object of the present invention is to provide a film-form preparation to be used in desensitization therapy and a method for producing the same. This film-form preparation enables the patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers. Additionally, this film-form preparation enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little gummy sensation in the mouth and better feeling when touched by the fingers. A film-form preparation including: an allergen; an edible polymer that is soluble in both water and a polar organic solvent; and one or two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof that have an average particle size of 0.1 to 100 μm.
摘要翻译：本发明的目的是提供一种用于脱敏治疗的薄膜状制剂及其制造方法。这种胶片形式的准备使患者能够自我管理过敏原并调整剂量，具有优异的携带性，无残留感，提供极好的防止意外吞咽的保护作用，易于护理人员进行管理，可大大提高患者的生活质量病人和护理人员。此外，该膜形式的制备能够任意地控制口中的溶解时间，特别是舌下，并且在口中具有非常小的粘性感，并且当被手指触摸时具有更好的感觉。一种膜形成制剂，包括：变应原; 可溶于水和极性有机溶剂的可食用聚合物; 以及选自平均粒径为0.1〜100μm的选自单糖至六糖的一种或两种以上的粒子及其糖醇。

18. 发明授权

US5183665A Composition for percutaneous administration and method for enhancing percutaneous absorption of a physiologically active ingredient empolying the same 失效
标题翻译：用于经皮给药的组合物和用于增强赋予其生理活性成分的经皮吸收的方法
公开(公告)号：US5183665A
公开(公告)日：1993-02-02
申请号：US299506
申请日：1989-01-23
申请人： Mitsuhiko Hori
发明人： Mitsuhiko Hori
IPC分类号： A61K31/54 , A61K45/06
CPC分类号： A61K45/06 , A61K31/54 , Y10S514/946
摘要： The present invention relates to a composition for percutaneous administration which can enhance percutaneous absorption of a physiologically active ingredient and a method of enhancing percutaneous absorption of a physiologically active ingredient employing the same.
摘要翻译：本发明涉及能够提高生理活性成分的经皮吸收的经皮给药用组合物和使用其的生理活性成分的经皮吸收增强方法。

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