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11. 发明授权

US08239159B2 Method used to yield irradiation product with minimal impurity for solid target for gallium (Ga)-68/germanium (Ge)-68 generator 有权
标题翻译：用于为镓（Ga）-68 /锗（Ge）-68发生器的固体靶产生最小杂质的辐射产物的方法
公开(公告)号：US08239159B2
公开(公告)日：2012-08-07
申请号：US12569908
申请日：2009-09-30
申请人： Ming-Hsin Li , Ting Shien Duh , Wuu-Jyn Lin
发明人： Ming-Hsin Li , Ting Shien Duh , Wuu-Jyn Lin
IPC分类号： G06F15/00
CPC分类号： G21G1/10 , G21G2001/0094
摘要： A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.
摘要翻译：用于产生镓（Ga）-68 /锗（Ge）-68发生器的固体靶的杂质最小的辐射产物的方法主要包括以下步骤：首先计算电镀镓（Ga）-69的厚度d 坚实的目标; 然后通过包括69 Ga（p，2n）68Ge目标厚度和入射能量与5个不同入射能量剂量的衰减曲线图，得出每个组在衰变后的相应的照射能量剂量Yi; 通过包括69Ga（p，2n）68Ge入射能和反应截面积的图，得出锗（Ge）-68，镓（Ga）-68，锌（Zn）的每个组的核反应截面积）-65，计算每组反应截面积的平均反应面积（MRA）; 并选择最大锗（Ge）-68 MRA值和最小镓（Ga）-68和锌（Zn）-65 MRA值; 并为每组的MRA产生所需的默认照射能量。

12. 发明申请

US20110041950A1 Automatic Filling Machine for Radiopharmaceuticals 有权
标题翻译：放射性药物自动灌装机
公开(公告)号：US20110041950A1
公开(公告)日：2011-02-24
申请号：US12543507
申请日：2009-08-19
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
IPC分类号： B67C3/02
CPC分类号： B65B3/003
摘要： An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle. The drug pump withdraws the radiopharmaceuticals from the drug bottle to the injection needle and allows the front end of the injection needle activated to go through the injection hole into the syringe and fill the radiopharmaceuticals into the syringe.
摘要翻译：一种自动放射性药物灌装机主要包括具有执行三维往复运动的激活机构的主单元。激活机构具有可以被激活以沿着横向X轴往复运动的横向滑块。在横向滑动器上，有一个垂直滑动件可以垂直延伸并沿横向Y轴往复运动。注射针位于垂直滑块上，可以被激活以沿着与轴向滑动件垂直的Z轴往复运动。注射器架位于注射针的移动范围内，以容纳多个注射器，每个注射器都具有注射孔。药泵具有入口和出口。入口连接到高剂量放射性药物药瓶。出口连接到注射针。药物泵将放射性药物从药瓶抽出到注射针上，并且允许注射针的前端被激活以通过注射孔进入注射器并将放射性药物填充到注射器中。

13. 发明申请

US20070062865A1 Novel biological flocculants and production methods 审中-公开
标题翻译：新型生物絮凝剂及生产方法
公开(公告)号：US20070062865A1
公开(公告)日：2007-03-22
申请号：US11601693
申请日：2006-11-20
申请人： Heng-Chuan Wang , Ming-Hsin Li , Hsu-Wen Tsang , Mei-Mao Wu , Hsui-Ping Lin
发明人： Heng-Chuan Wang , Ming-Hsin Li , Hsu-Wen Tsang , Mei-Mao Wu , Hsui-Ping Lin
IPC分类号： B01D69/02 , C12N1/20
CPC分类号： C02F1/5272 , C02F3/34 , C02F2209/06 , C12N1/20
摘要： The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.
摘要翻译：本发明涉及包含在包含大豆蛋白，葡萄糖，糖蜜和酵母的培养基中培养的芽孢杆菌属细菌的新型絮凝剂。或者，絮凝剂包括大豆蛋白。本发明还涉及制备絮凝剂的方法，包括大规模生产的发酵方法，以及在水处理中使用絮凝剂的方法。

14. 发明授权

US6162686A Method for forming a fuse in integrated circuit application 有权
标题翻译：集成电路应用中形成保险丝的方法
公开(公告)号：US6162686A
公开(公告)日：2000-12-19
申请号：US156362
申请日：1998-09-18
申请人： Kuo Ching Huang , Tse-Liang Ying , Yu-Hua Lee , Ming-Hsin Li
发明人： Kuo Ching Huang , Tse-Liang Ying , Yu-Hua Lee , Ming-Hsin Li
IPC分类号： H01L23/525 , H01L21/336 , H01L21/00 , H01L21/331 , H01L21/44 , H01L21/82
CPC分类号： H01L23/5258 , H01L2924/0002 , H01L2924/00
摘要： A method of forming a grooved fuse (plug fuse) in the same step that via plugs are formed in the guard ring area 14 and in product device areas. A key point of the invention is to form fuses from the via plug layer, not from the metal layers. Also, key guard rings are formed around the plug guise. The invention can include the following: a semiconductor structure is provided having a fuse area, a guard ring area surrounding the fuse area; and a device area. First and second conductive strips are formed. First and second insulating layers are formed over the first and second conductive strips. Plug contacts and fuse plugs are formed through the first and second insulating layers to the first and second conductive strips. A third insulating layer is formed over the second insulating layer. Metal lines are formed over the third insulating layer in the device area. A fuse via opening is formed in the third insulating layer. A plug fuse is formed in the fuse via opening. A fourth insulating layer is formed over the plug fuse and the third insulating layer. A fuse opening is formed at least partially though the fourth insulating layer over the fuse area.
摘要翻译：在通过塞子形成在保护环区域14和产品装置区域中的相同步骤中形成带槽保险丝（插头保险丝）的方法。本发明的一个关键点是从通孔塞层而不是金属层形成保险丝。此外，围绕插头形状形成关键保护环。本发明可以包括：提供具有保险丝区域的半导体结构，围绕保险丝区域的保护环区域; 和设备区域。形成第一和第二导电条。第一和第二绝缘层形成在第一和第二导电条上。插头触点和熔丝插头通过第一和第二绝缘层形成到第一和第二导电条。在第二绝缘层上形成第三绝缘层。金属线形成在器件区域中的第三绝缘层上。在第三绝缘层中形成保险丝通孔。保险丝通过开口形成插头保险丝。在插头熔断器和第三绝缘层上形成第四绝缘层。保险丝开口至少部分地通过保险丝区域上的第四绝缘层形成。

15. 发明申请

US20190076552A1 Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases 审中-公开
公开(公告)号：US20190076552A1
公开(公告)日：2019-03-14
申请号：US15698672
申请日：2017-09-08
申请人： Ming-Hsin Li , Chyng-Yann Shiue , Han-Chih Chang , Chun-Fang Feng
发明人： Ming-Hsin Li , Chyng-Yann Shiue , Han-Chih Chang , Chun-Fang Feng
IPC分类号： A61K49/00 , G06T7/00 , G01T1/29 , A61K51/00 , G06T7/40
摘要： Method provided for labeling a nuclear medicine for imaging tracing, comprising a labeling precursor of the HDAC inhibitor BNL-26 (C22H23N3O) and the derivatives that are separated into two classes. The first class comprises a BNL-26 (C22H23N3O) and derivatives BNL-26a (C21H21N3O), BNL-26b (C22H22N2O), and other compounds of the labeling precursors which are categorized into two parts, the first part includes BNL-26-CH2CH2OTs (C31H33N3O4S), BNL-26a-CH2CH2OTs (C30H31N3O4S), and BNL-26b-CH2CH2OTs (C31H32N2O4S), which provides labeling precursor through —CH2CH2OTs structure, and the second part includes pre-BNL-26 (C28H34N3O3B), pre-BNL-26a (C27H32N3O3B), pre-BNL-26b (C28H33N2O3B), which provides labeling precursor through 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl structure. The second class includes BNL-26 (C22H23N3O) indole/indoline, which provides a series of derivative labeling precursors derived from a secondary amide bond.

16. 发明授权

US10005727B2 Compound and analogues for tracing histone acetylation inhibitors PET imaging for diagnosis and treatment of tumors 有权
公开(公告)号：US10005727B2
公开(公告)日：2018-06-26
申请号：US15286596
申请日：2016-10-06
申请人： Ming-Hsin Li , Chyng-Yann Shiue , Han-Chih Chang , Chun-Fang Feng
发明人： Ming-Hsin Li , Chyng-Yann Shiue , Han-Chih Chang , Chun-Fang Feng
IPC分类号： C07D209/04 , C07D401/12 , C07D401/14
CPC分类号： C07D209/04 , C07D209/08 , C07D401/12 , C07D401/14
摘要： The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with HDAC overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.

17. 发明授权

US09266084B2 Automatic synthesizer apparatus for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE and method thereof 有权
标题翻译：用于制备放射性药物肿瘤成像剂的自动合成装置Gallium-68- DOTATATE及其方法
公开(公告)号：US09266084B2
公开(公告)日：2016-02-23
申请号：US13916599
申请日：2013-06-13
申请人： Ming-Hsin Li , Hsin-Han Hsieh
发明人： Ming-Hsin Li , Hsin-Han Hsieh
IPC分类号： A61K51/00 , A61M36/14 , B01J19/00 , A61K51/08 , C07B59/00
CPC分类号： B01J19/0053 , A61K51/083 , C07B59/00
摘要： The invention provides an automatic synthesizer apparatus and method for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE with one button control process to effectively isolate the medication in vials from the contamination of environment and manual operations, saving the costs of investment in production with alleviation of the critical standard required for the environmental equipments to be used for production.
摘要翻译：本发明提供一种用于制造放射性药物肿瘤成像剂Gallium-68-DOTATATE的自动合成装置和方法，其具有一个按钮控制过程，以有效地将小瓶中的药物与环境污染和手动操作隔离，从而节省了生产投资的成本，减轻了环境设备用于生产所需的关键标准。

18. 发明申请

US20140378830A1 Method for stimulating a brain to form a cognitive reaction image 审中-公开
标题翻译：刺激大脑形成认知反应形象的方法
公开(公告)号：US20140378830A1
公开(公告)日：2014-12-25
申请号：US13925806
申请日：2013-06-24
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/501 , A61B5/055 , A61B5/4064 , A61B6/037 , A61B6/486 , G01R33/4806
摘要： A method for stimulating a brain to form a cognitive reaction image is provided, which includes administrating 11C-isotope labeled glucose to a test recipient closing eyes, exposing the test recipient to visual stimulus, auditory stimulus and cognitive stimulus, respectively, and then monitoring the test recipient by a brain imaging device and collecting brain imaging data to compare variation between actions of the administrated 11C-isotope labeled glucose in the test recipient's brain before and after the test recipient being exposed to the stimulus. The brain images in correspondence with the brain reacting to the visual, auditory and cognitive stimuli are obtained by detecting the metabolic process of the 11C-isotope labeled glucose in brain.
摘要翻译：提供了一种刺激大脑形成认知反应图像的方法，其包括将11C同位素标记的葡萄糖施用于接受闭合眼睛的测试受体，分别将测试受体暴露于视觉刺激，听觉刺激和认知刺激，然后监测通过脑成像装置测试受体，并收集脑成像数据，以比较测试受体暴露于刺激之前和之后给予的11C同位素标记的葡萄糖在受试者的大脑中的作用之间的变化。通过检测大脑中11C同位素标记的葡萄糖的代谢过程，获得与大脑对视觉，听觉和认知刺激反应的大脑图像。

19. 发明授权

US08347925B2 Automatic filling machine for radiopharmaceuticals 有权
标题翻译：放射性药物自动灌装机
公开(公告)号：US08347925B2
公开(公告)日：2013-01-08
申请号：US12543507
申请日：2009-08-19
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
IPC分类号： B65B1/04
CPC分类号： B65B3/003
摘要： An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle. The drug pump withdraws the radiopharmaceuticals from the drug bottle to the injection needle and allows the front end of the injection needle activated to go through the injection hole into the syringe and fill the radiopharmaceuticals into the syringe.
摘要翻译：一种自动放射性药物灌装机主要包括具有执行三维往复运动的激活机构的主单元。激活机构具有可以被激活以沿着横向X轴往复运动的横向滑块。在横向滑动器上，有一个垂直滑动件可以垂直延伸并沿横向Y轴往复运动。注射针位于垂直滑块上，可以被激活以沿着与轴向滑动件垂直的Z轴往复运动。注射器架位于注射针的移动范围内，以容纳多个注射器，每个注射器都具有注射孔。药泵具有入口和出口。入口连接到高剂量放射性药物药瓶。出口连接到注射针。药物泵将放射性药物从药瓶抽出到注射针上，并且允许注射针的前端被激活以通过注射孔进入注射器并将放射性药物填充到注射器中。

20. 发明授权

US08181677B2 Automated dispenser for radiopharmaceuticals 有权
标题翻译：放射性药物自动分配器
公开(公告)号：US08181677B2
公开(公告)日：2012-05-22
申请号：US11868540
申请日：2007-10-08
申请人： Ming-Hsin Li , Wuu-Jyh Lin , Tain-Shi Zen
发明人： Ming-Hsin Li , Wuu-Jyh Lin , Tain-Shi Zen
IPC分类号： B67C3/00
CPC分类号： A61J1/2096 , B65B3/003 , G21G1/0005
摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
摘要翻译：用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。注射器支架用于容纳多个注射器。瓶架有一个反向药瓶。移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。

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