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11. 发明授权

US5599815A Antipsychotic benzoisothiazolyl piperazine derivatives 失效
标题翻译：抗精神病药苯并异噻唑基哌嗪衍生物
公开(公告)号：US5599815A
公开(公告)日：1997-02-04
申请号：US318857
申请日：1994-12-20
申请人： Yoshimasa Fukuda , Toshiro Sasaki , Yuuko Nakatani , Yasuyuki Ichimaru , Taiichiro Imanishi
发明人： Yoshimasa Fukuda , Toshiro Sasaki , Yuuko Nakatani , Yasuyuki Ichimaru , Taiichiro Imanishi
IPC分类号： C07D417/12 , C07D417/14 , A61K31/495 , A61K31/50 , A61K31/55
CPC分类号： C07D417/12
摘要： Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects.
摘要翻译： PCT No.PCT / JP94 / 00159 Sec。 371日期1994年12月20日第 102（e）1994年12月20日日期PCT 1994年2月3日PCT PCT。公开号WO94 / 18197 （I）化合物及其药理学上可接受的盐：（I）这些化合物具有很小的锥体束外效应，因此作为具有很少副作用的抗精神病药是有效的。

12. 发明授权

US08773938B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US08773938B2
公开(公告)日：2014-07-08
申请号：US13064915
申请日：2011-04-26
申请人： Toshiro Sasaki
发明人： Toshiro Sasaki
IPC分类号： G11C5/14
CPC分类号： G06F1/26 , G11C5/145 , G11C16/30 , H01L24/06 , H01L2224/05554
摘要： A semiconductor device includes a drive circuit that outputs a drive signal to drive an external device; a voltage output circuit that outputs a first voltage and a second voltage that is larger than the first voltage; a selector that, when supplying a power supply voltage to the drive circuit, selects the first voltage and, when supplying a power supply voltage to an internal device, selects the second voltage; and a step-up circuit that, when the first voltage selected by the selector is input, boosts the first voltage to a third voltage and outputs the third voltage as the power supply voltage to the drive circuit and, when the second voltage selected by the selector is inputted, boosts the second voltage to a fourth voltage and outputs the fourth voltage as the power supply voltage to the internal device.
摘要翻译：半导体器件包括：驱动电路，其输出用于驱动外部器件的驱动信号; 电压输出电路，其输出大于所述第一电压的第一电压和第二电压; 选择器，当向所述驱动电路供给电源电压时，选择所述第一电压，并且当向所述内部装置供应电源电压时，选择所述第二电压; 以及升压电路，当输入由选择器选择的第一电压时，将第一电压升压到第三电压，并将作为电源电压的第三电压输出到驱动电路，并且当由第二电压选择选择器被输入，将第二电压升压到第四电压，并将第四电压作为电源电压输出到内部装置。

13. 发明授权

US08344154B2 2-thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-硫代乙烯基取代的碳青霉烯衍生物
公开(公告)号：US08344154B2
公开(公告)日：2013-01-01
申请号：US12656606
申请日：2010-02-04
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： C07D277/24 , C07D277/26
CPC分类号： C07D487/04
摘要： 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including β-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.
摘要翻译：提供式（I）的2-乙烯基硫代碳代青霉烯衍生物或其药学上可接受的盐。根据本发明的化合物具有有效的抗微生物活性和抗肺炎球菌的广谱抗菌谱，包括耐青霉素肺炎链球菌（PRSP），流感嗜血杆菌，包括β-内酰胺酶阴性，氨苄青霉素抗性流感嗜血杆菌（BLNAR）和莫拉氏菌）卡他氏菌

14. 发明申请

US20100145063A1 2- thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-硫代乙烯基取代的碳青霉烯衍生物
公开(公告)号：US20100145063A1
公开(公告)日：2010-06-10
申请号：US12656606
申请日：2010-02-04
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： C07D277/34 , C07D417/02
CPC分类号： C07D487/04
摘要： 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including β-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.
摘要翻译：提供式（I）的2-乙烯基硫代碳代青霉烯衍生物或其药学上可接受的盐。根据本发明的化合物具有有效的抗微生物活性和抗肺炎球菌的广谱抗菌谱，包括耐青霉素肺炎链球菌（PRSP），流感嗜血杆菌，包括β-内酰胺酶阴性，氨苄青霉素抗性流感嗜血杆菌（BLNAR）和莫拉氏菌）卡他氏菌

15. 发明申请

US20090082571A1 Intermediates of 2-substituted carbapenem derivatives and process for production thereof 审中-公开
标题翻译： 2-取代的碳青霉烯衍生物的中间体及其制备方法
公开(公告)号：US20090082571A1
公开(公告)日：2009-03-26
申请号：US12289750
申请日：2008-11-03
申请人： Toshiro Sasaki , Takashi Ando , Takahiro Imai , Dai Kubota , Eiki Shitara , Kunio Atsumi
发明人： Toshiro Sasaki , Takashi Ando , Takahiro Imai , Dai Kubota , Eiki Shitara , Kunio Atsumi
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , C07F9/6561 , Y02P20/55
摘要： The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
摘要翻译：本发明涉及由式（1）表示的化合物及其制备方法。这些化合物的使用可以以安全和成本有效的方式实现具有有效抗微生物活性和广谱抗菌谱的碳青霉烯衍生物的生产。

16. 发明申请

US20090036685A1 Process for Producing Imidazothiazole Derivatives 审中-公开
标题翻译：生产咪唑噻唑衍生物的方法
公开(公告)号：US20090036685A1
公开(公告)日：2009-02-05
申请号：US11989139
申请日：2006-07-21
申请人： Dai Kubota , Yasuo Yamamoto , Toshiro Sasaki , Takashi Ando , Eiki Shitara , Katsuya Sakata , Kenji Suzuki
发明人： Dai Kubota , Yasuo Yamamoto , Toshiro Sasaki , Takashi Ando , Eiki Shitara , Katsuya Sakata , Kenji Suzuki
IPC分类号： C07D401/14
CPC分类号： C07D519/00 , C07D513/04
摘要： Disclosed is a process for producing an imidazothiazole derivative of formula (I) useful as an intermediate for the production of carbapenem derivatives having potent antimicrobial activity and a broad antimicrobial spectrum, that is, a novel method for nicotinoylating an imidazo[5,1-b]thiazole ring at its 7-position. The process comprises reacting a compound of formula (II) with a compound of formula (III).
摘要翻译：公开了一种制备式（I）的咪唑并噻唑衍生物的方法，其用作制备具有有效抗微生物活性和广谱抗菌谱的碳青霉烯衍生物的中间体，即咪唑并[5,1-b ]噻唑环。该方法包括使式（II）化合物与式（III）化合物反应。

17. 发明授权

US6163496A Semiconductor memory device having a common column decoder shared by plurality of banks 失效
标题翻译：半导体存储器件具有由多个存储体共享的公共列解码器
公开(公告)号：US6163496A
公开(公告)日：2000-12-19
申请号：US418040
申请日：1999-10-14
申请人： Toshiro Sasaki , Yuichi Matsushita
发明人： Toshiro Sasaki , Yuichi Matsushita
IPC分类号： G11C11/407 , G11C7/10 , G11C11/401 , G11C8/00
CPC分类号： G11C7/1006
摘要： A column switching circuit that connects a bit line pair and sub-data buses is constituted of first through fourth N transistors. The first and third N transistors are connected in series to a first bit line of the bit line pair whereas the second and fourth N transistors are connected in series to the second bit line of the bit line pair. The gate of the first N transistor and the gate of the second N transistor are connected to commonly receive a column switch selection signal. The gate of the third N transistor and the gate of the fourth N transistor are commonly connected to a column line. By adopting this structure, the generation of a through current is prevented from occurring between the bit line pair and the sub-data buses to result in a reduction in power consumption and miniaturization of the chip is achieved.
摘要翻译：连接位线对和子数据总线的列切换电路由第一至第四N晶体管构成。第一和第三N晶体管与位线对的第一位线串联连接，而第二和第三N晶体管串联连接到位线对的第二位线。第一N晶体管的栅极和第二N晶体管的栅极被连接以共同接收列开关选择信号。第三N晶体管的栅极和第四N晶体管的栅极共同连接到列线。通过采用这种结构，防止在位线对和子数据总线之间产生直通电流，导致功耗的降低，并且实现了芯片的小型化。

18. 发明授权

US07563901B2 Intermediates of 2-substituted carbapenem derivatives and process for production thereof 失效
公开(公告)号：US07563901B2
公开(公告)日：2009-07-21
申请号：US12071120
申请日：2008-02-15
申请人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
发明人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
IPC分类号： C07D513/02 , A61K31/429
CPC分类号： C07D513/04 , C07F9/6561 , Y02P20/55
摘要： The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.

19. 发明授权

US06825187B2 Carbapenem derivatives of quarternary salt type 失效
标题翻译：八氯化碳衍生物的季盐型
公开(公告)号：US06825187B2
公开(公告)日：2004-11-30
申请号：US10182180
申请日：2002-07-25
申请人： Yuko Kano , Takahisa Maruyama , Yasuo Yamamoto , Eiki Shitara , Toshiro Sasaki , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
发明人： Yuko Kano , Takahisa Maruyama , Yasuo Yamamoto , Eiki Shitara , Toshiro Sasaki , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
IPC分类号： C07D51906
CPC分类号： C07D477/14
摘要： An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl; R2 and R3 each independently represent H, halogen, lower alkyl or the like; R4 represents optionally substituted lower alkylthio or the like; and R5 represents optionally substituted lower alkyl or the like.
摘要翻译：本发明的目的是提供对MRSA，PRSP，流感病毒和产生β-内酰胺酶的细菌具有有效抗生素活性的碳青霉烯衍生物，并且对DHP-1是稳定的。根据本发明的化合物是由式（I）表示的化合物或其药学上可接受的盐：其中R 1表示H或甲基; R 2和R 3各自独立地表示H，卤素，低级烷基等; R 4表示任选取代的低级烷硫基等; R 5表示任选取代的低级烷基等。

20. 发明授权

US5922724A Benzimidazole compounds and their use as modulators of the GABA a receptor complex 失效
标题翻译：苯并咪唑化合物及其用作GABA受体复合物的调节剂
公开(公告)号：US5922724A
公开(公告)日：1999-07-13
申请号：US945023
申请日：1998-02-05
申请人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
发明人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00 , A61K31/425
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF.sub.3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; andone of R.sup.6 and R.sup.7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01606 Sec。 371日期：1998年2月5日 102（e）1998年2月5日PCT PCT 1996年4月17日PCT公布。出版物WO96 / 33194 日本特开1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个为N，其他都是CH; R11是苯基，苯并咪唑基或单环杂芳基，其全部可以被选自烷基，烷氧基，苯基，卤素，CF 3，氨基，硝基，氰基，酰基，酰氨基，苯基和单环杂芳基的取代基取代一次或多次; 并且R6和R7中的一个是氢，另一个是呋喃基或异恶唑基，其各自可以被选自卤素，烷基，烷氧基和苯基的取代基取代一次或多次。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

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