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11. 发明授权

US08557253B2 Stabilizing excipient for inactivated whole virus vaccine 有权
公开(公告)号：US08557253B2
公开(公告)日：2013-10-15
申请号：US12899492
申请日：2010-10-06
申请人： Alain Francon , Michel Chevalier , Nadege Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
发明人： Alain Francon , Michel Chevalier , Nadege Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
IPC分类号： A61K39/205 , A61K47/00 , C12N7/02
CPC分类号： A61K47/26 , A61K39/12 , A61K39/205 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K2039/5252 , C12N2760/20134
摘要： The invention relates to a vaccine composition comprising: a) inactivated whole virus, and b) a stabilizing excipient which comprises: i. a buffer solution, ii. a mixture of essential and nonessential amino acids, iii. a disaccharide, iv. a polyol, v. a chelating agent, vi. urea or a urea derivative, and vii. a nonionic surfactant.

12. 发明授权

US06821723B2 GP41 antigen 失效
标题翻译： GP41抗原
公开(公告)号：US06821723B2
公开(公告)日：2004-11-23
申请号：US10263103
申请日：2002-10-02
申请人： Michel Chevalier , Raphaëlle El Habib , Tino Krell , Règis Sodoyer
发明人： Michel Chevalier , Raphaëlle El Habib , Tino Krell , Règis Sodoyer
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C12N2740/16122
摘要： The present invention comprises novel polypeptide antigens that can be used for therapeutic and prophylactic immunization against HIV-related infections. The polypeptide of the invention mimics the intermediate state of gp41 and is capable of inducing antibodies which neutralize primary isolates of HIV. The invention also comprises compositions comprising the polypeptide and methods of using it.
摘要翻译：本发明包括可用于针对HIV相关感染的治疗和预防性免疫的新型多肽抗原。本发明的多肽模拟gp41的中间状态，并能够诱导中和HIV分离株的抗体。本发明还包括包含多肽的组合物及其使用方法。

13. 发明授权

US06737067B1 Trimer of HIV env gene expression product 失效
标题翻译：艾滋病毒基因表达产物三聚体
公开(公告)号：US06737067B1
公开(公告)日：2004-05-18
申请号：US09744659
申请日：2001-04-18
申请人： Michel Chevalier
发明人： Michel Chevalier
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： The invention concerns a purified recombinant glycoprotein having the following properties: a) an adherence capacity to CD4; b) an affinity with a anti-gp120 antibody capable of neutralizing in vitro HIV cell infection; c) an affinity with an anti-gp41 antibody; d) a timeric form free from inter-chain disulphide bonds. The invention also concerns a vaccine comprising said purified glycoprotein and an adjuvant. The invention further concerns a method for obtaining said glycoprotein, which consists in expressing, by means of genetic recombining techniques, a glycoprotein corresponding to the properties a), b) and c) mentioned above; purifying it, and subjecting it to steps involving at least a reducing agent, an ionic detergent and/or a neutral detergent in conditions leading to a glycoprotein having said properties.
摘要翻译：本发明涉及具有以下特性的纯化重组糖蛋白：a）对CD4的粘附能力; b）与能够中和体外HIV细胞感染的抗gp120抗体的亲和力; c）与抗gp41抗体的亲和力; d）不含链间二硫键的定时形式。本发明还涉及包含所述纯化糖蛋白和佐剂的疫苗。本发明还涉及一种获得所述糖蛋白的方法，其包括通过遗传重组技术表达对应于上述性质a），b）和c）的糖蛋白; 对其进行纯化，并在导致具有所述性质的糖蛋白的条件下使其至少涉及还原剂，离子洗涤剂和/或中性洗涤剂的步骤。

14. 发明授权

US06641816B1 Use of poxviruses as enhancer of specific immunity 失效
标题翻译：使用痘病毒作为特异性免疫的增强剂
公开(公告)号：US06641816B1
公开(公告)日：2003-11-04
申请号：US09720466
申请日：2001-03-09
申请人： Michel Chevalier , Bernard Meignier , Catherine Moste , Suryaprakash Sambhara
发明人： Michel Chevalier , Bernard Meignier , Catherine Moste , Suryaprakash Sambhara
IPC分类号： A61K3912
CPC分类号： A61K39/39 , A61K35/768 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/555 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , A61K2039/70 , C12N2710/24032 , C12N2710/24043 , C12N2740/15034 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16134
摘要： The invention relates to a method for enhancing the specific immune response against an immunogenic compound which comprises administering the immunogenic compound together with a poxvirus recombinant and a vaccinal antigen, which is not a poxvirus. The immunological material may be any biological material useful as a vaccine e.g., a polypeptide characteristic of a pathogenic microorganism or associated with a tumoral disorder, a DNA plasmid encoding a peptide or a polypeptide characteristic of a pathogenic microorganism or a tumor-associated antigen, or an hapten coupled to a carrier molecule. The poxvirus may be a live, attenuated or inactivated virus or a recombinant virus. Recombinant virus may encode a heterologous polypeptide such as chemokines, cytokines or co-immunostimulatory molecules or an homologous polypeptide, which is immunologically cross reactive with the immunogenic polypeptide or peptide.
摘要翻译：本发明涉及增强针对免疫原性化合物的特异性免疫应答的方法，其包括将免疫原性化合物与不是痘病毒的痘病毒重组体和疫苗抗原一起施用。免疫学材料可以是用作疫苗的任何生物材料，例如病原微生物特征的多肽或与肿瘤病症有关的多肽，编码病原微生物或肿瘤相关抗原特征的肽或多肽的DNA质粒，或与载体分子偶联的半抗原。痘病毒可以是活的，减毒的或灭活的病毒或重组病毒。重组病毒可以编码与免疫原性多肽或肽免疫交叉反应的异源多肽，例如趋化因子，细胞因子或共免疫刺激分子或同源多肽。

15. 发明授权

US4806744A Identification card reader encoder 失效
标题翻译：识别卡阅读器编码器
公开(公告)号：US4806744A
公开(公告)日：1989-02-21
申请号：US906495
申请日：1986-09-12
申请人： Alain Briane , Michel Chevalier , Joel Bouaziz
发明人： Alain Briane , Michel Chevalier , Joel Bouaziz
IPC分类号： G06K7/015 , G06K7/08 , G06K13/08 , G11B25/04 , G06K13/00
CPC分类号： G06K7/084 , G06K13/08 , G06K7/015
摘要： A card reader contains an admission chamber, a fixed guide path, including card feeding rollers, and a read station for a magnetic track of a data bearing identification card. The read station and idler wheel are on opposite sides of a card guide path. The read station comprises first and second heads, respectively mounted to turn about first and second parallel axes that extend in the same direction as the guide path. Shafts defining the first and second axes are mounted at the extremities of first and second swing arms positioned on opposite sides of the heads. The swing arms are mounted to turn about a third axis that extends toward the guide path. A shaft defining the third axis is carried on a bifurcated bracket, mounted to rotate about a fourth axis that also extends in the guide path direction. A tension spring exerts a force on the bifurcated bracket to hold the heads constantly against a face of the car as it travels through a nip formed between the heads and a drive roller.
摘要翻译：读卡器包括准入室，固定引导路径，包括卡片进给辊和用于数据承载识别卡的磁迹的读取站。读取站和惰轮在卡引导路径的相对侧。读站包括第一和第二头部，分别安装成围绕与引导路径相同的方向延伸的第一和第二平行轴线。限定第一轴和第二轴的轴安装在位于头部的相对侧上的第一和第二摆臂的末端。摆臂安装成围绕朝向引导路径延伸的第三轴线转动。限定第三轴线的轴承在分叉支架上，安装成围绕也沿引导路径方向延伸的第四轴线旋转。张力弹簧在分叉支架上施加力，当其行进通过形成在头部和驱动辊之间的辊隙时，将头部恒定地抵靠在汽车的表面上。

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