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11. 再颁专利

USRE42194E1 Percutaneous registration apparatus and method for use in computer-assisted surgical navigation 有权
标题翻译：用于计算机辅助外科导航的经皮注册装置和方法
公开(公告)号：USRE42194E1
公开(公告)日：2011-03-01
申请号：US11451594
申请日：2006-06-12
申请人： Kevin T. Foley , John B. Clayton , Anthony Melkent , Michael Sherman
发明人： Kevin T. Foley , John B. Clayton , Anthony Melkent , Michael Sherman
IPC分类号： A61B5/05
CPC分类号： A61B17/70 , A61B17/7032 , A61B17/7083 , A61B34/10 , A61B34/20 , A61B90/11 , A61B2017/00477 , A61B2034/2055 , A61B2034/2072 , A61B2090/363 , A61B2090/3945 , A61B2090/3983
摘要： An apparatus and procedures for percutaneous placement of surgical implants and instruments such as, for example, screws, rods, wires and plates into various body parts using image guided surgery. The invention includes an apparatus for use with a surgical navigation system, an attaching device rigidly connected to a body part, such as the spinous process of a vertebrae, with an identification superstructure rigidly but removably connected to the attaching device. This identification superstructure, for example, is a reference arc and fiducial array which accomplishes the function of identifying the location of the superstructure, and, therefore, the body part to which it is fixed, during imaging by CAT scan or MRI, and later during medical procedures.
摘要翻译：使用图像引导手术将外科植入物和器械（例如螺钉，杆，线和板）经皮放置到各种身体部位中的装置和程序。本发明包括一种与外科导航系统一起使用的装置，刚性地连接到身体部位的附接装置，例如椎骨的棘突，其具有刚性但可拆卸地连接到附接装置的识别上部结构。该识别超结构例如是参考电弧和基准阵列，其在通过CAT扫描或MRI进行成像期间实现识别上部结构的位置以及因此固定的身体部位的功能，并且稍后在医疗程序。

12. 发明申请

US20100031760A1 SYSTEM FOR TRANSFERANCE OF TEST TUBES FROM TUBE RACK TO CENTRIFUGE ROTOR 审中-公开
标题翻译：测试管从管架转移到离心转子的系统
公开(公告)号：US20100031760A1
公开(公告)日：2010-02-11
申请号：US11773386
申请日：2007-07-03
申请人： Yury Sherman , Michael Sherman , Ian Glasgow
发明人： Yury Sherman , Michael Sherman , Ian Glasgow
IPC分类号： B01L9/06 , B04B5/02
CPC分类号： B04B5/0414 , B01L3/5021 , B01L9/06 , B01L2300/043 , B01L2300/123 , B01L2400/0409 , B04B2005/0435
摘要： The present invention includes a system and method for the management of specimens ordinarily manipulated via tubes. The invention may include a flexible, removable tube holder that is linear when placed in a rack and curved when placed into a centrifuge rotor. The system provides for the elimination of manual recording of the individual tubes, and also provides for the transference of the tubes from the rack to the centrifuge and back in a group.
摘要翻译：本发明包括用于管理通常经由管操作的样本的系统和方法。本发明可以包括柔性可拆卸的管保持器，其在放置在搁架中时是线性的，并且当放置在离心机转子中时弯曲。该系统提供消除各个管的手动记录，并且还提供将管从架架转移到离心机并在一组中返回。

13. 发明申请

US20070270819A1 Surgical instruments and techniques for controlling spinal motion segments with positioning of spinal stabilization elements 有权
标题翻译：用于通过脊柱稳定元件定位来控制脊柱运动节段的手术器械和技术
公开(公告)号：US20070270819A1
公开(公告)日：2007-11-22
申请号：US11410727
申请日：2006-04-25
申请人： Jeff Justis , Fred Molz , Michael Sherman
发明人： Jeff Justis , Fred Molz , Michael Sherman
IPC分类号： A61F2/30
CPC分类号： A61B17/701 , A61B17/7004 , A61B17/7083 , A61B17/7085 , A61B17/7089
摘要： Elongated connecting elements include bodies having anisotropic cross-sectional shapes defining a first moment of inertia about a first bending axis and a second moment of inertia about a second bending axis that is transverse to the first bending axis. The connecting elements are positioned along one or more spinal motion segments and engaged to vertebrae with anchors with the first and second bending axes in the desired orientation relative to the spinal motion segments.
摘要翻译：细长的连接元件包括具有围绕第一弯曲轴限定第一转动惯量的各向异性横截面形状的主体和围绕横向于第一弯曲轴线的第二弯曲轴线的第二转动惯量。连接元件沿着一个或多个脊柱运动节段定位并且与锚固件接合到具有相对于脊柱运动段的期望取向的第一和第二弯曲轴的锚固件。

14. 发明申请

US20070270814A1 Vertebral stabilizer 有权
标题翻译：椎体稳定器
公开(公告)号：US20070270814A1
公开(公告)日：2007-11-22
申请号：US11407642
申请日：2006-04-20
申请人： Roy Lim , Michael Sherman
发明人： Roy Lim , Michael Sherman
IPC分类号： A61F2/30
CPC分类号： A61B17/7025 , A61B17/7004 , A61B17/7007 , A61B17/7031 , A61B17/7046 , F16F1/028 , F16F1/445
摘要： A system for flexibly stabilizing a vertebral motion segment by connecting a first vertebra and a second vertebra is disclosed. The system includes a bumper with a resilient central member. The system is designed such that the resilient central member is compressed in both compression and extension of the bumper or vertebral motion segment. The system includes first and second means for connecting the bumper to the vertebrae.
摘要翻译：公开了一种通过连接第一椎骨和第二椎骨来柔性地稳定椎体运动节段的系统。该系统包括具有弹性中心构件的保险杠。该系统被设计成使得弹性中心构件在缓冲器或椎体运动段的压缩和延伸中被压缩。该系统包括用于将保险杠连接到椎骨的第一和第二装置。

15. 发明申请

US20060149238A1 Systems and methods for spinal stabilization with flexible elements 有权
公开(公告)号：US20060149238A1
公开(公告)日：2006-07-06
申请号：US11028999
申请日：2005-01-04
申请人： Michael Sherman , Roy Lim
发明人： Michael Sherman , Roy Lim
IPC分类号： A61F2/30
CPC分类号： A61B17/70 , A61B17/7004 , A61B17/7031 , A61B17/7032 , A61B17/7089
摘要： Systems and methods are provided for spinal stabilization with flexible elements and other elements engaged to the vertebrae. Also provided are instruments and methods for insertion of the flexible stabilization elements and other elements and for reduction of displacement between adjacent vertebrae in a minimally invasive surgical approach.

16. 发明申请

US20060136064A1 Intervertebral disc implants and methods for manufacturing and using the same 有权
标题翻译：椎间盘植入物及其制造和使用方法
公开(公告)号：US20060136064A1
公开(公告)日：2006-06-22
申请号：US11293070
申请日：2005-12-02
申请人： Michael Sherman
发明人： Michael Sherman
IPC分类号： A61F2/44
CPC分类号： A61L27/52 , A61B2017/00261 , A61F2/3094 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30075 , A61F2002/30093 , A61F2002/30291 , A61F2002/30293 , A61F2002/30505 , A61F2002/4415 , A61F2002/444 , A61F2002/4635 , A61F2210/0019 , A61F2210/0061 , A61F2220/0025 , A61F2230/0091 , A61L27/446 , A61L2400/16 , A61L2430/38
摘要： Described are intervertebral disc implants that include an elastomeric polymer body, especially a hydrogel body, and a superelastic element. Also described are methods for making and using such implants.
摘要翻译：描述的是椎间盘植入物，其包括弹性聚合物体，特别是水凝胶体和超弹性元件。还描述了制造和使用这种植入物的方法。

17. 发明申请

US20060130262A1 Quick release paint roller assembly 审中-公开
标题翻译：快速涂漆辊组件
公开(公告)号：US20060130262A1
公开(公告)日：2006-06-22
申请号：US11182222
申请日：2005-07-15
申请人： John Visk , Dennis Futo , Scott Pyle , Michael Sherman
发明人： John Visk , Dennis Futo , Scott Pyle , Michael Sherman
IPC分类号： B05C17/02
CPC分类号： B05C17/0245 , B05C17/02
摘要： A quick-release paint roller having a roller cover that can be removed from a handle assembly without requiring the user to apply a force directly to the roller cover. The paint roller includes a tube-shaped roller cover having an outer surface of paint absorbing material and a rotatably mounted roller core. The roller cover is mounted on the roller core so as to be rotatable with the roller core. The roller core has a length less than the length of the roller cover such that a first end of the roller core is adjacent an end of the roller cover and a second end of the roller core is within the roller cover. The second end of the roller core includes a roller mounting device. The paint roller also has a handle assembly including a housing having an extension member configured to extend inside the roller core, the extension member having an opening configured to receive the roller mounting device. The handle assembly also has a latching mechanism that is movable between a latched position and a release position. The latching mechanism includes an actuator and a pair of catch bars, wherein when the actuator is in the latched position, the latching mechanism engages the roller mounting device to couple the roller core to the handle assembly and prevent movement of the roller cover in a direction along the axis of rotation away from the housing. When the actuator is in the release position, the roller mounting device is free of the latching mechanism, thus permitting the roller core and roller cover to be removed from the handle assembly.
摘要翻译：一种快速涂漆辊，其具有可以从手柄组件移除的辊盖，而不需要用户将力直接施加到辊盖。涂漆辊包括具有涂料吸收材料的外表面和可旋转地安装的辊芯的管状辊盖。辊盖安装在辊芯上，以便与辊芯一起旋转。辊芯的长度小于辊盖的长度，使得辊芯的第一端邻近辊盖的端部，并且辊芯的第二端在辊盖内。辊芯的第二端包括辊安装装置。油漆辊还具有手柄组件，其包括具有延伸构件的壳体，该延伸构件构造成在辊芯内部延伸，所述延伸构件具有构造成容纳辊安装装置的开口。手柄组件还具有可在锁定位置和释放位置之间移动的闩锁机构。闩锁机构包括致动器和一对卡扣杆，其中当致动器处于闩锁位置时，闩锁机构接合滚子安装装置，以将滚子芯连接到手柄组件，并防止滚筒盖沿方向移动沿着旋转轴线远离壳体。当致动器处于释放位置时，辊安装装置没有闩锁机构，因此允许辊芯和辊盖从手柄组件移除。

18. 发明授权

US06960430B2 Screening methods for compounds useful in the regulation of cell proliferation 失效
标题翻译：用于调节细胞增殖的化合物的筛选方法
公开(公告)号：US06960430B2
公开(公告)日：2005-11-01
申请号：US10132556
申请日：2002-04-25
申请人： Vladimir Z. Volloch , Michael Sherman
发明人： Vladimir Z. Volloch , Michael Sherman
IPC分类号： A61K38/00 , C07K14/47 , C07K16/30 , C12Q1/42 , G01N33/50 , G01N33/574 , C12Q1/00
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , C07K16/30 , C12N2799/022 , C12Q1/42 , G01N33/5011
摘要： The present invention relates to drug screening assays and methods for the treatment of proliferative disorders associated with elevated levels of heat shock protein 72 (Hsp72) expression in a cell. The invention is based on the discovery that overexpression of full length Hsp72 protein, or the C-terminal protein binding domain of Hsp72, results in oncogenic transformation of cells.
摘要翻译：本发明涉及用于治疗与细胞中热休克蛋白72（Hsp72）表达水平升高相关的增殖性疾病的药物筛选测定和方法。本发明基于以下发现：全长Hsp72蛋白或Hsp72的C-末端蛋白结合结构域的过表达导致细胞的致癌转化。

19. 发明申请

US20050197707A1 Collagen-based materials and methods for augmenting intervertebral discs 有权
标题翻译：基于胶原的材料和增加椎间盘的方法
公开(公告)号：US20050197707A1
公开(公告)日：2005-09-08
申请号：US11117025
申请日：2005-04-28
申请人： Hai Trieu , Michael Sherman
发明人： Hai Trieu , Michael Sherman
IPC分类号： A61B17/56 , A61B17/70 , A61B17/88 , A61F2/00 , A61F2/08 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61K38/39 , A61L27/36 , A61L27/50 , A61L31/00 , A61L31/14 , A61L31/18
CPC分类号： A61L31/18 , A61B17/562 , A61B17/7064 , A61B17/7095 , A61B2017/564 , A61F2/08 , A61F2/442 , A61F2/4601 , A61F2002/30075 , A61F2002/3008 , A61F2002/30224 , A61F2002/30588 , A61F2002/30677 , A61F2002/444 , A61F2002/445 , A61F2002/4627 , A61F2210/0061 , A61F2230/0069 , A61F2250/0098 , A61F2310/00365 , A61L27/24 , A61L27/36 , A61L27/3856 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2430/24 , A61L2430/38
摘要： A method of augmenting an intervertebral disc by injecting particles of collagen-based material into the disc. The particles may be dehydrated before implantation, and rehydrated after implantation, or they may be implanted in a “wet” state—such as a slurry or gel. Radiocontrast materials may be included to enhance imaging of the injected material. Other additives may include analgesics, antibiotics, proteoglycans, growth factors, and/or other cells effective to promote healing and/or proper disc function.
摘要翻译：通过将基于胶原的材料的颗粒注入椎间盘来增加椎间盘的方法。颗粒可以在植入前脱水，并在植入后再水合，或者它们可以以“湿”状态植入，例如浆料或凝胶。可以包括放射对比材料以增强注射材料的成像。其它添加剂可以包括止痛剂，抗生素，蛋白聚糖，生长因子和/或有效促进愈合和/或适当的椎间盘功能的其他细胞。

20. 发明申请

US20050136764A1 Designed composite degradation for spinal implants 审中-公开
标题翻译：脊柱植入物的设计复合降解
公开(公告)号：US20050136764A1
公开(公告)日：2005-06-23
申请号：US10740055
申请日：2003-12-18
申请人： Michael Sherman , Fred Molz
发明人： Michael Sherman , Fred Molz
IPC分类号： A61B17/00 , A61B17/70 , A61B17/80 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/40 , A61L27/48 , A61L27/58 , A61L31/12 , A61L31/14 , B32B27/04 , B32B5/02 , B32B5/26 , B32B27/12
CPC分类号： A61B17/8085 , A61B17/7001 , A61B17/7059 , A61B17/86 , A61B2017/00004 , A61F2/28 , A61F2/30767 , A61F2/30942 , A61F2/30965 , A61F2/4455 , A61F2002/2817 , A61F2002/2825 , A61F2002/30004 , A61F2002/30009 , A61F2002/30014 , A61F2002/30018 , A61F2002/30034 , A61F2002/30062 , A61F2002/30064 , A61F2002/30092 , A61F2002/30153 , A61F2002/30154 , A61F2002/30224 , A61F2002/30242 , A61F2002/30263 , A61F2002/30289 , A61F2002/30327 , A61F2002/30448 , A61F2002/30677 , A61F2002/30914 , A61F2002/30957 , A61F2002/4495 , A61F2210/0004 , A61F2210/0014 , A61F2220/005 , A61F2230/0019 , A61F2230/0021 , A61F2230/0069 , A61F2230/0071 , A61F2230/0084 , A61F2230/0091 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2250/0029 , A61F2250/0031 , A61F2250/0039 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00095 , A61F2310/00125 , A61F2310/00131 , A61F2310/00137 , A61F2310/00179 , A61F2310/00293 , A61L27/40 , A61L27/48 , A61L27/58 , A61L31/129 , A61L31/148 , Y10T442/109 , Y10T442/164 , Y10T442/172 , Y10T442/178 , Y10T442/2361 , Y10T442/3382 , Y10T442/3472 , Y10T442/3854 , Y10T442/3976
摘要： The invention includes a composite material for use in the construction of orthopedic devices and methods for using these composites. The composite material is comprised of at least one filament or cord that can be non-biodegradable and a biodegradable matrix. In other forms the composite material contains at least two components formed of a biodegradable material, which components can be a matrix or a filament or a combination of matrices and filaments. The degradation rate of the two components need not be the same. The composite material is used in the construction of orthopedic devices such as bone plates, bone rods, spinal rods, and laminate sheets that change physical properties in vivo.
摘要翻译：本发明包括用于矫形装置的构造的复合材料以及使用这些复合材料的方法。复合材料由至少一个可以是不可生物降解的细丝或绳索和可生物降解的基质组成。在其它形式中，复合材料包含由可生物降解的材料形成的至少两种组分，该组分可以是基质或长丝或基质和长丝的组合。两个部件的退化率不一定相同。复合材料用于矫形装置的构造，例如改变体内物理性质的骨板，骨棒，脊柱杆和层压片。

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