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    • 12. 发明授权
    • Medical devices coated with drug carrier macromolecules
    • 用药物载体大分子涂覆的医疗器械
    • US07572625B2
    • 2009-08-11
    • US11435690
    • 2006-05-18
    • Liza J. DavisKim RobertsonRichard C. Tooley, Jr.
    • Liza J. DavisKim RobertsonRichard C. Tooley, Jr.
    • C12M3/00
    • A61L31/16A61L27/227A61L27/34A61L27/54A61L31/04A61L31/10A61L2300/602
    • A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.
    • 涂覆有载体大分子的医疗装置,其中载体大分子与治疗剂缀合。 载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。 载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。 载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。 载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。 在一些情况下,靶抗原的结合导致治疗剂从双特异性抗体释放。 还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。
    • 13. 发明申请
    • Inclined mattress pad
    • US20060179580A1
    • 2006-08-17
    • US11352909
    • 2006-02-13
    • Kim RobertsonRobert GreenRobert Ackley
    • Kim RobertsonRobert GreenRobert Ackley
    • A47C27/14
    • A47C21/046A47C27/144A47C27/146A47C27/148
    • A full length mattress pad is provides improved patient support for all parts of the user's body through provision of a support surface supplement for use with existing support surfaces, such as for use on top of a conventional mattress or hospital bed. The pad has a body of resilient material having a relatively flat, planar lower surface for being received on top of the existing support surface, and has a length at least generally the same as that of the mattress, or at least long enough to support the full length of a user. An inclined upper surface is defined by the body of resilient material, and has a plurality of different longitudinal sections. The plurality of different longitudinal sections collectively define a predetermined angle of inclination for the inclined upper surface which is relatively constant along the entire length of the body of resilient material relative to its planar lower surface. At least one of the plurality of different longitudinal sections has a relatively flat surface inclined at the predetermined angle of inclination, while at least one other of the plurality of different longitudinal sections has a surface formed with respective or different projections therein, so that improved patient support is provided through a combination of the inclined upper surface and the plurality of different longitudinal sections. Preferably, the predetermined angle of inclination is no more than about 10°. Characteristics of the plurality of longitudinal sections are selected based upon one or more of the type of resilient material used, the thickness of such material, the change in thickness of such material due to the predetermined angle of inclination, the material density, and the indention load deflection characteristics of such material, with such selection and combination of characteristics determined so as to optimize the inclined pad for support for the user's body which is engineered on the basis of the intended end use of said mattress pad. The longitudinal sections are also formed by one or both of longitudinal and lateral cuts within a selected portion of the inclined upper surface, also preselected to address the relieving of support pressure points to decrease the chance of decubitus ulcers in users of the mattress pad. At least one of the depths, widths, and lengths of such cuts, forming cross-sectional shapes of the different or respective projections, are preselected on the basis of the intended end use of said mattress pad. A plurality of channels may be formed between adjacent of the respective projections, for dissipating heat and moisture from a user who is supported on the inclined upper surface, to increase the health and comfort of such user.