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11. 发明授权

US08246869B2 Photo-responsive microencapsulation materials, compositions and methods of use thereof 有权
标题翻译：光敏微囊化材料，组合物及其使用方法
公开(公告)号：US08246869B2
公开(公告)日：2012-08-21
申请号：US12091297
申请日：2006-10-30
申请人： Michael H. B. Stowell
发明人： Michael H. B. Stowell
IPC分类号： B01J13/02 , B01J13/06 , B01J13/16 , C08G63/60
CPC分类号： C08L61/02 , A61K8/11 , A61K2800/412 , A61K2800/56 , A61K2800/81 , A61Q13/00 , B01J13/185 , C07C45/567 , C07C45/68 , C07C49/84 , C07C217/10 , C08G6/00 , Y10T428/2984 , Y10T428/2985
摘要： Photoactivatable prepolymers and methods of use thereof are disclosed for microencapsulation of a substantially water-insoluble material within a nonporous shell. As provided herein, the microencapsulated material is released with no more than a slow release rate. Upon exposure of the nonporous shell to light, the nonporous shell is converted into a porous shell having an increased release rate for the microencapsulated material.
摘要翻译：公开了可光活化的预聚物及其使用方法，用于在无孔壳内微囊化基本上不溶于水的材料。如本文所提供的，微囊化材料以不超过缓释速率释放。当无孔壳暴露于光时，无孔壳被转化成具有增加的微胶囊化材料释放速率的多孔壳。

12. 发明申请

US20120065709A1 METHODS AND DEVICES FOR VISIBLE LIGHT MODULATION OF MITOCHONDRIAL FUNCTION IN HYPOXIA AND DISEASE 审中-公开
标题翻译：用于可视光调制高血压和疾病的麻醉功能的方法和装置
公开(公告)号：US20120065709A1
公开(公告)日：2012-03-15
申请号：US13076114
申请日：2011-03-30
申请人： John Dunning , Robert O. Poyton , Michael H. B. Stowell
发明人： John Dunning , Robert O. Poyton , Michael H. B. Stowell
IPC分类号： A61N5/06
CPC分类号： A61N5/0618 , A61N5/06 , A61N5/0622 , A61N2005/0626 , A61N2005/0645 , A61N2005/0647 , A61N2005/0653 , A61N2005/0662 , A61N2005/0667
摘要： The present invention provides methods of using electromagnetic radiation in the visible portion of the spectrum to modulate mitochondrial function in the treatment of various conditions, including Alzheimer's disease, other demential, hypoxia and diabetic peripheral neuropathy, and sensory disorders of the extremities.
摘要翻译：本发明提供了在光谱的可见部分中使用电磁辐射来调节治疗包括阿尔茨海默病，其他痴呆，缺氧和糖尿病周围神经病变以及四肢感觉障碍的各种病症的线粒体功能的方法。

13. 发明授权

US06280711B1 Photoresponsive sunscreen compositions 有权
标题翻译：光敏防晒组合物
公开(公告)号：US06280711B1
公开(公告)日：2001-08-28
申请号：US09436685
申请日：1999-11-08
申请人： Ronald S. Rock , Michael H. B. Stowell
发明人： Ronald S. Rock , Michael H. B. Stowell
IPC分类号： A61K742
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/42 , A61K8/4973 , A61K8/4986
摘要： The disclosure provides sunscreen compositions comprising a carrier for topical administration and photoresponsive first sunscreen agents which are capable of undergoing intramolecular photorearrangements to form second sunscreen agents. The second sunscreen agents absorb more ultraviolet radiation than the first sunscreen agents. The sunscreen composition may comprise the prephotorearrangement first sunscreen agent, the photorearranged second sunscreen agent, a combination of the first and second sunscreen agents, or any of the above in combination with a known sunscreen agent.
摘要翻译：本公开提供了防晒组合物，其包含用于局部给药的载体和光响应性第一防晒剂，其能够进行分子内的光结构以形成第二防晒剂。第二防晒剂比第一防晒剂吸收更多的紫外线辐射。防晒组合物可以包含第一防晒剂，第二防晒剂，第二防晒剂，第二防晒剂和第二防晒剂的组合，或上述任何一种与已知的防晒剂组合。

14. 发明授权

US6022529A Photoresponsive sunscreen compositions 失效
标题翻译：光敏防晒组合物
公开(公告)号：US6022529A
公开(公告)日：2000-02-08
申请号：US907188
申请日：1997-08-06
申请人： Ronald S. Rock , Michael H. B. Stowell
发明人： Ronald S. Rock , Michael H. B. Stowell
IPC分类号： A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61K7/42 , A61K7/00
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/42 , A61K8/4973 , A61K8/4986
摘要： The disclosure provides sunscreen compositions comprising a carrier for topical administration and photoresponsive first sunscreen agents which are capable of undergoing intramolecular photorearrangements to form second sunscreen agents. The second sunscreen agents absorb more ultraviolet radiation than the first sunscreen agents. The sunscreen composition may comprise the prephotorearrangement first sunscreen agent, the photorearranged second sunscreen agent, a combination of the first and second sunscreen agents, or any of the above in combination with a known sunscreen agent.
摘要翻译：本公开提供了防晒组合物，其包含用于局部给药的载体和光响应性第一防晒剂，其能够进行分子内的光结构以形成第二防晒剂。第二防晒剂比第一防晒剂吸收更多的紫外线辐射。防晒组合物可以包含第一防晒剂，第二防晒剂，第二防晒剂，第二防晒剂和第二防晒剂的组合，或上述任何一种与已知的防晒剂组合。

15. 发明授权

US5840674A Covalent microparticle-drug conjugates for biological targeting 失效
公开(公告)号：US5840674A
公开(公告)日：1998-11-24
申请号：US691891
申请日：1996-08-01
申请人： Milton B. Yatvin , Michael H. B. Stowell , Vincent S. Gallicchio , Michael J. Meredith
发明人： Milton B. Yatvin , Michael H. B. Stowell , Vincent S. Gallicchio , Michael J. Meredith
IPC分类号： A61K9/16 , A61K47/48 , C07H19/06 , C07H19/10 , C12N5/08 , A01N37/18 , A01N57/26
CPC分类号： A61K9/167 , A61K47/48046 , A61K47/48053 , A61K47/48315 , A61K47/48884 , B82Y5/00 , C07H19/06 , C07H19/10 , Y10S530/811 , Y10S530/813 , Y10S530/814 , Y10S530/815
摘要： This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such compounds to specific sites intracellularly. The invention specifically relates to methods of facilitating the entry of antiviral and antimicrobial drugs and other agents into phagocytic cells and for targeting such compounds to specific organelles within the cell. The invention specifically provides compositions of matter and pharmaceutical embodiments of such compositions comprising conjugates of such antimicrobial drugs and agents covalently linked to particulate carriers generally termed microparticles. In particular embodiments, the antimicrobial drug is covalently linked to a microparticle via an organic linker molecule which is the target of a microorganism-specific protein having enzymatic activity. Thus, the invention provides cell targeting of drugs wherein the targeted drug is only released in cells infected with a particular microorganism. Alternative embodiments of such specific drug delivery compositions also contain polar lipid carrier molecules effective in achieving intracellular organelle targeting in infected phagocytic mammalian cells. Particular embodiments of such conjugates comprise antimicrobial drugs or agents covalently linked both to a microparticle via an organic linker molecule and to a polar lipid compound, to facilitate targeting of such drugs or agents to particular subcellular organelles within the cell. Also provided are porous microparticles impregnated with antiviral and antimicrobial drugs and agents wherein the surface or outside extent of the microparticle is covered with a degradable coating that is specifically degraded within an infected phagocytic mammalian cell. Also provided are nonporous microparticles coated with an antiviral or antimicrobial drug and further coated wherein the surface or outside extent of the microparticle is covered with a degradable coating that is specifically degraded within an infected phagocytic mammalian cell. Methods of inhibiting, attenuating, arresting, combating and overcoming microbial infection of phagocytic mammalian cells in vivo and in vitro are also provided.

16. 发明授权

US5827819A Covalent polar lipid conjugates with neurologically active compounds for targeting 失效
公开(公告)号：US5827819A
公开(公告)日：1998-10-27
申请号：US735977
申请日：1996-10-25
申请人： Milton B. Yatvin , Michael H. B. Stowell , Michael J. Meredith
发明人： Milton B. Yatvin , Michael H. B. Stowell , Michael J. Meredith
IPC分类号： A61K47/48 , A61K31/00 , A61K31/196 , A61K31/198 , A61K31/513 , A61K31/519 , A61K31/55 , A61P25/00 , A61P43/00 , C07H19/06 , C07H19/10 , A61K38/00 , A61K9/127 , A61K31/135
CPC分类号： C07H19/06 , A61K31/00 , A61K47/48046 , A61K47/48053 , B82Y5/00 , C07H19/10
摘要： This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This polar lipid/drug conjugate targeting invention embodies an advance over other drug targeting methods known in the prior art, because the invention provides drug concentrations in such physiologically protected sites that can reach therapeutically-effective levels after administration of systemic levels much lower than are currently administered to achieve a therapeutic dose. This technology is appropriate for use with psychotropic, neurotropic and neurological drugs, agents and compounds, for rapid and efficient introduction of such agents across the blood-brain barrier. Further, the invention provides means for retention and prolonged enzymatic release of psychotropic, neurotropic and neurological drugs, agents and compounds comprising the conjugates of the invention, in the brain and central nervous system.

17. 发明授权

US5767288A Photolabile linkers and probes 失效
标题翻译：光不连续接头和探头
公开(公告)号：US5767288A
公开(公告)日：1998-06-16
申请号：US583994
申请日：1996-01-05
申请人： Ronald S. Rock , Michael H. B. Stowell , Sunney I. Chan
发明人： Ronald S. Rock , Michael H. B. Stowell , Sunney I. Chan
IPC分类号： C07C45/56 , C07C49/83 , C07C49/84 , C07C235/20 , C07D339/08 , C07F9/09 , C07H21/00 , C07K7/06 , G01N33/58 , C07C49/23 , C07D271/12 , C07D307/78
CPC分类号： C07H21/00 , C07C235/20 , C07C45/567 , C07C49/83 , C07C49/84 , C07D339/08 , C07F9/094 , C07K7/06 , G01N33/582 , Y02P20/55
摘要： The invention relates to dithiane adducts of substituted benzoins and substituted benzoins derived therefrom each of which are useful as protecting groups, photolabile linkers, and fluorescent probes.
摘要翻译：本发明涉及取代的苯偶姻的二噻吩加合物和由其衍生的取代的苯偶姻，其各自可用作保护基，光不连续接头和荧光探针。

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