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11. 发明授权

US06586436B2 Serotonergic agents 失效
公开(公告)号：US06586436B2
公开(公告)日：2003-07-01
申请号：US10218251
申请日：2002-08-14
申请人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
发明人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
IPC分类号： A61K31496
CPC分类号： C07D405/12
摘要： Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.

12. 发明授权

US06518272B2 Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents 失效
标题翻译：环烷基取代的芳基哌嗪，哌啶和四氢吡啶作为血清素能药
公开(公告)号：US06518272B2
公开(公告)日：2003-02-11
申请号：US10107866
申请日：2002-03-27
申请人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
发明人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
IPC分类号： A61K3150
CPC分类号： C07D239/42 , C07D209/08 , C07D211/22 , C07D213/74 , C07D217/22 , C07D277/82 , C07D295/125 , C07D295/13 , C07D319/20
摘要： This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; R1 is optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is H or alkyl; R3 is H, COR5, COOR5, and CONR5R6; R4 is H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; R5 and R6 are H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or R5 and R6 taken together may form a 5-7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR4; when R5 or R6 are chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C1-C3 alkyl group; or an optical isomer; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有作为5-HT 1A激动剂和拮抗剂的活性的化合物，其可用于治疗具有下列基团的焦虑，抑郁，认知缺陷和前列腺癌：X是选自以下的部分：n是从整数1到5中选择; R 1是任选取代的芳基或单或双环杂芳基，条件是杂芳基不是噻二唑; R2是H或烷基; R3是H，COR5，COOR5和CONR5R6; R 4是H，烷基，烯基，炔基，芳基，单或双环杂芳基，芳烷基和单或双环杂芳烷基，其中芳基或杂芳基任选被取代; R5和R6是H，烷基，烯基，炔基，环烷基，环烯基，金刚烷基和去月桂烷基或R5和R6一起可以形成5-7元的氮杂环，任选地含有选自O，S或NR4的另外的杂原子; 当R5或R6选自环烷基或环烯基时，环状基团可以任选在1-位被C1-C3烷基取代;或光学异构体; 或其药学上可接受的盐。

13. 发明授权

US06326381B1 Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates 失效
标题翻译：芳基哌啶和芳基-1,2,5,6-四氢吡啶酰胺衍生物
公开(公告)号：US06326381B1
公开(公告)日：2001-12-04
申请号：US09459801
申请日：1999-12-13
申请人： Michael G. Kelly , Gan Zhang , Yvette L. Palmer , Wayne E. Childers
发明人： Michael G. Kelly , Gan Zhang , Yvette L. Palmer , Wayne E. Childers
IPC分类号： C07D40106
CPC分类号： C07D401/06 , C07D211/22
摘要： Compounds of the formula wherein R1, R2, R3, R4, X and n are defined in the specification, are useful for the treatment of anxiety, depression and related CNS disorders, and other related conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and Alzheimer's disease.
摘要翻译：化学式R 1，R 2，R 3，R 4，X和n的化合物在本说明书中定义，可用于治疗焦虑，抑郁和相关的中枢神经系统疾病以及其他相关病症，例如治疗酒精和药物戒断，性功能障碍和阿尔茨海默病。

14. 发明授权

US06204274B1 Indolyl derivatives as serotonergic agents 失效
标题翻译：吲哚衍生物作为血清素能药
公开(公告)号：US06204274B1
公开(公告)日：2001-03-20
申请号：US09298200
申请日：1999-04-23
申请人： Michael G. Kelly , Young H. Kang
发明人： Michael G. Kelly , Young H. Kang
IPC分类号： A61K31445
CPC分类号： C07D401/14
摘要： The present invention provides compounds of the formula (1): wherein R1 and R2 each independently represent hydrogen, hydroxy, F, Cl, Br, I, CN, 1 to 6 carbon alkyl, 1 to 6 carbon alkoxy, nitro, CF3 and phenyloxy or benzyloxy, in which the aromatic ring can be optionally substituted by from 1 to 3 groups selected from C1-C6 alkoxy (preferably OMe), F, Cl, Br, I, and CF3; R3 and R4 are each independently a hydrogen, a 1 to 6 carbon alkyl or a CH2Ph in which the phenyl ring can be optionally substituted by from 1 to 3 groups selected from C1-C6 alkoxy (preferably OMe), F, Cl, Br, I, and CF3; Y is selected from CH2 or CH and, X is selected from a group represented by N, CR3, CHR3, CHCH; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of using the compounds to treat central nervous system disorders, such as depression, anxiety, drug withdrawal, eating and sexual disorders and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译：本发明提供式（1）的化合物：其中R 1和R 2各自独立地表示氢，羟基，F，Cl，Br，I，CN，1至6个碳原子的烷基，1至6个碳烷氧基，硝基，CF 3和苯氧基或苄氧基，其中芳环可以任选被1至3个选自C 1 -C 6烷氧基（优选OMe），F，Cl，Br，I和CF 3的基团取代; R 3和R 4各自独立地为氢，至6碳烷基或CH 2 Ph，其中苯环可以任选被1至3个选自C 1 -C 6烷氧基（优选OMe），F，Cl，Br，I和CF 3的基团取代; Y选自CH 2或 CH，X选自由N，CR 3，CHR 3，CHCH表示的基团;或其药学上可接受的盐，以及使用该化合物治疗中枢神经系统疾病如抑郁症，焦虑症，药物戒断，饮食和性障碍以及使用5-羟色胺再摄取抑制剂的其他条件。

15. 发明授权

US6110943A N-substituted (thiophen-2-yl)-piperidines and tetrahydropyridines as serotonergic agents 失效
标题翻译： N-取代的（噻吩-2-基） - 哌啶和四氢吡啶作为血清素能药剂
公开(公告)号：US6110943A
公开(公告)日：2000-08-29
申请号：US286753
申请日：1999-04-06
申请人： Reinhartd B. Baudy , Wayne E. Childers, Jr. , Michael G. Kelly
发明人： Reinhartd B. Baudy , Wayne E. Childers, Jr. , Michael G. Kelly
IPC分类号： C07D409/04 , A61K31/445
CPC分类号： C07D409/04
摘要： This invention provides compounds having the structure ##STR1## that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.
摘要翻译：本发明提供了具有可用作治疗和缓解这些疾病状态症状的抗精神病药，抗抑郁药和抗焦虑剂的结构的化合物。

16. 发明授权

US4550189A Soil repellents derived from fluorinated acrylates and aromatic amines 失效
标题翻译：衍生自氟化丙烯酸酯和芳族胺的防污剂
公开(公告)号：US4550189A
公开(公告)日：1985-10-29
申请号：US697293
申请日：1985-02-01
申请人： Michael G. Kelly , James H. Covill
发明人： Michael G. Kelly , James H. Covill
IPC分类号： C08K5/18 , C07C101/447
CPC分类号： C08K5/18
摘要： Soil repellents derived from fluorinated acrylates and aromatic amines are disclosed which have excellent durability and resistance to laundering. The compounds are represented by the formula(R).sub.m --Ar--(NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.f).sub.nwherein n is 1 to 3 and m is 0 to 4, Ar is an aromatic radical containing from 1 to 3 benzene rings which may be fused together or linked through a single carbon-carbon bond or a linking group, R.sub.f is a fluorinated radical, R.sub.1 is H or CH.sub.3, and R is independently selected from lower alkyl, lower alkoxy, halogen, hydroxy, nitro, cyano, amino, lower alkylamino, lower acylamino, --CO.sub.2 R.sub.3 and --NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.3 wherein R.sub.3 is lower alkyl, --CH.sub.2 CH.sub.2 OH, or --CH.sub.2 CH(OH)CH.sub.2 Cl. Also disclosed are polyester and nylon fibers having these compounds incorporated therein.
摘要翻译：公开了从氟化丙烯酸酯和芳族胺衍生的防污剂，其具有优异的耐久性和耐洗涤性。化合物由式（R）m-Ar-（NHCH 2 CH（R 1）CO 2 R f）n表示，其中n为1至3，m为0至4，Ar为含有1至3个苯环的芳族基团，其可以是稠合在一起或通过单个碳 - 碳键或连接基团连接，Rf是氟化基团，R1是H或CH3，R独立地选自低级烷基，低级烷氧基，卤素，羟基，硝基，氰基，氨基，低级烷基氨基，低级酰基氨基，-CO 2 R 3和-NHCH 2 CH（R 1）CO 2 R 3，其中R 3是低级烷基，-CH 2 CH 2 OH或-CH 2 CH（OH）CH 2 Cl。还公开了具有这些化合物的聚酯和尼龙纤维。

17. 发明授权

US4534770A Multi-ring fluorinated carbamates with textiles soil repellent activity 失效
标题翻译：多环氟化氨基甲酸酯具有纺织品防污性能
公开(公告)号：US4534770A
公开(公告)日：1985-08-13
申请号：US674398
申请日：1984-11-23
申请人： Michael G. Kelly
发明人： Michael G. Kelly
IPC分类号： C07C271/06 , D06M13/428 , D06M13/40 , C07C125/06 , C09B67/00
CPC分类号： C07C271/06 , D06M13/428 , Y10S8/922 , Y10S8/924 , Y10S8/93
摘要： Multi-ring fluorinated carbamates are disclosed which have excellent anti-soiling properties, durability and resistance to laundering. The compounds are represented by the formula ##STR1## wherein R.sub.f is a fluorinated radical. Compositions containing at least 10% of such compounds are also disclosed, as well as polyester and nylon fibers having such compounds incorporated therein.
摘要翻译：公开了具有优异的防污性能，耐久性和耐洗涤性的多环氟化氨基甲酸酯。化合物由式（Ⅰ）表示，其中Rf是氟化基团。还公开了含有至少10％的这类化合物的组合物，以及掺入其中的这种化合物的聚酯和尼龙纤维。

18. 发明授权

US08802499B2 Methods for temporary wafer molding for chip-on-wafer assembly 有权
标题翻译：片上晶片组装的临时晶片成型方法
公开(公告)号：US08802499B2
公开(公告)日：2014-08-12
申请号：US13678026
申请日：2012-11-15
申请人： Michael G. Kelly , David Jon Hiner , Ronald Patrick Huemoeller
发明人： Michael G. Kelly , David Jon Hiner , Ronald Patrick Huemoeller
IPC分类号： H01L21/00
CPC分类号： H01L21/486 , H01L21/56 , H01L21/561 , H01L21/568 , H01L22/14 , H01L22/20 , H01L23/04 , H01L23/147 , H01L23/3675 , H01L23/49816 , H01L23/49827 , H01L23/49833 , H01L24/81 , H01L24/83 , H01L24/94 , H01L24/95 , H01L2224/16145 , H01L2224/16225 , H01L2224/32145 , H01L2224/73204 , H01L2224/73253 , H01L2224/81001 , H01L2224/81191 , H01L2224/81908 , H01L2224/81986 , H01L2224/83192 , H01L2224/83908 , H01L2224/83986 , H01L2224/92125 , H01L2924/12042 , H01L2924/16152 , H01L2924/1616 , H01L2924/18161 , H01L2924/19105 , H01L2924/00
摘要： Methods for temporary wafer molding for chip-on-wafer assembly may include bonding one or more semiconductor die to an interposer wafer, applying a temporary mold material to encapsulate the bonded die, and backside processing the interposer, which may be singulated to generate assemblies comprising the bonded die, the interposer die, which may be bonded to packaging substrates. The temporary mold material may be removed and the bonded die may be tested. Additional die may be bonded to the assemblies based on the electrical testing. The interposer may be singulated utilizing one or more of: a laser cutting process, reactive ion etching, a sawing technique, and a plasma etching process. The backside processing may comprise thinning the interposer wafer to expose through-silicon-vias (TSVs) and placing metal contacts on the exposed TSVs. The die may be bonded to the interposer utilizing a mass reflow or thermal compression process.
摘要翻译：用于片上晶片组装的临时晶片成型的方法可以包括将一个或多个半导体管芯接合到插入器晶片，施加临时模制材料以封装接合的管芯，以及背面处理插入件，其可以被单个化以产生组件，可以粘合到封装衬底上的粘合模，插入模。可以移除临时模具材料并且可以测试粘合的模具。基于电气测试，附加模具可以结合到组件。可以使用激光切割工艺，反应离子蚀刻，锯切技术和等离子体蚀刻工艺中的一种或多种来切割插入器。背面处理可以包括使内插器晶片变薄以暴露穿过硅通孔（TSV）并且将金属触点放置在暴露的TSV上。可以使用质量回流或热压缩工艺将管芯结合到插入件。

19. 发明授权

US08779144B2 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof 有权
标题翻译：双环杂芳基化合物作为P2X7调节剂及其用途
公开(公告)号：US08779144B2
公开(公告)日：2014-07-15
申请号：US11722514
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Jianhua He
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Yeyu Cao , Carl Kaub , Sumithra Gowlugari
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D217/24 , C07D401/06 , C07D405/06 , C07D405/10 , C07D471/04
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

20. 发明授权

US08390130B1 Through via recessed reveal structure and method 有权
公开(公告)号：US08390130B1
公开(公告)日：2013-03-05
申请号：US12985888
申请日：2011-01-06
申请人： David Jon Hiner , Ronald Patrick Huemoeller , Michael G. Kelly
发明人： David Jon Hiner , Ronald Patrick Huemoeller , Michael G. Kelly
IPC分类号： H01L23/48
CPC分类号： H01L21/76898 , H01L21/6836 , H01L23/481 , H01L23/528 , H01L24/03 , H01L24/05 , H01L24/06 , H01L24/13 , H01L24/16 , H01L24/17 , H01L24/81 , H01L24/94 , H01L25/0657 , H01L2221/68327 , H01L2221/6834 , H01L2221/6835 , H01L2224/0401 , H01L2224/05009 , H01L2224/0557 , H01L2224/05571 , H01L2224/06181 , H01L2224/13025 , H01L2224/13082 , H01L2224/131 , H01L2224/13147 , H01L2224/16145 , H01L2224/16146 , H01L2224/17181 , H01L2224/73204 , H01L2224/81141 , H01L2224/81191 , H01L2224/81203 , H01L2224/94 , H01L2225/06513 , H01L2225/06541 , H01L2225/06544 , H01L2225/06555 , H01L2225/06593 , H01L2924/00014 , H01L2924/10158 , H01L2224/81 , H01L2924/014 , H01L2224/05552
摘要： A stacked assembly includes a stacked structure stacked on a through via recessed reveal structure. The through via recessed reveal structure includes recesses within a backside surface of an electronic component that expose backsides of through vias. Pillars of the stacked structure are attached to the exposed backsides of the through vias through the recesses. The recesses in combination with the pillars work as a lock and key arrangement to insure self-alignment of the pillars with the backsides of the through vias allowing fine pitch interconnections to be realized. Further, by forming the interconnections to the backsides of the through vias within the recesses, the overall thickness of the stacked assembly is minimized. Further still, by forming the interconnections to the backsides of the through vias within the recesses, shorting between adjacent through vias is minimized or eliminated.

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