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11. 发明授权

US5455925A Data processing device for maintaining coherency of data stored in main memory, external cache memory and internal cache memory 失效
标题翻译：用于维护存储在主存储器，外部高速缓冲存储器和内部高速缓冲存储器中的数据的一致性的数据处理设备
公开(公告)号：US5455925A
公开(公告)日：1995-10-03
申请号：US111731
申请日：1993-08-23
申请人： Takeshi Kitahara , Masato Mitsuhashi , Atsushi Fujihira
发明人： Takeshi Kitahara , Masato Mitsuhashi , Atsushi Fujihira
IPC分类号： G06F12/08 , G06F12/06 , G06F13/00
CPC分类号： G06F12/0811 , G06F12/0897
摘要： A fetching operation break unit breaks a fetching operation of a block data from a main memory, when a system bus is released during the fetching of the block data and also when data written due to a write access by an external device into the main memory coincides with the fetching of one block data. Further, a notification means notifies the state of the fetching operation to an external cache memory. Therefore, the external cache memory can confirm whether a block-in operation of the microprocessor is broken or not, and the contents of the external cache can correctly coincide with the contents of the internal cache and the main memory by carrying out a steal operation, so that the operational reliability of a computer system can be increased.
摘要翻译：获取操作中断单元在取出块数据期间当系统总线被释放以及由于外部设备对主存储器的写访问而写入的数据重合时，从主存储器中断块数据的取出操作获取一个块数据。此外，通知装置将获取操作的状态通知给外部高速缓冲存储器。因此，外部高速缓冲存储器可以确认微处理器的嵌入操作是否损坏，并且通过执行窃取操作，外部高速缓存的内容可以正确地与内部高速缓存和主存储器的内容一致，从而可以提高计算机系统的操作可靠性。

12. 发明授权

US08684492B2 Recording apparatus and recording method 有权
标题翻译：记录装置和记录方法
公开(公告)号：US08684492B2
公开(公告)日：2014-04-01
申请号：US13528678
申请日：2012-06-20
申请人： Masato Mitsuhashi , Koji Higuchi
发明人： Masato Mitsuhashi , Koji Higuchi
IPC分类号： B41J29/393
CPC分类号： B41J29/38 , B41J11/0085 , B41J11/42 , B41J15/04
摘要： A recording apparatus includes: a transport unit that unrolls and transports a recording medium being wound in a roll to the downstream side along a transport path of the recording medium; a recording unit that performs recording processing on the recording medium in a recording region positioned halfway on the transport path; and a control unit that controls the transport unit so that an amount of protrusion of the leading edge portion of the recording medium from the recording region to the downstream side is varied based on an amount of curling of the leading edge portion of the recording medium due to the curling tendency of the recording medium having been unrolled by the transport unit when the recording processing is performed on the recording medium by the recording unit.
摘要翻译：记录装置包括：传送单元，其沿着记录介质的传送路径将卷绕在卷筒上的记录介质展开和传送到下游侧; 记录单元，其对位于传送路径中途的记录区域中的记录介质进行记录处理; 以及控制单元，其控制传送单元，使得记录介质的前边缘部分从记录区域到下游侧的突出量基于记录介质的前缘部分的卷曲量而变化，涉及当由记录单元在记录介质上执行记录处理时由传送单元展开的记录介质的卷曲趋势。

13. 发明授权

US08562128B2 Recording apparatus, recording method 有权
标题翻译：记录装置，记录方法
公开(公告)号：US08562128B2
公开(公告)日：2013-10-22
申请号：US13020472
申请日：2011-02-03
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： B41J2/01
CPC分类号： B41J11/002 , B41J11/66 , B41J13/0009
摘要： A recording apparatus includes: an upstream conveying unit that intermittently conveys a recording medium from an upstream side to a downstream side in a conveying direction; a downstream conveying unit that continuously conveys the recording medium; a recording unit that deposits a liquid and performs a recording process on the recording medium while the recording medium is being intermittently conveyed by the upstream conveying unit and has stopped; a fixing unit that performs a fixing process for fixing the liquid on the recording medium being continuously conveyed by the downstream conveying unit after the liquid has been deposited by the recording unit; and a control unit that controls the downstream conveying unit so that the downstream conveying unit conveys the recording medium at a conveying velocity that is higher than an average conveying velocity when the recording medium is conveyed by the upstream conveying unit.
摘要翻译：记录装置包括：上游输送单元，其在输送方向上从上游侧向下游侧间歇地输送记录介质; 连续地传送记录介质的下游传送单元; 记录单元，其在记录介质被所述上游输送单元间歇地输送并且停止时，将液体沉积并对所述记录介质执行记录处理; 定影单元，在由所述记录单元沉积所述液体之后，执行用于将所述液体固定在所述记录介质上的定影处理，所述定影处理由所述下游输送单元连续输送; 以及控制单元，其控制下游输送单元，使得下游输送单元以高于由上游输送单元输送记录介质时的平均输送速度的输送速度输送记录介质。

14. 发明申请

US20120258076A1 METHOD FOR CHARACTERIZING HOST IMMUNE FUNTION BY EX VIVO INDUCTION OF OFFENSIVE AND DEFENSIVE IMMUNE MARKERS 审中-公开
标题翻译：通过EXVIVO诱导有害和免疫免疫标记表征宿主免疫功能的方法
公开(公告)号：US20120258076A1
公开(公告)日：2012-10-11
申请号：US13516552
申请日：2010-12-08
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： C12Q1/68 , A61K38/20 , A61K31/716
CPC分类号： G01N33/57496 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： A host's immune function can be characterized by quantifying changes in offensive and defensive immune function associated markers. Certain methods can be used to identify a potentially efficacious therapy for a subject based on the induction of expression of offensive and defensive immune function-associated markers. Additionally, some methods can be used to identify drugs that allow the stimulation of either the offensive or defensive immune response while inhibiting the other of offensive or defensive immune response.
摘要翻译：宿主的免疫功能可以通过量化进攻性和防御性免疫功能相关标志物的变化来表征。可以使用某些方法基于进攻性和防御性免疫功能相关标志物的表达的诱导来鉴定受试者的潜在有效治疗。此外，一些方法可用于鉴定允许刺激进攻性或防御性免疫应答同时抑制另一种进攻性或防御性免疫应答的药物。

15. 发明申请

US20120024124A1 TARGET TRANSPORTATION DEVICE AND RECORDING APPARATUS 有权
标题翻译：目标运输装置和记录装置
公开(公告)号：US20120024124A1
公开(公告)日：2012-02-02
申请号：US13178433
申请日：2011-07-07
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： B26D7/06
CPC分类号： B41J13/025 , B41J11/70 , B41J15/04 , Y10T83/647 , Y10T83/664
摘要： A target transportation device includes a first transportation portion which is capable of applying a transportation force toward a downstream side from an upstream side of a transportation path to a target, a second transportation portion which is provided on the transportation path at a position at the downstream side with respect to the first transportation portion in a transportation direction and is capable of applying a transportation force toward the downstream side from the upstream side of the transportation path to the target while nipping the target, and a cutting member which is provided on the transportation path at a position between the first transportation portion and the second transportation portion and is capable of cutting the target in the width direction perpendicular to the transportation direction of the target. The second transportation portion is configured so as to be capable of changing a nipping position of the target in the transportation direction of the target.
摘要翻译：目标运送装置包括：第一输送部，其能够向从输送路径的上游侧向目标的下游侧施加输送力;第二输送部，其设置在输送路径上的位于下游的位置在输送方向上相对于第一输送部分的一侧，并且能够在夹持目标的同时向输送路径的上游侧向下游侧施加输送力;以及切割构件，其设置在输送在第一输送部和第二输送部之间的位置处的路径，并且能够在垂直于目标的输送方向的宽度方向上切割目标。第二输送部被配置为能够改变目标在目标的输送方向上的夹持位置。

16. 发明申请

US20100279296A1 ENHANCED FC RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS 有权
标题翻译：加强FC受体介导的肿瘤坏死因子超家族MRNA在外周血白细胞介素中的表达与患有红斑狼疮的患者
公开(公告)号：US20100279296A1
公开(公告)日：2010-11-04
申请号：US12743220
申请日：2008-11-11
申请人： Masato Mitsuhashi , Katsuya Endo , Kazuhiko Obara , Hiroshi Izutsu , Shuji Ohta
发明人： Masato Mitsuhashi , Katsuya Endo , Kazuhiko Obara , Hiroshi Izutsu , Shuji Ohta
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily (“TNFSF”)-2, TNFSF-8, or TNFSF-15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.
摘要翻译：公开了一种预测患者对涉及改变肿瘤坏死因子超家族（“TNFSF”）-2，TNFSF-8或TNFSF-15表达的类风湿关节炎治疗反应性的方法。还公开了一种用于监测这种疗法的有效性的方法。此外，公开了一种筛选用于治疗类风湿性关节炎的化合物的方法。还公开了一种在类风湿性关节炎患者中监测疾病状态随时间变化的方法。

17. 发明授权

US07745180B2 Device and method for high-throughput quantification of mRNA from whole blood 有权
标题翻译：从全血中高通量定量mRNA的装置和方法
公开(公告)号：US07745180B2
公开(公告)日：2010-06-29
申请号：US10796298
申请日：2004-03-09
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12N15/1006 , C12N1/066 , C12Q1/6806 , C12Q1/6846 , C12Q2565/537 , C12Q2521/107 , C12Q2527/137 , C12Q2527/125
摘要： Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.
摘要翻译：公开了一种用于从全血中简单，可重复和高通量定量mRNA的方法，装置试剂盒和自动化系统。更具体地，方法，装置，试剂盒和自动化系统涉及附着于寡聚（dT）活化的多孔板的白细胞过滤器的组合。

18. 发明申请

US20090298071A1 METHOD FOR TESTING DRUG SENSITIVITY IN SOLID TUMORS BY QUANTIFYING MRNA EXPRESSION IN THINLY-SLICED TUMOR TISSUE 审中-公开
标题翻译：通过在薄片肿瘤组织中定量检测MRNA表达来测定固体肿瘤中药物灵敏度的方法
公开(公告)号：US20090298071A1
公开(公告)日：2009-12-03
申请号：US12300183
申请日：2007-05-08
申请人： Masato Mitsuhashi , Kazuhiko Obara
发明人： Masato Mitsuhashi , Kazuhiko Obara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A method is disclosed for assaying the sensitivity of neoplastic tissue to therapeutic agents, and in particular, for the quantification of pro-apoptotic marker mRNA expression in cells obtained from thinly-sliced living tumor tissue in such methods. The method may comprise ascertaining a particular apoptosis marker mRNA for an individual tumor or tumor type as well as exposure of thin-sliced live cancer tissues from the individual tumor to candidate chemotherapeutic drug regimes in vitro, followed by an assessment of the level of the marker mRNA in the tissue.
摘要翻译：公开了一种用于测定肿瘤组织对治疗剂的敏感性的方法，特别是用于定量在这样的方法中从薄切片的活体肿瘤组织获得的细胞中促凋亡标记物mRNA表达。该方法可以包括确定个体肿瘤或肿瘤类型的特定细胞凋亡标志物mRNA，以及将来自个体肿瘤的薄切活活组织从体外暴露于候选化疗药物方案，随后评估标志物的水平组织中的mRNA。

19. 发明申请

US20090253133A1 ENHANCED T CELL RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH CROHN'S DISEASE 有权
标题翻译：增强T细胞受体介导的肿瘤坏死因子超家族和CHEMOKINE在外周血白细胞介素的表达与患有慢性疾病的患者
公开(公告)号：US20090253133A1
公开(公告)日：2009-10-08
申请号：US12296425
申请日：2007-04-05
申请人： Masato Mitsuhashi , Stephan R. Targan
发明人： Masato Mitsuhashi , Stephan R. Targan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
摘要翻译：公开了一种用于通过测量响应于刺激的某些mRNA的水平来确定克罗恩病患者是否可能对靶向TNFSF成员或细胞因子的治疗作出反应的方法。还公开了评估人类克罗恩病治疗有效性的方法。此外，公开了一种筛选用于治疗克罗恩病的化合物的方法。还公开了一种在克罗恩病患者中随时间监测疾病状态的方法。

20. 发明申请

US20090111128A1 METHOD FOR PREDICTING IMMUNE RESPONSE TO NEOPLASTIC DISEASE BASED ON mRNA EXPRESSION PROFILE IN NEOPLASTIC CELLS AND STIMULATED LEUKOCYTES 有权
标题翻译：基于神经细胞和刺激白血病细胞中mRNA表达谱的免疫应答预防神经病变的方法
公开(公告)号：US20090111128A1
公开(公告)日：2009-04-30
申请号：US11917151
申请日：2006-06-08
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： G01N33/53
CPC分类号： G01N33/505 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/574
摘要： Tumor necrosis factor (TNF) is capable of inducing apoptosis by interacting with specific TNF receptors on the surface of cancer cells. Because multiple members of TNF ligand and receptor are present within each superfamily, over 300 different ligand-receptor combinations exist. Activated blood leukocytes produce TNF as part of the immune response to cancer, as well as producing chemokines to attract other leukocytes to the site. A method is disclosed of detecting significant induction of a variety of TNF superfamily subtype and chemokine mRNAs in blood leukocytes when whole blood is exposed to heat-aggregated IgG or anti-T cell receptor antibodies as a model of immune system interactions. Substantial individual-to-individual variation is observed in TNF subtypes and chemokines induced. Since peripheral blood leukocytes are the supply of anti-cancer immune cells, the quantitation of ex vivo inducibility of appropriate TNF ligands and chemokines in blood will be useful in individualized cancer immunotherapy. If the tumor mass is small, such as with early invisible metastatic lesions, appropriate TNF assaults may be sufficient to prevent relapse.
摘要翻译：肿瘤坏死因子（TNF）能够通过与癌细胞表面的特异性TNF受体相互作用诱导细胞凋亡。由于TNF配体和受体的多个成员存在于每个超家族中，所以存在超过300种不同的配体 - 受体组合。活化的血液白细胞产生TNF作为对癌症的免疫应答的一部分，以及产生趋化因子以吸引其他白细胞到该部位。公开了当全血暴露于作为免疫系统相互作用的模型的热聚集的IgG或抗T细胞受体抗体时，检测血白细胞中各种TNF超家族亚型和趋化因子mRNA的显着诱导的方法。在TNF亚型和趋化因子诱导中观察到显着的个体与个体差异。由于外周血白细胞是抗癌免疫细胞的供应，所以在个体化的癌症免疫治疗中定量适当的TNF配体和趋化因子在血液中的离体诱导性将是有用的。如果肿瘤质量小，如早期隐形转移性病变，适当的TNF攻击可能足以防止复发。

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