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11. 发明申请

US20120132103A1 FLUORINE-CONTAINING COMPOUND, FLUORINE-CONTAINING SURFACTANT AND COMPOSITIONS CONTAINING SAME 有权
标题翻译：含氟化合物，含荧光体的表面活性剂及其组合物
公开(公告)号：US20120132103A1
公开(公告)日：2012-05-31
申请号：US13388195
申请日：2010-07-26
申请人： Katsuyuki Tsugita , Masato Mitsuhashi
发明人： Katsuyuki Tsugita , Masato Mitsuhashi
IPC分类号： C09G1/04 , C07C309/14
CPC分类号： C07C309/14 , C07C305/04 , C09G1/14
摘要： A fluorine-containing compound exhibiting excellent surface tension-reducing ability despite the absence of perfluoroalkyl group having a chain length of 8 or more which had been the cause of the PFOS and PFOA problems and use of a fluorine material with low environmental load is provided. Also provided are a fluorine-containing surfactant and a composition thereof, an aqueous resin emulsion and a floor polish composition containing such surfactant. The fluorine-containing compound is represented by the following formula (1): Rf1—CpH2p—CH(OH)—CqH2q—NR—CrH2r—(O)n—SO3M (1) wherein Rf1 is a C1-6 perfluoroalkyl group, p, q, and r are independently an integer of 1 to 6, M is a cationic atom or atomic group, n is 0 or 1, R is hydrogen atom, a C1-12 alkyl group, or a group represented by the following formula (2): Rf2—CsH2s—CH(OH)—CtH2t— (2) wherein Rf2 is a C1-6 perfluoroalkyl group, and s and t are independently an integer of 1 to 6.
摘要翻译：提供了尽管不具有全氟烷基的链长为8或更大的全氟烷基，其具有优异的表面张力降低能力的含氟化合物，这是PFOS和PFOA问题的原因，以及使用环境负荷低的氟材料。还提供了含氟表面活性剂及其组合物，水性树脂乳液和含有这种表面活性剂的地板油漆组合物。含氟化合物由下式（1）表示：Rf1-CpH2p-CH（OH）-CqH2q-NR-CrH2r-（O）n-SO3M（1）其中Rf1为C1-6全氟烷基，p ，q和r分别为1〜6的整数，M为阳离子性原子或原子团，n为0或1，R为氢原子，碳原子数为1〜12的烷基或下述式 2）：Rf2-CsH2s-CH（OH）-CtH2t-（2）其中Rf2为C1-6全氟烷基，s和t独立地为1〜6的整数。

12. 发明授权

US07838239B2 Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease 有权
标题翻译：关于克罗恩病患者外周血白细胞增强的T细胞受体介导的肿瘤坏死因子超家族mRNA表达的方法
公开(公告)号：US07838239B2
公开(公告)日：2010-11-23
申请号：US12296425
申请日：2007-04-05
申请人： Masato Mitsuhashi , Stephan R. Targan
发明人： Masato Mitsuhashi , Stephan R. Targan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
摘要翻译：公开了一种用于通过测量响应于刺激的某些mRNA的水平来确定克罗恩病患者是否可能对靶向TNFSF成员或细胞因子的治疗作出反应的方法。还公开了评估人类克罗恩病治疗有效性的方法。此外，公开了一种筛选用于治疗克罗恩病的化合物的方法。还公开了一种在克罗恩病患者中随时间监测疾病状态的方法。

13. 发明申请

US20080206761A1 Ex Vivo Gene Expression in Whole Blood as a Model of Assessment of Individual Variation to Dietary Supplements 审中-公开
标题翻译：全血中的体内基因表达作为膳食补充剂个体差异评估的模型
公开(公告)号：US20080206761A1
公开(公告)日：2008-08-28
申请号：US11913058
申请日：2006-04-28
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： C12Q1/68
CPC分类号： A61K36/07 , A61K31/07 , A61K31/34 , A61K31/355 , A61K31/593 , A61K36/746 , A61K36/8962 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5308
摘要： A method is disclosed for individually tailoring the administration of dietary components such as supplements. In the method, whole blood of a mammal is exposed to a dietary component. The level of a marker mRNA linked to a disease state is measured in leukocytes after exposure to the dietary component, and in some cases after further stimulation of the exposed blood cells. By comparing the mRNA level after exposure with the value found in unexposed blood cells, it is possible to determine what the effect of the dietary component will be in the mammal. By screening blood of the mammal against a number of possible dietary components, it is possible to develop an optimized set of dietary components tailored to the specific mammal to treat or prevent a disease state.
摘要翻译：公开了一种单独定制膳食成分如补充剂的施用的方法。在该方法中，哺乳动物的全血暴露于饮食组分。在暴露于饮食组分之后，在白细胞中测量与疾病状态相关的标记物mRNA的水平，并且在一些情况下在进一步刺激暴露的血细胞后测量。通过将暴露后的mRNA水平与未暴露的血细胞中发现的值进行比较，可以确定饮食成分在哺乳动物中的作用。通过筛选哺乳动物对许多可能的饮食组分的血液，可以开发针对特定哺乳动物定制的优化的膳食组分，以治疗或预防疾病状态。

14. 发明申请

US20060199212A1 Device and method for high-throughput quantification of MRNA from whole blood 有权
标题翻译：从全血中高通量定量MRNA的装置和方法
公开(公告)号：US20060199212A1
公开(公告)日：2006-09-07
申请号：US11376018
申请日：2006-03-15
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： C12Q1/68 , C12N1/08
CPC分类号： C12N15/1006 , C12N1/066 , C12Q1/6806 , C12Q1/6846 , C12Q2565/537 , C12Q2521/107 , C12Q2527/137 , C12Q2527/125
摘要： Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.
摘要翻译：公开了一种用于从全血中简单，可重复和高通量定量mRNA的方法，装置试剂盒和自动化系统。更具体地，方法，装置，试剂盒和自动化系统涉及附着于寡聚（dT）活化的多孔板的白细胞过滤器的组合。

15. 发明授权

US06300058B1 Method for measuring messenger RNA 失效
标题翻译：测量信使RNA的方法
公开(公告)号：US06300058B1
公开(公告)日：2001-10-09
申请号：US07974409
申请日：1992-11-12
申请人： Tatsuo Akitaya , Masato Mitsuhashi , Allan Cooper
发明人： Tatsuo Akitaya , Masato Mitsuhashi , Allan Cooper
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C12N15/1006 , C12N15/1096 , C12P19/34 , C12Q1/68 , C12Q1/6813 , C12Q1/6834 , C12Q1/6876 , C12Q1/6886 , C12Q2600/158 , C12Q2537/125 , C12Q2527/107 , C12Q2525/173
摘要： The present invention provides a method for detecting and quantifying mRNA in a sample. The mRNA that can be detected has a unique sequence. The method includes immobilizing a first polynucleotide to an insoluble support. The first polynucleotide has a first sequence that hybridizes to the unique sequence on the mRNA. After immobilization of the first polynucleotide, the sample is applied to the insoluble support under conditions that allow the unique sequence on the mRNA to hybridize with the first polynucleotide. Thereafter, a second polynucleotide is applied to the insoluble support. This second polynucleotide has a second sequence thereon that hybridizes to a portion of the mRNA other than the unique sequence. The application of the second polynucleotide is performed under conditions that allow the second polynucleotide to hybridize with mRNA immobilized on said support, if present. Finally, the amount of the second polynucleotide immobilized on the support is measured to provide an indication of the amount of mRNA present in the sample. Polynucleotide immobilized supports and sequences useful in the method are also provided.
摘要翻译：本发明提供了检测和定量样品中的mRNA的方法。可检测的mRNA具有独特的序列。该方法包括将第一多核苷酸固定在不溶性支持物上。第一多核苷酸具有与mRNA上的唯一序列杂交的第一序列。在固定第一多核苷酸之后，在使得mRNA上的唯一序列与第一多核苷酸杂交的条件下将样品施用于不溶性载体。此后，将第二个多核苷酸应用于不溶性支持物。该第二多核苷酸具有与唯一序列以外的mRNA的一部分杂交的第二序列。第二多核苷酸的应用在允许第二多核苷酸与固定在所述载体上的mRNA（如果存在）杂交的条件下进行。最后，测量固定在载体上的第二个多核苷酸的量，以提供样品中存在的mRNA的量的指示。还提供了多核苷酸固定的载体和用于该方法的序列。

16. 发明授权

US5455925A Data processing device for maintaining coherency of data stored in main memory, external cache memory and internal cache memory 失效
标题翻译：用于维护存储在主存储器，外部高速缓冲存储器和内部高速缓冲存储器中的数据的一致性的数据处理设备
公开(公告)号：US5455925A
公开(公告)日：1995-10-03
申请号：US111731
申请日：1993-08-23
申请人： Takeshi Kitahara , Masato Mitsuhashi , Atsushi Fujihira
发明人： Takeshi Kitahara , Masato Mitsuhashi , Atsushi Fujihira
IPC分类号： G06F12/08 , G06F12/06 , G06F13/00
CPC分类号： G06F12/0811 , G06F12/0897
摘要： A fetching operation break unit breaks a fetching operation of a block data from a main memory, when a system bus is released during the fetching of the block data and also when data written due to a write access by an external device into the main memory coincides with the fetching of one block data. Further, a notification means notifies the state of the fetching operation to an external cache memory. Therefore, the external cache memory can confirm whether a block-in operation of the microprocessor is broken or not, and the contents of the external cache can correctly coincide with the contents of the internal cache and the main memory by carrying out a steal operation, so that the operational reliability of a computer system can be increased.
摘要翻译：获取操作中断单元在取出块数据期间当系统总线被释放以及由于外部设备对主存储器的写访问而写入的数据重合时，从主存储器中断块数据的取出操作获取一个块数据。此外，通知装置将获取操作的状态通知给外部高速缓冲存储器。因此，外部高速缓冲存储器可以确认微处理器的嵌入操作是否损坏，并且通过执行窃取操作，外部高速缓存的内容可以正确地与内部高速缓存和主存储器的内容一致，从而可以提高计算机系统的操作可靠性。

17. 发明授权

US08684492B2 Recording apparatus and recording method 有权
标题翻译：记录装置和记录方法
公开(公告)号：US08684492B2
公开(公告)日：2014-04-01
申请号：US13528678
申请日：2012-06-20
申请人： Masato Mitsuhashi , Koji Higuchi
发明人： Masato Mitsuhashi , Koji Higuchi
IPC分类号： B41J29/393
CPC分类号： B41J29/38 , B41J11/0085 , B41J11/42 , B41J15/04
摘要： A recording apparatus includes: a transport unit that unrolls and transports a recording medium being wound in a roll to the downstream side along a transport path of the recording medium; a recording unit that performs recording processing on the recording medium in a recording region positioned halfway on the transport path; and a control unit that controls the transport unit so that an amount of protrusion of the leading edge portion of the recording medium from the recording region to the downstream side is varied based on an amount of curling of the leading edge portion of the recording medium due to the curling tendency of the recording medium having been unrolled by the transport unit when the recording processing is performed on the recording medium by the recording unit.
摘要翻译：记录装置包括：传送单元，其沿着记录介质的传送路径将卷绕在卷筒上的记录介质展开和传送到下游侧; 记录单元，其对位于传送路径中途的记录区域中的记录介质进行记录处理; 以及控制单元，其控制传送单元，使得记录介质的前边缘部分从记录区域到下游侧的突出量基于记录介质的前缘部分的卷曲量而变化，涉及当由记录单元在记录介质上执行记录处理时由传送单元展开的记录介质的卷曲趋势。

18. 发明授权

US08562128B2 Recording apparatus, recording method 有权
标题翻译：记录装置，记录方法
公开(公告)号：US08562128B2
公开(公告)日：2013-10-22
申请号：US13020472
申请日：2011-02-03
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： B41J2/01
CPC分类号： B41J11/002 , B41J11/66 , B41J13/0009
摘要： A recording apparatus includes: an upstream conveying unit that intermittently conveys a recording medium from an upstream side to a downstream side in a conveying direction; a downstream conveying unit that continuously conveys the recording medium; a recording unit that deposits a liquid and performs a recording process on the recording medium while the recording medium is being intermittently conveyed by the upstream conveying unit and has stopped; a fixing unit that performs a fixing process for fixing the liquid on the recording medium being continuously conveyed by the downstream conveying unit after the liquid has been deposited by the recording unit; and a control unit that controls the downstream conveying unit so that the downstream conveying unit conveys the recording medium at a conveying velocity that is higher than an average conveying velocity when the recording medium is conveyed by the upstream conveying unit.
摘要翻译：记录装置包括：上游输送单元，其在输送方向上从上游侧向下游侧间歇地输送记录介质; 连续地传送记录介质的下游传送单元; 记录单元，其在记录介质被所述上游输送单元间歇地输送并且停止时，将液体沉积并对所述记录介质执行记录处理; 定影单元，在由所述记录单元沉积所述液体之后，执行用于将所述液体固定在所述记录介质上的定影处理，所述定影处理由所述下游输送单元连续输送; 以及控制单元，其控制下游输送单元，使得下游输送单元以高于由上游输送单元输送记录介质时的平均输送速度的输送速度输送记录介质。

19. 发明申请

US20120258076A1 METHOD FOR CHARACTERIZING HOST IMMUNE FUNTION BY EX VIVO INDUCTION OF OFFENSIVE AND DEFENSIVE IMMUNE MARKERS 审中-公开
标题翻译：通过EXVIVO诱导有害和免疫免疫标记表征宿主免疫功能的方法
公开(公告)号：US20120258076A1
公开(公告)日：2012-10-11
申请号：US13516552
申请日：2010-12-08
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： C12Q1/68 , A61K38/20 , A61K31/716
CPC分类号： G01N33/57496 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： A host's immune function can be characterized by quantifying changes in offensive and defensive immune function associated markers. Certain methods can be used to identify a potentially efficacious therapy for a subject based on the induction of expression of offensive and defensive immune function-associated markers. Additionally, some methods can be used to identify drugs that allow the stimulation of either the offensive or defensive immune response while inhibiting the other of offensive or defensive immune response.
摘要翻译：宿主的免疫功能可以通过量化进攻性和防御性免疫功能相关标志物的变化来表征。可以使用某些方法基于进攻性和防御性免疫功能相关标志物的表达的诱导来鉴定受试者的潜在有效治疗。此外，一些方法可用于鉴定允许刺激进攻性或防御性免疫应答同时抑制另一种进攻性或防御性免疫应答的药物。

20. 发明申请

US20120024124A1 TARGET TRANSPORTATION DEVICE AND RECORDING APPARATUS 有权
标题翻译：目标运输装置和记录装置
公开(公告)号：US20120024124A1
公开(公告)日：2012-02-02
申请号：US13178433
申请日：2011-07-07
申请人： Masato Mitsuhashi
发明人： Masato Mitsuhashi
IPC分类号： B26D7/06
CPC分类号： B41J13/025 , B41J11/70 , B41J15/04 , Y10T83/647 , Y10T83/664
摘要： A target transportation device includes a first transportation portion which is capable of applying a transportation force toward a downstream side from an upstream side of a transportation path to a target, a second transportation portion which is provided on the transportation path at a position at the downstream side with respect to the first transportation portion in a transportation direction and is capable of applying a transportation force toward the downstream side from the upstream side of the transportation path to the target while nipping the target, and a cutting member which is provided on the transportation path at a position between the first transportation portion and the second transportation portion and is capable of cutting the target in the width direction perpendicular to the transportation direction of the target. The second transportation portion is configured so as to be capable of changing a nipping position of the target in the transportation direction of the target.
摘要翻译：目标运送装置包括：第一输送部，其能够向从输送路径的上游侧向目标的下游侧施加输送力;第二输送部，其设置在输送路径上的位于下游的位置在输送方向上相对于第一输送部分的一侧，并且能够在夹持目标的同时向输送路径的上游侧向下游侧施加输送力;以及切割构件，其设置在输送在第一输送部和第二输送部之间的位置处的路径，并且能够在垂直于目标的输送方向的宽度方向上切割目标。第二输送部被配置为能够改变目标在目标的输送方向上的夹持位置。

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