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11. 发明授权

US09320714B2 Tablet 有权
标题翻译：片剂
公开(公告)号：US09320714B2
公开(公告)日：2016-04-26
申请号：US13082890
申请日：2011-04-08
申请人： Masahiko Koike , Hiroyoshi Koyama
发明人： Masahiko Koike , Hiroyoshi Koyama
IPC分类号： A61K9/28 , A61K9/20
CPC分类号： A61K9/2072
摘要： The present invention can retain the volume of a tablet large without increasing the thickness of the tablet or the like dimension and prevents a plurality of tablets from sticking to each other even if they are subjected to a film-coating or the like treatment, so as to improve the yield. The tablet is a tablet (1) longer in one direction when seen in plan. The tablet (1) has side edges (6) each of which extends in a longitudinal direction and is formed in the shape of a curve projecting outwardly in plan view. The curve has a radius of curvature (R1) set to at least 1.5 times a length (L) of the tablet. This makes a projected area of the tablet (1) in plan view at least 97% with respect to a projected area of a standard elliptical tablet having opposite end portions each of which is formed by a semi-circle having a diameter of a width (W) of the tablet.
摘要翻译：本发明可以在不增加片剂厚度等的情况下保持片剂的体积，并且即使进行薄膜包衣或类似的处理也能防止多个片剂彼此粘附，因此提高产量。平板电脑是平板电脑（1）在计划中看到的时间长一个方向。片剂（1）具有侧边缘（6），每个边缘沿纵向方向延伸并且形成为在平面图中向外突出的曲线形状。曲线的曲率半径（R1）设定为片剂长度（L）的至少1.5倍。这使得平面图（1）中的平板（1）的投影面积相对于具有相对端部的标准椭圆形片的投影面积至少为97％，每个端部均由直径为宽度的半圆形成 W）。

12. 发明申请

US20110189282A1 TABLET 有权
标题翻译：片剂
公开(公告)号：US20110189282A1
公开(公告)日：2011-08-04
申请号：US13082890
申请日：2011-04-08
申请人： Masahiko Koike , Hiroyoshi Koyama
发明人： Masahiko Koike , Hiroyoshi Koyama
IPC分类号： A61K9/28
CPC分类号： A61K9/2072
摘要： The present invention can retain the volume of a tablet large without increasing the thickness of the tablet or the like dimension and prevents a plurality of tablets from sticking to each other even if they are subjected to a film-coating or the like treatment, so as to improve the yield. The tablet is a tablet (1) longer in one direction when seen in plan. The tablet (1) has side edges (6) each of which extends in a longitudinal direction and is formed in the shape of a curve projecting outwardly in plan view. The curve has a radius of curvature (R1) set to at least 1.5 times a length (L) of the tablet. This makes a projected area of the tablet (1) in plan view at least 97% with respect to a projected area of a standard elliptical tablet having opposite end portions each of which is formed by a semi-circle having a diameter of a width (W) of the tablet.
摘要翻译：本发明可以在不增加片剂厚度等的情况下保持片剂的体积，并且即使进行薄膜包衣或类似的处理，也可以防止多个片剂彼此粘附，从而提高产量。平板电脑是平板电脑（1）在计划中看到的时间长一个方向。片剂（1）具有侧边缘（6），每个边缘沿纵向方向延伸并且形成为在平面图中向外突出的曲线形状。曲线的曲率半径（R1）设定为片剂长度（L）的至少1.5倍。这使得平面图（1）中的平板（1）的投影面积相对于具有相对端部的标准椭圆形片的投影面积至少为97％，每个端部均由直径为宽度的半圆形成 W）。

13. 发明授权

US08865217B2 Oral preparation comprising pioglitazone 有权
标题翻译：包含吡格列酮的口服制剂
公开(公告)号：US08865217B2
公开(公告)日：2014-10-21
申请号：US12227572
申请日：2007-05-22
申请人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
发明人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
IPC分类号： A61K9/14 , A61K31/4439 , A61K9/20 , A61K9/00
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/2009 , A61K9/2077 , A61K31/4439
摘要： The present invention provides an oral preparation sufficiently masking the bitter taste of pioglitazone and a salt thereof. The present invention provides an oral preparation containing pioglitazone or a salt thereof and alkali metal chloride.
摘要翻译：本发明提供足以掩蔽吡格列酮及其盐的苦味的口服制剂。本发明提供含有吡格列酮或其盐和碱金属氯化物的口服制剂。

14. 发明申请

US20050238712A1 Quickly disintegrating solid preparations 审中-公开
标题翻译：快速分解固体制剂
公开(公告)号：US20050238712A1
公开(公告)日：2005-10-27
申请号：US11167139
申请日：2005-06-28
申请人： Kazuhiro Ohkouchi , Hiroyoshi Koyama
发明人： Kazuhiro Ohkouchi , Hiroyoshi Koyama
IPC分类号： A61K9/00 , A61K9/20 , A61K9/26 , A61K31/41 , A61K31/426
CPC分类号： A61K31/41 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K31/426
摘要： Quickly disintegrating solid preparations which contain: a) an active ingredient; b) D-mannitol having an average particle size of 30 μm to 300 μm; c) a disintegrating agent; and d) celluloses.
摘要翻译：快速分解固体制剂，其含有：a）活性成分; b）平均粒径为30μm〜300μm的D-甘露糖醇; c）崩解剂; 和d）纤维素。

15. 发明申请

US20110014299A2 SOLID PREPARATION COMPRISING ALOGLIPTIN AND METFORMIN HYDROCHLORIDE 有权
标题翻译：包含阿洛克丁和羟基氯化氢的固体制剂
公开(公告)号：US20110014299A2
公开(公告)日：2011-01-20
申请号：US12452705
申请日：2008-07-16
申请人： Kazumichi Yamamoto , Hiroyoshi Koyama
发明人： Kazumichi Yamamoto , Hiroyoshi Koyama
IPC分类号： A61K9/48 , C07D239/545 , A61P3/04 , A61P3/10 , A61K31/513
CPC分类号： A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2086 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K31/155 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof, and metformin hydrochloride, which is useful as a therapeutic drug for diabetes and the like, and superior in the preservation stability. A solid preparation having a first part and a second part: a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydrochloride and substantially free of compound (I) and a salt thereof.
摘要翻译：本发明提供含有化合物（I）[化合物（I）如说明书中所定义的]或其盐的固体制剂和盐酸二甲双胍，其可用作糖尿病等的治疗药物，保存稳定。具有第一部分和第二部分的固体制剂：第一部分：含有化合物（I）或其盐并且基本上不含二甲双胍盐酸盐的部分第二部分：含有盐酸二甲双胍并基本上不含化合物（I）的部分，及其盐。

16. 发明授权

US08900638B2 Solid preparation comprising alogliptin and metformin hydrochloride 有权
标题翻译：固体制剂，包含阿格列汀和盐酸二甲双胍
公开(公告)号：US08900638B2
公开(公告)日：2014-12-02
申请号：US12452705
申请日：2008-07-16
申请人： Kazumichi Yamamoto , Hiroyoshi Koyama
发明人： Kazumichi Yamamoto , Hiroyoshi Koyama
IPC分类号： A61K9/50 , C07D239/02 , A61K31/505 , A61K9/24 , A61K45/06 , A61K9/20 , A61K9/28 , A61K31/155 , A61K31/513
CPC分类号： A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2086 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K31/155 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof, and metformin hydrochloride, which is useful as a therapeutic drug for diabetes and the like, and superior in the preservation stability. A solid preparation having a first part and a second part: a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydrochloride and substantially free of compound (I) and a salt thereof.
摘要翻译：本发明提供含有化合物（I）[化合物（I）如说明书中所定义的]或其盐的固体制剂和盐酸二甲双胍，其可用作糖尿病等的治疗药物，并且在保存稳定。具有第一部分和第二部分的固体制剂：第一部分：含有化合物（I）或其盐并且基本上不含二甲双胍盐酸盐的部分第二部分：含有盐酸二甲双胍并且基本上不含化合物（I）的部分，及其盐。

17. 发明授权

US06740339B1 Quickly disintegrating solid preparations 失效
公开(公告)号：US06740339B1
公开(公告)日：2004-05-25
申请号：US10009835
申请日：2001-12-17
申请人： Kazuhiro Ohkouchi , Hiroyoshi Koyama
发明人： Kazuhiro Ohkouchi , Hiroyoshi Koyama
IPC分类号： A61K920
CPC分类号： A61K31/41 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K31/426
摘要： Quickly disintegrating solid preparations which contain: a) an active ingredient; b) D-mannitol having an average particle size of 30 &mgr;m to 300 &mgr;m; c) a disintegrating agent; and d) celluloses.

18. 发明授权

US5464612A Solid preparation comprising ion exchanger and active agent 失效
标题翻译：包含离子交换剂和活性剂的固体制剂
公开(公告)号：US5464612A
公开(公告)日：1995-11-07
申请号：US233964
申请日：1994-04-28
申请人： Hiroshi Matoba , Shinji Ohmori , Hiroyoshi Koyama , Toshio Kashihara
发明人： Hiroshi Matoba , Shinji Ohmori , Hiroyoshi Koyama , Toshio Kashihara
IPC分类号： A61K9/20 , A61K47/48 , A61K31/74
CPC分类号： A61K9/2081 , A61K47/48184 , A61K9/2027 , Y10S514/974
摘要： (A) A clad powdery or granular preparation of a medicinally active ingredient and (B) a powdery or granular ion exchanger such as a cation exchange resin are blended to prepare a solid preparation. The active ingredient includes .beta.-lactam antibiotics having a basic group. The clad powdery or granular preparation includes not only coated preparation wherein the active ingredient or preparation is coated but also a variety of preparations in which the contact of the active ingredient with the ion exchanger is suppressed or inhibited. Polymers such as a water-soluble polymer, an enteric polymer and so on can be used as the coating agent for the coated preparation. The using amount of the ion exchanger is about 10 to 5,000 parts by weight per 100 parts by weight of the active ingredient. Said solid preparation can remarkably decrease the unpleasant taste and odor of the active ingredient such as bitterness, being excellent in dissolution property and absorbability of the active ingredient.
摘要翻译：（A）将药物活性成分的包覆粉状或粒状制剂和（B）粉末状或粒状离子交换剂如阳离子交换树脂混合，制备固体制剂。活性成分包括具有基本组的β-内酰胺抗生素。包覆粉末或颗粒制剂不仅包括其中涂覆活性成分或制剂的包衣制剂，而且包括活性成分与离子交换剂的接触被抑制或抑制的各种制剂。可以使用聚合物如水溶性聚合物，肠溶聚合物等作为涂布制剂的包衣剂。离子交换剂的使用量为每100重量份活性成分约10至5,000重量份。所述固体制剂可以显着降低活性成分的不良味道和气味，例如苦味，有效成分的溶解性和吸收性优异。

19. 发明授权

US5456920A Uncoated tablets and method of producing the same 失效
标题翻译：无涂层片剂及其制造方法
公开(公告)号：US5456920A
公开(公告)日：1995-10-10
申请号：US187908
申请日：1994-01-28
申请人： Hiroshi Matoba , Hiroyoshi Koyama , Jun-ichi Kikuta
发明人： Hiroshi Matoba , Hiroyoshi Koyama , Jun-ichi Kikuta
IPC分类号： A61K9/20
CPC分类号： A61K9/2031 , A61K9/2013 , F04C2210/26
摘要： A compression-moldable composition comprising an active ingredient, an excipient and an oily or fatty substance having a lower melting point of about 20.degree. to 90.degree. C. is compression-molded into uncoated tablets without coating to improve the abrasion resistance. The oily or fatty substance includes a higher fatty acid or a salt thereof, a wax, a fatty acid ester, a hardened oil, a polyalkylene oxide, etc., and the amount thereof is about 0.01 to 10% by weight. The composition may comprise (1) a granulated powder containing the active ingredient and the excipient, and the powdery or granular oily or fatty substance having a lower melting point, or (2) a granulated powder containing the active ingredient, the excipient and said oily or fatty substance. Compression-molding of the composition improves the abrasion resistance of the tablet and significantly inhibits the development of powder by wearing or abrasion even when the oily or fatty substance is used in a small amount of about 0.1 to 0.5% by weight.
摘要翻译：包含活性成分，赋形剂和具有约20-90℃的较低熔点的油性或脂肪物质的可压缩模制的组合物被压制成未涂覆的片剂，以改善耐磨性。油性或脂肪物质包括高级脂肪酸或其盐，蜡，脂肪酸酯，硬化油，聚环氧烷等，其用量为约0.01〜10重量％。组合物可以包含（1）含有活性成分和赋形剂的造粒粉末和具有较低熔点的粉末或颗粒状油状物或脂肪物质，或（2）含有活性成分，赋形剂和油性的造粒粉末或脂肪物质。组合物的压制成型提高了片剂的耐磨性，并且即使当以少量约0.1至0.5重量％的油性或脂肪物质使用时，磨损或磨损也显着抑制了粉末的发展。

20. 发明授权

US5194464A Enteric film and preparatoin thereof 失效
标题翻译：肠溶片及其制备
公开(公告)号：US5194464A
公开(公告)日：1993-03-16
申请号：US497655
申请日：1990-03-23
申请人： Shunichi Itoh , Hiroyoshi Koyama , Toshio Kashihara , Shin-ichiro Hirai
发明人： Shunichi Itoh , Hiroyoshi Koyama , Toshio Kashihara , Shin-ichiro Hirai
IPC分类号： A61K9/50
CPC分类号： A61K9/5078 , A61K9/5015 , A61K9/5031 , A61K9/5042
摘要： An enteric film is produced by spraying on a material a mixed solution of (a) hydroxypropylmethylcellulose phthalate exhibiting a viscosity of about 136 to 204 centistokes as 10% methanol/dichloromethane (1:1 by weight) solution at 20.degree. C., (b) polyethylene glycol presenting solid state at ambient temperature and (c) shellac, wherein respective ratios of (b) and (c) to (a) are 0.1 to 20 weight percent and 5 to 40 weight percent; and then drying the solution.The enteric film excels in film strength and acid resistance, and can be employed in pharmaceutical preparations.
摘要翻译：通过在20℃下将（a）羟丙基甲基纤维素邻苯二甲酸酯的粘度为约136〜204厘沲作为10％甲醇/二氯甲烷（1：1重量比）溶液的混合溶液喷洒在材料上来制备肠溶薄膜，（b ）聚环氧乙烷呈现固态，（c）虫胶，其中（b）和（c）至（a）的各自的比例为0.1至20重量％和5至40重量％; 然后干燥溶液。肠膜在膜强度和耐酸性方面优异，可用于药物制剂。

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