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11. 发明授权

US08974809B2 Medical devices having a filter insert for controlled diffusion 有权
标题翻译：具有用于受控扩散的过滤嘴的医疗装置
公开(公告)号：US08974809B2
公开(公告)日：2015-03-10
申请号：US11860188
申请日：2007-09-24
申请人： John Clarke , Tim O'Connor , Yixin Xu , Barry J. O'Brien
发明人： John Clarke , Tim O'Connor , Yixin Xu , Barry J. O'Brien
IPC分类号： A61F2/00 , A61F2/82 , A61F2/91 , A61F2/01 , A61F2/04
CPC分类号： A61F2/82 , A61F2/00 , A61F2/01 , A61F2/04 , A61F2/91 , A61F2220/0058 , A61F2250/0068
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo.
摘要翻译：提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的治疗剂材料的凹陷，和（b）预形成过滤器插入件设置在凹陷中，使得其在体内植入或插入装置时调节化学物质在装置的凹陷和外部之间的运输。

12. 发明申请

US20070224239A1 Method of making a coated medical device 审中-公开
标题翻译：制造涂敷医疗器械的方法
公开(公告)号：US20070224239A1
公开(公告)日：2007-09-27
申请号：US11390801
申请日：2006-03-27
申请人： Niall Behan , Anthony Malone , John Clarke
发明人： Niall Behan , Anthony Malone , John Clarke
IPC分类号： B05D3/00
CPC分类号： B05D5/00 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2420/02 , B05D3/007
摘要： The present invention relates to a method of making a coated medical device with a porous coating. The method includes coating at least a portion of the surface of a medical device with a coating composition comprising a polymer, solvent, and a gas, and then removing an amount of gas from the coating composition sufficient to form a porous coating. A biologically active material can be included in the coating composition.
摘要翻译：本发明涉及一种制备具有多孔涂层的涂覆医疗装置的方法。该方法包括用包含聚合物，溶剂和气体的涂料组合物涂覆医疗装置的表面的至少一部分，然后从足以形成多孔涂层的涂料组合物中除去一定量的气体。生物活性物质可以包含在涂料组合物中。

13. 发明申请

US20110020404A1 DIAGNOSTIC METHOD AND KIT 审中-公开
标题翻译：诊断方法和包装
公开(公告)号：US20110020404A1
公开(公告)日：2011-01-27
申请号：US12673798
申请日：2008-08-18
申请人： Shane A. Olwill , James A. Johnston , Hang Fai Kwok , Clare Whelan , John Clarke
发明人： Shane A. Olwill , James A. Johnston , Hang Fai Kwok , Clare Whelan , John Clarke
IPC分类号： A61K39/04 , C12Q1/04 , C12Q1/02 , G01N33/53 , C12Q1/68 , A61P31/06
CPC分类号： G01N33/5695 , A61K39/04
摘要： The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising (i) the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, and ESAT 6 antigen; or (ii) at least seven of the antigens of the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, ESAT 6 antigen, CFP10 antigen, α crystalline 2 antigen, PE35 antigen, and PPE68 antigen. Also provided is a method for the diagnosis of the presence of tuberculosis in a reservoir animal e.g. a badger, said method comprising determining the presence or absence of, or an immune response to Rv3616 antigen, MPB70 antigen, and MPB83 antigen. Kits for carrying out the methods are also provided.
摘要翻译：本发明涉及用于诊断动物结核病的方法，所述方法包括确定对抗原组的存在或不存在或免疫应答，所述抗原组包含（i）由Rv3616抗原，MPB70抗原，MPB83抗原和 ESAT 6抗原; 或（ii）由Rv3616抗原，MPB70抗原，MPB83抗原，ESAT6抗原，CFP10抗原，α结晶2抗原，PE35抗原和PPE68抗原组成的组中的至少7种抗原。还提供了用于诊断储存动物中结核病存在的方法，例如，所述方法包括确定Rv3616抗原，MPB70抗原和MPB83抗原的存在或不存在或免疫应答。还提供了实施方法的工具包。

14. 外观设计

USD575408S1 Apparatus for laboratories 有权
标题翻译：实验室仪器
公开(公告)号：USD575408S1
公开(公告)日：2008-08-19
申请号：US29222727
申请日：2005-02-02
申请人： John Clarke , Peter Le Feuvre , David Inder
设计人： John Clarke , Peter Le Feuvre , David Inder

15. 发明申请

US20080179325A1 Internally Threaded Cap 审中-公开
标题翻译：内螺纹帽
公开(公告)号：US20080179325A1
公开(公告)日：2008-07-31
申请号：US11668021
申请日：2007-01-29
申请人： John Clarke , David Butler
发明人： John Clarke , David Butler
IPC分类号： B65D51/16
CPC分类号： B60K15/0406 , B60K2015/0451
摘要： A closure assembly for a tank includes a cap shell and a cylindrical insert connected by a lost motion connection defining a first stop and a second stop for relative axial movement. A dome extends inwardly from the cylindrical insert and includes an orifice defining a valve seat. A stem includes a mating edge for engaging the valve seat. The mating edge abuts the valve seat and displaces the dome axially to seal the orifice at the first stop, and is spaced from the valve seat to at the second stop. Opening the valve allows vapor to vent from the tank along a tortuous path defined through an aperture and between the cap shell and the cylindrical insert. The aperture is open or sealed with the valve depending on the relative position of the cap shell and cylindrical insert.
摘要翻译：用于罐的封闭组件包括帽壳和通过限定第一止动件和第二止挡件的空动连接件连接的圆柱形插入件，用于相对轴向运动。圆顶从圆柱形插入件向内延伸并且包括限定阀座的孔口。杆包括用于接合阀座的配合边缘。配合边缘邻接阀座并且轴向移动圆顶以在第一止动件处密封孔口，并且与阀座间隔开至第二挡块。打开阀门允许蒸汽从沿着通过孔口限定的弯曲路径和盖壳体与圆柱形插入件之间排出。根据盖壳和圆柱形插入件的相对位置，孔与阀打开或密封。

16. 发明授权

US07107802B2 Wheel immobilizer 有权
标题翻译：车轮防盗器
公开(公告)号：US07107802B2
公开(公告)日：2006-09-19
申请号：US10839223
申请日：2004-05-06
申请人： John Clarke
发明人： John Clarke
IPC分类号： B60R25/00
CPC分类号： B60R25/093 , Y10T70/40 , Y10T70/5765 , Y10T70/5841
摘要： An immobilization apparatus for a vehicle having a wheel with a tire. The apparatus comprises first and second elongated members having inner ends and outer ends. The inner ends are connected together and the outer ends are angularly spaced apart. There is an L-shaped clasp at each of the outer ends for grasping the tire. The clasps are rotatable about the outer ends. A third elongated member has an inner portion and an outer portion and is angularly spaced-apart from the first and second members. The inner portion is tubular and the outer portion of the third elongated member is telescopically received therein. The outer portion has an L-shaped clasp, and the outer portion is rotatable with respect to the inner portion. A locking mechanism secures the outer portion at a fixed telescopic position with respect to the inner portion of the third elongated member.
摘要翻译：一种具有带有轮胎的车轮的车辆的固定装置。该装置包括具有内端和外端的第一和第二细长构件。内端连接在一起，并且外端部成角度间隔开。在每个外端都有一个L形扣环，用于抓紧轮胎。夹子可绕外端旋转。第三细长构件具有内部部分和外部部分，并且与第一和第二构件成角度地间隔开。内部是管状的，并且第三细长构件的外部可伸缩地容纳在其中。外部具有L形扣环，并且外部部分可相对于内部部分旋转。锁定机构将外部部分固定在相对于第三细长构件的内部的固定的伸缩位置。

17. 发明授权

US07053610B2 Squid detected NMR and MRI at ultralow fields 有权
标题翻译：鱿鱼在超低场检测到核磁共振和核磁共振
公开(公告)号：US07053610B2
公开(公告)日：2006-05-30
申请号：US10995765
申请日：2004-11-22
申请人： John Clarke , Robert McDermott , Alexander Pines , Andreas Heinz Trabesinger
发明人： John Clarke , Robert McDermott , Alexander Pines , Andreas Heinz Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/445
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

18. 发明授权

US5254950A DC superconducting quantum interference device usable in nuclear quadrupole resonance and zero field nuclear magnetic spectrometers 失效
标题翻译：可用于核四极共振和零场核磁光谱仪的直流超导量子干涉装置
公开(公告)号：US5254950A
公开(公告)日：1993-10-19
申请号：US759997
申请日：1991-09-13
申请人： Non Q. Fan , John Clarke
发明人： Non Q. Fan , John Clarke
IPC分类号： G01R33/035 , G01R33/36 , G01R33/44 , G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/441
摘要： A spectrometer for measuring the nuclear quadrupole resonance spectra or the zero-field nuclear magnetic resonance spectra generated by a sample is disclosed. The spectrometer uses an amplifier having a dc SQUID operating in a flux-locked loop for generating an amplified output as a function of the intensity of the signal generated by the sample. The flux-locked loop circuit includes an integrator. The amplifier also includes means for preventing the integrator from being driven into saturation. As a result, the time for the flux-locked loop to recover from the excitation pulses generated by the spectrometer is reduced.
摘要翻译：公开了用于测量由样品产生的核四极共振谱或零场核磁共振谱的光谱仪。光谱仪使用具有在磁通锁定环路中工作的直流SQUID的放大器，以产生作为由样本产生的信号的强度的函数的放大输出。磁通锁定环电路包括积分器。放大器还包括用于防止积分器被驱动到饱和的装置。结果，磁通锁定环从由光谱仪产生的激发脉冲恢复的时间减少。

19. 发明授权

US5136300A Modular solid state radar transmitter 失效
标题翻译：模块化固态雷达发射机
公开(公告)号：US5136300A
公开(公告)日：1992-08-04
申请号：US713259
申请日：1991-06-13
申请人： John Clarke , Joseph A. Faulkner, Jr. , Gregory K. Sinon , Brian J. Misek , John E. Kositz
发明人： John Clarke , Joseph A. Faulkner, Jr. , Gregory K. Sinon , Brian J. Misek , John E. Kositz
IPC分类号： G01S7/282 , G01S7/03 , G01S7/40 , G01S13/95 , G01W1/00 , H03F3/60
CPC分类号： H03F3/604 , G01S13/953 , G01S7/032 , G01S7/4008
摘要： A solid state radar transmitter for use in airborne applications has a modular design which extends into the transmitter. The transmitter is formed of a plurality of power modules the number of which is selected based on the power required for a particular application. For example, two 75 to 100 watt modules may be used for weather radar, while 30 to 60 or more modules may be used for fire control in a military fighter. A radio frequency signal from a stabilized local oscillator is distributed by a splitter to the power modules and a combiner is used to combine the output from the power modules to produce the transmitter output signal. Each power module is formed of parallel connected power amplifiers, preferably formed by GaAs FETs and a power conditioning and control unit. The power conditioning and control unit produces a DC bias across the FETs as desired to produce a particular signal. The transmitter output signals which can be produced in this manner include rectangular, Gaussian on a pedestal and one amplifier at a time for testing purposes.
摘要翻译：用于机载应用的固态雷达发射机具有延伸到发射机中的模块化设计。发射机由多个功率模块形成，其数量基于特定应用所需的功率来选择。例如，两个75至100瓦模块可用于天气雷达，而30至60个或更多的模块可用于军事战斗机中的消防。来自稳定的本地振荡器的射频信号由分离器分配到功率模块，并且组合器用于组合来自功率模块的输出以产生发射机输出信号。每个功率模块由并联连接的功率放大器形成，优选由GaAs FET和功率调节和控制单元形成。功率调节和控制单元根据需要产生跨FET的直流偏置，以产生特定的信号。可以以这种方式产生的发射机输出信号在基座上包括矩形高斯，一个放大器用于测试目的。

20. 发明授权

US4880858A Water absorbing polymers 失效
标题翻译：吸水聚合物
公开(公告)号：US4880858A
公开(公告)日：1989-11-14
申请号：US91551
申请日：1987-08-31
申请人： David Farrar , Peter Flesher , Malcolm Skinner , John Clarke , David Marshall , Malcolm Hawe
发明人： David Farrar , Peter Flesher , Malcolm Skinner , John Clarke , David Marshall , Malcolm Hawe
IPC分类号： C02F11/12 , C10L9/10 , C22B1/244
CPC分类号： C02F11/12 , C10L9/10 , C22B1/244
摘要： A wet filter cake of coal fines or other inorganic particulate material is converted to a crumbly mass by blending with water absorbent polymer particles.
摘要翻译：通过与吸水性聚合物颗粒混合，将煤粉或其它无机颗粒材料的湿滤饼转化成粉碎物质。

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