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11. 发明授权

US09766850B2 Multiple screen arrangement for mobile device 有权
公开(公告)号：US09766850B2
公开(公告)日：2017-09-19
申请号：US14616737
申请日：2015-02-08
申请人： David Eisenberg
发明人： David Eisenberg
IPC分类号： G06F3/14 , H04M1/725 , H04M1/02
CPC分类号： G06F3/1431 , H04M1/0208 , H04M1/0247 , H04M1/0266 , H04M1/72527 , H04M1/7253 , H04M2250/16
摘要： A multiple screen arrangement for a mobile device that includes a screen module and a communication module for communicatively linking the screen module with the mobile device. The screen module includes first and second screens movably coupled with each other between a first state and a second state, wherein at the first state, the second screen is overlapped behind the first screen in a single screen size manner, and at the second state, the first and second screens are moved side-by-side to provide two viewing windows. The communication module is adapted for receiving data from the mobile device to be displayed on at least one of the first and second screens, such that the first and second screens are adapted for selectively displaying the data from the mobile device between the first state and said second state.

12. 发明申请

US20150268916A1 Multiple Screen Arrangement for Mobile Device 审中-公开
标题翻译：移动设备多屏安排
公开(公告)号：US20150268916A1
公开(公告)日：2015-09-24
申请号：US14616737
申请日：2015-02-08
申请人： David Eisenberg
发明人： David Eisenberg
IPC分类号： G06F3/14 , H04M1/02
CPC分类号： G06F3/1431 , H04M1/0208 , H04M1/0247 , H04M1/0266 , H04M1/72527 , H04M1/7253 , H04M2250/16
摘要： A multiple screen arrangement for a mobile device that includes a screen module and a communication module for communicatively linking the screen module with the mobile device. The screen module includes first and second screens movably coupled with each other between a first state and a second state, wherein at the first state, the second screen is overlapped behind the first screen in a single screen size manner, and at the second state, the first and second screens are moved side-by-side to provide two viewing windows. The communication module is adapted for receiving data from the mobile device to be displayed on at least one of the first and second screens, such that the first and second screens are adapted for selectively displaying the data from the mobile device between the first state and said second state.
摘要翻译：一种用于移动设备的多屏幕布置，其包括屏幕模块和用于将屏幕模块与移动设备通信地链接的通信模块。屏幕模块包括在第一状态和第二状态之间彼此可移动地耦合的第一和第二屏幕，其中在第一状态下，第二屏幕以单一屏幕大小的方式重叠在第一屏幕后面，并且在第二状态下，第一和第二屏幕并排移动以提供两个观看窗口。所述通信模块适于从所述移动设备接收要显示在所述第一和第二屏幕中的至少一个屏幕上的数据，使得所述第一和第二屏幕适于在所述第一状态和所述第二屏幕之间选择性地显示来自所述移动设备的数据，所述数据来自所述移动设备第二个状态。

13. 发明授权

US07314916B2 Methods and materials for characterizing and modulating interaction between heregulin and HER3 有权
标题翻译：表征和调节蛋白与HER3之间相互作用的方法和材料
公开(公告)号：US07314916B2
公开(公告)日：2008-01-01
申请号：US11406679
申请日：2006-04-19
申请人： Elizabeth Singer , Ralf Landgraf , Dennis J. Slamon , David Eisenberg
发明人： Elizabeth Singer , Ralf Landgraf , Dennis J. Slamon , David Eisenberg
IPC分类号： C07K14/00 , C07K17/00
CPC分类号： C07K14/71 , G01N2333/705 , G01N2333/9121
摘要： The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein are methods and materials for identifying compounds that bind to the heregulin binding domain in HER3 as well as methods and materials for modulating the interaction between HER3 and heregulin.
摘要翻译：本文提供的公开内容鉴定并表征HER3受体中与拟胰岛素配体相互作用的结构域。本文公开的本发明的典型实施方案包括具有不同于天然HER3多肽序列并且具有改变的胰岛素亲和力的氨基酸序列的HER3变体多肽。本文还公开了用于鉴定结合HER3中的调节蛋白结合结构域的化合物的方法和材料，以及用于调节HER3与调节蛋白之间的相互作用的方法和材料。

14. 发明申请

US20050251375A1 Method for simulating the dynamics of biological networks in silico 审中-公开
标题翻译：用于模拟计算机生物网络动力学的方法
公开(公告)号：US20050251375A1
公开(公告)日：2005-11-10
申请号：US11123846
申请日：2005-05-06
申请人： Lukasz Salwinski , David Eisenberg
发明人： Lukasz Salwinski , David Eisenberg
IPC分类号： G06G7/48 , G06G7/58 , G06N3/00
CPC分类号： G06N3/002 , B82Y10/00
摘要： A stochastic simulation method for simulating the kinetics of chemical networks implemented using reprogrammable Field Programmable Gate Array (FPGA) devices. Such devices, built as an array of simple configurable logic blocks embedded in a programmable interconnection matrix, implement highly parallel architectures comparable in complexity to biochemical networks. Circuits based on FPGAs scale efficiently so that simulations of realistic biological systems are possible.
摘要翻译：一种用于模拟使用可重编程现场可编程门阵列（FPGA）器件实现的化学网络动力学的随机模拟方法。这些设备被构建为嵌入可编程互连矩阵中的简单可配置逻辑块阵列，实现了与生物化学网络相当的高度并行架构。基于FPGA的电路有效扩展，使现实生物系统的仿真成为可能。

15. 发明授权

US06466874B1 Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences 有权
标题翻译：用于从基因组序列检测蛋白质功能和蛋白质 - 蛋白质相互作用的Rosetta石方法
公开(公告)号：US06466874B1
公开(公告)日：2002-10-15
申请号：US09493497
申请日：2000-01-28
申请人： David Eisenberg , Edward M. Marcotte , Matteo Pellegrini , Michael J. Thompson , Todd O. Yeates
发明人： David Eisenberg , Edward M. Marcotte , Matteo Pellegrini , Michael J. Thompson , Todd O. Yeates
IPC分类号： G06F1900
CPC分类号： G06F19/14 , G06F19/18 , G06F19/22
摘要： A computational method system, and computer program are provided for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins A′ and B′ have homologs in another organism fused into a single protein chain AB. A trans-genome comparison of sequences can reveal these AB sequences, which are Rosetta Stone sequences because they decipher an interaction between A′ and B. Another method compares the genomic sequence of two or more organisms to create a phylogenetic profile for each protein indicating its presence or absence across all the genomes. The profile provides information regarding functional links between different families of proteins. In yet another method a combination of the above two methods is used to predict functional links.
摘要翻译：提供了一种计算方法系统和计算机程序，用于从基因组序列推断功能链接。一种方法是基于一些观察结果，一些蛋白质A'和B'在另一个生物融合成单个蛋白质链AB的同源物。序列的跨基因组比较可以揭示这些AB序列，它们是Rosetta Stone序列，因为它们破译了A'和B之间的相互作用。另一种方法比较了两种或更多种生物体的基因组序列，以创建每种蛋白质的系统发育谱，存在或不存在所有基因组。该资料提供了不同蛋白质家族之间的功能链接信息。在另一种方法中，使用上述两种方法的组合来预测功能链接。

16. 发明授权

US6093573A Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) 失效
标题翻译：杀菌/渗透性增加蛋白（BPI）三维结构
公开(公告)号：US6093573A
公开(公告)日：2000-07-25
申请号：US879565
申请日：1997-06-20
申请人： Lesa J. Beamer , Stephen F. Carroll , David Eisenberg
发明人： Lesa J. Beamer , Stephen F. Carroll , David Eisenberg
IPC分类号： C07K1/00 , C07K14/47 , G06F17/30 , G06F17/50 , G01N33/48
CPC分类号： G06F19/706 , C07K1/306 , C07K14/4742 , G06F19/701
摘要： The present invention provides a crystallized Bactericidal Permeability-Increasing (BPI) protein; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.
摘要翻译：本发明提供结晶的杀菌渗透性增加（BPI）蛋白; 基于使用氨基酸序列数据和/或x射线，x射线衍射分析的方法提供足够高分辨率的X射线衍射图案用于蛋白质的三维结构测定，以及合理药物设计的方法在具有合适的计算机算法的计算机系统上分析的在计算机可读介质上提供的晶体学数据; 并提供原子坐标，产生包含BPI，LBP，CETP和PLTP的脂质结合和脂质转运蛋白家族的结构信息。

17. 发明授权

US11627675B2 Extensible display screen apparatus for mobile electronic device 有权
公开(公告)号：US11627675B2
公开(公告)日：2023-04-11
申请号：US17384687
申请日：2021-07-23
申请人： David Eisenberg
发明人： David Eisenberg
IPC分类号： G06F1/16 , H05K5/02
摘要： An extensible display screen apparatus includes a power supply device and a screen display device. The screen display device includes at least one screen unit and a screen support assembly, wherein the at least one screen unit is disposed on the screen support assembly and the screen support assembly is arranged to support the at least one screen unit, whereas the at least one screen support assembly can electrically connect with the screen display device through the power supply device. The power supply device is configured to provide a working power to the at least one screen unit for a mobile electronic device to communicate with the at least one screen unit, wherein the said screen unit provides additional information of the mobile electronic device while being electrically connected with the screen display device.

18. 发明授权

US07125680B2 Methods and materials for characterizing and modulating interaction between heregulin and HER3 失效
标题翻译：表征和调节蛋白与HER3之间相互作用的方法和材料
公开(公告)号：US07125680B2
公开(公告)日：2006-10-24
申请号：US10207498
申请日：2002-07-29
申请人： Elizabeth Singer , Ralf Landgraf , Dennis J. Slamon , David Eisenberg
发明人： Elizabeth Singer , Ralf Landgraf , Dennis J. Slamon , David Eisenberg
IPC分类号： G01N33/53
CPC分类号： C07K14/71 , G01N2333/705 , G01N2333/9121
摘要： The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include methods for identifying compounds which specifically bind the heregulin binding domain in HER3.
摘要翻译：本文提供的公开内容鉴定并表征HER3受体中与拟胰岛素配体相互作用的结构域。本文公开的本发明的典型实施方案包括用于鉴定特异性结合HER3中的调节蛋白结合结构域的化合物的方法。

19. 发明申请

US20060177907A1 Methods and materials for characterizing and modulating interaction between heregulin and HER3 有权
公开(公告)号：US20060177907A1
公开(公告)日：2006-08-10
申请号：US11406679
申请日：2006-04-19
申请人： Elizabeth Singer , Ralf Landgraf , Dennis Slamon , David Eisenberg
发明人： Elizabeth Singer , Ralf Landgraf , Dennis Slamon , David Eisenberg
IPC分类号： C12P21/06 , C07H21/04 , C07K14/72
CPC分类号： C07K14/71 , G01N2333/705 , G01N2333/9121
摘要： The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein are methods and materials for identifying compounds that bind to the heregulin binding domain in HER3 as well as methods and materials for modulating the interaction between HER3 and heregulin.

20. 发明申请

US20060128623A1 Granulysin peptides and methods of use thereof 有权
标题翻译：颗粒溶素肽及其使用方法
公开(公告)号：US20060128623A1
公开(公告)日：2006-06-15
申请号：US11304911
申请日：2005-12-14
申请人： Robert Modlin , Jenny Kim , Daniel Anderson , David Eisenberg , Richard Gallo
发明人： Robert Modlin , Jenny Kim , Daniel Anderson , David Eisenberg , Richard Gallo
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C07K14/4723 , A61K38/00 , C07K14/47
摘要： Granulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.
摘要翻译：颗粒素蛋白肽是对细菌和炎症具有强力活性的小抗微生物剂。包含颗粒溶素肽作为活性剂的药物组合物治疗性地给患有微生物感染的患者施用。

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