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11. 发明授权

US5871964A Human C-type lectin 失效
标题翻译：人类C型凝集素
公开(公告)号：US5871964A
公开(公告)日：1999-02-16
申请号：US688342
申请日：1996-07-30
申请人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/54 , C12N15/00
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
摘要翻译：本发明提供鉴定和编码新型人C型凝集素（MCTL）的多核苷酸（mct1）。本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。另外，本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸，其片段或其互补体的诊断组合物的诊断测定法。本发明还涉及特异性结合MCTL的抗MCTL抗体。

12. 发明授权

US06204021B1 DNA encoding a cytokine 失效
标题翻译：编码细胞因子的DNA
公开(公告)号：US06204021B1
公开(公告)日：2001-03-20
申请号：US08792013
申请日：1997-01-31
申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
IPC分类号： C12N1500
CPC分类号： C07K14/52
摘要： The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
摘要翻译：本发明提供新型人细胞因子（单独命名为NHC-1和NHC-2，统称为NHC）和识别和编码NHC的多核苷酸。本发明还提供了包含编码NHC的核酸序列和生产NHC的方法的遗传工程表达载体和宿主细胞。本发明还提供使用NHC和特异性结合NHC的激动剂，抗体或拮抗剂来预防和治疗与NHC表达有关的疾病。另外，本发明提供了将反义分子用于编码NHC的多核苷酸用于治疗与NHC表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHC的抗体的诊断测定法。

13. 发明授权

US5969104A Human C-type lectin 失效
公开(公告)号：US5969104A
公开(公告)日：1999-10-19
申请号：US113788
申请日：1998-07-10
申请人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.

14. 发明授权

US5874286A Tumor proteins 失效
公开(公告)号：US5874286A
公开(公告)日：1999-02-23
申请号：US715204
申请日：1996-09-17
申请人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/85
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention provides novel human tumor proteins (collectively called TUPRO) and polynucleotides which identify and encode TUPRO. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TUPRO. The invention also provides pharmaceutical compositions containing TUPRO or antagonists to TUPRO, and in the use of these compositions for the treatment of diseases associated with the expression of TUPRO. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TUPRO for the treatment of diseases associated with the expression of TUPRO. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding TUPRO or anti-TUPRO antibodies which specifically bind to TUPRO.

15. 发明授权

US5843714A DNA encoding a novel human proteolipid 失效
标题翻译：编码新型人类蛋白脂类的DNA
公开(公告)号：US5843714A
公开(公告)日：1998-12-01
申请号：US695736
申请日：1996-07-26
申请人： Janice Au-Young , Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12N15/11 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode a novel human proteolipid (PLHu). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PLHu. The invention also provides for the use of substantially purified PLHu and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of PLHu. Additionally, the invention provides for the use of antisense molecules to PLHu in the treatment of diseases associated with the expression of PLHu. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding PLHu and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新的人类蛋白脂质（PLHu）的多核苷酸。本发明提供了包含编码PLHu的核酸序列的基因工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质中用于治疗与PLHu表达相关的疾病的基本上纯化的PLHu及其激动剂的用途。另外，本发明提供了用于PLHu的反义分子用于治疗与PLHu表达相关的疾病的用途。本发明还描述了利用包含与编码PLHu的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

16. 发明授权

US6043343A Tumor proteins 失效
标题翻译：肿瘤蛋白
公开(公告)号：US6043343A
公开(公告)日：2000-03-28
申请号：US162597
申请日：1998-09-29
申请人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C07K14/47 , A61K38/17 , C07K16/30 , G01N33/53
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention provides novel human tumor proteins (collectively called TUPRO) and polynucleotides which identify and encode TUPRO. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TUPRO. The invention also provides pharmaceutical compositions containing TUPRO or antagonists to TUPRO, and in the use of these compositions for the treatment of diseases associated with the expression of TUPRO. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TUPRO for the treatment of diseases associated with the expression of TUPRO. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding TUPRO or anti-TUPRO antibodies which specifically bind to TUPRO.
摘要翻译：本发明提供新型人肿瘤蛋白（统称为TUPRO）和识别和编码TUPRO的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码TUPRO的核酸序列的宿主细胞。本发明还提供含有TUPRO或TUPRO拮抗剂的药物组合物，以及这些组合物用于治疗与TUPRO表达相关的疾病的药物组合物。另外，本发明提供了将反义分子用于编码TUPRO的多核苷酸用于治疗与TUPRO表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补序列与编码特异性结合TUPRO的TUPRO或抗TUPRO抗体的多核苷酸的基因组序列或转录物进行杂交的诊断测定。

17. 发明授权

US6018028A Human proteasome subunit proteins 失效
标题翻译：人类蛋白酶体亚基蛋白
公开(公告)号：US6018028A
公开(公告)日：2000-01-25
申请号：US134591
申请日：1998-08-13
申请人： Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N1/21 , C12N9/64 , C07K14/47
CPC分类号： C12N9/6421 , C12Y304/25001 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
摘要翻译：本发明提供鉴定和编码新的人蛋白酶体亚基蛋白的多核苷酸。本发明提供了包含编码PSUB的核酸序列的基因工程表达载体和宿主细胞。本发明还提供使用基本上纯化的PSUB，拮抗剂和药物组合物来治疗与PSUB表达相关的疾病。另外，本发明提供了用于治疗与PSUB表达相关的疾病的药物组合物中PSUB的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码与PSUB特异性结合的PSUB或抗PSUB抗体的多核苷酸的基因组序列或转录物杂交。

18. 发明授权

US5869637A Human Kallikrein 失效
标题翻译：人激肽释放酶
公开(公告)号：US5869637A
公开(公告)日：1999-02-09
申请号：US681151
申请日：1996-07-22
申请人： Janice Au-Young , Olga Bandman , Scott Michael Braxton , Surya K. Goli
发明人： Janice Au-Young , Olga Bandman , Scott Michael Braxton , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K38/48 , A61P7/02 , A61P9/04 , A61P9/12 , A61P29/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/12 , C12N15/57 , C12P21/02 , C12P21/08 , C07H21/02 , C07H21/04 , C12N15/63
CPC分类号： C12N9/6445 , A61K38/00 , C07K2319/00
摘要： The present provides a polynucleotide which identifies and encodes a novel human kallikrein (HKLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HKLP. The invention also provides for the use of substantially purified HKLP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HKLP. Additionally, the invention provides for the use of antisense molecules to HKLP in pharmaceutical compositions for treatment of diseases associated with the expression of HKLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HKLP or anti-HKLP antibodies which specifically bind to HKLP.
摘要翻译：本发明提供鉴定和编码新型人激肽释放酶（HKLP）的多核苷酸。本发明提供了包含编码HKLP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与HKLP表达相关的疾病的药物组合物中使用基本上纯化的HKLP及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与HKLP表达相关的疾病的药物组合物中HKLP的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码HKLP或特异性结合HKLP的抗HKLP抗体的多核苷酸的基因组序列或转录物杂交。

19. 发明授权

US5840866A Human ubiquitin-conjugating enzyme 失效
公开(公告)号：US5840866A
公开(公告)日：1998-11-24
申请号：US679765
申请日：1996-07-10
申请人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/00 , C12Q1/68 , C12R1/19 , C07H21/04 , C12N1/20 , C12N9/10 , C12N15/00
CPC分类号： C12N9/93 , C07K16/40
摘要： The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.

20. 发明授权

US6033869A Polynucleotide encoding a novel human cytokine/steroid receptor 失效
标题翻译：编码新型人细胞因子/类固醇受体的多核苷酸
公开(公告)号：US6033869A
公开(公告)日：2000-03-07
申请号：US822264
申请日：1997-03-20
申请人： Surya K. Goli , Jennifer L. Hillman , Lynn E. Murry
发明人： Surya K. Goli , Jennifer L. Hillman , Lynn E. Murry
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P5/00 , A61P13/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/63
CPC分类号： C07K14/72 , C07K14/715 , A61K38/00
摘要： The present invention provides a human cytokine/steroid receptor protein (CYSTAR) and polynucleotides which identify and encode CYSTAR. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of CYSTAR, as well as diagnostic assays.
摘要翻译：本发明提供了人细胞因子/类固醇受体蛋白（CYSTAR）和识别和编码CYSTAR的多核苷酸。本发明还提供表达载体，宿主细胞，抗体和拮抗剂。本发明还提供了用于预防和治疗与CYSTAR表达相关的疾病的方法以及诊断测定法。

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