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11. 发明授权

US06319240B1 Methods and apparatus for ocular iontophoresis 失效
标题翻译：眼用离子电渗法的方法和装置
公开(公告)号：US06319240B1
公开(公告)日：2001-11-20
申请号：US09318181
申请日：1999-05-25
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/30 , A61N1/306
摘要： An iontophoretic apparatus for ocular iontophoresis comprising a housing element formed to cooperate with the eye. In cooperation with the housing element is a flexible current distribution element that is capable of transmitting electrical current. Coupled to the current distribution element is a conformable medicament containment element that is filled with a medicament which is released under the influence of an electrical current, while a barrier element is provided that is configured to reduce current flow outside of the barrier and aid in the preferential delivery of medicament.
摘要翻译：一种用于眼部离子电渗疗法的离子电渗疗法装置，其包括形成为与眼睛配合的壳体元件。与外壳元件配合是能够传输电流的柔性电流分配元件。与电流分配元件相耦合的是符合要求的药物容纳元件，其填充有在电流影响下被释放的药物，同时提供了阻挡元件，该阻挡元件被配置为减少屏障外部的电流并帮助药物优先递送。

12. 发明申请

US20080058700A1 IONTOPHORESIS APPARATUS AND METHOD 有权
标题翻译： IOPOPHORESIS设备和方法
公开(公告)号：US20080058700A1
公开(公告)日：2008-03-06
申请号：US11733700
申请日：2007-04-10
申请人： Robert F. Hause , Jon E. Beck
发明人： Robert F. Hause , Jon E. Beck
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoresis apparatus and method is disclosed that is suited to deliver a plurality of treatment methods such as, but not limited to, body site conductivity enhancement followed by low voltage iontophoresis.
摘要翻译：公开了一种离子电渗疗法装置和方法，其适于递送多种治疗方法，例如但不限于体部电导率增强，接着是低电压离子电渗疗法。

13. 发明授权

US5947920A Self-contained hydrating system and iontophoresis bioelectrode 失效
标题翻译：自给式水合系统和离子电渗生物电极
公开(公告)号：US5947920A
公开(公告)日：1999-09-07
申请号：US821104
申请日：1997-03-20
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N1/30
CPC分类号： A61N1/0448
摘要： The present invention provides methods and apparatus permitting at least one hydrating liquid to be maintained in isolation and, when desired, permitting thorough release of the hydrating liquid. In particular, the self-contained hydrating system comprises a releasable seal for isolating hydrating liquid which can be progressively unsealed to release the hydrating liquid. The unsealing process involves an "unpeeling" of the releasable seal and, thus, does not involve breaking or rupturing of the seal material. In this manner, the hydrating liquid is made accessible but is never exposed to broken or ruptured sealing material. The self-contained hydrating system can be manufactured using existing equipment and techniques and can subsequently be easily associated with a separate device requiring hydration when desired.
摘要翻译：本发明提供允许至少一种保湿液保持分离的方法和装置，并且在需要时允许水合液体的彻底释放。特别地，独立的水合系统包括用于隔离可以逐渐未密封以释放保湿液体的保湿液体的可释放密封件。开封过程涉及可剥离密封件的“脱皮”，因此不涉及密封材料的破裂或破裂。以这种方式，使保湿液体可接近，但不会暴露于破裂或破裂的密封材料。独立的水合系统可以使用现有的设备和技术制造，并且随后可以容易地与需要水合的单独的装置相关联。

14. 发明授权

US5645527A Hydration assembly for hydrating a bioelectrode element 失效
标题翻译：用于水合生物电极元件的水合组件
公开(公告)号：US5645527A
公开(公告)日：1997-07-08
申请号：US599129
申请日：1996-02-09
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N1/30 , A61B17/06 , B65D35/24
CPC分类号： A61N1/30
摘要： The present invention provides methods and apparatus permitting rapid and thorough hydration of an initially dry hydratable matrix element contained within a bioelectrode element for use in an iontophoretic delivery device. The apparatus of the invention comprises a bioelectrode element for iontophoretic delivery of medicaments having at least one hydratable matrix element and associated removable hydration assembly. The removable hydration assembly includes an initially sealed liquid-storage component which maintains the desired hydrating liquid in isolation from the hydratable matrix element until such time as hydration is desired. At that time, the removable hydration assembly can be activated by the user through application of force to a pocket in a side of the sealed liquid-storage component to cause the pocket to become inverted and substantially aligned within an opposing pocket in the other side such that the sealed liquid-storage component unseals at a predetermined release location. The hydrating liquid is then released into the hydratable matrix element. Following hydration of the matrix element, the spent hydration assembly can be separated from the now-hydrated bioelectrode element.
摘要翻译：本发明提供允许快速且彻底水合包含在生物电极元件内的用于离子电渗疗法输送装置的初始干燥的可水合的基质元素的方法和装置。本发明的装置包括用于离子电渗疗法递送药物的生物电极元件，其具有至少一个可水合的基质元件和相关的可移除的水合组合物。可移除水合组件包括初始密封的液体储存组分，其将期望的保湿液体与可水合的基质元件隔离，直到需要水合为止。此时，可移除的水合组件可以由用户通过向密封的液体储存部件的侧面上的口袋施加力来致动，从而导致口袋在另一侧的相对的口袋内反转并基本对准，密封的液体储存组件在预定的释放位置处开封。然后将水合液体释放到可水合的基质元件中。在基质元素水化后，废水合组合物可以与现在水合的生物电极元件分离。

15. 发明授权

US07252655B2 Ocular iontophoretic apparatus handle 失效
标题翻译：眼部离子电渗疗法手柄
公开(公告)号：US07252655B2
公开(公告)日：2007-08-07
申请号：US09922559
申请日：2001-08-03
申请人： Jon E. Beck , Alex Koss
发明人： Jon E. Beck , Alex Koss
IPC分类号： A61M35/00
CPC分类号： A61N1/303 , A61F9/00 , A61N1/0428 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/306
摘要： An iontophoretic apparatus comprising a housing member, a current distribution member, a medicament containment member and at least one of a lateral and medial straddling member. The straddling member are configured to correspond to the surrounding soft tissue.
摘要翻译：一种离子电渗疗法装置，其包括壳体构件，电流分配构件，药物容纳构件以及横向和内侧跨接构件中的至少一个。跨骑构件构造成对应于周围的软组织。

16. 发明授权

US06731977B2 Iontophoretic electrode with improved current distribution 有权
标题翻译：具有改善电流分布的离子电渗电极
公开(公告)号：US06731977B2
公开(公告)日：2004-05-04
申请号：US09766767
申请日：2001-01-22
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0492 , A61N1/303
摘要： An electrode for use in an iontophoretic drug delivery having a substantially uniform distribution of current about the electrode. One such electrode includes a substrate, at least one first conductive layer of material disposed upon the substrate and at least one dielectric layer of material disposed upon at least a portion of the at least one conductive layer of material. The dielectric layer cooperates with the conductive layer of material to promote the substantially uniform distribution of current. Another such electrode includes a substrate, a conductive layer of material and a sacrificial layer of material.
摘要翻译：一种用于离子电渗药物递送的电极，其电极具有基本上均匀的电流分布。一个这样的电极包括衬底，设置在衬底上的至少一个材料的第一导电层和设置在材料的至少一个导电层的至少一部分上的材料的至少一个电介质层。电介质层与材料的导电层配合以促进电流的基本均匀分布。另一个这样的电极包括衬底，材料的导电层和材料的牺牲层。

17. 发明授权

US06687536B1 Connection system for an iontophoretic drug delivery device 有权
标题翻译：离子电渗药物输送装置的连接系统
公开(公告)号：US06687536B1
公开(公告)日：2004-02-03
申请号：US09458239
申请日：1999-12-09
申请人： Jon E. Beck , Brian Keith Leaf
发明人： Jon E. Beck , Brian Keith Leaf
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/303 , A61N1/325
摘要： A connection system for an iontophoretic drug delivery apparatus comprises an electrode assembly, a power source and a structure for facilitating mating engagement therebetween. The electrode assembly includes a first interface and two electrical leads and the power source includes a second interface and two electrical contacts. The interfaces are configured to facilitate mating engagement therebetween and operative secured electrical continuity between the electrical leads of the electrode assembly and the electrical contacts of the power source.
摘要翻译：用于离子电渗药物递送装置的连接系统包括电极组件，电源和用于促进它们之间的配合接合的结构。电极组件包括第一接口和两个电引线，并且电源包括第二接口和两个电触头。接口被构造成便于它们之间的配合接合，并且在电极组件的电引线和电源的电触点之间具有可操作的固定的电连续性。

18. 发明授权

US5846217A Iontophoretic bioelectrode and method of using same 失效
标题翻译：离子电渗生物电极及其使用方法
公开(公告)号：US5846217A
公开(公告)日：1998-12-08
申请号：US902251
申请日：1997-07-29
申请人： Jon E. Beck , Ralph Karl Koschinsky
发明人： Jon E. Beck , Ralph Karl Koschinsky
IPC分类号： A61N1/30 , A61N1/04
CPC分类号： A61N1/0448 , A61N1/044
摘要： An improved iontophoretic bioelectrode constructed with a novel access window that conveniently allows a clinician direct access to the drug reservoir without prematurely exposing the adhesive layer. The access window is a partial cut out or perforation of a release liner that, when opened, only reveals the drug reservoir to the clinician while the remainder of the release liner simultaneously remains protectively covering the adhesive layer.
摘要翻译：改进的离子电渗生物电极用新颖的入口窗构成，其方便地允许临床医生直接进入药物储存器而不会过早地暴露粘合剂层。进入窗口是释放衬垫的局部切除或穿孔，当打开时，仅将药物储存器暴露给临床医师，同时释放衬垫的其余部分同时保持覆盖粘合剂层。

19. 发明授权

US08386029B2 Apparatus for electrotherapy drug delivery with added impurities 有权
标题翻译：电疗药物递送装置，附加杂质
公开(公告)号：US08386029B2
公开(公告)日：2013-02-26
申请号：US10907429
申请日：2005-03-31
申请人： Robert F. Hause, Jr. , Jon E. Beck
发明人： Robert F. Hause, Jr. , Jon E. Beck
IPC分类号： A61N1/30 , A61K9/22
CPC分类号： A61N1/0436 , A61N1/0428 , A61N1/30 , A61N1/325
摘要： The present invention is directed to a method and apparatus for an electrotherapeutic system including a first and second electrode. Each electrode includes a respective resistance wherein during operation of the electrotherapeutic system, an electrochemical reaction involving one or both of the electrodes varies the respective resistance of at least one of the electrodes.
摘要翻译：本发明涉及一种包括第一和第二电极的电疗系统的方法和装置。每个电极包括相应的电阻，其中在电疗系统的操作期间，涉及电极中的一个或两个的电化学反应改变至少一个电极的相应电阻。

20. 发明授权

US08214030B2 Iontophoresis apparatus and method 有权
标题翻译：离子渗透装置及方法
公开(公告)号：US08214030B2
公开(公告)日：2012-07-03
申请号：US11733700
申请日：2007-04-10
申请人： Robert F. Hause, Jr. , Jon E. Beck
发明人： Robert F. Hause, Jr. , Jon E. Beck
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoresis apparatus and method is disclosed that is suited to deliver a plurality of treatment methods such as, but not limited to, body site conductivity enhancement followed by low voltage iontophoresis.
摘要翻译：公开了一种离子电渗疗法装置和方法，其适于递送多种治疗方法，例如但不限于体部电导率增强，接着是低电压离子电渗疗法。

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