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11. 发明授权

US08880193B1 Cochlear electrode array 有权
标题翻译：耳蜗电极阵列
公开(公告)号：US08880193B1
公开(公告)日：2014-11-04
申请号：US12781137
申请日：2010-05-17
申请人： Chuladatta Thenuwara , Timothy Beerling
发明人： Chuladatta Thenuwara , Timothy Beerling
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0541 , A61N1/36032 , A61N1/36038
摘要： A method for forming a cochlear electrode array with a plurality of electrodes which are spaced so as to stimulate sites within a cochlea includes shaping a sheet of electrically conductive material to form a support structure and a plurality of electrodes, in which the electrodes are tethered to the support structure at the spacing of the cochlear electrode array. A cochlear lead includes a flexible body that has frictional characteristics that vary about its circumference. A cochlear lead includes a flexible body with a first region and a second region with different surface textures. This generates differential sliding forces during insertion of the cochlear lead which influence a motion of the cochlear lead during insertion. The cochlear lead having an electrode array with varying stiffness along its length is also provided.
摘要翻译：用于形成具有间隔开以刺激耳蜗内的部位的多个电极的耳蜗电极阵列的方法包括成形导电材料片以形成支撑结构和多个电极，其中电极被束缚至在耳蜗电极阵列的间隔处的支撑结构。耳蜗引线包括具有围绕其周长变化的摩擦特性的柔性体。耳蜗引线包括具有第一区域的柔性体和具有不同表面纹理的第二区域。这在耳蜗引线的插入期间产生差别的滑动力，其在插入期间影响耳蜗导线的运动。还提供了具有沿其长度具有变化的刚度的电极阵列的耳蜗引线。

12. 发明授权

US08753353B2 Tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice 有权
标题翻译：用于将铅的电极阵列部分插入身体孔口的工具，系统和方法
公开(公告)号：US08753353B2
公开(公告)日：2014-06-17
申请号：US12824120
申请日：2010-06-25
申请人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
发明人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61B2017/00787 , A61N1/0541
摘要： Exemplary insertion tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice are described herein. An exemplary insertion tool includes a handle assembly, a slider assembly, a retractor assembly disposed at least partially within the handle assembly, and a rocker lever. The retractor assembly may include a stiffening member configured to be inserted into the electrode array portion and a spring-loaded retractor member coupled at a proximal end of the stiffening member. The spring-loaded retractor member may be configured to move from a distal position to a proximal position to at least partially retract the stiffening member from the electrode array portion. The rocker lever may be configured to selectively retain the spring-loaded retractor member in the distal position. Corresponding tools, systems, and methods are also described.
摘要翻译：本文描述了用于将铅的电极阵列部分插入身体孔的示例性插入工具，系统和方法。示例性插入工具包括手柄组件，滑块组件，至少部分地设置在手柄组件内的牵开器组件和摇杆。牵开器组件可以包括构造成插入到电极阵列部分中的加强构件和联接在加强构件的近端处的弹簧加载的牵开器构件。弹簧加载的牵缩器构件可以构造成从远侧位置移动到近侧位置，以将加强构件至少部分地从电极阵列部分缩回。摇杆可以被构造成选择性地将弹簧加载的牵开器构件保持在远侧位置。还描述了相应的工具，系统和方法。

13. 发明授权

US08753352B2 Tools, systems, and methods for inserting a pre-curved electrode array portion of a lead into a bodily orifice 有权
标题翻译：用于将铅的预弯曲电极阵列部分插入身体孔口的工具，系统和方法
公开(公告)号：US08753352B2
公开(公告)日：2014-06-17
申请号：US12824119
申请日：2010-06-25
申请人： Chuladatta Thenuwara , Timothy Beerling , Mark Downing , Paul Hoffman , William G. Orinski
发明人： Chuladatta Thenuwara , Timothy Beerling , Mark Downing , Paul Hoffman , William G. Orinski
IPC分类号： A61B19/00
CPC分类号： A61B17/00 , A61B17/3468 , A61F11/04 , A61N1/05 , A61N1/0541
摘要： Exemplary insertion tools, systems, and methods for inserting a pre-curved electrode array portion of a lead into a bodily orifice are described herein. An exemplary insertion tool includes a handle assembly, a slider assembly, an insertion assembly coupled to the handle assembly, and a retractor assembly disposed at least partially within the handle assembly and configured to selectively couple to a straightening member inserted into the pre-curved electrode array portion and at least partially retract the straightening member from the pre-curved electrode array portion in response to actuation by a user of the slider assembly. The retractor assembly may comprise a spring-loaded retractor member configured to move from a distal position to a proximal position in response to actuation by the user of the slider assembly to at least partially retract the straightening member from the pre-curved electrode array portion. Corresponding insertion tools, systems, and methods are also described.
摘要翻译：本文描述了用于将引线的预弯曲电极阵列部分插入身体孔口的示例性插入工具，系统和方法。示例性的插入工具包括手柄组件，滑块组件，联接到手柄组件的插入组件和至少部分地设置在手柄组件内并被配置为选择性地联接到插入到预弯曲电极中的矫正构件的牵开器组件并且响应于滑块组件的使用者的致动，至少部分地将矫正构件从预弯曲的电极阵列部分缩回。牵开器组件可以包括弹簧加载的牵开器构件，其构造成响应于滑块组件的使用者的致动而从远侧位置移动到近侧位置，以使矫正构件至少部分地从预弯曲电极阵列部分缩回。还描述了相应的插入工具，系统和方法。

14. 发明申请

US20120296405A1 COCHLEAR ELECTRODE ARRAY 有权
标题翻译： COCHLEAR电极阵列
公开(公告)号：US20120296405A1
公开(公告)日：2012-11-22
申请号：US13516982
申请日：2010-12-14
申请人： Chuladatta Thenuwara , Timothy Beerling
发明人： Chuladatta Thenuwara , Timothy Beerling
IPC分类号： A61N1/05 , H01R43/16
CPC分类号： C25D11/34 , A61N1/0541 , A61N1/36036 , B23K26/38 , C25D7/0642 , H01R43/16 , Y10T29/49204 , Y10T29/49213 , Y10T29/49218 , Y10T29/49222
摘要： A cochlear lead includes a plurality of electrode assemblies partially embedded in a flexible body configured to stimulate an auditory nerve from within a cochlea. Each of the electrode assemblies includes a flexible electrically conductive material forming a plurality of support structures and an electrode pad attached a support structure, the electrode pad having a surface that is configured to be exposed to cochlear tissue and fluids and has a charge transfer to the cochlear tissue and fluids that is higher than the flexible electrically conductive material.
摘要翻译：耳蜗引线包括部分地嵌入柔性体中的多个电极组件，其构造成从耳蜗内刺激听觉神经。每个电极组件包括形成多个支撑结构的柔性导电材料和附接有支撑结构的电极垫，电极垫具有被配置为暴露于耳蜗组织和流体的表面，并具有电荷转移到耳蜗组织和高于柔性导电材料的流体。

15. 发明申请

US20110295352A1 Cochlear Lead 有权
标题翻译：人工耳蜗
公开(公告)号：US20110295352A1
公开(公告)日：2011-12-01
申请号：US12789264
申请日：2010-05-27
申请人： Chuladatta Thenuwara , Timothy Beerling
发明人： Chuladatta Thenuwara , Timothy Beerling
IPC分类号： A61N1/04
CPC分类号： A61N1/0541 , A61N1/36036
摘要： A cochlear lead includes a plurality of electrodes configured to stimulate an auditory nerve from within a cochlea and a flexible body supporting the plurality of electrodes along a length of the flexible body. A stiffening element is slidably encapsulated within the flexible body and positioned such that the stiffening element plastically deforms upon insertion into a curved portion of the cochlea.
摘要翻译：耳蜗引线包括构造成从耳蜗内刺激听觉神经的多个电极和沿柔性体的长度支撑多个电极的柔性体。加强元件可滑动地封装在柔性体内并且定位成使得加强元件在插入耳蜗的弯曲部分时塑性变形。

16. 发明申请

US20110022145A1 INTEGRATED WIRE CARRIER FOR ELECTRODE ARRAY 有权
标题翻译：用于电极阵列的集成线载体
公开(公告)号：US20110022145A1
公开(公告)日：2011-01-27
申请号：US12506964
申请日：2009-07-21
申请人： Timothy Beerling , Chuladatta Thenuwara
发明人： Timothy Beerling , Chuladatta Thenuwara
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61F11/004 , Y10T29/49185
摘要： A method for forming a cochlear electrode array with a plurality of electrodes which are spaced so as to stimulate sites within a cochlea includes shaping a sheet of electrically conductive material to form a support structure and a plurality of electrodes, in which the electrodes are tethered to the support structure at the spacing of the cochlear electrode array. A cochlear lead includes a flexible body that has frictional characteristics that vary about its circumference. A cochlear lead includes a flexible body with a first region and a second region with different surface textures. This generates differential sliding forces during insertion of the cochlear lead which influence a motion of the cochlear lead during insertion. The cochlear lead having an electrode array with varying stiffness along its length is also provided.
摘要翻译：用于形成具有间隔开以刺激耳蜗内的部位的多个电极的耳蜗电极阵列的方法包括成形导电材料片以形成支撑结构和多个电极，其中电极被束缚至在耳蜗电极阵列的间隔处的支撑结构。耳蜗引线包括具有围绕其周长变化的摩擦特性的柔性体。耳蜗引线包括具有第一区域的柔性主体和具有不同表面纹理的第二区域。这在耳蜗引线的插入期间产生差别的滑动力，其在插入期间影响耳蜗导线的运动。还提供了具有沿其长度具有变化的刚度的电极阵列的耳蜗引线。

17. 发明授权

US08552311B2 Electrical feedthrough assembly 有权
标题翻译：电气馈通组件
公开(公告)号：US08552311B2
公开(公告)日：2013-10-08
申请号：US12836831
申请日：2010-07-15
申请人： Kurt J. Koester , Timothy Beerling
发明人： Kurt J. Koester , Timothy Beerling
IPC分类号： H05K1/00 , H05K13/00
CPC分类号： A61N1/3754 , A61N1/36036 , B23K1/0016 , B23K1/19 , B23K26/28 , B23K35/0238 , B23K35/3013 , B23K35/32 , B23K35/322 , B23K2101/12 , B23K2101/36 , B23K2103/14 , B23K2103/18 , B23K2103/52 , B32B15/018 , C22C5/04 , C22C32/00 , H05K5/069 , Y10T29/49117
摘要： An electrical feedthrough includes a ceramic body and a ribbon via extending through the ceramic body, an interface between the ribbon via and the ceramic body being sealed using partial transient liquid phase bonding. The ribbon via extends out of the ceramic body and makes an electrical connection with an external device.
摘要翻译：电馈通包括陶瓷体和延伸通过陶瓷体的带通过部分瞬态液相结合密封带状通孔和陶瓷体之间的界面。带状通孔延伸出陶瓷体，并与外部设备进行电气连接。

18. 发明申请

US20120012374A1 ELECTRICAL FEEDTHROUGH ASSEMBLY 有权
标题翻译：电气充足的组装
公开(公告)号：US20120012374A1
公开(公告)日：2012-01-19
申请号：US12836831
申请日：2010-07-15
申请人： Kurt J. Koester , Timothy Beerling
发明人： Kurt J. Koester , Timothy Beerling
IPC分类号： H05K1/00 , H05K13/00
CPC分类号： A61N1/3754 , A61N1/36036 , B23K1/0016 , B23K1/19 , B23K26/28 , B23K35/0238 , B23K35/3013 , B23K35/32 , B23K35/322 , B23K2101/12 , B23K2101/36 , B23K2103/14 , B23K2103/18 , B23K2103/52 , B32B15/018 , C22C5/04 , C22C32/00 , H05K5/069 , Y10T29/49117
摘要： An electrical feedthrough includes a ceramic body and a ribbon via extending through the ceramic body, an interface between the ribbon via and the ceramic body being sealed using partial transient liquid phase bonding. The ribbon via extends out of the ceramic body and makes an electrical connection with an external device.
摘要翻译：电馈通包括陶瓷体和延伸通过陶瓷体的带通过部分瞬态液相结合密封带状通孔和陶瓷体之间的界面。带状通孔延伸出陶瓷体，并与外部设备进行电气连接。

19. 发明申请

US20110139484A1 Hermetic Electrical Feedthrough 审中-公开
标题翻译：气密电气馈通
公开(公告)号：US20110139484A1
公开(公告)日：2011-06-16
申请号：US12963367
申请日：2010-12-08
申请人： Kurt J. Koester , Timothy Beerling
发明人： Kurt J. Koester , Timothy Beerling
IPC分类号： H01B17/26 , B05D5/12 , C25D13/00 , C25D5/34 , B32B38/04 , H05K5/06
CPC分类号： A61N1/375 , C25D11/02 , C25D13/02 , C25D13/22 , H01G2/103 , H01G4/236 , H01G4/35 , H01L2224/16 , H01L2924/0002 , Y10T156/1062 , H01L2924/00
摘要： A method for fabricating a hermetic electrical feedthrough includes engraving a circuitous groove into a surface of an electrically conductive monolithic slab so that the interior of the circuitous groove forms a pin. A dielectric material is formed in the circuitous groove. The pin is then electrically isolated from the surrounding material and provides electrical access through the hermetic feedthrough.
摘要翻译：用于制造气密电馈通的方法包括将迂回凹槽雕刻到导电整体板的表面中，使得迂回凹槽的内部形成销。电路材料形成在迂回沟槽中。然后，引脚与周围的材料电隔离，并提供通过气密馈电的电气通路。

20. 发明授权

US08647590B2 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US08647590B2
公开(公告)日：2014-02-11
申请号：US11384149
申请日：2006-03-16
申请人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
发明人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

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