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11. 发明申请

US20090035353A1 NON-ABSORBENT ARTICLES CONTAINING ADDITIVES 审中-公开
标题翻译：含吸附剂的非吸收性物品
公开(公告)号：US20090035353A1
公开(公告)日：2009-02-05
申请号：US12252842
申请日：2008-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K9/70 , A61K31/407
CPC分类号： A61F13/8405 , A61K31/12 , A61K31/335 , A61K31/381 , A61K31/407 , A61K31/60 , A61K31/655 , A61L15/46 , A61L2300/202 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： Non-absorbent articles containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound such as cerulenin, triclosan, or hexachloroprene, for example, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
摘要翻译：公开了含有添加剂的非吸收性物品。非吸收性物品包括例如有效量的抑制性化合物，例如可霉酚酸，三氯生或六氯丁二烯，以实质上抑制革兰氏阳性菌产生TSST-1。

12. 发明授权

US07348023B2 Absorbent articles containing additives 失效
标题翻译：含有添加剂的吸收制品
公开(公告)号：US07348023B2
公开(公告)日：2008-03-25
申请号：US10271509
申请日：2002-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61F6/06 , A61F13/02
CPC分类号： A61F13/8405 , A61F13/2051 , A61L15/46 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： Absorbent articles containing an additive are disclosed. The absorbent articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
摘要翻译：公开了含有添加剂的吸收制品。吸收性物品包括有效量的抑制性化合物，例如硫乳杆菌素或硫代苹果酸盐，以显着抑制革兰氏阳性细菌产生TSST-1。

13. 发明授权

US06596290B2 Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions 失效
公开(公告)号：US06596290B2
公开(公告)日：2003-07-22
申请号：US09969198
申请日：2001-10-02
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A01N2534
CPC分类号： A61L15/46 , A61L2300/22 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an isoprenoid inhibitory compound such as a terpene to substantially inhibit the production of exotoxins by Gram positive bacteria.

14. 发明授权

US07323186B2 Non-absorbent articles containing additives 失效
标题翻译：含有添加剂的非吸收性物品
公开(公告)号：US07323186B2
公开(公告)日：2008-01-29
申请号：US10271457
申请日：2002-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A01N25/34 , A61F6/06 , A61F13/02
CPC分类号： A61F13/8405 , A61K31/12 , A61K31/335 , A61K31/381 , A61K31/407 , A61K31/60 , A61K31/655 , A61L15/46 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： Non-absorbent articles, such as tampon applicators, containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate, for example, to substantially inhibit the production of TSST-1 or exoprotein by Gram positive bacteria.
摘要翻译：公开了包含添加剂的非吸收性物品，例如棉塞施用器。非吸收性物品包括有效量的抑制性化合物，例如硫乳杆菌素或硫代苹果酸盐，以实质上抑制革兰氏阳性菌产生TSST-1或外蛋白。

15. 发明授权

US07118759B2 Absorbent articles containing additives 失效
标题翻译：含有添加剂的吸收制品
公开(公告)号：US07118759B2
公开(公告)日：2006-10-10
申请号：US10271513
申请日：2002-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A01N25/34 , A61F6/06 , A61F13/02
CPC分类号： A61F13/8405 , A61K31/12 , A61K31/335 , A61K31/407 , A61K31/60 , A61K31/655 , A61L15/20 , A61L15/46 , A61L2300/202 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： Effective amounts of the inhibitory compounds described herein capable of significantly reducing the production of TSST-1 are as follows: (1) compounds of Structure (I): from about 0.0001 micromoles/gram absorbent product to about 0.08 micromoles/gram absorbent product, desirably from about 0.0005 micromoles/gram of absorbent product to about 0.05 micromoles/gram of absorbent product; and (2) compounds of Structures (II) and (III): from about 0.05 micromoles/gram of absorbent product to 5 micromoles/gram of absorbent product, desirably from about 0.1 micromoles/gram of absorbent product to about 1 micromole/gram of absorbent product. Specifically, effective amounts of hexachlorophene include from about 0.00024 micromoles/gram of absorbent product to about 0.08 micromoles/gram of absorbent product, desirably from about 0.001 micromoles/gram of absorbent product to about 0.05 micromoles/gram of absorbent product. Specifically, effective amounts of triclosan include from about 0.0005 micromoles/gram of absorbent product to about 0.03 micromoles/gram of absorbent product. Specifically, effective amounts of cerulenin include from about 0.1 micromoles/gram of absorbent product to about 1 micromole/gram of absorbent product.
摘要翻译：能够显着降低TSST-1生产的抑制化合物的有效量如下：（1）结构（I）的化合物：约0.0001微摩尔/克吸收产物至约0.08微摩尔/克吸收产物，期望地约0.0005微摩尔/克吸收产品至约0.05微摩尔/克吸收产品; 和（2）结构（II）和（III）的化合物：约0.05微摩尔/克吸收产物至5微摩尔/克吸收产物，理想地约0.1微摩尔/克吸收产物至约1微摩尔/克吸收性产品。具体地，有效量的六氯酚包括约0.00024微摩尔/克吸收产物至约0.08微摩尔/克的吸收产品，理想的是约0.001微摩尔/克的吸收产物至约0.05微摩尔/克的吸收产品。具体地，有效量的三氯生包括约0.0005微摩尔/克的吸收产物至约0.03微摩尔/克的吸收产品。具体地，有效量的苏氨酸包括约0.1微摩尔/克吸收产物至约1微摩尔/克的吸收产品。

16. 发明授权

US06911480B2 Methods for the inhibition of exoprotein production from Gram positive bacteria 失效
标题翻译：抑制革兰氏阳性菌产生外源蛋白的方法
公开(公告)号：US06911480B2
公开(公告)日：2005-06-28
申请号：US10330156
申请日：2002-12-27
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K9/00 , A61K31/045 , A61K45/06 , A61K31/05
CPC分类号： A61K45/06 , A61K9/0034 , A61K31/045 , Y10S514/967 , A61K2300/00
摘要： Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.
摘要翻译：公开了抑制外毒素生产的方法和组合物。组合物包括有效量的类异戊二烯抑制化合物，以显着抑制革兰氏阳性细菌产生外毒素。

17. 发明授权

US06534548B1 Isoprenoid compositions for the inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的异戊二醛组合物
公开(公告)号：US06534548B1
公开(公告)日：2003-03-18
申请号：US09968769
申请日：2001-10-02
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K3105
CPC分类号： A61K45/06 , A61K9/0034 , A61K31/045 , Y10S514/967 , A61K2300/00
摘要： Compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.
摘要翻译：公开了抑制外毒素生成的组合物。组合物包括有效量的类异戊二烯抑制化合物，以显着抑制革兰氏阳性细菌产生外毒素。

18. 发明授权

US07691403B2 Non-absorbent tampon containing additives inhibiting TSST-1 失效
标题翻译：含有抑制TSST-1的添加剂的非吸收性棉塞
公开(公告)号：US07691403B2
公开(公告)日：2010-04-06
申请号：US10271445
申请日：2002-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61F6/06 , A61F13/02 , A61F6/14
CPC分类号： A61F13/8405 , A61K31/12 , A61K31/335 , A61K31/381 , A61K31/407 , A61K31/60 , A61K31/655 , A61L15/46 , A61L2300/202 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： Non-absorbent articles containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound such as cerulenin, triclosan, or hexachloroprene, for example, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
摘要翻译：公开了含有添加剂的非吸收性物品。非吸收性物品包括例如有效量的抑制性化合物，例如可霉酚酸，三氯生或六氯丁二烯，以实质上抑制革兰氏阳性菌产生TSST-1。

19. 发明授权

US07022333B2 Inhibition of exoprotein production in non-absorbent articles uisng aromatic compositions 失效
标题翻译：抑制非吸收性物品中的外来蛋白生成
公开(公告)号：US07022333B2
公开(公告)日：2006-04-04
申请号：US09969391
申请日：2001-10-02
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A01N25/34
CPC分类号： A61K31/165 , A61K31/325 , A61L15/46 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: wherein R1 is selected from the group consisting of H, —OR5, —R6C(O)H, —R6OH, —R6COOH, —OR6OH, —OR6COOH, —C(O)NH2, and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.
摘要翻译：公开了非吸收性物品。非吸收性物品包括有效量的芳香族抑制化合物，以显着抑制革兰氏阳性菌产生外毒素。本发明的芳族抑制化合物具有以下通式：其中R 1选自H，-OR 5，-R 6， C（O）H，-R 6 OH，-R 6 COOH，-OR 6 OH，-OR， COOH，-C（O）NH 2和NH 2和它们的盐; R 5是单价饱和或不饱和脂族烃基部分; R 6是二价饱和或不饱和脂族烃基部分; R 7是三价饱和或不饱和脂族烃基部分; R 8是单价取代或未取代的饱和或不饱和脂族烃基部分，其可以或不会被杂原子中断; R 2，R 3和R 4独立地选自H，OH，COOH和-C（O） 9＆lt; 9＆gt; R 9是氢或一价饱和或不饱和脂族烃基部分。

20. 发明授权

US06821999B2 Methods for inhibiting the production of TSST-1 失效
标题翻译：抑制TSST-1生产的方法
公开(公告)号：US06821999B2
公开(公告)日：2004-11-23
申请号：US10271474
申请日：2002-10-16
申请人： Rae Ellen Syverson , Richard A. Proctor
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K3138
CPC分类号： A61F13/8405 , A61K31/12 , A61K31/335 , A61K31/381 , A61K31/407 , A61K31/60 , A61K31/655 , A61L15/46 , A61L2300/204 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/432 , A61L2300/45
摘要： The present invention relates to inhibiting the production of TSST-1 using absorbent products and non-absorbent products comprising an additive, as well as methods for inhibiting such production. The absorbent and non-absorbent products or articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate to substantially inhibit the production of TSST-1 or exoprotein by Gram positive bacteria.
摘要翻译：本发明涉及使用吸收性产品和包含添加剂的非吸收性产品抑制TSST-1的生产，以及抑制这种生产的方法。吸收剂和非吸收性产品或制品包括有效量的抑制性化合物，例如硫乳杆菌素或硫代苹果酸盐，以显着抑制革兰氏阳性菌产生TSST-1或外蛋白。

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