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11. 发明申请

US20110111108A1 COMPOSITIONS AND METHOD FOR ASSISTING SWALLOWING 审中-公开
标题翻译：组合物和辅助吞噬方法
公开(公告)号：US20110111108A1
公开(公告)日：2011-05-12
申请号：US12866715
申请日：2009-02-06
申请人： Duncan Craig , David J. Wright , Giovanna Mencarelli , Madeleine Rogerson
发明人： Duncan Craig , David J. Wright , Giovanna Mencarelli , Madeleine Rogerson
IPC分类号： A23P1/08
CPC分类号： A61K9/0056 , A61K9/06 , A61K47/38 , A61K47/42 , Y02A50/414
摘要： A method of assisting a subject to swallow an object such as a solid pharmaceutical dosage form comprises providing on the object an at least partial surface covering comprising a lubricating edible gel composition.
摘要翻译：辅助受试者吞咽诸如固体药物剂型的物体的方法包括在物体上提供包含润滑可食用凝胶组合物的至少部分表面覆盖物。

12. 发明授权

US08456327B2 Automatic vehicle equipment monitoring, warning, and control system 有权
标题翻译：自动车辆设备监控，报警和控制系统
公开(公告)号：US08456327B2
公开(公告)日：2013-06-04
申请号：US13034748
申请日：2011-02-25
申请人： Jon H. Bechtel , Jeremy C. Andrus , Gregory S. Bush , David J. Wright , Jim L. Schneider , Tom B. Sherman
发明人： Jon H. Bechtel , Jeremy C. Andrus , Gregory S. Bush , David J. Wright , Jim L. Schneider , Tom B. Sherman
IPC分类号： G08G1/017
CPC分类号： G06K9/2018 , B60R1/04 , B60R2001/1215 , B60R2001/1223 , B60R2001/1253 , B60R2001/1284 , B60W30/12 , B60W30/14 , G06K9/00798 , G06K9/00825 , G06K9/209 , G08G1/166
摘要： An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.
摘要翻译：提供了一种自动车辆设备控制系统及其方法，该系统包括至少一个成像器，被配置成获取高动态范围单帧图像的连续序列，处理器，包括多个滤色器的色谱滤波器阵列，至少其一部分是不同的颜色，并且成像器像素阵列的像素与基本上一个光谱滤色器光学通信，以及透镜，其中所述成像器被配置为捕获附近的即将到来的前大灯的不饱和图像和至少一个在高动态范围单帧图像的连续序列的一个图像帧中的漫射车道标记和远距离尾灯，并且被配置为检测所述公路标记和所述尾灯中的至少一个的系统，并且量化来自迎面而来的头灯从一个图像帧中的数据。

13. 发明申请

US20120050074A1 AUTOMATIC VEHICLE EQUIPMENT MONITORING, WARNING, AND CONTROL SYSTEM 有权
标题翻译：自动车辆设备监控，警告和控制系统
公开(公告)号：US20120050074A1
公开(公告)日：2012-03-01
申请号：US13034748
申请日：2011-02-25
申请人： Jon H. Bechtel , Jeremy C. Andrus , Gregory S. Bush , David J. Wright , Jim L. Schneider , Tom B. Sherman
发明人： Jon H. Bechtel , Jeremy C. Andrus , Gregory S. Bush , David J. Wright , Jim L. Schneider , Tom B. Sherman
IPC分类号： G08G1/123 , G06K9/00 , H04N7/18
CPC分类号： G06K9/2018 , B60R1/04 , B60R2001/1215 , B60R2001/1223 , B60R2001/1253 , B60R2001/1284 , B60W30/12 , B60W30/14 , G06K9/00798 , G06K9/00825 , G06K9/209 , G08G1/166
摘要： An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.
摘要翻译：提供了一种自动车辆设备控制系统及其方法，该系统包括至少一个成像器，被配置成获取高动态范围单帧图像的连续序列，处理器，包括多个滤色器的色谱滤波器阵列，至少其一部分是不同的颜色，并且成像器像素阵列的像素与基本上一个光谱滤色器光学通信，以及透镜，其中所述成像器被配置为捕获附近的即将到来的前大灯的不饱和图像和至少一个在高动态范围单帧图像的连续序列的一个图像帧中的漫射车道标记和远距离尾灯，并且被配置为检测所述公路标记和所述尾灯中的至少一个的系统，并且量化来自迎面而来的头灯从一个图像帧中的数据。

14. 发明授权

US07851593B2 Binding proteins as biosensors 有权
标题翻译：结合蛋白作为生物传感器
公开(公告)号：US07851593B2
公开(公告)日：2010-12-14
申请号：US10776643
申请日：2004-02-12
申请人： Helen Vivian Hsieh , J. Bruce Pitner , Terry J. Amiss , Colleen M. Nycz , Douglas B. Sherman , David J. Wright
发明人： Helen Vivian Hsieh , J. Bruce Pitner , Terry J. Amiss , Colleen M. Nycz , Douglas B. Sherman , David J. Wright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： G01N33/54373 , C07K14/245 , G01N33/543 , G01N33/5438 , G01N33/66
摘要： The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived therefrom, and their use as analyte biosensors both in vitro and in vivo.
摘要翻译：本发明涉及含有报告基团的突变结合蛋白的组合物，从其衍生的分析物生物传感器装置及其作为体外和体内分析物生物传感器的用途。

15. 发明授权

US07223536B2 Methods for detecting single nucleotide polymorphisms 失效
标题翻译：检测单核苷酸多态性的方法
公开(公告)号：US07223536B2
公开(公告)日：2007-05-29
申请号：US09778168
申请日：2001-02-07
申请人： David J. Wright , Maria A. Milla , James G. Nadeau , G. Terrance Walker
发明人： David J. Wright , Maria A. Milla , James G. Nadeau , G. Terrance Walker
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2565/1025 , C12Q2535/125 , C12Q2531/119 , C12Q2531/101
摘要： The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3′ end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3′ end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target. The methods are particularly well suited for detecting and identifying single nucleotide differences between a target sequence of interest (e.g., a mutant allele of a gene) and a second nucleic acid sequence (e.g., a wild type allele for the same gene).
摘要翻译：本发明提供使用检测器引物检测和鉴定感兴趣的核酸序列中的序列变异的方法。已经发现，当引物的3'端没有与靶完全杂交时，通过DNA聚合酶的引物延伸的效率降低可以适用于区分或鉴定靶中的核苷酸的手段发现检测器引物与靶标之间的诊断不匹配的位置。检测引物与感兴趣的序列杂交，并用聚合酶扩增。检测器引物延伸的效率被检测为目标中序列变异的存在和/或身份的指示。本发明的方法利用在检测器引物的3'末端附近或其附近的核苷酸错配来区分目的核苷酸序列和可能发生在靶的相同位点的第二核苷酸序列。所述方法特别适用于检测和鉴定靶标目标序列（例如，基因的突变等位基因）和第二核酸序列（例如，相同基因的野生型等位基因）之间的单核苷酸差异。

16. 发明授权

US06855556B2 Binding protein as biosensors 失效
标题翻译：结合蛋白作为生物传感器
公开(公告)号：US06855556B2
公开(公告)日：2005-02-15
申请号：US10040077
申请日：2002-01-04
申请人： Terry J. Amiss , Colleen M. Nycz , J. Bruce Pitner , Douglas B. Sherman , David J. Wright
发明人： Terry J. Amiss , Colleen M. Nycz , J. Bruce Pitner , Douglas B. Sherman , David J. Wright
IPC分类号： G01N33/53 , C07K14/245 , G01N21/78 , G01N33/543 , G01N33/566 , G01N33/58 , G01N33/48
CPC分类号： G01N33/5438 , C07K14/245 , Y10S435/817 , Y10T436/144444
摘要： The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and in vivo.
摘要翻译：本发明涉及含有报道基团的突变结合蛋白的组合物，从其衍生的分析物生物传感器装置，以及它们在体外和体内作为分析物生物传感器的用途。

17. 发明授权

US5811269A Detection of mycobacteria by multiplex nucleic acid amplification 失效
标题翻译：通过多重核酸扩增检测分枝杆菌
公开(公告)号：US5811269A
公开(公告)日：1998-09-22
申请号：US640378
申请日：1996-04-30
申请人： James G. Nadeau , Cheryl H. Dean , James L. Schram , Deborah R. Howard , Margaret S. Dey , David J. Wright
发明人： James G. Nadeau , Cheryl H. Dean , James L. Schram , Deborah R. Howard , Margaret S. Dey , David J. Wright
IPC分类号： C12N15/09 , C07H21/04 , C12Q1/04 , C12Q1/68 , C12R1/32 , C12R1/325 , C12R1/33 , C12P19/34
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Primers and methods for adapter-mediated multiplex amplification of the IS6110 insertion element of the Mycobacterium tuberculosis (M.tb) complex and a 16S rDNA target common to essentially all mycobacteria are described. In certain embodiments, the primers are optimized for efficient multiplex amplification in thermophilic SDA. The multiplex Strand Displacement Amplification methods of the invention are capable, in a single amplification reaction, of simultaneously identifying M. tuberculosis and providing a screen for substantially all of the clinically relevant species of mycobacteria. Also disclosed are internal control sequences designed for coamplification with the two targets, allowing assessment of amplification efficiency and/or quantitation of the targets.
摘要翻译：描述了针对结核分枝杆菌（M.tb）复合物的IS6110插入元件和基本上所有分枝杆菌共同的16S rDNA靶的衔接子介导的多重扩增的引物和方法。在某些实施方案中，针对嗜热SDA中的有效多重扩增优化引物。本发明的多重链位移扩增方法能够在单个扩增反应中同时鉴定结核分枝杆菌并提供基本上所有临床相关分枝杆菌物种的筛选。还公开了设计用于与两个靶标共扩增的内部控制序列，允许评估靶标的扩增效率和/或定量。

18. 发明授权

US5626739A Electrokinetic leaching 失效
标题翻译：电动浸出
公开(公告)号：US5626739A
公开(公告)日：1997-05-06
申请号：US360781
申请日：1995-02-27
申请人： Colin J. Burns , David J. Wright
发明人： Colin J. Burns , David J. Wright
IPC分类号： B01D43/00 , C22B3/04 , C22B3/22 , C22B11/08 , C25C1/00
CPC分类号： B01D43/00 , C22B11/04 , C22B11/08 , C22B3/045 , Y02P10/234
摘要： A method of treating a solid material containing a substance of economic importance so as to recover or extract the substance from the material involving the following: forming a conducting mixture of the solid with a liquid so that at least some of the substance of economic importance is dissolved in the liquid, applying an electrical potential difference between at least two electrodes in contact with the mixture at spaced apart locations so as to impart opposite charges to the respective electrodes thereby attracting the liquid containing the dissolved substance to one of the electrodes, removing the liquid from an area surrounding or from a vicinity of the one electrode, and treating the liquid containing the substance of economic importance so as to recover or extract the substance. The liquid used is at least partially conducting. The present method is particularly useful for extracting or recovering gold from gold-containing or gold bearing ores.
摘要翻译： PCT No.PCT / AU93 / 00318 Sec。 371日期：1995年2月27日 102（e）日期1995年2月27日PCT提交1993年6月29日PCT公布。出版物WO94 / 00608 日期1994年1月6日一种处理含有经济重要物质的固体材料的方法，以便从涉及以下物质的物质中回收或提取物质：形成固体与液体的导电混合物，使得至少一些具有经济重要性的物质溶解在液体中，在间隔开的位置处在与混合物接触的至少两个电极之间施加电位差，从而对各个电极赋予相反的电荷，从而将含有溶解物质的液体吸引到电极，从一个电极周围或附近的区域除去液体，以及处理含有经济重要物质的液体，以回收或提取物质。使用的液体至少部分导电。本方法特别适用于从含金或含金矿石中提取或回收金。

19. 发明授权

US5564826A Reciprocating bath shaker 失效
标题翻译：往复式摇床
公开(公告)号：US5564826A
公开(公告)日：1996-10-15
申请号：US534578
申请日：1995-09-27
申请人： Hans D. Neumann , Arthur J. Robbins , David J. Wright
发明人： Hans D. Neumann , Arthur J. Robbins , David J. Wright
IPC分类号： B01F11/00 , B01L7/02
CPC分类号： B01F11/0014 , B01L7/02
摘要： A bath shaker (10) is provided for agitating liquid baths. The bath shaker (10) incorporates a "flexible parallelogram" mode of movement wherein a bath shelf (20) is attached to and supported by two, parallel opposing flexible arms (112). Present on each flexible arm (112) is a first attachment portion (124) sandwichedly held by an upright extension (120) and a first hold plate (110), the arrangement causing the first attachment portion (124) to serve as a flexible hinge. A drive mechanism (16) produces a reciprocating action of the bath shelf (20) through the use of an eccentric (80) and a pivoting lever (46) attached to both the eccentric (80) and the bath shelf (20). The flexible parallelogram arrangement defines the reciprocating motion to be substantially rectilinear and makes for an entirely noiseless mode of travel, while producing an extremely smooth transition between reciprocations. Two bath containers (24) are supported by the bath shelf (20) and are provided with a highly accurate temperature control system (26).
摘要翻译：提供用于搅拌液浴的洗浴摇床（10）。洗浴摇床（10）包含“柔性平行四边形”运动模式，其中浴架（20）附接到两个平行的相对的柔性臂（112）并由其支撑。存在于每个柔性臂（112）上的是由直立延伸部（120）和第一保持板（110）夹持的第一附接部分（124），该第一连接部分使得第一附接部分（124）用作柔性铰链。驱动机构（16）通过使用连接到偏心轮（80）和浴架（20）两者的偏心轮（80）和枢转杆（46）来产生浴架（20）的往复运动。柔性平行四边形布置将往复运动定义为基本上直线的，并且使得完全无噪声的行进模式，同时在往复运动之间产生非常平滑的过渡。两个洗浴容器（24）由浴架（20）支撑，并设置有高精度的温度控制系统（26）。

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