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11. 发明授权

US07175719B2 Extruded aluminum alloy which excels in machinability, caulking properties, and wear resistance 有权
公开(公告)号：US07175719B2
公开(公告)日：2007-02-13
申请号：US11121150
申请日：2005-05-03
申请人： Nobuyuki Higashi , Kinji Hashimoto
发明人： Nobuyuki Higashi , Kinji Hashimoto
IPC分类号： C22C21/02
CPC分类号： C22F1/043 , C22C21/02
摘要： Extruded aluminum alloy which excels in machinability, caulking properties, and wear resistance, the extruded aluminum alloy including 3.0 to 6.0 mass % of Si, 0.1 to 0.45 mass % of Mg, 0.01 to 0.5 mass % of Cu, 0.01 to 0.5 mass % of Mn, and 0.40 to 0.90 mass % of Fe, with the balance being Al and unavoidable impurities.

12. 发明申请

US20060189500A1 Aqueous olanexidine solution, method of preparing the same, and disinfectant 有权
标题翻译：奥兰西汀水溶液，其制备方法和消毒剂
公开(公告)号：US20060189500A1
公开(公告)日：2006-08-24
申请号：US10557736
申请日：2004-05-25
申请人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
发明人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
IPC分类号： C11D3/48
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.
摘要翻译：本发明提供一种消毒剂，其含有浓度足以显示出有效杀菌作用的奥拉西丁，并且几乎没有任何副作用，例如皮肤刺激。具体而言，本发明提供一种含有含有奥拉西丁和至少等摩尔量葡萄糖酸的水溶液的消毒剂，除了葡萄糖酸以外，基本上既不含葡萄糖酸以外的酸也不含有酸。

13. 发明授权

US5707997A Pyrazolo�1,5-a!pyrimidine derivative 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物
公开(公告)号：US5707997A
公开(公告)日：1998-01-13
申请号：US602824
申请日：1996-02-21
申请人： Yasuo Shoji , Makoto Inoue , Takashi Okamura , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
发明人： Yasuo Shoji , Makoto Inoue , Takashi Okamura , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
IPC分类号： C07D487/04 , A61K31/505 , C07D403/02
CPC分类号： C07D487/04
摘要： The invention provides a pyrazolo�1,5-a!pyrimidine derivative of the following formula (1): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Q, A and n are defined in the description; and R.sup.2 is naphthyl, cycloalkyl, furyl, thienyl, optionally halogen-substituted pyridyl, optionally halogen-substituted phenoxy, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro, halogen-substituted lower alkyl, halogen-substituted lower alkoxy, lower alkoxycarbonyl, hydroxyl, phenyl(lower)alkoxy, amino, cyano, lower alkanoyloxy, phenyl and di(lower)alkoxyphos-phoryl(lower)alkyl. This derivative is useful as a potent analgesic.
摘要翻译： PCT No.PCT / JP95 / 01104 Sec。 371日期1996年2月21日 102（e）日期1996年2月21日PCT提交1995年6月5日PCT公布。出版物WO95 / 35298 日期：1995年12月28日本发明提供下述通式（1）的吡唑并[1,5-a]嘧啶衍生物：d n在说明书中定义; R 2为萘基，环烷基，呋喃基，噻吩基，任选卤素取代的吡啶基，任选卤素取代的苯氧基，或可具有1至3个选自低级烷基，低级烷氧基，卤素，硝基，取代的低级烷基，卤素取代的低级烷氧基，低级烷氧基羰基，羟基，苯基（低级）烷氧基，氨基，氰基，低级烷酰氧基，苯基和二（低级）烷氧基磷酰基（低级）烷基。该衍生物作为有效的止痛剂是有用的。

14. 发明授权

US5688949A Pyrazolo�1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same 失效
标题翻译：吡唑并[1,5-A]嘧啶衍生物和含有它们的抗炎剂
公开(公告)号：US5688949A
公开(公告)日：1997-11-18
申请号：US133086
申请日：1993-10-07
申请人： Makoto Inoue , Kinji Hashimoto , Toshiko Kuwahara , Yukio Sugimoto , Takuji Uesako , Toshiaki Funato
发明人： Makoto Inoue , Kinji Hashimoto , Toshiko Kuwahara , Yukio Sugimoto , Takuji Uesako , Toshiaki Funato
IPC分类号： A61K31/505 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： Pyrazolo�1,5-a!pyrimidine derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H, carboxyl, lower alkoxy-carbonyl, phenyl, lower alkyl optionally having a substituent selected from OH, carboxyl and lower alkoxy-carbonyl, or cycloalkyl, or R.sub.1 and R.sub.2 may combine each other to form lower alkylene; R.sub.5 is group of --SR.sub.6 or group of --NR.sub.7 R.sub.8 in which R.sub.6 is pyridyl or phenyl optionally having 1 to 3 substituents selected from OH and lower alkyl; and R.sub.7 and R.sub.8 are H, phenyl optionally having 1 to 3 substituents selected from OH, lower alkyl, lower alkoxycarbonyl and carboxyl, or R.sub.7 and R.sub.8 may combine each other to form with a nitrogen atom with which they bond 1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, or 1-piperazinyl group substituted by a phenyl group optionally being substituted by halogen or trihalomethyl, hydroxy-lower alkyl or diphenyl-lower alkyl, or a salt thereof, and anti-inflammatory agent containing as active ingredient compound of the above formula, wherein R.sub.1, R.sub.3 and R.sub.4 are H, R.sub.2 is lower alkyl or cycloalkyl, R.sub.5 is group of --NR.sub.7 R.sub.8 (R.sub.7 is H, R.sub.8 is phenyl substituted by OH and two lower alkyl).
摘要翻译： PCT No.PCT / JP91 / 01043 Sec。 371日期：1993年10月7日 102（e）日期1993年10月7日PCT 1991年8月6日PCT PCT。出版物WO92 / 18504 日期：1992年10月29日具有下式的吡唑并[1,5-a]嘧啶衍生物：其中R1，R2，R3和R4是H，羧基，低级烷氧基 - 羰基，苯基，任选具有选自 OH，羧基和低级烷氧基 - 羰基或环烷基，或者R 1和R 2可以相互结合形成低级亚烷基; R5是-SR6或-NR7R8基团的基团，其中R6是吡啶基或任选具有1至3个选自OH和低级烷基的取代基的苯基; 并且R 7和R 8是H，任选具有1至3个选自OH，低级烷基，低级烷氧基羰基和羧基的取代基的苯基，或者R 7和R 8可以彼此结合形成氮原子，与它们键合1-吡咯烷基，被卤素或三卤代甲基，羟基 - 低级烷基或二苯基 - 低级烷基或其盐任选取代的苯基取代的1-氧代-1-吡咯烷基或1-哌嗪基，以及含有作为活性成分的化合物的抗炎剂其中R1，R3和R4是H，R2是低级烷基或环烷基，R5是-NR7R8基团（R7是H，R8是被OH取代的苯基和两个低级烷基）。

15. 发明申请

US20100331423A1 AQUEOUS SOLUTION OF OLANEXIDINE, METHOD OF PREPARING THE AQUEOUS SOLUTION, AND DISINFECTANT 有权
标题翻译：奥兰西汀的水溶液，制备水溶液的方法和消毒剂
公开(公告)号：US20100331423A1
公开(公告)日：2010-12-30
申请号：US12879467
申请日：2010-09-10
申请人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
发明人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
IPC分类号： A01N37/52 , A01P15/00
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.
摘要翻译：本发明提供一种消毒剂，其含有浓度足以显示出有效杀菌作用的奥拉西丁，并且几乎没有任何副作用，例如皮肤刺激。具体而言，本发明提供一种含有含有奥拉西丁和至少等摩尔量葡萄糖酸的水溶液的消毒剂，除了葡萄糖酸以外，基本上既不含葡萄糖酸以外的酸也不含有酸。

16. 发明授权

US07829518B2 Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant 有权
公开(公告)号：US07829518B2
公开(公告)日：2010-11-09
申请号：US10557736
申请日：2004-05-25
申请人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
发明人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
IPC分类号： C11D7/26 , C11D7/32 , C11D7/50
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

17. 发明授权

US5985882A Pyrazolo[1,5-a]pyrimidine derivatives 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物
公开(公告)号：US5985882A
公开(公告)日：1999-11-16
申请号：US930974
申请日：1997-10-10
申请人： Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
发明人： Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
IPC分类号： C07D487/04 , A61K31/505 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention provides pyrazolo[1,5-a]pyrimidine derivatives which are useful as potent analgesics and represented by the formula ##STR1## wherein R.sup.1 is lower alkenyl, hydroxy(lower)alkyl, (lower)alkylthio(lower)alkyl, (lower)alkanoyloxy(lower)alkyl, (lower)alkoxy(lower)alkyl, furyl or thienyl, R.sup.2 is pyridyl, 1-oxide-pyridyl, lower alkyl-substituted pyrazinyl, lower alkyl-substituted pyrimidinyl, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy and halogen, R.sup.3 is hydrogen or halogen, and A is a single bond or lower alkylene.
摘要翻译： PCT No.PCT / JP96 / 00955 Sec。 371日期：1997年10月10日 102（e）1997年10月10日PCT PCT 1996年4月5日PCT公布。公开号WO96 / 32394 日期：1996年10月17日本发明提供了吡唑并[1,5-a]嘧啶衍生物，其可用作强力止痛剂并由下式表示：其中R1为低级烯基，羟基（低级）烷基，（低级）烷硫基（低级）烷基，（低级）烷酰氧基（低级）烷基，（低级）烷氧基（低级）烷基，呋喃基或噻吩基，R2是吡啶基，1-氧化物 - 吡啶基，低级烷基取代的吡嗪基，低级烷基取代的嘧啶基或苯基，至3个选自低级烷基，低级烷氧基和卤素的取代基，R3为氢或卤素，A为单键或低级亚烷基。

18. 发明授权

US5608398A Differential coding method and an apparatus therefor 失效
标题翻译：差分编码方法及其装置
公开(公告)号：US5608398A
公开(公告)日：1997-03-04
申请号：US183654
申请日：1994-01-19
申请人： Kinji Hashimoto , Masakazu Nishino , Tatsuro Juri , Takumi Hasebe
发明人： Kinji Hashimoto , Masakazu Nishino , Tatsuro Juri , Takumi Hasebe
IPC分类号： H04N19/50 , G06T9/00 , H03M7/42 , H04N19/42 , H04N19/423 , H04N19/426 , H04N19/46 , H04N19/463 , H04N19/517 , H04N19/52 , H04N19/70 , H04N19/85 , H01M6/00 , H04N7/32
CPC分类号： H03M7/42 , H04N19/593 , H04N19/13 , H04N19/60 , H04N19/91
摘要： The differential coding apparatus comprises a delay unit for storing an adjacent value, a transmission value conversion unit for assigning a transmission value to a value of difference between the value to be coded and the adjacent value in the ascending order of the absolute value of the difference value, and a variable-length coding device for assigning a code in the order that the code is increasing in code length as the transmission value increases in number. In the range in which positive and negative difference values exist, positive and negative numbers are alternately given to difference values in the order in which the difference value is increasing in distance from a center difference value of 0. In the range in which either positive or negative difference value exists, serial numbers are successively given to difference values in the order in which the difference value is increasing in distance from the difference value of 0. Then codes are assigned in the order of their increasing in code length to the difference values in the order of the given numbers of transmission values.
摘要翻译：差分编码装置包括用于存储相邻值的延迟单元，发送值转换单元，用于将发送值分配为要被编码的值与相邻值之间的差的值，该差值以差异的绝对值的升序值，以及可变长度编码装置，用于按照传输值增加的代码在代码长度上增加的顺序分配代码。在存在正和负差值的范围内，正数和负数交替地以差分值与中心差值0之间的距离增加的顺序给出。在正值或正数的范围内存在负差值，序列号按差值从差值0开始的顺序依次给出差分值。然后，代码按代码长度增加的顺序分配给差值给定数量的传输值的顺序。

19. 发明授权

US5420128A Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor 失效
公开(公告)号：US5420128A
公开(公告)日：1995-05-30
申请号：US854619
申请日：1992-06-09
申请人： Hiroshi Kiyokawa , Satoshi Yamada , Keisuke Miyajima , Kinji Hashimoto , Masatoshi Inai , Makoto Inoue , Kunihiko Tatsumi , Takeshi Yamauchi , Kazunobu Kurisu , Yoshifumi Chone
发明人： Hiroshi Kiyokawa , Satoshi Yamada , Keisuke Miyajima , Kinji Hashimoto , Masatoshi Inai , Makoto Inoue , Kunihiko Tatsumi , Takeshi Yamauchi , Kazunobu Kurisu , Yoshifumi Chone
IPC分类号： C07D487/04 , A61K31/53 , A61K31/505 , C07D231/38
CPC分类号： C07D487/04
摘要： The invention discloses a pyrimidien derivative expressed in Formula [I]: ##STR1## where R.sup.1 denotes a hydrogen atom or hydroxyl group, R.sup.2 denotes a hydrogen atom, lower alkoxycarbonyl group, lower alkoxy group, halogen atom, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, lower alkoxycarbonyl lower alkyl group, carboxyl group, carboxy lower alkyl group, group: --CONHR.sup.6 (R.sup.6 represents a hydrogen atom, a phenyl group, which may possess halogen atom, or lower alkyl group), cyano group, phenyl group which may possess a group selected from the group consisting of hydroxyl group, halogen atom, lower alkyl group, lower alkoxy group and phenylthio group as a substituent, phenyl lower alkyl group which may possess a group selected from the group consisting of hydroxyl group and lower alkoxy group as a substituent on a phenyl ring, lower alkanoyloxy lower alkyl group, benzoyl group, lower alkanoyl group which may possess a halogen atom, or hydroxy lower alkyl group which may possess a group selected from the group consisting of phenyl group and halogen atom as a substituent, R.sup.3 denotes a hydrogen atom, hydroxyl group, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, halogen lower alkyl group, or phenyl group, R.sup.4 denotes a hydrogen atom, lower alkyl group, or lower alkoxy group, and R.sup.5 denotes a hydrogen atom, lower alkyl group, lower alkoxy lower alkyl group, or halogen lower alkyl group; provided that R.sup.2 and R.sup.3 may be bonded to each other to form a lower alkylene group with 3 to 5 carbon atoms, or its pharmaceutically available salt. This derivative is excellent in therapeutic effects of benign prostatic hypertrophy, prostatic carcinoma, female hairiness, male baldness or pimple as an androgen inhibitor.

20. 发明申请

US20070107812A1 Extruded aluminum alloy which excels in machinability, caulking properties, and wear resistance 有权
标题翻译：挤出铝合金，其切削性，铆接性和耐磨性优异
公开(公告)号：US20070107812A1
公开(公告)日：2007-05-17
申请号：US11651841
申请日：2007-01-10
申请人： Nobuyuki Higashi , Kinji Hashimoto
发明人： Nobuyuki Higashi , Kinji Hashimoto
IPC分类号： C22C21/02
CPC分类号： C22F1/043 , C22C21/02
摘要： Extruded aluminum alloy which excels in machinability, caulking properties, and wear resistance, the extruded aluminum alloy including 3.0 to 6.0 mass % of Si, 0.1 to 0.45 mass % of Mg, 0.01 to 0.5 mass % of Cu, 0.01 to 0.5 mass % of Mn, and 0.40 to 0.90 mass % of Fe, with the balance being Al and unavoidable impurities.
摘要翻译：挤出铝合金，其具有3.0质量％〜6.0质量％的Si，0.1〜0.45质量％的Mg，0.01〜0.5质量％的Cu，0.01〜0.5质量％的Cu，0.01〜0.5质量％的Cu， Mn和0.40〜0.90质量％的Fe，余量为Al和不可避免的杂质。

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