专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20090275137A1 HIGH AFFINITY TCR PROTEINS AND METHODS 审中-公开
标题翻译：高亲和力TCR蛋白和方法
公开(公告)号：US20090275137A1
公开(公告)日：2009-11-05
申请号：US12494458
申请日：2009-06-30
申请人： David M. Kranz , K. Dane Wittrup , Phillip D. Holler
发明人： David M. Kranz , K. Dane Wittrup , Phillip D. Holler
IPC分类号： C12N15/09 , C12N5/08 , C07H21/04
CPC分类号： C07K14/7051 , C12N5/0636 , C12N15/1037 , C12N2510/00 , C40B40/02 , G01N33/56972 , G01N33/68 , G01N33/6842 , G01N33/6854 , G01N2333/39 , G01N2333/7051
摘要： T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T cell receptor mutant coding sequence into yeast cells; inducing expression of the T cell receptor mutant coding sequence on the surface of yeast cells; and selecting those cells expressing T cell receptor mutants that have higher affinity for the peptide/MHC ligand than the wild type T cell receptor protein. The high affinity TCRs can be used in place of an antibody or single chain antibody.
摘要翻译：提供了比野生型TCR对配体具有更高亲和力的T细胞受体（TCRS）。通过诱变T细胞受体蛋白质编码序列产生T细胞受体蛋白编码序列突变体的杂色群体，形成这些高亲和性TCR。将T细胞受体突变体编码序列转化为酵母细胞; 在酵母细胞表面诱导T细胞受体突变体编码序列的表达; 并选择那些表达与野生型T细胞受体蛋白相比对肽/ MHC配体具有更高亲和力的T细胞受体突变体的细胞。高亲和性TCR可用于代替抗体或单链抗体。

12. 发明申请

US20100322937A1 EGF receptor epitope peptides and uses thereof 有权
标题翻译： EGF受体表位肽及其用途
公开(公告)号：US20100322937A1
公开(公告)日：2010-12-23
申请号：US12657919
申请日：2010-01-29
申请人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
发明人： Terrance Grant Johns , Andrew Mark Scott , Antony Wilks Burgess , Lloyd J. Old , Timothy E. Adams , K. Dane Wittrup , Ginger Chao , Peter Anthony Hoyne
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K14/71 , A61K39/00
摘要： The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
摘要翻译：本发明一般涉及生长因子受体表位肽，特别是EGF家族受体表位肽。本发明还涉及受体肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。本发明还涉及特异性针对受体肽的抗体。还提供了产生免疫应答和治疗肿瘤和癌症的方法。

13. 发明申请

US20090012267A1 ANTI-HYDROXYLASE ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗羟基酶抗体及其用途
公开(公告)号：US20090012267A1
公开(公告)日：2009-01-08
申请号：US12055108
申请日：2008-03-25
申请人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
发明人： K. Dane Wittrup , Jack R. Wands , Yik Andy Yeung
IPC分类号： C07K16/18
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , G01N33/57407 , G01N2500/00
摘要： Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) β-hydroxylase are provided. The anti-aspartyl (asparaginyl) β-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) β-hydroxylase.
摘要翻译：提供了天冬氨酰（天冬酰胺酰基）β-羟化酶的抗体或其抗原结合部分。抗天冬氨酰基（天冬酰胺酰基）β-羟化酶抗体或其抗原结合部分可调节天冬氨酰（天冬酰胺酰基）β-羟化酶的活性。

14. 发明授权

US08247531B2 Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor 有权
标题翻译：突变表皮生长因子多肽，核酸及其用途
公开(公告)号：US08247531B2
公开(公告)日：2012-08-21
申请号：US11725695
申请日：2007-03-20
申请人： Jennifer R. Cochran , K. Dane Wittrup
发明人： Jennifer R. Cochran , K. Dane Wittrup
IPC分类号： C07K14/485 , A61K38/18
CPC分类号： C07K14/485 , A61K38/00
摘要： The present invention is based, in part, on our discovery that EGF can be engineered to generate mutants that bind to the EGF receptor (EGFR) of a cell and that have a desirable effect on the activity of the cell. For example, the mutants can agonize the receptor (i.e., increase a biological activity of the receptor), or antagonize the receptor (i.e., decrease or inhibit a biological activity of the receptor). In turn, the rate at which the cell proliferates, for example, can be changed. Moreover, some of these mutants bind EGFR with a higher affinity than wild-type EGF exhibits. The affinity may increase by about, for example, 2-, 5-, 10-, 15-, 20-, 25-, 30-, 50-, or 100-fold relative to wild-type EGF.
摘要翻译：本发明部分基于我们的发现，EGF可以被工程化以产生结合细胞的EGF受体（EGFR）的突变体，并且对细胞的活性具有期望的作用。例如，突变体可以激动受体（即，增加受体的生物活性）或拮抗受体（即降低或抑制受体的生物活性）。反过来，细胞增殖的速度例如可以改变。此外，这些突变体中的一些以比野生型EGF显示更高的亲和力结合EGFR。相对于野生型EGF，亲和力可以增加约例如2-，5-，10-，15-，20-，25-，30-，50-或100倍。

15. 发明申请

US20090311803A1 Treatment Of Tumors Expressing Mutant EGF Receptors 审中-公开
标题翻译：治疗表达突变型EGF受体的肿瘤
公开(公告)号：US20090311803A1
公开(公告)日：2009-12-17
申请号：US12544495
申请日：2009-08-20
申请人： Jeffrey C. Way , Ginger Chao , Catherine Cresson , Douglas Lauffenburger , K. Dane Wittrup
发明人： Jeffrey C. Way , Ginger Chao , Catherine Cresson , Douglas Lauffenburger , K. Dane Wittrup
IPC分类号： G01N33/566
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/34 , C07K2317/567 , C07K2317/77
摘要： The invention discloses methods for identifying antibodies that reduce or prevent signaling by intact epidermal growth factor receptor (EGFR), or mutant EGFRs, such as EGFRvIII.
摘要翻译：本发明公开了用于鉴定减少或预防完整表皮生长因子受体（EGFR）或突变EGFR（如EGFRvIII）的信号传导的抗体的方法。

16. 发明授权

US07626011B2 Antibodies against tumor surface antigens 有权
标题翻译：针对肿瘤表面抗原的抗体
公开(公告)号：US07626011B2
公开(公告)日：2009-12-01
申请号：US11802989
申请日：2007-05-29
申请人： Richard J. H. Begent , Kerry Ann Chester , Christilyn P. Graff , K. Dane Wittrup
发明人： Richard J. H. Begent , Kerry Ann Chester , Christilyn P. Graff , K. Dane Wittrup
IPC分类号： C07H21/04
CPC分类号： C07K16/3007 , A61K2039/505 , C07K16/00 , C07K16/005 , C07K2317/24 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity antibodies against carcinoembryonic antigen (CEA), especially the antibody we have termed sm3E, which is derived from the scFv antibody MFE-23. Such antibodies have the potential for improved therapeutic efficacy.
摘要翻译：本发明涉及抗肿瘤表面抗原的改进抗体及其在治疗肿瘤中的用途。特别令人感兴趣的是高度稳定的，人源化的，高亲和力的针对癌胚抗原（CEA）的抗体，特别是源自scFv抗体MFE-23的称为sm3E的抗体。这样的抗体具有改善治疗功效的潜力。

17. 发明授权

US07569215B2 Mutant interleukin-2 (IL-2) polypeptides 有权
标题翻译：突变型白细胞介素-2（IL-2）多肽
公开(公告)号：US07569215B2
公开(公告)日：2009-08-04
申请号：US10894833
申请日：2004-07-19
申请人： K. Dane Wittrup , Balaji M. Rao , Douglas A. Lauffenburger
发明人： K. Dane Wittrup , Balaji M. Rao , Douglas A. Lauffenburger
IPC分类号： C07K14/55 , A61K38/20
CPC分类号： C07K14/55 , A61K38/00 , G01N33/6869 , G01N2333/55 , G01N2500/04
摘要： The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.
摘要翻译：本发明涉及对IL-2α受体亚单位（IL-2Rα）具有增加的亲和力的IL-2突变体。因此，本发明包括具有改善的生物效能的IL-2突变体。本发明还包括用于使用酵母表面显示产生IL-2α的定向进化以产生具有增加的对IL-2Rα的亲和力的突变体的方法。

18. 发明申请

US20090181855A1 Rationally Designed, Synthetic Antibody Libraries and Uses Therefor 有权
标题翻译：合理设计的合成抗体库及其用途
公开(公告)号：US20090181855A1
公开(公告)日：2009-07-16
申请号：US12210072
申请日：2008-09-12
申请人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
发明人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
IPC分类号： C40B30/04 , C40B40/08 , C07K16/18 , C40B40/10 , C40B40/02 , C40B50/06
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译：本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。

19. 发明申请

US20090137784A1 Epidermal Growth Factor Receptor Polypeptides and Antibodies 审中-公开
标题翻译：表皮生长因子受体多肽和抗体
公开(公告)号：US20090137784A1
公开(公告)日：2009-05-28
申请号：US12353225
申请日：2009-01-13
申请人： Ginger Chao , Mark Olsen , Alejandro Wolf-Yadlin , K. Dane Wittrup , Douglas A. Lauffenburger
发明人： Ginger Chao , Mark Olsen , Alejandro Wolf-Yadlin , K. Dane Wittrup , Douglas A. Lauffenburger
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , A61K38/00 , C07K14/71 , C07K2317/21 , C07K2317/34 , C07K2317/622 , G01N2333/71
摘要： Antibodies and polypeptides that bind to and/or modulate the activity of receptors in the epidermal growth factor family are provided herein.
摘要翻译：本文提供结合和/或调节表皮生长因子家族中受体活性的抗体和多肽。

20. 发明授权

US08877688B2 Rationally designed, synthetic antibody libraries and uses therefor 有权
标题翻译：合理设计的合成抗体文库及其用途
公开(公告)号：US08877688B2
公开(公告)日：2014-11-04
申请号：US12404059
申请日：2009-03-13
申请人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
发明人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
IPC分类号： C40B40/08
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译：本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库，具有或不具有衍生自其他物种的DH区段，并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式