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11. 发明申请

US20090170787A1 COSMETIC COMPOSITION CONTAINING HYDROLYSATES OF ICARIIN 有权
标题翻译：含有ICARIIN水解物的化妆品组合物
公开(公告)号：US20090170787A1
公开(公告)日：2009-07-02
申请号：US12095654
申请日：2006-10-30
申请人： Jun Seong Park , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang
发明人： Jun Seong Park , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang
IPC分类号： A61K8/60 , A61Q19/08
CPC分类号： A61K8/498 , A61K8/602 , A61K2800/522 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to a cosmetic composition containing hydrolysates of icariin, and more particularly, a cosmetic composition containing hydrolysates of icariin including icaritin, icariside I and icariside II. The hydrolysates of icariin is prepared by a method comprising the steps of: (a) obtaining an extract from a plant containing icariin using water or an organic solvent; and (b) hydrolyzing the plant extract with an acid, a base, an enzyme or a microorganism producing the enzyme. The cosmetic composition according to the present invention is employed for anti-oxidant, anti-aging, whitening or anti-wrinkling effects.
摘要翻译：本发明涉及含有淫羊藿苷的水解物的化妆品组合物，更具体地说，涉及包含淫羊藿苷，吡螨苷I和鸢尾苷II的淫羊藿苷的水解物的化妆品组合物。淫羊The苷的水解物是通过包括以下步骤的方法制备的：（a）使用水或有机溶剂从含有淫羊藿苷的植物中获得提取物; 和（b）用产生该酶的酸，碱，酶或微生物水解植物提取物。根据本发明的化妆品组合物用于抗氧化，抗衰老，增白或起皱作用。

12. 发明授权

US07943599B2 Sesamol derivatives or their salts, the process for preparing the same, and the skin external composition containing the same 有权
标题翻译：芝麻酚衍生物或其盐，其制备方法以及含有它们的皮肤外用组合物
公开(公告)号：US07943599B2
公开(公告)日：2011-05-17
申请号：US11921180
申请日：2006-05-29
申请人： Jae Won You , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang , Ok Sub Lee
发明人： Jae Won You , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang , Ok Sub Lee
IPC分类号： A61K31/66 , C07F9/12
CPC分类号： A61K8/55 , A61K2800/522 , A61Q19/08 , C07F9/65517
摘要： The present invention relates to a sesamol derivative or its salt, and a skin external composition containing the same. More particularly, the invention relates to a sesamol derivative or its salt, which consists of sesamol and 3-aminopropane phosphoric acid, linked with each other by a phosphoric acid diester bond, and can be degraded into sesamol and 3-aminopropane phosphoric acid by enzymes present on the skin so as to simultaneously show the physiological activities of sesamol and 3-aminopropane phosphoric acid, as well as a preparation method thereof and a skin external composition containing the same.
摘要翻译：本发明涉及一种芝麻酚衍生物或其盐，以及包含其的皮肤外用组合物。更具体地，本发明涉及由芝麻酚和3-氨基丙烷磷酸组成的芝麻酚衍生物或其盐，其通过磷酸二酯键彼此连接，并且可以通过酶降解成芝麻酚和3-氨基丙烷磷酸存在于皮肤上，以同时显示西沙莫酚和3-氨基丙烷磷酸的生理活性，以及其制备方法和含有它们的皮肤外用组合物。

13. 发明申请

US20080280989A1 Hydroxybenzamide Derivatives, the Method For Preparing Thereof and the Cosmetic Composition Containing the Same 审中-公开
标题翻译：羟基苯甲酰胺衍生物，其制备方法和含有其的化妆品组合物
公开(公告)号：US20080280989A1
公开(公告)日：2008-11-13
申请号：US11990223
申请日：2006-03-20
申请人： Sung Joong Kim , Heung Soo Baek , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang , Ok Sub Lee , Hong Ju Shin , Woo Ram Park
发明人： Sung Joong Kim , Heung Soo Baek , Ho Sik Rho , Duck Hee Kim , Ih Seop Chang , Ok Sub Lee , Hong Ju Shin , Woo Ram Park
IPC分类号： A61K31/165 , C07C233/07 , A61P17/00
CPC分类号： C07C235/56 , A61K8/42 , A61K2800/522 , A61Q19/08 , Y02P20/55
摘要： Disclosed is a hydroxybenzamide derivative represented by the following Formula. A method for preparing the same and a cosmetic composition comprising the same are also disclosed. More particularly, the hydroxybenzamide derivative is obtained by reacting a hydroxybenzoic acid having a protecting group introduced thereto with a hydroxyphenyl amine to form a benzamide derivative and by hydrolyzing the benzamide derivative in an aqueous base solution to form a hydroxybenzamide derivative. The cosmetic composition comprising the hydroxybenzamide derivative as an active ingredient has excellent anti-oxidative, anti-aging and skin wrinkle-alleviating effects. wherein R1 represents a C1˜C10 alkyl group, and n is an integer ranging from 1 to 3.
摘要翻译：公开了由下式表示的羟基苯甲酰胺衍生物。还公开了其制备方法和包含其的化妆品组合物。更具体地，羟基苯甲酰胺衍生物通过使具有引入其的保护基的羟基苯甲酸与羟基苯基胺反应形成苯甲酰胺衍生物，并通过在碱性水溶液中水解苯甲酰胺衍生物以形成羟基苯甲酰胺衍生物而获得。包含羟基苯甲酰胺衍生物作为活性成分的化妆品组合物具有优异的抗氧化，抗衰老和抗皱纹作用。其中R1表示C1〜C10烷基，n为1〜3的整数。

14. 发明申请

US20120158042A1 METHOD FOR NECK CARE, AND NECK CARE KIT COMPRISING THE METHOD 有权
标题翻译：用于护理的方法和包含该方法的NECK护理套件
公开(公告)号：US20120158042A1
公开(公告)日：2012-06-21
申请号：US13392192
申请日：2010-08-24
申请人： Ga Young Cho , Eun Joo Kim , Ho Sik Rho , Duck Hee Kim , Han Kon Kim
发明人： Ga Young Cho , Eun Joo Kim , Ho Sik Rho , Duck Hee Kim , Han Kon Kim
IPC分类号： A61H39/04
CPC分类号： A61H99/00 , A61H23/06 , A61H39/04
摘要： Provided are a method for neck care and a neck care kit comprising the method, the method comprising: the step of applying acupressure to a Cheonchu acupoint and then applying acupressure downward along a back neckline from the Cheonchu acupoint; the step of applying acupressure to a Yepung acupoint and then applying acupressure downward along the sternocleidomastoid muscle from the Yepung acupoint to the upper margin of the collarbone; the step of applying acupressure to the upper margin of the collarbone and the decollete region (the upper part of breast); and the step of applying acupressure to the region connecting the low margin of the lower jaw and the neck. The method for neck care is considered to have effects of relieving skin wrinkles, improving blood circulation, relieving tension and giving a pleasant stimulation, thereby enabling various applications in the fields of skin care, cosmetics and medicine.
摘要翻译：提供了一种颈部护理方法和颈部护理套件，其包括该方法，该方法包括：向天u穴位施加指压，然后沿着来自天u穴的背部颈部向下施加指压; 将指压应用于Yepung穴位，然后沿着肩峰乳突肌从Yepung穴向下向锁骨上缘施加指压; 将针灸应用于锁骨和祛斑区域（乳房上部）的上缘的步骤; 以及将指压施加到连接下颚和颈部的低边缘的区域的步骤。认为颈部护理的方法具有减轻皮肤皱纹，改善血液循环，缓解紧张和令人愉快的刺激的作用，从而能够在皮肤护理，化妆品和医药领域中的各种应用。

15. 发明授权

US06410752B1 Tocopherol derivatives and method for preparation thereof 有权
标题翻译：生育酚衍生物及其制备方法
公开(公告)号：US06410752B1
公开(公告)日：2002-06-25
申请号：US09756179
申请日：2001-01-09
申请人： Kil Joong Kim , Duck Hee Kim , Ho Sik Rho , Jae Won You , Chun Ja Nam , Jong Eoun Hong , Hak Hee Kang , Ih Seob Chang
发明人： Kil Joong Kim , Duck Hee Kim , Ho Sik Rho , Jae Won You , Chun Ja Nam , Jong Eoun Hong , Hak Hee Kang , Ih Seob Chang
IPC分类号： C07F906
CPC分类号： C07F9/65522 , A61K8/678 , A61Q19/08
摘要： An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: Wherein, R1, R2 and R3 are H or methyl group, and at least one positions selected from group consisting of the R1, R2 and R3 positions are methyl group; and, A is CH2—CH(CH3)— or CH═C(CH3)— The other object of the present invention is to provide a method for preparing the above tocopherol derivatives. The tocopherol derivatives is prepared by reacting tocopherol with phosphorous oxychloride in an equivalent ratio of 1:1˜1.3, in presence of an organic base, in an organic solvent; reacting the tocopherol dichlorophosphate produced by the above reaction with 3-aminopropanol in presence of an organic base, in an organic solvent; and, hydrolyzing the above products. The tocopherol derivatives according to the present invention can be hydrolyzed by biological enzymes in a living body to produce tocopherol and 3-aminopropane phosphate. And they can induce physiological activities including recovery of injured skin, prevention from aging of bio-membrane, etc. Also, the tocopherol derivatives according to the present invention have improved stability, safety to skin and anti-oxidant effect superior to preceding tocopherol and its derivatives.
摘要翻译：本发明的目的是提供由下式（I）表示的生育酚衍生物及其盐：其中，R1，R2和R3为H或甲基，以及至少一个选自R1 R2和R3位是甲基; 并且A是CH 2 -CH（CH 3） - 或CH = C（CH 3） - 本发明的另一个目的是提供一种制备上述生育酚衍生物的方法。生育酚衍生物通过在有机碱存在下，在有机溶剂中使生育酚与磷酰氯以1：1〜1.3的当量比反应制备; 在有机溶剂中，通过上述反应生成的生育酚二氯磷酸与有机碱存在下的3-氨基丙醇反应; 并且水解上述产物。根据本发明的生育酚衍生物可以通过活体中的生物酶水解以产生生育酚和3-氨基丙烷磷酸酯。它们可以诱导生理活性，包括恢复受伤的皮肤，防止生物膜老化等。此外，根据本发明的生育酚衍生物具有改善的稳定性，对皮肤的安全性和优于前述生育酚的抗氧化作用及其衍生品

16. 发明授权

US09333145B2 Method for neck care, and neck care kit comprising the method 有权
标题翻译：颈部护理方法和包括该方法的颈部护理套装
公开(公告)号：US09333145B2
公开(公告)日：2016-05-10
申请号：US13392192
申请日：2010-08-24
申请人： Ga Young Cho , Eun Joo Kim , Ho Sik Rho , Duck Hee Kim , Han Kon Kim
发明人： Ga Young Cho , Eun Joo Kim , Ho Sik Rho , Duck Hee Kim , Han Kon Kim
IPC分类号： A61H99/00 , A61H39/04 , A61H23/06
CPC分类号： A61H99/00 , A61H23/06 , A61H39/04
摘要： Provided are a method for neck care and a neck care kit comprising the method, the method comprising: the step of applying acupressure to a Cheonchu acupoint and then applying acupressure downward along a back neckline from the Cheonchu acupoint; the step of applying acupressure to a Yepung acupoint and then applying acupressure downward along the sternocleidomastoid muscle from the Yepung acupoint to the upper margin of the collarbone; the step of applying acupressure to the upper margin of the collarbone and the decollete region (the upper part of breast); and the step of applying acupressure to the region connecting the low margin of the lower jaw and the neck. The method for neck care is considered to have effects of relieving skin wrinkles, improving blood circulation, relieving tension and giving a pleasant stimulation, thereby enabling various applications in the fields of skin care, cosmetics and medicine.
摘要翻译：提供了一种颈部护理方法和颈部护理套件，其包括该方法，该方法包括：向天u穴位施加指压，然后沿着来自天u穴的背部颈部向下施加指压; 将指压应用于Yepung穴位，然后沿着肩峰乳突肌从Yepung穴向下向锁骨上缘施加指压; 将针灸应用于锁骨和祛斑区域（乳房上部）的上缘的步骤; 以及将指压施加到连接下颚和颈部的低边缘的区域的步骤。认为颈部护理的方法具有减轻皮肤皱纹，改善血液循环，缓解紧张和令人愉快的刺激的作用，从而能够在皮肤护理，化妆品和医药领域中的各种应用。

17. 发明授权

US06521662B2 Ceramide-like compounds having antioxidant property and a method for preparation thereof, and a cosmetic composition containing the same 有权
标题翻译：具有抗氧化性的神经酰胺类化合物及其制备方法，以及含有该化合物的化妆品组合物
公开(公告)号：US06521662B2
公开(公告)日：2003-02-18
申请号：US09764426
申请日：2001-01-19
申请人： Ho Sik Rho , Duck Hee Kim , Kil Joong Kim , Jae Won You , Hak Hee Kang , Ok Sub Lee , Jong Ho Park , Su Sun An , Eui Dong Son
发明人： Ho Sik Rho , Duck Hee Kim , Kil Joong Kim , Jae Won You , Hak Hee Kang , Ok Sub Lee , Jong Ho Park , Su Sun An , Eui Dong Son
IPC分类号： A61K31355
CPC分类号： C07F9/65522 , A61K8/68 , A61Q19/08 , C07D311/70
摘要： A ceramide-like compound having properties of the natural ceramides are represented by the following formula (I), and a method for producing the same , and a cosmetic composition containing the same as an active ingredient:
摘要翻译：具有天然神经酰胺性质的神经酰胺样化合物由下式（I）表示，及其制备方法和含有该活性成分的化妆品组合物：

18. 发明申请

US20110135773A1 COMPOSITION FOR EXTERNAL SKIN APPLICATION CONTAINING PINE KNOT EXTRACT AND METHOD FOR PREPARATION OF THE SAME 审中-公开
标题翻译：用于含有菠萝提取物的外用皮肤应用的组合物及其制备方法
公开(公告)号：US20110135773A1
公开(公告)日：2011-06-09
申请号：US13001010
申请日：2009-06-23
申请人： Ho Sik Rho , Sujong Kim , Eun Joo Kim , Eunjeong Moon , Gayoung Cho , Sung II Park , Youn Jun Kim , Duck Hee Kim , Han Kon Kim
发明人： Ho Sik Rho , Sujong Kim , Eun Joo Kim , Eunjeong Moon , Gayoung Cho , Sung II Park , Youn Jun Kim , Duck Hee Kim , Han Kon Kim
IPC分类号： A61K8/97 , A61Q19/08
CPC分类号： A61K8/97 , A61K8/0208 , A61Q19/08
摘要： Disclosed is a composition for external skin application for preventing skin aging comprising pine knot extract as an effective ingredient. The composition prevents and improves wrinkles through of skin cell proliferation and collagen biosynthesis, and may be widely applied in the field of skin beauty care and cosmetics.
摘要翻译：公开了一种用于防止皮肤老化的外用皮肤用组合物，其包含松果提取物作为有效成分。该组合物通过皮肤细胞增殖和胶原合成来预防和改善皱纹，并可广泛应用于皮肤美容护理和化妆品领域。

19. 发明授权

US08580964B2 Cinchona-based bifucntional organocatalysts and method for preparing chiral hemiesters using the same 有权
标题翻译：基于Cinchona的双功能有机催化剂和使用其制备手性半成品的方法
公开(公告)号：US08580964B2
公开(公告)日：2013-11-12
申请号：US13008793
申请日：2011-01-18
申请人： Choong Eui Song , Sang Ho Oh , Ho Sik Rho , Ji Woong Lee , Je Wun Lee , Sung Hoon Youk , Jik Chin
发明人： Choong Eui Song , Sang Ho Oh , Ho Sik Rho , Ji Woong Lee , Je Wun Lee , Sung Hoon Youk , Jik Chin
IPC分类号： C07D453/04
CPC分类号： C07D453/04
摘要： The present invention relates to cinchona-based bifunctional organocatalysts and methods for preparing chiral hemiesters using the same. More specifically, the present invention relates to methods for preparing chiral hemiesters from prochiral or meso cyclic acid anhydrides via desymmetrization, using bifunctional cinchona alkaloid catalysts comprising sulfonamide functional groups.
摘要翻译：本发明涉及基于cinchona的双功能有机催化剂以及使用其制备手性半成品的方法。更具体地，本发明涉及使用包含磺酰胺官能团的双官能螯合生物碱催化剂通过去对称制备由前手性或内消旋环酸酐制备手性半酯的方法。

20. 发明申请

US20110311662A1 COSMETIC COMPOSITION FOR SKIN MOISTURISATION COMPRISING PINE-RESIN EXTRACT, PINUS DENSIFLORA NEEDLE EXTRACT AND PINUS DENSIFLORA ROOT EXTRACT 审中-公开
标题翻译：化妆品组合物，包括皮肤提取物，PINUS DENSIFLORA针刺提取物和PINUS DENSIFLORA ROOT提取物的皮肤水分
公开(公告)号：US20110311662A1
公开(公告)日：2011-12-22
申请号：US13203474
申请日：2010-02-25
申请人： Jeong Cheol Ha , Lee Kyoun Kwon , Youn Joon Kim , Ho Sik Rho , Sang Hoon Han
发明人： Jeong Cheol Ha , Lee Kyoun Kwon , Youn Joon Kim , Ho Sik Rho , Sang Hoon Han
IPC分类号： A61K36/15 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00 , A61Q19/007
摘要： The present invention relates to a skin moisturizing cosmetic composition that includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients. More specifically, the present invention includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients, and has advantageous effects of improving moisturizing activity on the skin and enhancing skin texture, skin clearness and skin contour.
摘要翻译：本发明涉及一种皮肤保湿化妆品组合物，其包含松树树脂提取物，松属松提取物和松属根提取物作为活性成分。更具体地说，本发明包括作为活性成分的松树脂提取物，松属松提取物和松属根提取物，并且具有改善对皮肤的保湿活性和增强皮肤纹理，皮肤清晰度和皮肤轮廓的有益效果。

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