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11. 发明授权

US08735568B2 Methods of modulating smooth muscle cell proliferation and differentiation 有权
标题翻译：调节平滑肌细胞增殖和分化的方法
公开(公告)号：US08735568B2
公开(公告)日：2014-05-27
申请号：US13254984
申请日：2010-03-08
申请人： Deepak Srivastava , Kimberly R. Cordes
发明人： Deepak Srivastava , Kimberly R. Cordes
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： A61K35/34 , C12N5/0661 , C12N5/0691 , C12N15/113 , C12N15/85 , C12N2310/113 , C12N2310/141 , C12N2320/32 , C12N2501/65 , C12N2506/02 , C12N2506/45 , C12N2840/007
摘要： The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.
摘要翻译：本公开提供诱导平滑肌细胞分化的方法。本公开提供了包含外源miR-143和/或miR-145核酸的经遗传修饰的细胞; 和包含转基因细胞的人造组织。本公开提供了用于减少病理性血管发生的方法和组合物。本公开提供诱导治疗性血管发生的方法。本公开提供了用于抑制血管平滑肌细胞增殖的方法，组合物和装置。

12. 发明申请

US20120129189A1 Methods of Controlling Cell Proliferation 审中-公开
标题翻译：控制细胞增殖的方法
公开(公告)号：US20120129189A1
公开(公告)日：2012-05-24
申请号：US13383819
申请日：2010-07-16
申请人： Chulan Kwon , Deepak Srivastava
发明人： Chulan Kwon , Deepak Srivastava
IPC分类号： G01N33/567 , C12Q1/37 , G01N33/53 , C12N5/0789 , C12N15/85
CPC分类号： C12N5/0606 , C12N5/0623 , C12N5/0658 , C12N2501/42
摘要： The present disclosure provides methods for increasing self-renewal/expansion of stem cells. The present disclosure provides methods of reducing uncontrolled cell proliferation. The present disclosure provides methods of identifying agents that modulate Notch1/-catenin binding, and methods of identifying agents that inhibit enzyme-mediated cleavage of Notch1 intracellular domain from Notch1 transmembrane domain.
摘要翻译：本公开提供了用于增加干细胞的自我更新/扩增的方法。本公开提供减少不受控制的细胞增殖的方法。本公开提供了鉴定调节Notch1 / - 连环素结合的试剂的方法，以及鉴定抑制Notch1跨膜结构域的Notch1细胞内结构域酶促介导的切割的试剂的方法。

13. 发明申请

US20120093789A1 Methods of Modulating Smooth Muscle Cell Proliferation and Differentiation 有权
标题翻译：调节平滑肌细胞增殖和分化的方法
公开(公告)号：US20120093789A1
公开(公告)日：2012-04-19
申请号：US13254984
申请日：2010-03-08
申请人： Deepak Srivastava , Kimberly R. Cordes
发明人： Deepak Srivastava , Kimberly R. Cordes
IPC分类号： A61K31/7088 , C12N5/10 , A61P9/10 , C07H21/02 , A61P9/00 , C12N5/071 , A61K35/12
CPC分类号： A61K35/34 , C12N5/0661 , C12N5/0691 , C12N15/113 , C12N15/85 , C12N2310/113 , C12N2310/141 , C12N2320/32 , C12N2501/65 , C12N2506/02 , C12N2506/45 , C12N2840/007
摘要： The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.
摘要翻译：本公开提供诱导平滑肌细胞分化的方法。本公开提供包含外源miR-143和/或miR-145核酸的经遗传修饰的细胞; 和包含转基因细胞的人造组织。本公开提供了用于减少病理性血管发生的方法和组合物。本公开提供诱导治疗性血管发生的方法。本公开提供了用于抑制血管平滑肌细胞增殖的方法，组合物和装置。

14. 发明申请

US20110172293A1 Methods and Compositions for Modulating Angiogenesis 审中-公开
标题翻译：调节血管生成的方法和组合
公开(公告)号：US20110172293A1
公开(公告)日：2011-07-14
申请号：US13001604
申请日：2009-07-01
申请人： Jason E. Fish , Deepak Srivastava
发明人： Jason E. Fish , Deepak Srivastava
IPC分类号： A61K31/7088 , C07H21/04 , C12N15/63 , A61P35/00
CPC分类号： C12N15/113 , A61K31/70 , A61K31/7088 , A61K45/06 , C12N2310/11 , C12N2310/141 , C12N2320/30
摘要： The present invention provides compositions comprising antisense nucleic acids that reduce miR-126 levels in an endothelial cell. The present invention provides compositions comprising a target protector nucleic acid. The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to the individual an effective amount of an agent that increases or that decreases the level of miR-126 in endothelial cells of the individual.
摘要翻译：本发明提供包含减少内皮细胞中的miR-126水平的反义核酸的组合物。本发明提供了包含靶标保护核酸的组合物。本发明提供了调节个体血管发生的方法，所述方法通常涉及向个体施用有效量的增加或降低个体内皮细胞中miR-126水平的药剂。

15. 发明授权

US07776816B2 Preserving hypoxic tissue 有权
标题翻译：保存缺氧组织
公开(公告)号：US07776816B2
公开(公告)日：2010-08-17
申请号：US11336237
申请日：2006-01-20
申请人： Deepak Srivastava , Ankur Saxena
发明人： Deepak Srivastava , Ankur Saxena
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A01N1/0226 , A01N1/02 , A61K38/195
摘要： Hypoxic tissue is preserved by prophylactically administering Stromal Derived Factor 1 Alpha (SDF-1α) before hypoxia induces cell death in the tissue.
摘要翻译：缺氧组织在缺氧前预防性施用基质来源因子1α（SDF-1α），在组织中诱导细胞死亡。

16. 发明申请

US20100129915A1 METHODS FOR INDUCING CARDIOMYOGENESIS 审中-公开
标题翻译：诱导心肌细胞发生的方法
公开(公告)号：US20100129915A1
公开(公告)日：2010-05-27
申请号：US12513657
申请日：2007-11-09
申请人： Deepak Srivastava , Chulan Kwon
发明人： Deepak Srivastava , Chulan Kwon
IPC分类号： C12N15/86 , C12N5/02
CPC分类号： C12N5/0657 , C12N2501/415
摘要： The present invention provides methods of inducing cardiomyogenesis and expansion of cardiac progenitors in a population of stem cells or progenitor cells, the methods generally involving inducing a canonical Wnt signaling pathway in the stem cells or progenitor cells. The present invention provides methods of generating a population of cardiomyocytes or cardiac progenitors from a population of stem cells or progenitor cells, the methods generally involving contacting the stem cells or progenitor cells with an agent that induces canonical Wnt signaling. A subject method is useful for generating a population of cardiomyocytes or cardiac progenitors, which can be used in research and therapeutic applications.
摘要翻译：本发明提供了在干细胞或祖细胞群中诱导心脏发生和扩增心脏祖细胞的方法，所述方法通常涉及在干细胞或祖细胞中诱导典型的Wnt信号通路。本发明提供从干细胞或祖细胞群体产生心肌细胞群或心脏祖细胞的方法，所述方法通常包括使干细胞或祖细胞与诱导规范Wnt信号传导的药物接触。主题方法可用于产生心肌细胞或心脏祖细胞群体，其可用于研究和治疗应用。

17. 发明授权

US07718630B2 MicroRNA1 therapies 有权
标题翻译： MicroRNA1疗法
公开(公告)号：US07718630B2
公开(公告)日：2010-05-18
申请号：US12014761
申请日：2008-01-15
申请人： Deepak Srivastava , Chulan Kwon
发明人： Deepak Srivastava , Chulan Kwon
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： G01N33/566 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2330/10 , G01N33/574
摘要： Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.
摘要翻译：通过将miR-1引入细胞中并检测细胞中Delta蛋白表达的减少来减少细胞中的Delta蛋白表达。

18. 发明申请

US20100029501A1 METHOD OF IDENTIFYING MICRO-RNA TARGETS 审中-公开
标题翻译：鉴定微RNA靶标的方法
公开(公告)号：US20100029501A1
公开(公告)日：2010-02-04
申请号：US12496481
申请日：2009-07-01
申请人： Eva Samal , Deepak Srivastava
发明人： Eva Samal , Deepak Srivastava
IPC分类号： C40B30/04 , G01N33/566 , C12Q1/68
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/141 , C12N2320/11 , C12Q1/6837 , C12Q2565/518 , C12Q2525/207
摘要： The present invention provides methods of identifying an mRNA target of a microRNA. The present invention further provides kits and systems for carrying out a subject method.
摘要翻译：本发明提供鉴定微小RNA的mRNA靶标的方法。本发明还提供了用于实施本发明方法的套件和系统。

19. 发明申请

US20080124737A1 MicroRNA1 Therapies 有权
标题翻译： MicroRNA1治疗
公开(公告)号：US20080124737A1
公开(公告)日：2008-05-29
申请号：US12014761
申请日：2008-01-15
申请人： Deepak Srivastava , Chulan Kwon
发明人： Deepak Srivastava , Chulan Kwon
IPC分类号： C12Q1/68
CPC分类号： G01N33/566 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2330/10 , G01N33/574
摘要： Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a reduction of Delta protein expression in the cell.
摘要翻译：通过将miR-1引入细胞并检测细胞中Delta蛋白表达的降低来减少细胞中的Delta蛋白表达。

20. 发明申请

US20060246491A1 Micro-RNA's that regulate muscle cells 失效
公开(公告)号：US20060246491A1
公开(公告)日：2006-11-02
申请号：US11397961
申请日：2006-04-04
申请人： Deepak Srivastava
发明人： Deepak Srivastava
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , A61K48/00 , C12P21/06 , C07K14/705
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/10
摘要： The present invention describes microRNAs that regulate the differentiation, proliferation and death of cardiac and skeletal muscles cells. These molecules represent unique targets in the developmental pathways of muscle cells. They also can be used as active agents to induce differentiation in progenitor cells, and their down-regulation permits the maintenance and expansion of progenitor cell populations.

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