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11. 发明授权

US07141234B1 Imaging of drug accumulation as a guide to antitumor therapy 有权
标题翻译：成像药物积累作为抗肿瘤治疗的指南
公开(公告)号：US07141234B1
公开(公告)日：2006-11-28
申请号：US10088561
申请日：2000-09-21
申请人： Jerry M. Collins , Raymond W. Klecker , Lawrence Anderson
发明人： Jerry M. Collins , Raymond W. Klecker , Lawrence Anderson
IPC分类号： A61K49/00
CPC分类号： A61K51/0491 , A61K51/0417 , A61K51/0421 , A61K51/0455
摘要： The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging. The method is used to monitor delivery of antitumor drugs to tumors and may be used to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radio-labeled drug, e.g. 11C-topotecan and 11C-mitoxantrone. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.
摘要翻译：本发明描述了通过向患者施用放射性标记的抗癌药物并使用正电子发射断层扫描成像对至少一部分患者进行成像的方法来使用放射性标记的抗肿瘤药物来治疗实体瘤。该方法用于监测抗肿瘤药物对肿瘤的递送，并且可用于预测用特定抗肿瘤药物或抗肿瘤药物组合治疗的有效性，以评估细胞积聚调节剂的有效性，个体化治疗和评价抗肿瘤药物对特定癌症的有效性。特别优选的药物是标记的紫杉烷类，例如，11 C-紫杉醇和11 C-多西他赛，标记的蒽环类药物，例如，11-多柔比星和 C-表柔比星和其他放射性标记的药物，例如， C-托泊替康和11-西米托蒽醌。本发明还描述了用放射性标记物11C标记的抗肿瘤药物和制备放射性标记药物的方法。

12. 发明授权

US06682715B2 Nucleosides for imaging and treatment applications 失效
标题翻译：用于成像和治疗应用的核苷
公开(公告)号：US06682715B2
公开(公告)日：2004-01-27
申请号：US09941721
申请日：2001-08-30
申请人： Raymond W. Klecker , Lawrence Anderson , Aspandiar G. Katki , Jerry M. Collins
发明人： Raymond W. Klecker , Lawrence Anderson , Aspandiar G. Katki , Jerry M. Collins
IPC分类号： A61K5100
CPC分类号： C07H21/00 , C07H19/06
摘要： Methods of diagnosing and/or of treating tumors by administering a nucleoside analog which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analog compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.
摘要翻译：通过将由胸苷酸合酶和/或胸苷激酶所激活的核苷类似物施用于诊断或毒性代谢物，以及尿苷类似物化合物及其具有药学上可接受的载体的组合物来诊断和/或治疗肿瘤的方法。对于诊断应用，描述了含有标记的化合物和使用这些化合物的方法。

13. 发明授权

US06677314B2 Nucleosides for imaging and treatment applications 失效
标题翻译：用于成像和治疗应用的核苷
公开(公告)号：US06677314B2
公开(公告)日：2004-01-13
申请号：US09941550
申请日：2001-08-30
申请人： Raymond W. Klecker , Lawrence Anderson , Aspandiar G. Katki , Jerry M. Collins
发明人： Raymond W. Klecker , Lawrence Anderson , Aspandiar G. Katki , Jerry M. Collins
IPC分类号： A01N4304
CPC分类号： C07H21/00 , C07H19/06
摘要： Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described
摘要翻译：通过将由胸苷酸合酶和/或胸苷激酶酶活化的核苷类似物施用于诊断或毒性代谢物，以及尿苷类似物化合物及其具有药学上可接受的载体的组合物来诊断和/或治疗肿瘤的方法。对于诊断应用，描述了含有标记的化合物和使用这些化合物的方法

14. 发明授权

US4240161A Arcuate disc heart valve 失效
标题翻译：弧形心脏瓣膜
公开(公告)号：US4240161A
公开(公告)日：1980-12-23
申请号：US13375
申请日：1979-02-21
申请人： Miles C. Huffstutler, Jr. , Marshall S. Kriesel , Lawrence Anderson
发明人： Miles C. Huffstutler, Jr. , Marshall S. Kriesel , Lawrence Anderson
IPC分类号： A61F2/24 , A61F1/22
CPC分类号： A61F2/2406 , Y10T137/7903
摘要： A free floating pivoting disc heart valve in which the disc has a generally arcuate segment configuration positioned so as to present a generally convex surface toward the outflow side of said base and a generally concave surface toward the inflow side of the base when viewed in the closed configuration.
摘要翻译：一种自由浮动的枢转心脏瓣膜，其中盘具有大致弓形的段构造，其定位成当在闭合状态下观察时呈现朝向所述基部的流出侧的大致凸形表面和朝向底部的流入侧的大致凹入表面组态。

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