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    • 14. 发明授权
    • Amphiphilic networks, implantable immunoisolatory devices, and methods of preparation
    • 两亲网络,可植入免疫隔离装置及其制备方法
    • US06727322B2
    • 2004-04-27
    • US10114647
    • 2002-04-01
    • Joseph P. KennedyIrada S. Isayeva
    • Joseph P. KennedyIrada S. Isayeva
    • C08L5302
    • C08F290/042Y10S514/866
    • The present invention provides high mechanical strength amphiphilic polymeric networks and implantable biological devices made therefrom that are capable of encasing and, thus, immunoisolating biological material from an immunological response of a host individual. The present invention also provides methods for making the amphiphilic networks and implantable biological devices. The present invention also provides a method for the treatment of type I diabetes mellitus comprising the steps of encasing a sufficient amount of islet of Langerhans cells within said biological device, wherein said biological device is capable of immunoisolating said encased islet cells upon implantation into an individual; implanting said biological device into a diabetic host individual; allowing said implanted biological device to remain implanted in said diabetic individual for a time sufficient to normalize the blood glucose level in said diabetic individual.
    • 本发明提供高机械强度两亲性聚合物网络和由其制备的可植入生物装置,其能够包裹并因此免疫分离生物材料免受宿主个体的免疫应答。 本发明还提供了制造两亲网络和可植入生物装置的方法。 本发明还提供了一种治疗I型糖尿病的方法,包括以下步骤:在所述生物装置内​​包含足够量的朗格汉斯细胞胰岛,其中所述生物装置能够在植入个体时对所述包封的胰岛细胞进行免疫隔离 ; 将所述生物学装置植入糖尿病宿主个体中; 允许所述植入的生物装置保持植入所述糖尿病个体中足以使所述糖尿病个体中的血糖水平归一化的时间。