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11. 发明授权

US5559207A Texaphyrin metal complex mediated ester hydrolysis 失效
标题翻译： Texaphyrin金属络合物介导酯水解
公开(公告)号：US5559207A
公开(公告)日：1996-09-24
申请号：US227370
申请日：1994-04-14
申请人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
发明人： Jonathan L. Sessler , Daniel A. Smith , Richard A. Miller , Kevin L. Ross , Meredith Wright , William C. Dow , Vladimir A. Kr al , Brent Iverson , Darren Magda
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/04 , A61L2/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07B61/00 , C07D487/22 , C07F9/06 , C07F9/6558 , C07F9/6561 , C07H21/00 , C07K2/00 , C07F5/00 , C07H3/00 , C07K16/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K41/0076 , A61K49/0021 , A61K49/0036 , A61K49/085 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.
摘要翻译：磷酸酯水解的方法，包括将磷酸酯水溶液与泰克萨菲金属络合物的溶液孵育。金属是具有催化活性的金属阳离子，用于在水溶液中酯键水解，特别是镧系元素金属阳离子，优选Eu（III）或Dy（III）。优选的底物是RNA，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到定点分子，优选寡核苷酸的泰克萨菲林。

12. 发明授权

US07838536B2 Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer 有权
标题翻译：水溶性锌离子载体，锌螯合剂和/或锌络合物，用于治疗癌症
公开(公告)号：US07838536B2
公开(公告)日：2010-11-23
申请号：US12410392
申请日：2009-03-24
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： A61K31/444 , C07D401/02
CPC分类号： C07D213/89 , C07D491/08
摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.
摘要翻译：本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

13. 发明授权

US5714328A RNA photocleavage using texaphyrins 失效
标题翻译：使用泰克萨菲瑞的RNA光切割
公开(公告)号：US5714328A
公开(公告)日：1998-02-03
申请号：US484551
申请日：1995-06-07
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： C07D487/22 , A61K31/40 , A61K31/7125 , A61K31/7135 , A61K41/00 , A61K51/04 , A61P35/00 , C07H21/00 , C07H23/00 , C12N15/09 , C12Q1/65 , A61K48/00 , C07H21/04 , C12Q1/70
CPC分类号： A61K41/0042 , A61K51/0497
摘要： Methods for photocleavage of a polymer of ribonucleic acid using a texaphyrin or a texaphyrin metal complex are provided. A preferred method of use is the site-specific cleavage of a polymer of ribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide. Possible substrates for cleavage include messenger, ribosomal, transfer, small nuclear, and small cytosolic ribonucleic acids, and RNA cofactors, thereby inactivating these ribonucleic acids and providing a multifaceted approach for treating benign or malignant cancer cells, or other undesired cells or tissues.
摘要翻译：提供了使用泰克萨菲瑞或泰克萨菲瑞金属络合物对核糖核酸聚合物进行光切割的方法。优选的使用方法是核糖核酸聚合物的位点特异性切割，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到位点定向分子，优选寡核苷酸的泰克萨菲林。可能的切割底物包括信使，核糖体，转移，小核和小细胞溶质核糖核酸和RNA辅因子，从而使这些核糖核酸失活，并提供治疗良性或恶性癌细胞或其它不想要的细胞或组织的多方面方法。

14. 发明申请

US20110034431A1 WATER-SOLUBLE ZINC IONOPHORES, ZINC CHELATORS, AND/OR ZINC COMPLEXES AND USE FOR TREATING CANCER 有权
标题翻译：水溶性锌离子，锌化合物和/或锌化合物复合物和用于治疗癌症
公开(公告)号：US20110034431A1
公开(公告)日：2011-02-10
申请号：US12905823
申请日：2010-10-15
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： A61K31/555 , C07F3/06 , A61P35/00
CPC分类号： C07D213/89 , C07D491/08
摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.
摘要翻译：本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

15. 发明授权

US07528125B2 Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer 有权
标题翻译：水溶性锌离子载体，锌螯合剂和/或锌络合物，用于治疗癌症
公开(公告)号：US07528125B2
公开(公告)日：2009-05-05
申请号：US11688789
申请日：2007-03-20
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： A61K31/555 , C07F3/06
CPC分类号： C07D213/89 , C07D491/08
摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.
摘要翻译：本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

16. 发明授权

US5837866A Phosphoramidite derivatives of macrocycles 失效
标题翻译：大环的亚磷酰胺衍生物
公开(公告)号：US5837866A
公开(公告)日：1998-11-17
申请号：US862778
申请日：1997-05-23
申请人： Darren Magda , Jonathan L. Sessler , Shaun P. Crofts
发明人： Darren Magda , Jonathan L. Sessler , Shaun P. Crofts
IPC分类号： C07H21/00 , C07D187/22 , C07F7/00 , C07F9/6524
CPC分类号： C07H21/00 , A61K47/48069
摘要： The invention is directed to phosphoramidite derivatives of macrocycles, such as porphyrins and expanded porphyrins, including sapphyrins and texaphyrins. The phosphoramidite derivatives are useful as intermediates in the preparation of macrocycle-oligonucleotide conjugates.
摘要翻译：本发明涉及大环化合物的亚磷酰胺衍生物，例如卟啉和膨胀卟啉，包括卟啉和泰克萨菲。亚磷酰胺衍生物可用作制备大环 - 寡核苷酸共轭物的中间体。

17. 发明授权

US5798491A Multi-mechanistic chemical cleavage using certain metal complexes 失效
标题翻译：使用某些金属络合物进行多机械化学裂解
公开(公告)号：US5798491A
公开(公告)日：1998-08-25
申请号：US458347
申请日：1995-06-02
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： C12N15/09 , A61K31/40 , A61K31/70 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61P31/12 , A61P35/00 , B01J31/18 , C07D487/22 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C07B61/00
CPC分类号： C12N15/113 , A61K41/0038 , A61K41/0042 , A61K41/0076 , A61K47/48069 , A61K49/0021 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/36 , C12N2310/15 , C12N2310/321 , C12N2310/3511
摘要： The invention is directed to a particular class of metal complexes, specifically certain texaphyrin metal complexes, which both hydrolyze and photocleave RNA, and which also both hydrolyze RNA and photocleave DNA. In one embodiment, the present invention is directed to a method for both hydrolyzing and photocleaving a polymer of ribonucleic acid, the method comprising the steps of contacting the polymer of ribonucleic acid with a texaphyrin metal complex exhibiting catalytic activity for both hydrolysis and photocleavage of ribonucleic acid polymers, incubating the polymer and the metal complex under conditions and for a time sufficient to hydrolyze the phosphate ester bond of the polymer, and exposing the texaphyrin metal complex to light for a time sufficient to photocleave the polymer. In another embodiment of the present invention, the invention is directed to a method for both hydrolyzing a polymer of ribonucleic acid and photocleaving a polymer of deoxyribonucleic acid, the method comprising the steps of contacting a mixture of the ribonucleic acid polymer and the deoxyribonucleic acid polymer with a texaphyrin metal complex exhibiting catalytic activity for both hydrolysis of ribonucleic acid polymers and photocleavage of deoxyribonucleic acid polymers, incubating the polymer mixture and the metal complex under conditions and for a time sufficient to hydrolyze the phosphate ester bond of the ribonucleic acid polymer, and exposing the texaphyrin metal complex to light for a time sufficient to photocleave the deoxyribonucleic acid polymer.
摘要翻译：本发明涉及特定类别的金属络合物，特别是某些泰克萨菲瑞金属络合物，它们水解和脱色RNA，并且还水解RNA和光切割DNA。在一个实施方案中，本发明涉及水解和光切割核糖核酸聚合物的方法，所述方法包括以下步骤：使核糖核酸的聚合物与表现出用于核糖核酸的水解和光切割的催化活性的泰克萨菲瑞金属络合物酸性聚合物，在足以水解聚合物的磷酸酯键的条件和时间下孵育聚合物和金属络合物，并将泰克萨菲瑞金属络合物暴露于光下足以使聚合物光滑的时间。在本发明的另一个实施方案中，本发明涉及水解核糖核酸聚合物和光切割脱氧核糖核酸聚合物的方法，该方法包括以下步骤：使核糖核酸聚合物和脱氧核糖核酸聚合物具有表现出对核糖核酸聚合物的水解和脱氧核糖核酸聚合物的光切割的催化活性的特沙弗林金属络合物，在足以水解核糖核酸聚合物的磷酸酯键的条件和时间下孵育聚合物混合物和金属络合物，以及将泰克萨菲芬金属络合物曝光一段足以使脱氧核糖核酸聚合物光滑的时间。

18. 发明授权

US5633354A Phosphoramidite derivatives of texaphyrins 失效
标题翻译：泰克萨菲瑞的亚磷酰胺衍生物
公开(公告)号：US5633354A
公开(公告)日：1997-05-27
申请号：US614638
申请日：1996-03-13
申请人： Darren Magda , Jonathan L. Sessler , Brent L. Iverson , Petra I. Sansom , Shaun P. Crofts
发明人： Darren Magda , Jonathan L. Sessler , Brent L. Iverson , Petra I. Sansom , Shaun P. Crofts
IPC分类号： C07H21/00 , C07F7/00 , C07F9/6524 , C07D187/22
CPC分类号： C07H21/00 , A61K47/48069
摘要： The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.
摘要翻译：本发明涉及在低聚物的化学合成之前，期间或之后掺入膨胀的卟啉，特别是引入卟啉或特沙弗林的方法，以形成发泡的卟啉 - 寡核苷酸缀合物，特别是卟啉 - 或泰克萨菲瑞 - 寡核苷酸缀合物。该方法包括在具有固体支持物的自动或手动DNA合成仪中以期望的顺序使衍生化的核苷酸与泰夫沙弗反应形成卟啉或泰克萨菲瑞 - 寡核苷酸缀合物。

19. 发明授权

US07579338B2 Methods and compositions for treating atheroma, tumors and other neoplastic tissues 有权
标题翻译：治疗动脉粥样硬化，肿瘤和其他肿瘤组织的方法和组合物
公开(公告)号：US07579338B2
公开(公告)日：2009-08-25
申请号：US11465054
申请日：2006-08-16
申请人： Jonathan L. Sessler , Darren Magda , Greg Hemmi , Tarak Mody
发明人： Jonathan L. Sessler , Darren Magda , Greg Hemmi , Tarak Mody
IPC分类号： A61K31/40 , A61K31/409
CPC分类号： A61K9/0019 , A61K41/0038
摘要： The radiation sensitization potential of a candidate compound can be screened by determine its ability to generate one or more reactive oxygen species under appropriate conditions. Compounds determined to have radiation sensitization potential are employed in methods for treating atheroma, tumors and other neoplastic tissue as well as other conditions that typically responsive to radiation sensitization.
摘要翻译：可以通过确定其在合适条件下产生一种或多种活性氧物质的能力来筛选候选化合物的辐射致敏电位。被确定为具有辐射致敏潜能的化合物用于治疗动脉粥样化，肿瘤和其它肿瘤组织以及通常对辐射敏化反应的其它病症的方法。

20. 发明申请

US20090209509A1 WATER-SOLUBLE ZINC IONOPHORES, ZINC CHELATORS, AND/OR ZINC COMPLEXES AND USE FOR TREATING CANCER 有权
标题翻译：水溶性锌离子，锌化合物和/或锌化合物复合物和用于治疗癌症
公开(公告)号：US20090209509A1
公开(公告)日：2009-08-20
申请号：US12410392
申请日：2009-03-24
申请人： Darren Magda , Jonathan L. Sessler
发明人： Darren Magda , Jonathan L. Sessler
IPC分类号： A61K31/315 , C07F3/06
CPC分类号： C07D213/89 , C07D491/08
摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.
摘要翻译：本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

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