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11. 发明授权

US07754455B2 Biocatalytic manufacturing of (meth) acrylylcholine or 2-(N, N-dimethylamino) ethyl (meth) acrylate 失效
标题翻译：（甲基）丙烯酰胆碱或（甲基）丙烯酸2-（N，N-二甲基氨基）乙酯的生物催化制备
公开(公告)号：US07754455B2
公开(公告)日：2010-07-13
申请号：US10591775
申请日：2005-03-09
申请人： Jonathan Hughes , Kenneth Charles Symes
发明人： Jonathan Hughes , Kenneth Charles Symes
IPC分类号： C12P7/62
CPC分类号： C12P13/00 , C12P7/62 , C12P13/001
摘要： A biocatalytic method for the synthesis of 2-(N,N-dimethyl amino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-coA in the presence of a biocatalyst with choline acetyltransferase activity. The acrylyl-CoA and/or the methacrylyl CoA is formed by the reaction of acrylate and/or methacrylate with coenzyme A in the presence of ATP and a biocatalyst with S-acetyl coenzyme A synthetase activity.
摘要翻译：一种用于合成丙烯酸和/或甲基丙烯酸的2-（N，N-二甲基氨基）乙醇和/或胆碱酯的生物催化方法，包括使2-（N，N-二甲基氨基）乙醇和/或胆碱与丙烯酰基 - CoA和/或甲基丙烯酰辅酶A在具有胆碱乙酰转移酶活性的生物催化剂存在下进行。通过丙烯酸酯和/或甲基丙烯酸酯与辅酶A在ATP和具有S-乙酰辅酶A合成酶活性的生物催化剂的存在下的反应形成丙烯酰辅酶A和/或甲基丙烯酰CoA。

12. 发明授权

US07582444B2 Use of flocculating agents for separating the solid residue in hydrolysed fermentation substrates 失效
标题翻译：使用絮凝剂分离水解发酵底物中的固体残余物
公开(公告)号：US07582444B2
公开(公告)日：2009-09-01
申请号：US10523229
申请日：2003-07-28
申请人： Jonathan Hughes
发明人： Jonathan Hughes
IPC分类号： C12P1/00 , C12P13/20
CPC分类号： C13K1/04 , Y02E50/16
摘要： Process for improving the separation efficiency of residual solid matter from the liquid phase of an aqueous acid hydrolysate of a naturally occurring polysaccharide comprising dissolved sugars, and residual acid wherein a flocculating agent(s) is added to the aqueous mixture in an effective amount, and a process of producing fermentation products comprising the steps of, (i) hydrolysing a particulate polysaccharide based plant derived material in an acid medium, and thereby forming an aqueous mixture comprising dissolved sugar and solid matter, (ii) subjecting the aqueous mixture to one or more separation stages in which solid matter are removed from the aqueous phase, (iii) adjusting the pH of the obtained aqueous phase to a pH of at least 4, (iv) fermenting the dissolved sugars of the aqueous phase by a microorganism to produce a fermentation product, (v) isolating the fermentation product, wherein in at least one separation stage in step (ii) a flocculating agent is added to the aqueous mixture in an effective amount.
摘要翻译：用于提高含有溶解糖的天然存在的多糖的酸性水解产物的水相中的残留固体物质的分离效率的方法和其中以有效量向所述含水混合物中加入絮凝剂的残余酸，以及一种生产发酵产物的方法，包括以下步骤：（i）在酸性介质中水解基于多糖的植物衍生物质，从而形成含有溶解的糖和固体物质的水性混合物，（ii）将含水混合物经1或更多的分离阶段，其中从水相中除去固体物质，（iii）将所得水相的pH调节至至少4的pH，（iv）通过微生物发酵水相的溶解糖以产生发酵产物，（v）分离发酵产物，其中在步骤（ii）的至少一个分离阶段中，将絮凝剂加入到水溶液有效的混合物。

13. 发明申请

US20050286117A1 Oaslm and a method and apparatus for driving an oaslm 有权
标题翻译： Oaslm以及用于驱动盎司的方法和装置
公开(公告)号：US20050286117A1
公开(公告)日：2005-12-29
申请号：US10531080
申请日：2003-10-06
申请人： Jonathan Hughes , Stuart Coomber , Carl Brown , Alexander Topping
发明人： Jonathan Hughes , Stuart Coomber , Carl Brown , Alexander Topping
IPC分类号： G02F1/135 , G02F1/141 , G02F1/35
CPC分类号： G02F1/135 , G02F1/141
摘要： A method of controlling the switching of an optically addressable spatial light modulator (OASLM), to a first surface of which a write light signal is applied and to a second surface of which a read light signal is applied. The method comprises applying a bipolar switching waveform to control electrodes of the (OASLM) during each write cycle such that the leading pulse of the waveform applies a voltage across the (OASLM) which is in the photosensitive direction and the trailing pulse applies a voltage which is not in the photosensitive direction.
摘要翻译：一种控制光可寻址空间光调制器（OASLM）切换到施加写入光信号的第一表面和施加读取光信号的第二表面的方法。该方法包括在每个写入周期期间将双极性切换波形施加到（OASLM）的控制电极，使得波形的引导脉冲施加在感光方向上的（OASLM）两端的电压，并且拖尾脉冲施加电压，不在感光方向。

14. 发明申请

US20050271770A1 Production of a fermentation product 失效
标题翻译：生产发酵产品
公开(公告)号：US20050271770A1
公开(公告)日：2005-12-08
申请号：US10523229
申请日：2003-07-28
申请人： Jonathan Hughes
发明人： Jonathan Hughes
IPC分类号： C13K1/04 , A23K1/00
CPC分类号： C13K1/04 , Y02E50/16
摘要： Process for improving the separation efficiency of residual solid matter from the liquid phase of an aqueous acid hydrolysate of a naturally occurring polysaccharide comprising dissolved sugars, and residual acid wherein a flocculating agent(s) is added to the aqueous mixture in an effective amount, and a process of producing fermentation products comprising the steps of, (i) hydrolysing a particulate polysaccharide based plant derived material in an acid medium, and thereby forming an aqueous mixture comprising dissolved sugar and solid matter, (ii) subjecting the aqueous mixture to one or more separation stages in which solid matter are removed from the aqueous phase, (iii) adjusting the pH of the obtained aqueous phase to a pH of at least 4, (iv) fermenting the dissolved sugars of the aqueous phase by a microorganism to produce a fermentation product, (v) isolating the fermentation product, wherein in at least one separation stage in step (ii) a flocculating agent is added to the aqueous mixture in an effective amount.
摘要翻译：用于提高含有溶解糖的天然存在的多糖的酸性水解产物的水相中的残留固体物质的分离效率的方法和其中以有效量向所述含水混合物中加入絮凝剂的残余酸，以及一种生产发酵产物的方法，包括以下步骤：（i）在酸性介质中水解基于多糖的植物衍生物质，从而形成含有溶解的糖和固体物质的水性混合物，（ii）将含水混合物经1或更多的分离阶段，其中固体物质从水相中除去，（iii）将所得水相的pH调节至至少4的pH，（iv）通过微生物发酵水相的溶解糖以产生发酵产物，（v）分离发酵产物，其中在步骤（ii）的至少一个分离阶段中，将絮凝剂加入到水溶液有效的混合物。

15. 发明授权

US06613325B1 Prevention of post surgical adhesions using a fibrin monomer sealant 失效
标题翻译：使用纤维蛋白单体密封剂预防手术后粘连
公开(公告)号：US06613325B1
公开(公告)日：2003-09-02
申请号：US09585030
申请日：2000-06-01
申请人： Michael J. Amery , Paul Sibbons , Stuart Burnett , Sally-Anne Rickets , Peter A. D. Edwardson , Jonathan Hughes , Derek A. Hollingsbee , Stewart A. Cederholm-Williams , Horace R. Trumbull , Herman Eugene Griffin
发明人： Michael J. Amery , Paul Sibbons , Stuart Burnett , Sally-Anne Rickets , Peter A. D. Edwardson , Jonathan Hughes , Derek A. Hollingsbee , Stewart A. Cederholm-Williams , Horace R. Trumbull , Herman Eugene Griffin
IPC分类号： A61K3848
CPC分类号： A61L31/046 , A61K38/363 , A61K38/482 , A61K38/4833 , A61L24/106 , A61K38/00 , A61K35/14 , A61K2300/00
摘要： In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i.e., has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patient's own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e.g., thrombin, etc., which catalyze the cleavage of fibrinopeptides A and/or B from fibrinogen. Preferably a fibrin monomer solution is sprayed over the wounded surgical site.
摘要翻译：根据本发明，已经发现通过将最接近类似于天然凝结材料的材料施加到外科粘连层形成的纤维蛋白聚合物膜。优选的实施方案涉及在聚合条件下将纤维蛋白单体应用于外科伤口部位。出人意料的是，除了这种改进的预防粘连之外，化学天然的凝块，特别是基于纤维蛋白单体的纤维蛋白聚合物，也起到纤维蛋白密封剂的作用，即具有粘附性，提供止血和促进伤口愈合，同时也作为屏障。在优选的实施方案中，本发明的新方法方便地使用衍生自患者自身血液的一种或多种血浆蛋白为自体的。此外，密封剂材料优选基本上不含任何加入或外源的酶，例如凝血酶等，其催化纤维蛋白肽A和/或B从纤维蛋白原的切割。优选地，将纤维蛋白单体溶液喷洒在受伤的外科手术部位上。

16. 外观设计

USD434027S Remote control unit 失效
公开(公告)号：USD434027S
公开(公告)日：2000-11-21
申请号：US111854
申请日：1999-10-04
申请人： Thomas B. Barhold , Jonathan Hughes , Chris Verzulli , Edward Thibault
设计人： Thomas B. Barhold , Jonathan Hughes , Chris Verzulli , Edward Thibault

17. 发明申请

US20100004390A1 BIODEGRADABLE METAL-CHELATING POLYMERS AND VACCINES 审中-公开
标题翻译：生物可降解金属螯合聚合物和疫苗
公开(公告)号：US20100004390A1
公开(公告)日：2010-01-07
申请号：US12437435
申请日：2009-05-07
申请人： William G. Turnell , Zaza D. Gomurashvill , Benjamin W. Parcher , Jonathan Hughes , Jeffrey N. Anderl
发明人： William G. Turnell , Zaza D. Gomurashvill , Benjamin W. Parcher , Jonathan Hughes , Jeffrey N. Anderl
IPC分类号： A61K47/48 , C08G69/44 , C08L77/12
CPC分类号： C08F283/04 , A61K47/593 , A61K47/595 , A61K47/60 , A61K47/6935 , A61K49/0047 , A61K49/0093 , A61K49/128 , C08G69/44 , C08G73/028 , C08L77/12 , C08L79/02
摘要： The invention provides metal-chelating poly(ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution.
摘要翻译：本发明提供了可用于制备用于递送各种货物分子的生物活性剂的聚合物组合物的金属螯合聚（醚酰胺）聚合物。在溶液中，金属离子和货物分子，如疫苗表位，包括金属氨基酸，可加载到聚合物组合物中并保持在非共价复合物中。这种聚合物组合物的纳米颗粒也可以直接从溶液制备。

18. 发明授权

US07582215B2 Production of a fermentation product 失效
标题翻译：生产发酵产品
公开(公告)号：US07582215B2
公开(公告)日：2009-09-01
申请号：US10523301
申请日：2003-07-30
申请人： Jonathan Hughes , Kenneth Charles Symes
发明人： Jonathan Hughes , Kenneth Charles Symes
IPC分类号： B01D37/02
CPC分类号： C02F1/56 , C02F1/5236 , C02F11/121 , C02F11/14 , C02F2101/30 , C02F2103/28 , Y02E50/17
摘要： A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation process for the production of a fermentation product, which liquor comprises water, lignin and BOD, wherein the solids liquid separation stage is assisted by a treatment system, characterised in that the treatment system comprises either, (i) a cationic polymer having an intrinsic viscosity (IV) of at least 4 dl/g at a dose of above 2 kg/tonne based on dry weight of suspension, or (ii) a cationic polymer having an intrinsic viscosity (IV) of at least 4 dl/g and, (iii) an anionic polymer, and/or (iv) a cationic polymer of intrinsic viscosity of below 4 dl/g and a cationic charge density of at least 3 meq/g and/or (v) inorganic coagulants and/or (vi) charged microparticulate material.
摘要翻译：一种通过对液体进行固体 - 液体分离阶段来分离悬浮固体的方法，其中发酵液体在用于生产发酵产物的发酵方法中产生，该液体包含水，木质素和BOD，其中固体液体分离阶段由处理系统辅助，其特征在于处理系统包括：（i）特征粘度（IV）至少为4dl / g的阳离子聚合物，剂量高于2kg / tonne 基于干悬浮液的重量，或（ii）特性粘度（IV）至少为4dl / g的阳离子聚合物，和（iii）阴离子聚合物和/或（iv）特性粘度的阳离子聚合物低于4dl / g和至少3meq / g的阳离子电荷密度和/或（v）无机凝结剂和/或（vi）带电微粒材料。

19. 发明授权

US07575912B2 Strain-of Rhodococcus rhodochrous NCIMB 41164 and its use as producer of nitrile hydratase 有权
标题翻译：菌株Rhodococcus rhodochrous NCIMB 41164及其用作腈水合酶的生产者
公开(公告)号：US07575912B2
公开(公告)日：2009-08-18
申请号：US10580448
申请日：2004-11-22
申请人： Jonathan Hughes , Yvonne Armitage , Jatinder Kullar , Stuart Greenhalgh
发明人： Jonathan Hughes , Yvonne Armitage , Jatinder Kullar , Stuart Greenhalgh
IPC分类号： C12N1/20 , C12N1/00
CPC分类号： C12R1/01 , C12N1/04 , C12N1/20 , C12N9/88 , C12P13/02 , Y10S435/822
摘要： A microorganism which is Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. A method of culturing the microorganism in a culture medium comprising urea or urea derivative is claimed. A nitrite hydratase obtainable from the microorganism is claimed. Also claimed is a process of preparing an amide from the corresponding nitrite wherein the nitrite is subjected to a hydration reaction in an aqueous medium in the presence of a biocatalyst selected from the group consisting of a microorganism which is a Rhodococcus rhodochrous strain NUMB 41164, a mutant thereof and a nitrite hydratase obtainable from Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. Also claimed is a method of storing the Rhodococcus rhodochrous NUMB 41164.
摘要翻译：作为玫瑰色红球菌菌株NCIMB 41164或其突变体的微生物。要求保护在包含尿素或尿素衍生物的培养基中培养微生物的方法。要求从微生物获得的亚硝酸盐水合酶。还要求的是从相应的亚硝酸盐制备酰胺的方法，其中亚硝酸盐在水性介质中在生物催化剂存在下进行水合反应，所述生物催化剂选自由玫瑰色红玫瑰色菌株NUMB 41164，其突变体和可从Rhodococcus rhodochrous strain NCIMB 41164获得的亚硝酸盐水合酶或其突变体。还要求保存红玫瑰色红球菌NUMB 41164的方法。

20. 发明申请

US20070204472A1 Hacksaw 审中-公开
标题翻译：钢锯
公开(公告)号：US20070204472A1
公开(公告)日：2007-09-06
申请号：US11366048
申请日：2006-03-01
申请人： Michael Circosta , Conor McNamara , John Sinisi , Jonathan Hughes
发明人： Michael Circosta , Conor McNamara , John Sinisi , Jonathan Hughes
IPC分类号： B27B21/06
CPC分类号： B23D49/12 , B23D51/12 , B27B21/02
摘要： A hand saw including a housing defining a channel. The channel is adapted to receive a blade having a top edge, a bottom edge and two sides. The hand saw includes at least one bias member positioned adjacent to one of the sides of the blade in the housing and a lever coupled to the bias member. The lever is movable between an open position where the bias member is disengaged from the blade, and a closed position, where the bias member substantially engages at least one of the sides of the blade to secure the blade in the housing.
摘要翻译：手锯包括限定通道的壳体。通道适于接收具有顶部边缘，底部边缘和两侧的叶片。手锯包括邻近壳体中的叶片的一个侧面定位的至少一个偏置构件和联接到偏置构件的杆。杠杆可在偏压构件与叶片脱离的打开位置和关闭位置之间移动，偏压构件基本上接合叶片的至少一侧以将叶片固定在壳体中。

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