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11. 发明授权

US07674812B2 Triple anti-irritant composition 失效
公开(公告)号：US07674812B2
公开(公告)日：2010-03-09
申请号：US12082027
申请日：2008-04-07
申请人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
发明人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
IPC分类号： A61K31/4166 , A61K31/045
CPC分类号： A61K45/06 , A61K31/045 , A61K31/4166 , Y10S514/828 , Y10S514/844 , A61K2300/00
摘要： The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.

12. 发明授权

US07189759B2 Compositions for the treatment of pigmentation disorders and methods for their manufacture 有权
标题翻译：用于治疗色素沉着病症的组合物及其制备方法
公开(公告)号：US07189759B2
公开(公告)日：2007-03-13
申请号：US09864083
申请日：2001-05-23
申请人： Mitchell S. Wortzman , Philip J. Gordon , Eugene H. Gans , Bhiku G. Patel
发明人： Mitchell S. Wortzman , Philip J. Gordon , Eugene H. Gans , Bhiku G. Patel
IPC分类号： A61K31/34 , A61K31/045
CPC分类号： A61Q19/02 , A61K8/23 , A61K8/347 , A61K8/676 , A61K31/02 , A61K31/20 , A61K31/34 , A61K31/375 , A61K45/06 , Y10S514/844 , Y10S514/846 , A61K2300/00
摘要： The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.
摘要翻译：本发明解决了中性pH的氢醌组合物过度变色的问题。氢醌相中的抗氧化剂和酸性抗坏血酸酯，优选偏亚硫酸氢钠和抗坏血酸磷酸镁的无机或氨基酰基阳离子盐分别有效稳定了这些用于治疗色素沉着病症的氢醌组合物。可以将保护的类视色素添加到这些组合物中以获得额外的皮肤益处效果。

13. 发明授权

US06998130B2 Compositions for the treatment of pigmentation disorders and methods for their manufacture 失效
公开(公告)号：US06998130B2
公开(公告)日：2006-02-14
申请号：US10616813
申请日：2003-07-10
申请人： Mitchell S. Wortzman , Philip J. Gordon , Eugene H. Gans , Bhiku G. Patel
发明人： Mitchell S. Wortzman , Philip J. Gordon , Eugene H. Gans , Bhiku G. Patel
IPC分类号： A01N25/34
CPC分类号： A61Q19/02 , A61K8/23 , A61K8/347 , A61K8/676 , A61K31/02 , A61K31/20 , A61K31/34 , A61K31/375 , A61K45/06 , Y10S514/844 , Y10S514/846 , A61K2300/00
摘要： The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.

14. 发明授权

US06765001B2 Compositions and methods for enhancing corticosteroid delivery 有权
标题翻译：促进皮质类固醇输送的组合物和方法
公开(公告)号：US06765001B2
公开(公告)日：2004-07-20
申请号：US10037360
申请日：2001-12-21
申请人： Eugene H. Gans , Mitchell S. Wortzman
发明人： Eugene H. Gans , Mitchell S. Wortzman
IPC分类号： A61K3158
CPC分类号： A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
摘要： The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
摘要翻译：本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。

15. 发明授权

US08232264B2 Compositions and methods for enhancing corticosteroid delivery 有权
标题翻译：促进皮质类固醇输送的组合物和方法
公开(公告)号：US08232264B2
公开(公告)日：2012-07-31
申请号：US12322346
申请日：2009-01-29
申请人： Eugene H. Gans , Mitchell S. Wortzman
发明人： Eugene H. Gans , Mitchell S. Wortzman
IPC分类号： A61K31/58 , A61K31/56 , A61K47/00 , A61K9/00
CPC分类号： A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
摘要： The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
摘要翻译：本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。

16. 发明申请

US20090176750A1 Compositions and methods for enhancing corticosteroid delivery 有权
标题翻译：促进皮质类固醇输送的组合物和方法
公开(公告)号：US20090176750A1
公开(公告)日：2009-07-09
申请号：US12322346
申请日：2009-01-29
申请人： Eugene H. Gans , Mitchell S. Wortzman
发明人： Eugene H. Gans , Mitchell S. Wortzman
IPC分类号： A61K31/573
CPC分类号： A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
摘要： The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
摘要翻译：本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。

17. 发明申请

US20080213409A1 Triple anti-irritant composition 失效
标题翻译：三重抗刺激成分
公开(公告)号：US20080213409A1
公开(公告)日：2008-09-04
申请号：US12082027
申请日：2008-04-07
申请人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
发明人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
IPC分类号： A61K36/886 , A61K31/045 , A61P17/10 , A61P17/00 , A61P17/06 , A61K31/4164
CPC分类号： A61K45/06 , A61K31/045 , A61K31/4166 , Y10S514/828 , Y10S514/844 , A61K2300/00
摘要： The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.
摘要翻译：本发明涉及包含两种或更多种抗氧化剂的组合物，每种抗氧化剂具有至少约7.2％的氧含量。在单独的实施方案中，组合物可以被定义为包括皮肤调理剂，皮肤保护剂和抗刺激剂，其各自具有至少约7.2％的氧含量。本发明还包括通过将组合物施用于皮肤，然后任选地洗涤皮肤来治疗和预防皮肤病症的方法。

18. 发明授权

US07220424B2 Compositions and methods for enhancing corticosteroid delivery 有权
公开(公告)号：US07220424B2
公开(公告)日：2007-05-22
申请号：US10407380
申请日：2003-04-04
申请人： Eugene H. Gans , Mitchell S. Wortzman
发明人： Eugene H. Gans , Mitchell S. Wortzman
IPC分类号： A61K31/56 , A61K47/44
CPC分类号： A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
摘要： The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.

19. 发明授权

US08865194B1 Reducing tackiness and greasiness of petrolatum-like materials 有权
标题翻译：降低凡士林类材料的粘性和油腻性
公开(公告)号：US08865194B1
公开(公告)日：2014-10-21
申请号：US12339411
申请日：2008-12-19
申请人： Eugene H. Gans , Hans R. Suess
发明人： Eugene H. Gans , Hans R. Suess
IPC分类号： A61K8/19 , A61K8/27 , A61K8/31 , A61K8/55 , A61K8/58 , A61K8/92 , A61Q19/00 , A61K8/02
CPC分类号： A61K8/19 , A61K8/0216 , A61K8/27 , A61K8/31 , A61K8/553 , A61K8/585 , A61K8/92 , A61Q19/00
摘要： Skin-protecting ointment compositions are disclosed that include a greasy material, a safe and minimally absorbed solid, and optionally, a phospholipid composition, and that exhibit reduced greasiness and tackiness relative to an otherwise identical composition lacking the safe and minimally absorbed solid and the optional phospholipid composition. Also disclosed are methods of making such skin-protecting ointment compositions. In one embodiment, the skin-protecting ointment composition comprises a safe and minimally absorbed solid, a lipid thickener, an ointment-like material, a volatile oil, and optionally a phospholipid composition. In another embodiment, the method of making the skin-protecting ointment composition comprises combining a greasy material and a safe and minimally absorbed solid, mixing the greasy material and the safe and minimally absorbed solid, optionally adding a phospholipid composition dissolved in a volatile oil, and cooling the combined composition to impede oxidation of the phospholipid composition.
摘要翻译：公开了皮肤保护软膏组合物，其包括油腻材料，安全和最低限度吸收的固体，以及任选的磷脂组合物，并且相对于缺乏安全和最低限度吸收的固体的任何相同的组合物和可选择性地显示出降低的油腻和粘性磷脂组成。还公开了制备这种皮肤保护软膏组合物的方法。在一个实施方案中，皮肤保护软膏组合物包含安全和最低限度吸收的固体，脂质增稠剂，软膏剂类物质，挥发性油和任选的磷脂组合物。在另一个实施方案中，制备皮肤保护软膏组合物的方法包括组合油腻材料和安全和最低限度吸收的固体，混合油腻材料和安全和最少吸收的固体，任选地加入溶于挥发油中的磷脂组合物，并冷却组合的组合物以阻止磷脂组合物的氧化。

20. 发明授权

US07655682B2 Triple anti-irritant composition 失效
标题翻译：三重抗刺激成分
公开(公告)号：US07655682B2
公开(公告)日：2010-02-02
申请号：US10884146
申请日：2004-07-02
申请人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
发明人： Kuljit S. Bhatia , Bhiku G. Patel , Eugene H. Gans
IPC分类号： A61K31/4166 , A61K31/045
CPC分类号： A61K45/06 , A61K31/045 , A61K31/4166 , Y10S514/828 , Y10S514/844 , A61K2300/00
摘要： The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.
摘要翻译：本发明涉及包含两种或更多种抗氧化剂的组合物，每种抗氧化剂具有至少约7.2％的氧含量。在单独的实施方案中，组合物可以被定义为包括皮肤调理剂，皮肤保护剂和抗刺激剂，其各自具有至少约7.2％的氧含量。本发明还包括通过将组合物施用于皮肤，然后任选地洗涤皮肤来治疗和预防皮肤病症的方法。

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