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11. 发明授权

US09012631B2 1,3-oxazolidine-2-one-like compound, preparation method and uses thereof 有权
标题翻译： 1,3-恶唑烷-2-酮样化合物，其制备方法和用途
公开(公告)号：US09012631B2
公开(公告)日：2015-04-21
申请号：US14125944
申请日：2011-08-10
申请人： Si-Qing Wang , Yong Deng , Zai-Xin Chen , Hui Zhang , Zhi-Pei San , Bai-Yang Mao , Zheng-Jun Xia , Long Jiang , Ming-Guang Zhang , Song Lin , Ming-Lin Wang
发明人： Si-Qing Wang , Yong Deng , Zai-Xin Chen , Hui Zhang , Zhi-Pei San , Bai-Yang Mao , Zheng-Jun Xia , Long Jiang , Ming-Guang Zhang , Song Lin , Ming-Lin Wang
IPC分类号： C07D263/20
CPC分类号： C07D263/20
摘要： This invention provides 1,3-oxazolidin-2-one compounds of formula I and their salts, their preparation methods, and use in the preparation of linezolid racemate and its optical isomer, which are used as oxazolidinone antibacterial agents. In the formula, R is H, hydroxyl, halogen, C1-C12 alkyl, C1-C12 alkoxy, nitro and carboxyl; and R can be placed at any position on the benzene rings; and the compound is a racemate or an optical isomer.
摘要翻译：本发明提供式I的1,3-恶唑烷-2-酮化合物及其盐，其制备方法和用于制备作为恶唑烷酮抗菌剂的利奈唑胺外消旋体及其旋光异构体。在该式中，R为H，羟基，卤素，C 1 -C 12烷基，C 1 -C 12烷氧基，硝基和羧基; 并且R可以置于苯环上的任何位置; 该化合物是外消旋物或旋光异构体。

12. 发明授权

US08996503B2 Query plan optimization for prepared SQL statements 有权
标题翻译：用于准备好的SQL语句的查询计划优化
公开(公告)号：US08996503B2
公开(公告)日：2015-03-31
申请号：US12897477
申请日：2010-10-04
申请人： Peter J. Schneider , Hui Zhang
发明人： Peter J. Schneider , Hui Zhang
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30463 , G06F17/30442 , G06F17/30457
摘要： System, methods and articles of manufacture for optimizing a query plan reuse in a database server system accessible by a plurality of client connections. An embodiment comprises providing at least one global cache storage and a private cache storage to a plurality of client connections, and coordinating utilization of the at least one global cache storage and the private cache storage to share light weight stored procedures and query plans for prepared SQL statements across the plurality of client connections via the at least one global cache storage while avoiding a spinlock access for executing the prepared SQL statements.
摘要翻译：用于优化由多个客户端连接可访问的数据库服务器系统中的查询计划重用的系统，方法和制造。一个实施例包括向多个客户端连接提供至少一个全局高速缓冲存储器和专用高速缓冲存储器，以及协调所述至少一个全局缓存存储器和专用高速缓存存储器的利用以共享用于准备的SQL的轻量级存储过程和查询计划通过所述至少一个全局高速缓冲存储器跨越所述多个客户端连接的语句，同时避免用于执行所准备的SQL语句的自旋锁存取。

13. 发明授权

US08979730B2 Method and system for providing behavioural therapy for insomnia 有权
标题翻译：为失眠提供行为治疗的方法和系统
公开(公告)号：US08979730B2
公开(公告)日：2015-03-17
申请号：US13375325
申请日：2010-06-01
申请人： Elke Naujokat , Hui Zhang , Sandrine Magali Laure Devot , William Arthur Hoos , Antonius Arnoldus Johannes Rademaker
发明人： Elke Naujokat , Hui Zhang , Sandrine Magali Laure Devot , William Arthur Hoos , Antonius Arnoldus Johannes Rademaker
IPC分类号： A61M21/02 , A61B5/11 , A61B5/0402 , A61B5/113 , A61B5/00 , G06F19/00 , G06Q50/22 , G09B19/00
CPC分类号： A61B5/1118 , A61B5/0205 , A61B5/0402 , A61B5/1135 , A61B5/4809 , A61B5/4812 , A61B5/4815 , A61B5/6804 , A61B5/6887 , A61B5/7267 , G06F19/00 , G06Q50/22 , G09B19/00 , G16H50/20 , Y02A90/22 , Y02A90/26
摘要： The disclosed system and method provide for the automatic assessment of the presence/severity of the sleep problem and its exact nature. The assessment is based on qualitative information about sleep patterns, insomnia-related factors and daytime consequences, as well as quantitative information about sleep patterns measured by a sensor. By combining the different sources of information (subjective as well as objective data), the diagnosis gives more insight into the nature of the sleep problem and is therefore more accurate. Furthermore, the disclosed system may be used to select specific components of the system that are medically relevant to the individual and therefore create a personalized program. The system teaches a selection of self-management skills that could help the individual to better cope with sleep disturbances and target those factors that maintain the problem or make it worse by a particular individual.
摘要翻译：所公开的系统和方法提供了对睡眠问题的存在/严重性及其确切性质的自动评估。评估是基于关于睡眠模式，失眠相关因素和日间后果的定性信息，以及由传感器测量的睡眠模式的定量信息。通过结合不同的信息来源（主观和客观数据），诊断能够更深入地了解睡眠问题的性质，因此更准确。此外，所公开的系统可以用于选择与个体在医学上相关的系统的特定组件，并因此创建个性化程序。该系统教授了一系列自我管理技能，可帮助个人更好地应对睡眠障碍，并针对那些维持问题的因素或使特定个体变得更糟。

14. 发明授权

US08906947B2 Method for the separation and purification of epothilones 有权
标题翻译：埃坡霉素分离纯化方法
公开(公告)号：US08906947B2
公开(公告)日：2014-12-09
申请号：US12865581
申请日：2008-02-01
申请人： Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
发明人： Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
IPC分类号： C07D493/04 , C07D417/06 , A61K31/427 , A61P35/00
CPC分类号： C07D417/06 , C07D493/04
摘要： The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.
摘要翻译：本发明公开了一种分离和纯化埃坡霉素的方法，特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法，该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物，或将样品与硅胶混合，然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱，最后得到产物。

15. 发明授权

US08775512B1 Distributing information over a network 有权
标题翻译：通过网络分发信息
公开(公告)号：US08775512B1
公开(公告)日：2014-07-08
申请号：US11800413
申请日：2007-05-04
申请人： Ion Stoica , Hui Zhang , Steven R. Mccanne , Jibin Zhan , Aditya R. Ganjam
发明人： Ion Stoica , Hui Zhang , Steven R. Mccanne , Jibin Zhan , Aditya R. Ganjam
IPC分类号： G06F15/173 , G06F15/16
CPC分类号： H04L43/16 , G06Q40/12 , H04L29/0818 , H04L29/08315 , H04L65/60 , H04L67/10 , H04L67/101 , H04L67/104 , H04L67/1063 , H04L67/1085 , H04N21/632
摘要： Distributing information over a network is disclosed. Nodes are grouped into regions. Preferred nodes are designated. A source of content to be delivered to a preferred node using a preferred algorithm is indicated to at least one preferred node. At least one common node is assigned the preferred node as a relay of information.
摘要翻译：公布了通过网络分发信息。节点被分组成区域。首选节点被指定。至少一个优选节点指示要使用优选算法传送到优选节点的内容的源。将至少一个公共节点分配为优选节点作为信息的中继。

16. 发明授权

US08768098B2 Apparatus, method, and medium for generating panoramic image using a series of images captured in various directions 有权
标题翻译：使用在各个方向上捕获的一系列图像产生全景图像的装置，方法和介质
公开(公告)号：US08768098B2
公开(公告)日：2014-07-01
申请号：US11902648
申请日：2007-09-24
申请人： Hui Zhang , Keun-ho Kim , Do-kyoon Kim
发明人： Hui Zhang , Keun-ho Kim , Do-kyoon Kim
IPC分类号： G06K9/40
CPC分类号： G06T3/4038
摘要： Provided are an apparatus, method, and medium for generating a panoramic image. In the apparatus, a previously captured image and a currently captured image are projected onto a predetermined curved surface so as to form a first mapping image and a second mapping image, respectively. Movement values in predetermined directions are calculated for maximizing a color similarity between overlapped sections of the first and second mapping images. A panoramic image is generated using the first and second mapping images and the calculated movement values. Therefore, overlapped sections of neighboring images can be precisely superposed and aligned when a panoramic image is generated using a series of images.
摘要翻译：提供了用于产生全景图像的装置，方法和介质。在该装置中，将先前拍摄的图像和当前拍摄的图像投影到预定的曲面上，以分别形成第一映射图像和第二映射图像。为了最大化第一和第二映射图像的重叠部分之间的颜色相似度，计算预定方向的运动值。使用第一和第二映射图像和所计算的移动值来生成全景图像。因此，当使用一系列图像生成全景图像时，相邻图像的重叠部分可以精确地重叠和对准。

17. 发明申请

US20140106369A1 BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER 有权
标题翻译：生物标志物用于肿瘤前列腺癌
公开(公告)号：US20140106369A1
公开(公告)日：2014-04-17
申请号：US14006503
申请日：2012-03-22
申请人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
发明人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57434
摘要： The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).
摘要翻译：本发明涉及生物标记领域，更具体地涉及可用于诊断侵略性前列腺癌的生物标志物。在具体实施方案中，用于诊断患者中侵袭性前列腺癌的方法包括（a）测量从患者收集的样品中的一种或多种生物标志物的水平; 和（b）将一种或多种生物标志物的水平与与具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平和与不具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平进行比较，其中相关性到其中一个预定义的级别提供诊断。在一个具体的实施方案中，一种或多种生物标志物可以包含组织蛋白酶-L（CTSL），骨膜素，微原纤维相关蛋白4（MFAP4），胶原XII，起泡蛋白，聚集蛋白，嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL），上皮细胞活化分子 EpCAM），前列腺特异性抗原（PSA），膜金属内肽酶（MME）和阿泊菌（ASPN）。

18. 发明授权

US08636836B2 Finned heat exchangers for metal hydride storage systems 有权
标题翻译：金属氢化物储存系统的翅片式换热器
公开(公告)号：US08636836B2
公开(公告)日：2014-01-28
申请号：US13147115
申请日：2010-02-04
申请人： Issam Mudawar , Milan Visaria , Hui Zhang , Timothee Pourpoint
发明人： Issam Mudawar , Milan Visaria , Hui Zhang , Timothee Pourpoint
IPC分类号： F17C13/00 , F25B17/12
CPC分类号： F28F1/12 , C01B3/0031 , F17C11/005 , F28D7/06 , F28D20/003 , F28D2021/0045 , F28F2275/205 , Y02E60/321 , Y02E60/327
摘要： Various apparatus and methods for exchanging heat from a solid to a liquid. Some embodiments pertain to removing heat from a pressure vessel in which a gas absorption reaction is occurring. Yet other embodiments pertain to pressure vessels in which hydrogen is being absorbed into a metal hydride.
摘要翻译：从固体到液体的热交换的各种装置和方法。一些实施方案涉及从发生气体吸收反应的压力容器中除去热量。其他实施方案涉及其中氢被吸收到金属氢化物中的压力容器。

19. 发明申请

US20130287286A1 Methods and Systems for Modifying a Parameter of an Automated Procedure 有权
公开(公告)号：US20130287286A1
公开(公告)日：2013-10-31
申请号：US13978344
申请日：2012-01-06
申请人： Gabriele Zingaretti , Mohan Bodduluri , Miguel G. Canales , Brian E. Tippett , Hui Zhang
发明人： Gabriele Zingaretti , Mohan Bodduluri , Miguel G. Canales , Brian E. Tippett , Hui Zhang
IPC分类号： G06T7/00
CPC分类号： A61B34/30 , A45D26/00 , A61B17/3468 , A61B34/20 , A61B90/37 , A61B2017/00203 , A61B2017/00207 , A61B2017/00752 , A61B2017/00969 , A61B2034/743 , G06T7/0004
摘要： A variety of systems and methods are described which enable quantitative information to be extracted regarding automated procedures, including those performed at a high speed that may require a user input, without having to interrupt the procedure. In addition, these systems and methods serve to provide information on one or more parameters of the automated procedure, whereby they may be modified, if required, to improve the automated procedure or the results from such a procedure. The systems and methods provided are especially useful in automated hair transplantation procedures.

20. 发明授权

US08560693B1 Method of and system for allocating resources to resource requests based on application of persistence policies 有权
公开(公告)号：US08560693B1
公开(公告)日：2013-10-15
申请号：US11924511
申请日：2007-10-25
申请人： Wei Wang , Hui Zhang , Erik De La Iglesia , Ricky K. Lowe , Kiet Tran , Mark Aaron Wallace
发明人： Wei Wang , Hui Zhang , Erik De La Iglesia , Ricky K. Lowe , Kiet Tran , Mark Aaron Wallace
IPC分类号： G06F15/16
CPC分类号： H04L12/66 , H04L12/4625 , H04L69/40
摘要： A system for and method of allocating a resource to a service request based on application of a persistence policy is described. In one embodiment, upon or after allocation of a resource to a resource request, an entry representing the allocation is made in a data structure using a first index derived from information relating to the resource request if such is available. An entry representing the allocation is also made in the data structure using a second index derived from information relating to the resource request. When a resource request is received, the data structure is accessed using the first index if such is available. If an entry corresponding to the first index is available, the resource corresponding to the entry is allocated to the request. If the first index or an entry corresponding to the first index is unavailable, the data structure is accessed using the second index. If an entry corresponding to the second index is available, the resource corresponding to the entry is allocated to the request. If an entry corresponding to the second index is unavailable, a resource is allocated to the request based on application of a load balancing policy or other persistence policy. One or more entries are then made in the table corresponding to the new allocation.

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