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11. 发明授权

US06365726B1 Polynucleotides encoding IL-1 Hy2 polypeptides 失效
标题翻译：编码IL-1 Hy2多肽的多核苷酸
公开(公告)号：US06365726B1
公开(公告)日：2002-04-02
申请号：US09578458
申请日：2000-05-22
申请人： Dennis G. Ballinger , John Ford , Alice Suk-Yue Ho , Hai Shan Lin , Ann M. Pace
发明人： Dennis G. Ballinger , John Ford , Alice Suk-Yue Ho , Hai Shan Lin , Ann M. Pace
IPC分类号： C07H2104
CPC分类号： C07K14/54 , A61K38/00
摘要： The present invention provides novel nucleic acids encoding IL-1 Hy2, a novel member of the Interleukin-1 Receptor Antagonist family, the novel polypeptides encoded by these nucleic acids and uses of these and related products.
摘要翻译：本发明提供编码IL-1 Hy2的新型核酸，白细胞介素-1受体拮抗剂家族的新成员，由这些核酸编码的新型多肽及其用途及相关产品。

12. 发明授权

US4762144A Valve cover apparatus 失效
标题翻译：阀盖装置
公开(公告)号：US4762144A
公开(公告)日：1988-08-09
申请号：US26545
申请日：1987-02-27
申请人： John Ford
发明人： John Ford
IPC分类号： F16K27/08 , F16K31/60
CPC分类号： F16K31/60 , F16K27/08 , Y10T137/7043 , Y10T137/7065
摘要： A cover for a valve (10) has a housing (20) mounting internally a component (24), with a collet (28) being located with play through an open end of the component (24). Resiliently deformable jaws (36) of the collet (28) co-operate with a profiled inner wall of the component (24) for opening and closing of the jaws (36) upon axial movement of the collet (28) relative to the component (24). When positioned on a stem (12, 14) of the valve (10), the cover is movable downwardly thereon to operate the valve and is freely rotatable, but on movement upwardly the cover is clamped by closing of the jaws (36) on the stem (12, 14). The housing (20) is formed of a material with a high degree of resistance to vandalism.
摘要翻译： PCT No.PCT / GB86 / 00379 Sec。 371日期1987年2月27日 102（e）日期1987年2月27日PCT Filed 1986年6月27日PCT公布。公开号WO87 / 00255 1987年1月15日。一种阀（10）的盖具有安装在组件（24）内部的壳体（20），其中夹头（28）通过组件（24）的开口端定位。夹头（28）的弹性可变形的夹爪（36）与零件（24）的成型内壁配合，用于在夹头（28）相对于部件（28）的轴向移动时打开和关闭夹爪（36） 24）。当定位在阀（10）的杆（12,14）上时，盖可向下移动以操作阀并且可自由旋转，但是在向上移动时，盖通过关闭阀（6）上的夹爪（36）而被夹紧茎（12,14）。壳体（20）由具有高度抗破坏性的材料形成。

13. 发明授权

US09216992B2 Thieno[3,2-c]pyridine potassium channel inhibitors 有权
标题翻译：噻吩并[3,2-c]吡啶钾通道抑制剂
公开(公告)号：US09216992B2
公开(公告)日：2015-12-22
申请号：US11635786
申请日：2006-12-08
申请人： John Ford , David John Madge , Helen Jane Payne , Jamie David Knight
发明人： John Ford , David John Madge , Helen Jane Payne , Jamie David Knight
IPC分类号： C07D495/04 , A61K31/4365
CPC分类号： C07D495/04
摘要： The present invention provides thienopyridine compounds which are potassium channel inhibitors. In another embodiment, the invention provides pharmaceutical compositions comprising thienopyridines. In another embodiment, the invention provides methods of using thienopyridines in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and inflammatory diseases, including gastric cancer, atrial fibrillation, type-2 diabetes mellitus, rheumatoid arthritis, type-1 diabetes, inflammatory bowel disorder and demyelinating disorders such as multiple sclerosis.
摘要翻译：本发明提供作为钾通道抑制剂的噻吩并吡啶化合物。在另一个实施方案中，本发明提供了包含噻吩并吡啶的药物组合物。在另一个实施方案中，本发明提供了使用噻吩并吡啶治疗或预防癌症，心律失常，自身免疫性疾病和炎性疾病的方法，包括胃癌，心房颤动，2型糖尿病，类风湿性关节炎，1型糖尿病，炎性肠紊乱和脱髓鞘疾病如多发性硬化。

14. 发明授权

US08578926B2 Self-heating systems and methods for rapidly heating a comestible substance 有权
标题翻译：用于快速加热食用物质的自加热系统和方法
公开(公告)号：US08578926B2
公开(公告)日：2013-11-12
申请号：US12719774
申请日：2010-03-08
申请人： John Ford , Douglas Lund
发明人： John Ford , Douglas Lund
IPC分类号： F24J1/00
CPC分类号： B65B3/04 , A23L5/10 , A47J36/28 , B65B7/2835 , B65D51/20 , B65D81/3484 , B65D2543/00046 , F24V30/00
摘要： Self-heating containers comprise a reaction chamber and a heating chamber. The heating chamber is sized to contain a substance to be heated. The reaction chamber contains reactants which, when contacted, exothermically react. The reaction chamber is divided into a first compartment and a second compartment with a barrier therebetween. The barrier comprises a first barrier portion and a second barrier portion. The first barrier portion is attached to a reaction chamber wall and has an opening sized to allow reactants to flow through from one compartment to the other. The second barrier portion is attached to the first barrier portion to close the opening. The barrier can be opened by moving an actuator into engagement with the second barrier portion to dislodge the second barrier portion from the first barrier portion and thereby open the barrier. In certain embodiments, the heating chamber can be a can with prepackaged comestible substance therein. Examples of components configured to facilitate such a can are disclosed.
摘要翻译：自加热容器包括反应室和加热室。加热室的大小适于容纳待加热物质。反应室含有当接触时放热反应的反应物。反应室被分成第一隔室和第二隔室，隔室之间具有阻挡层。阻挡层包括第一阻挡部分和第二阻挡部分。第一阻挡部分连接到反应室壁上，并且具有一定尺寸以允许反应物从一个隔室流过另一隔室的开口。第二阻挡部分附接到第一阻挡部分以封闭开口。可以通过将致动器移动到与第二阻挡部分接合以将第二阻挡部分从第一阻挡部分移开并从而打开阻挡物来打开阻挡物。在某些实施方案中，加热室可以是其中预包装的可食物质的罐。公开了配置成便于这种罐的部件的例子。

15. 发明授权

US08258138B2 Potassium channel blockers 有权
标题翻译：钾通道阻滞剂
公开(公告)号：US08258138B2
公开(公告)日：2012-09-04
申请号：US12550805
申请日：2009-08-31
申请人： Derek Edward John , Mushtaq Mulla , Richard John Hamlyn , Simon Mark Jones , Derek Roland Pollard , Basil Hartzoulakis , Helen Payne , David Madge , John Ford
发明人： Derek Edward John , Mushtaq Mulla , Richard John Hamlyn , Simon Mark Jones , Derek Roland Pollard , Basil Hartzoulakis , Helen Payne , David Madge , John Ford
IPC分类号： A61K31/41 , C07D207/00
CPC分类号： C07D295/18 , C07D207/12 , C07D211/10 , C07D211/16 , C07D211/22 , C07D211/48 , C07D211/52 , C07D217/20 , C07D231/18 , C07D233/84 , C07D241/04 , C07D265/30 , C07D277/36 , C07D307/64 , C07D311/58 , C07D333/34
摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives wherein R1, R2, R3, X1, and A are defined herein. The compounds are useful as potassium ion channel inhibitors.
摘要翻译：本发明提供式（I）化合物或其盐或药学上可接受的衍生物，其中R 1，R 2，R 3，X 1和A如本文所定义。该化合物可用作钾离子通道抑制剂。

16. 发明申请

US20100227027A1 SELF-HEATING SYSTEMS AND METHODS FOR RAPIDLY HEATING A COMESTIBLE SUBSTANCE 有权
标题翻译：自助加热系统和方法快速加热可触及的物质
公开(公告)号：US20100227027A1
公开(公告)日：2010-09-09
申请号：US12400730
申请日：2009-03-09
申请人： John Ford , Douglas Lund
发明人： John Ford , Douglas Lund
IPC分类号： B65D81/34 , B65B3/04
CPC分类号： F24V30/00 , A47J36/28 , B23P11/00 , B65D81/3484 , C09K5/18 , Y10T29/49826
摘要： Self-heating containers comprise a reaction chamber and a heating chamber. The heating chamber is sized to contain a substance to be heated. The reaction chamber contains reactants which, when contacted, exothermically react. The reaction chamber is divided into a first compartment and a second compartment with a barrier therebetween. The barrier comprises a first barrier portion and a second barrier portion. The first barrier portion is attached to a reaction chamber wall and has an opening sized to allow reactants to flow through from one compartment to the other. The second barrier portion is attached to the first barrier portion to close the opening. The barrier can be opened by moving an actuator into engagement with the second barrier portion to dislodge the second barrier portion from the first barrier portion and thereby open the barrier.
摘要翻译：自加热容器包括反应室和加热室。加热室的大小适于容纳待加热物质。反应室含有当接触时放热反应的反应物。反应室被分成第一隔室和第二隔室，隔室之间具有阻挡层。阻挡层包括第一阻挡部分和第二阻挡部分。第一阻挡部分连接到反应室壁上，并且具有一定尺寸以允许反应物从一个隔室流过另一隔室的开口。第二阻挡部分附接到第一阻挡部分以封闭开口。可以通过将致动器移动到与第二阻挡部分接合以将第二阻挡部分从第一阻挡部分移开并从而打开阻挡物来打开阻挡物。

17. 发明授权

US07691373B2 Isolated mammalian membrane proteins; related agents 有权
标题翻译：分离的哺乳动物膜蛋白; 相关代理商
公开(公告)号：US07691373B2
公开(公告)日：2010-04-06
申请号：US11620440
申请日：2007-01-05
申请人： Jenny Valladeau , Odile Ravel , Elizabeth Esther Mary Bates , John Ford , Sem Saeland , Serge J. E. Lebecque
发明人： Jenny Valladeau , Odile Ravel , Elizabeth Esther Mary Bates , John Ford , Sem Saeland , Serge J. E. Lebecque
IPC分类号： A61K39/395 , A61K39/00 , A61K39/38
CPC分类号： C07K14/705 , C07K14/7056 , C07K16/28 , C07K2317/77
摘要： Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译：描述了编码来自哺乳动物的各种淋巴细胞蛋白的核酸，包括与其相关的灵长类动物，包括特异性抗体的试剂和纯化的蛋白质。还提供了使用所述试剂和相关诊断试剂盒的方法。

18. 发明授权

US07672422B2 Radiation scanning of objects for contraband 失效
标题翻译：违禁物品的辐射扫描
公开(公告)号：US07672422B2
公开(公告)日：2010-03-02
申请号：US12151362
申请日：2008-05-06
申请人： Edward J. Seppi , Marcel Marc , John Ford
发明人： Edward J. Seppi , Marcel Marc , John Ford
IPC分类号： G01N23/00
CPC分类号： G01V5/005 , G01N23/04 , G01N2223/423 , G01T1/2985
摘要： Systems and methods for the radiation scanning of objects, including large objects such as cargo containers, to identify contraband.
摘要翻译：用于物体辐射扫描的系统和方法，包括大型物体，如货物集装箱，以识别违禁品。

19. 发明授权

US07576212B2 Thieno[2,3-B] pyridines as potassium channel inhibitors 失效
标题翻译：噻吩并[2,3-B]吡啶作为钾通道抑制剂
公开(公告)号：US07576212B2
公开(公告)日：2009-08-18
申请号：US11297330
申请日：2005-12-09
申请人： John Ford , Nicholas John Palmer , John Frederick Atherall , David John Madge , Derek John
发明人： John Ford , Nicholas John Palmer , John Frederick Atherall , David John Madge , Derek John
IPC分类号： C07D513/02
CPC分类号： C07D495/04 , C07D333/36 , C07D333/38 , C07D409/12
摘要： The invention provides compounds of the formula: wherein R1 is aryl, heteroaryl, cycloalkyl or alkyl; R2 is H, alkyl, nitro, CO2R7, CONR5R6 or halo; R3 and R4 are H, NR5R6, NC(O)R7, halo, trifluromethyl, alkyl, CONR5R6, CO2R7, nitrile or alkoxy; R5 and R6 may be the same or different and may be H, alkyl, aryl, heteroaryl or cycloalkyl; or R5 and R6 may together form a saturated, unsaturated or partially saturated 4 to 7 member ring, wherein said ring may optionally comprise one or more further heteroatoms selected from N, O or S; R7 is H or alkyl; A is H, halo, or a group of formula X-L-Y; X is O, S or NR8; R8 is H or alkyl; L is (CH2)n, where n is 0, 1, 2, 3 or 4; and Y is aryl, a heterocyclic group, alkyl, alkenyl or cycloalkyl; the products of mono- and di-oxidation of sulphur and/or mono-oxidation of nitrogen moieties in compounds of formula I; or a pharmaceutically acceptable salt thereof. These compounds find use as inhibitors of potassium ion channels and thus are useful in the treatment of various conditions including arrhythmia and type-2 diabetes mellitus.
摘要翻译：本发明提供下式的化合物：其中R1是芳基，杂芳基，环烷基或烷基; R2是H，烷基，硝基，CO 2 R 7，CONR 5 R 6或卤素; R3和R4是H，NR5R6，NC（O）R7，卤素，三氟甲基，烷基，CONR5R6，CO2R7，腈或烷氧基; R5和R6可以相同或不同，可以是H，烷基，芳基，杂芳基或环烷基; 或R 5和R 6可以一起形成饱和的，不饱和的或部分饱和的4至7元环，其中所述环可任选地包含一个或多个选自N，O或S的其它杂原子; R7是H或烷基; A是H，卤素或式X-L-Y基团; X是O，S或NR8; R8是H或烷基; L是（CH 2）n，其中n是0,1,2,3或4; Y为芳基，杂环基，烷基，链烯基或环烷基; 式I化合物中硫的单和二氧化和/或氮部分的单氧化的产物; 或其药学上可接受的盐。这些化合物可用作钾离子通道的抑制剂，因此可用于治疗各种病症，包括心律失常和2型糖尿病。

20. 发明授权

US07541181B2 Vector carrying a polynucleotide which encodes a GSD polypeptide from Mycobacterium paratuberculosis 有权
标题翻译：携带编码来自副结核分枝杆菌的GSD多肽的多核苷酸的载体
公开(公告)号：US07541181B2
公开(公告)日：2009-06-02
申请号：US11435142
申请日：2006-05-17
申请人： John Hermon-Taylor , Tim Doran , Douglas Millar , Mark Tizard , Mark Loughlin , Nazira Sumar , John Ford
发明人： John Hermon-Taylor , Tim Doran , Douglas Millar , Mark Tizard , Mark Loughlin , Nazira Sumar , John Ford
IPC分类号： C12N15/00 , C12N1/21 , C12N15/86 , C12N15/74 , C07H21/04 , C07H21/02
CPC分类号： C07K14/35 , A61K38/00
摘要： The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.
摘要翻译：本发明提供了表示在致病性分枝杆菌种中发现的致病性岛的核苷酸序列。这些岛被显示为SEQ ID NO：3和4，并且包含编码多肽的几个开放阅读框。这些多肽及其在诊断和治疗中的用途形成本发明的另一方面。

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