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    • 14. 发明授权
    • Refractory period tracking and arrhythmia detection
    • 难治期跟踪和心律失常检测
    • US07184832B2
    • 2007-02-27
    • US10680528
    • 2003-10-07
    • D. Curtis DenoRuth N. KlepferWilliam J. HavelDavid M. SchneiderVincent E. Splett
    • D. Curtis DenoRuth N. KlepferWilliam J. HavelDavid M. SchneiderVincent E. Splett
    • A61N1/365
    • A61N1/365A61N1/3622
    • Techniques and apparatus for estimating the temporal refractory period of a heart, for adjusting a parameter for delivery of extra-systolic stimulation (ESS) therapy and for detecting an arrhythmia during delivery of ESS therapy In some aspects, probe pulses are periodically delivered to estimate the location of the end boundary of the refractory period, and accordingly estimate its length. In some embodiments, the parameter is adjusted based on estimated length of the refractory period. For example, an extra-systolic interval (ESI) for delivery of ESS is adjusted to be a fixed interval longer than estimated lengths of the refractory period. In other aspects, the parameter is adjusted based on a measured delay (or latency) between delivery of an ESS pulse and detection of an evoked response resulting from the pulse. Also, delays between delivery of an ESS pulse and detection of a subsequent depolarization are monitored to detect an arrhythmia.
    • 用于估计心脏的时间不应期的技术和装置,用于调整用于递送收缩期刺激(ESS)治疗的参数和用于在递送ESS治疗期间检测心律失常的一些方面,定期递送探针脉冲以估​​计 不应期结束边界的位置,并据此估计其长度。 在一些实施例中,基于估计的不应期的长度来调整参数。 例如,用于递送ESS的收缩期间期(ESI)被调整为比不应期的估计长度更长的固定间隔。 在其他方面,基于在递送ESS脉冲和从脉冲产生的诱发响应的检测之间的测量延迟(或等待时间)来调整参数。 此外,监测递送ESS脉冲和检测随后的去极化之间的延迟以检测心律失常。