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11. 发明授权

US08013010B2 5-thioxylopyranose compounds 失效
标题翻译： 5-硫代羟基吡喃糖化合物
公开(公告)号：US08013010B2
公开(公告)日：2011-09-06
申请号：US12411765
申请日：2009-03-26
申请人： Véronique Barberousse , Didier Thomas , Michel Bondoux
发明人： Véronique Barberousse , Didier Thomas , Michel Bondoux
IPC分类号： A61K31/382 , C07D335/02
CPC分类号： C07H15/203
摘要： Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.
摘要翻译： 5-硫代羟基吡喃糖的化合物，优选5-硫代吡喃葡萄糖型的衍生物，制备这些化合物的方法，以及这些化合物作为有效成分在药物组合物中的用途，其特别用于治疗或抑制血栓形成或心力衰竭或血栓栓塞性疾病状态。

12. 发明授权

US07652032B2 5-Thioxylopyranose compounds 有权
标题翻译： 5-硫代番茄红素化合物
公开(公告)号：US07652032B2
公开(公告)日：2010-01-26
申请号：US12352382
申请日：2009-01-12
申请人： Didier Thomas , Michel Bondoux , Véronique Barberousse , Vincent Peyrou
发明人： Didier Thomas , Michel Bondoux , Véronique Barberousse , Vincent Peyrou
IPC分类号： A61K31/4355 , C07D498/04
CPC分类号： C07H1/00 , C07H17/00
摘要： 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.
摘要翻译： 5-硫代羟基化合物，特别是5-羟基吡喃糖化合物，其制备方法及其用于治疗和/或抑制血栓形成，特别是静脉血栓形成的用途。化合物对应于式I：其中五草酰基代表游离或取代的5-硫代-β-D-吡喃木糖基; R'，R“和R”'各自独立地表示氢原子，C 2 -C 6酰基或其两个相邻的一个形成1-甲基亚乙基桥; X1和X2各自表示碳或氮; Y1和Y2各自独立地表示碳，氮，硫或氧，条件是如果Y2表示氧或硫，则Y1表示碳或氮; R 1，R 2，R 3，R 4和R 5各自独立地表示氢，COOR 6基团，其中R 6表示氢或任选被苯环，卤素原子或-COOR 6基团取代的C 1 -C 4烷基; C1-C4烷氧基; C1-C6酰基; 苯甲酰基或苯环; 和这些化合物的加成盐和/或活性代谢物。

13. 发明申请

US20060025589A1 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes 审中-公开
标题翻译： 2-硫代乙内酰脲衍生物及其用于治疗糖尿病的用途
公开(公告)号：US20060025589A1
公开(公告)日：2006-02-02
申请号：US10529817
申请日：2003-10-03
申请人： Jean Binet , Benaissa Boubia , Evelyne Chaput , Alan Edgar , Khan Ou , Philippe Ratel , Soth Samreth , Didier Thomas
发明人： Jean Binet , Benaissa Boubia , Evelyne Chaput , Alan Edgar , Khan Ou , Philippe Ratel , Soth Samreth , Didier Thomas
IPC分类号： C07D413/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/04 , C07D233/86 , C07D401/12 , C07D405/04
摘要： The invention relates to 2-thiohydantoin compounds selected from compounds of general formula (I): in which, in particular, one of the radicals R1 and R2 comprises two aromatic rings in the structure or is the dibenzofuranyl group, R3 is a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a hydroxyl group, a phenyl group or a benzyl group, R4 is a hydrogen atom, a halogen atom or a C1-C4 alkyl group, and their addition salts with a non-toxic acid, especially the pharmaceutically acceptable salts. It further relates to the process for their preparation, to the pharmaceutical compositions in which they are present, and to their use as pharmacologically active substances, especially in the case of the treatment of diabetes, diseases due to hyperglycemia, hypertriglyceridemia, dyslipidemia or obesity.
摘要翻译：本发明涉及选自通式（I）的化合物的2-硫代乙内酰脲化合物：其中特别地，基团R 1和R 2中的一个包含两个芳族结构中的环或是二苯并呋喃基，R 3是氢原子，卤素原子，C 1 -C 4烷基 C 1 -C 4烷氧基，羟基，苯基或苄基，R 4是氢原子，卤素原子或C 1 -C 4烷基，以及它们与无毒酸，特别是药学上可接受的盐的加成盐。其进一步涉及其制备方法，其存在的药物组合物及其作为药理活性物质的用途，特别是在治疗糖尿病，由于高血糖症，高甘油三酯血症，血脂异常或肥胖症引起的疾病的情况下。

14. 发明授权

US06422293B1 Method and installation for low pressure die casting in a mould ceramic casting die 失效
标题翻译：低温压铸在模具陶瓷铸造模具中的方法和安装
公开(公告)号：US06422293B1
公开(公告)日：2002-07-23
申请号：US09380463
申请日：1999-11-18
申请人： Jean-Louis Comarteau , Christophe Liebaut , Alain Reny , Didier Thomas
发明人： Jean-Louis Comarteau , Christophe Liebaut , Alain Reny , Didier Thomas
IPC分类号： B22D1804
CPC分类号： B22D18/04
摘要： Placed in a box (1) is a ceramic shell (21) delimiting a casting space (22), the shell being surrounded by a mass of binder-free sand (23). The casting space is connected to a source (4) of liquid metal located underneath, in which are applied, in succession, a pressure (P1) bringing the liquid to the threshold of the casting space (22), a pressure (P2) slightly greater than that necessary for filling this space, and then a marked overpressure (P3); finally, the pressure is brought back down to the first value (P1). When the casting space has been filled, an underpressure is created in the space containing the mass of sand (23) in order to prevent any deformation of the shell (21) due to the overpressure (P3), at least until the formation of a metal skin against the shell and at most until the start of the reduction in the overpressure in the source (4) of liquid metal.
摘要翻译：放置在箱体（1）中的陶瓷壳体（21）限定了铸造空间（22），壳体被大量的无粘合剂砂（23）包围。铸造空间连接到位于下方的液态金属源（4），其中连续施加将液体提供到铸造空间（22）的阈值的压力（P1），稍微压力（P2）大于填充该空间所需的量，然后超过明显的超压（P3）; 最后，将压力恢复到第一个值（P1）。当铸造空间已经被填充时，在包含沙子（23）的空间中产生负压，以便防止壳体（21）由于过压（P3）而导致的任何变形，至少直到形成金属皮肤抵抗壳体，至多直到液态金属源（4）中的超压开始减少。

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